| 1. |
|
|
| 2. |
|
|
| 3. |
|
|
| 4. |
- Blain, H., et al.
(author)
-
A comprehensive fracture prevention strategy in older adults : the European union geriatric medicine society (EUGMS) statement
- 2016
-
In: European Geriatric Medicine. - : Elsevier. - 1878-7649 .- 1878-7657. ; 7:6, s. 519-525
-
Journal article (peer-reviewed)abstract
- Prevention of fragility fractures in older people has become a public health priority, although the most appropriate and cost-effective strategy remains unclear. In the present statement, the Interest group on falls and fracture prevention of the European union geriatric medicine society (EUGMS), in collaboration with the International association of gerontology and geriatrics for the European region (IAGG-ER), the European union of medical specialists (EUMS), the Fragility fracture network (FFN), the International osteoporosis foundation (IOF) - European society for clinical and economic aspects of osteoporosis and osteoarthritis (ECCEO), outlines its views on the main points in the current debate in relation to the primary and secondary prevention of falls, the diagnosis and treatment of bone fragility, and the place of combined falls and fracture liaison services for fracture prevention in older people.
|
|
| 5. |
|
|
| 6. |
|
|
| 7. |
|
|
| 8. |
|
|
| 9. |
|
|
| 10. |
- Magoulas, George E., et al.
(author)
-
Synthesis and antiproliferative activity of two diastereomeric lignan amides serving as dimeric caffeic acid-l-DOPA hybrids
- 2016
-
In: Bioorganic Chemistry. - : Elsevier BV. - 0045-2068. ; 66, s. 132-144
-
Journal article (peer-reviewed)abstract
- Two new diastereomeric lignan amides (4 and 5) serving as dimeric caffeic acid-l-DOPA hybrids were synthesized. The synthesis involved the FeCl3-mediated phenol oxidative coupling of methyl caffeate to afford trans-diester 1a as a mixture of enantiomers, protection of the catechol units, regioselective saponification, coupling with a suitably protected l-DOPA derivative, separation of the two diastereomers thus obtained by flash column chromatography and finally global chemoselective deprotection of the catechol units. The effect of hybrids 4 and 5 and related compounds on the proliferation of two breast cancer cell lines with different metastatic potential and estrogen receptor status (MDA-MB-231 and MCF-7) and of one epithelial lung cancer cell line, namely A-549, was evaluated for concentrations ranging from 1 to 256 μM and periods of treatment of 24, 48 and 72 h. Both hybrids showed interesting and almost equipotent antiproliferative activities (IC50 64-70 μM) for the MDA-MB-231 cell line after 24-48 h of treatment, but they were more selective and much more potent (IC50 4-16 μM) for the MCF-7 cells after 48 h of treatment. The highest activity for both hybrids and both breast cancer lines was observed after 72 h of treatment (IC50 1-2 μM), probably as the result of slow hydrolysis of their methyl ester functions.
|
|
| 11. |
|
|
| 12. |
- Slawinska, Malgorzata M., et al.
(author)
-
On the relativistic nature of predicted and real physical experiences : A field experiment
- 2015
-
In: Psychology of Sport And Exercise. - : Elsevier. - 1469-0292 .- 1878-5476. ; 16, s. 106-111
-
Journal article (peer-reviewed)abstract
- Objectives:An important yet unresolved question stemming from judgment and decision-makingliterature is whether individuals evaluate physical experiences in relative or absolute terms.Design and method:The study examined 181 experienced basketball players in a 2 (type of experience:predicted versus real) x 2 (evaluation mode: separate versus joint) x 2 (type of activity: running versusshooting) experimental research design.Results:We demonstrated that individuals who were familiar with physical tasks evaluated predictedand real physical experiences in absolute terms. In addition, we showed that relativistic modes ofevaluation applied to real physical experiences but not predicted physical experiences.Conclusions:This research contributes to the debate concerning whether prior task experience in-fluences formation of relative evaluations, and reveals that contexts that urge for relative evaluationsundermine happiness with physical tasks.
|
|
