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- Ostuni, A., et al.
(author)
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The hepatitis B x antigen anti-apoptotic effector URG7 is localized to the endoplasmic reticulum membrane
- 2013
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In: FEBS Letters. - : Wiley. - 0014-5793 .- 1873-3468. ; 587:18, s. 3058-3062
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Journal article (peer-reviewed)abstract
- Hepatitis B x antigen up-regulates the liver expression of URG7 that contributes to sustain chronic virus infection and to increase the risk for hepatocellular carcinoma by its anti-apoptotic activity. We have investigated the subcellular localization of URG7 expressed in HepG2 cells and determined its membrane topology by glycosylation mapping in vitro. The results demonstrate that URG7 is N-glycosylated and located to the endoplasmic reticulum membrane with an N-lumen-C-cytosol orientation. The results imply that the anti-apoptotic effect of URG7 could arise from the C-terminal cytosolic tail binding a pro-apoptotic signaling factor and retaining it to the endoplasmic reticulum membrane.
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