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| 2. |
- Olofsson, A M, et al.
(author)
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Heparin-binding protein targeted to mitochondrial compartments protects endothelial cells from apoptosis
- 1999
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In: Journal of Clinical Investigation. - 0021-9738. ; 104:7, s. 885-894
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Journal article (peer-reviewed)abstract
- Neutrophil-borne heparin-binding protein (HBP) is a multifunctional protein involved in the progression of inflammation. HBP is stored in neutrophil granules and released upon stimulation of the cells in proximity to endothelial cells. HBP affects endothelial cells in multiple ways; however, the molecular and cellular mechanisms underlying the interaction of HBP with these cells are unknown. Affinity isolation and enzymatic degradation demonstrated that HBP released from human neutrophils binds to endothelial cell-surface proteoglycans, such as syndecans and glypican. Flow cytometry indicated that a significant fraction of proteoglycan-bound HBP is taken up by the endothelial cells, and we used radiolabeled HBP to determine the internalization rate of surface-bound HBP. Confocal and electron microscopy revealed that internalized HBP is targeted to perinuclear compartments of endothelial cells, where it colocalizes with mitochondria. Western blotting of isolated mitochondria from HBP-treated endothelial cells showed that HBP is present in 2 forms - 28 and 22 kDa. Internalized HBP markedly reduced growth factor deprivation-induced caspase-3 activation and protected endothelial cells from apoptosis, suggesting that uptake and intracellular routing of exogenous HBP to mitochondria contributes to the sustained viability of endothelial cells in the context of locally activated neutrophils.
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| 4. |
- Wagner, W, et al.
(author)
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Europe ambivalent on biotechnology
- 1997
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In: Nature. - London : Nature Publishing Group. - 0028-0836 .- 1476-4687. ; 387, s. 845-847
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Journal article (peer-reviewed)abstract
- The Eurobarometer on Biotechnology (46.1) was conducted during October and November 1996. The survey conducted in each EU (European Union) country used a multi-stage random sampling procedure and provided a statistically representative sample of national residents aged 15 and over. The total sample within the EU was 16,246 respondents (about 1,000 per EU country). The survey questionnaire was designed by the authors as part of a larger study involving the comparative analysis of public perceptions, media coverage and public policy in relation to biotechnology from 1973 to the present.
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| 6. |
- Gustafsson, Bengt, et al.
(author)
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KI emission from envelopes around N-type stars - Spectroscopic observations and interpretations
- 1997
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In: ASTRONOMY AND ASTROPHYSICS. - : SPRINGER VERLAG. - 0004-6361. ; 318:2, s. 535-542
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Journal article (peer-reviewed)abstract
- Circumstellar envelopes around three bright N-type stars, R Scl, X TrA, and V Aql have been detected in emission in resonance lines from K I. This radiation, which is most probably scattered photospheric radiation, was first found spectroscopically, but h
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| 11. |
- Hellquist, H. B., et al.
(author)
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Bcl-2 immunoreactivity in salivary gland neoplasms is unrelated to the expression of mRNA for natural killer cell stimulatory cytokines interleukin (IL)-2 and IL-12
- 1996
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In: Virchows Archiv. - New York, USA : Springer. - 0945-6317 .- 1432-2307. ; 429:2-3, s. 149-158
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Journal article (peer-reviewed)abstract
- Certain cytokines are involved in the generation of natural killer (NK) cells and participate in the regulation of the proto-oncogene bcl-2. We aimed to study the mRNA expression of interleukin (IL)-2, IL-4 and IL-5, the composition of the tumour infiltrating lymphocytes (TIL), and the expression of bcl-2 in 14 benign and malignant human parotid tumours. T IL were predominantly composed of T lymphocytes and NK cells. We found evidence for the homing of T cells, and for generation of NK cells in the vicinity of the tumours. mRNA for IL-2 and IL-12, were identified but IL-4 mRNA was not found. The cytokine profiles and the composition of TIL of the two tumour categories were indistinguishable, suggesting that these host-response variables do not explain the differences in biological behaviour of these particular tumours. The results support a shift towards Th 1 (T helper 1) cells and interferon-gamma production, and that IL-12 also in vivo may play an important role in the regulatory interaction between innate resistance and adaptive immunity in tumour diseases. Most infiltrating lymphocytes showed strong expression of bcl-2; an interesting observation with regard to lymphocytic apoptosis in neoplastic diseases. The immunoreactivity for the bcl-2 protein varied considerably between and within tumours, and almost all benign tumours showed strong bcl-2 positively whereas several of the malignant tumours showed weak or absent staining. The variable expression of bcl-2 protein suggests a different susceptibility of tumour cells to apoptosis. The results also indicate that bcl-2 cannot pla a major role as protective agent in the specific apoptotic pathway induced by NK cells.
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| 12. |
- Karling, Pontus, et al.
(author)
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Spectral analysis of heart rate variability in patients with irritable bowel syndrome.
- 1998
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In: Scandinavian Journal of Gastroenterology. - : Informa UK Limited. - 0036-5521 .- 1502-7708. ; 33:6, s. 572-576
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Journal article (peer-reviewed)abstract
- BACKGROUND: Autonomic dysfunction, both adrenergic and cholinergic, has been associated with the irritable bowel syndrome (IBS). The accuracy of the methods in use, however, has been limited by the need for active co-operation by the patients, with consequent difficulties in standardization. The aim of this study was to investigate the function of the autonomic nervous system in patients with IBS by using spectral analysis of the heart rate variability, an accurate method depending very little on patient cooperation. METHODS: Eighteen patients with IBS were compared with 36 sex- and age-matched controls. Spectral analysis of heart rate variability was performed to quantify sympathetic and parasympathetic nerve activity. RESULTS: The patients with IBS had significantly higher sympathetic activity than controls (P = 0.005). There was no significant (P = 0.308) increase in parasympathetic activity. There were no significant differences in heart rate or blood pressure between the patients and controls. CONCLUSION: Spectral analysis of heart rate variability has been used to assess the function of the autonomic nervous system in patients with IBS. IBS patients have significantly increased symphathetic activity, whereas parasympathetic activity does not differ from that of controls.
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| 15. |
- LINDQVIST, M, et al.
(author)
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INTERFEROMETRIC OBSERVATIONS OF HCN AND CN TOWARDS CARBON STARS
- 1995
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In: ASTROPHYSICS AND SPACE SCIENCE. - : KLUWER ACADEMIC PUBL. ; , s. 501-502
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Conference paper (other academic/artistic)abstract
- Using the IRAM interferometer we have observed four carbon stars (U Cam, CIT6, Y CVn, IRC+40540) in the HCN(J = 1 --> 0) and CN(N = 1 --> 0) lines. Here we present some results for CIT6 and U Cam.
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| 16. |
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| 17. |
- Olofsson, Magnus, et al.
(author)
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Linear programming based optimal power flow using second order sensitivities
- 1995
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In: IEEE Transactions on Power Systems. - : Institute of Electrical and Electronics Engineers (IEEE). - 0885-8950 .- 1558-0679. ; 10:3, s. 1691-1697
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Journal article (peer-reviewed)abstract
- For the electric railway traction in Sweden, a system of 130 kV transmission lines connected parallel to the contact lines is being build. Within this system, the generation costs differs only slightly between different nodes with power injections. In order to optimize the power flow in the system, an extended optimal power flow algorithm based on successive linear programming, has been developed. To improve the convergence, a method based on a second order sensitivity approximation of the active power losses of the total system is applied. Numerical examples are given to show the enhanced convergence properties.
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| 21. |
- Ryde, Nils, et al.
(author)
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Modelling of molecular bands of oxygen-rich AGB stars
- 1998
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In: Asymptotic Giant Branch Stars, IAU Symposium 191.
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Conference paper (other academic/artistic)abstract
- ISO observations of infrared molecular bands of oxygen-rich AGB stars are compared with synthetic spectra generated using model atmospheres
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| 22. |
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| 23. |
- Ryde, Nils, et al.
(author)
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Tentative detection of circumstellar CO2 from the AGB star R Crateris
- 1998
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In: Astrophysics and Space Science. - 0004-640X .- 1572-946X. ; 255:1-2, s. 301-302
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Journal article (peer-reviewed)abstract
- We report on and discuss the detection of an emission feature at 14.98 mu m from the oxygen-rich, semi-regularly pulsating asymptotic Giant Branch star R Crateris, a feature which we suggest to be due to the 2(0)(1) Q-branch of circumstellar CO2. We also suggest a reasonable excitation mechanism, which could explain the height, the width and the asymmetry of the feature.
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| 24. |
- Ryde, Nils, et al.
(author)
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The carbon star IRAS 15194-5115: circumstellar CO radio and FIR rotational lines
- 1999
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In: ASTRONOMY AND ASTROPHYSICS. - 0004-6361. ; 345:3, s. 841-846
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Journal article (peer-reviewed)abstract
- We have modelled radio and far-infrared rotational lines of (CO)-C-12 and (CO)-C-13 Obtained from the circumstellar envelope of the infrared-bright carbon star IRAS 15194-5115. Eleven rotational lines between J=1-0 and 21-20 and nine rotational lines betw
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