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1.	Li, J, et al. (author) Artemisinins Target GABAA Receptor Signaling and Impair α Cell Identity 2017 In: Cell. - : Elsevier BV. - 1097-4172 .- 0092-8674. ; 168:1-2, s. 86- Journal article (peer-reviewed)
2.	Sardh, E, et al. (author) Phase 1, Randomized, Placebo Controlled Study of Givosiran, an Investigational RNA Interference (RNAi) Therapeutic, in Patients with Acute Intermittent Porphyria: Interim study results 2017 In: HEPATOLOGY. - 0270-9139. ; 66, s. 427A-427A Conference paper (other academic/artistic)
3.	Licciardello, Marco P., et al. (author) A combinatorial screen of the CLOUD uncovers a synergy targeting the androgen receptor 2017 In: Nature Chemical Biology. - : Nature Publishing Group. - 1552-4450 .- 1552-4469. ; 13:7, s. 771-778 Journal article (peer-reviewed)abstract Approved drugs are invaluable tools to study biochemical pathways, and further characterization of these compounds may lead to repurposing of single drugs or combinations. Here we describe a collection of 308 small molecules representing the diversity of structures and molecular targets of all FDA-approved chemical entities. The CeMM Library of Unique Drugs (CLOUD) covers prodrugs and active forms at pharmacologically relevant concentrations and is ideally suited for combinatorial studies. We screened pairwise combinations of CLOUD drugs for impairment of cancer cell viability and discovered a synergistic interaction between flutamide and phenprocoumon (PPC). The combination of these drugs modulates the stability of the androgen receptor (AR) and resensitizes AR-mutant prostate cancer cells to flutamide. Mechanistically, we show that the AR is a substrate for gamma-carboxylation, a post-translational modification inhibited by PPC. Collectively, our data suggest that PPC could be repurposed to tackle resistance to antiandrogens in prostate cancer patients.
4.	Penz, M, et al. (author) From work stress to coronary heart disease - Sex matters 2017 In: PSYCHONEUROENDOCRINOLOGY. - : Elsevier BV. - 0306-4530. ; 83, s. 37-38 Conference paper (other academic/artistic)

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Type of publication: conference paper (2); journal article (2)

Type of content: other academic/artistic (2); peer-reviewed (2)

Author/Editor: Bock, C. (1); Li, J. (1); Miller, R. (1); Simon, A (1); Ivanov, Vladimir (1); Stattin, Pär (1); show more...; Vieira, A (1); Bock, Christoph (1); Sardh, E (1); Harper, P (1); Harkany, T (1); Chan, A (1); Boidol, Bernd (1); Schuster, Michael (1); Al-Tawil, N (1); Romanov, RA (1); Balwani, M (1); Rees, D (1); Stein, P (1); Bissell, DM (1); Parker, C (1); Phillips, J (1); Penz, C (1); Anderson, KE (1); Bonkovsky, HL (1); Bloomer, JR (1); Querbes, W (1); Huber, KVM (1); Superti-Furga, G (1); Honoré, C. (1); Folkvaljon, Yasin (1); Walther, A. (1); Berishvili, E (1); Desnick, RJ (1); Avolio, F. (1); Meyer, D (1); Casteels, T (1); Frogne, T (1); Sturtzel, C (1); Lardeau, CH (1); Pauler, FM (1); Penz, T (1); Barbieux, C (1); Distel, M (1); Hecksher-Sorensen, J (1); Kubicek, S (1); Farlik, M (1); Penz, Thomas (1); Lardeau, Charles Hug ... (1); Kirschbaum, C (1); show less...

University: Karolinska Institutet (3); Umeå University (1); Uppsala University (1)

Language: English (4)

Research subject (UKÄ/SCB): Natural sciences (1); Medical and Health Sciences (1)

Year: 2017 (4)Undo refine

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