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Träfflista för sökning "WFRF:(Whittaker John) srt2:(2015-2019)"

Search: WFRF:(Whittaker John) > (2015-2019)

  • Result 1-4 of 4
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1.
  • Corbin, Laura J., et al. (author)
  • Formalising recall by genotype as an efficient approach to detailed phenotyping and causal inference
  • 2018
  • In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 9:1
  • Journal article (peer-reviewed)abstract
    • Detailed phenotyping is required to deepen our understanding of the biological mechanisms behind genetic associations. In addition, the impact of potentially modifiable risk factors on disease requires analytical frameworks that allow causal inference. Here, we discuss the characteristics of Recall-by-Genotype (RbG) as a study design aimed at addressing both these needs. We describe two broad scenarios for the application of RbG: studies using single variants and those using multiple variants. We consider the efficacy and practicality of the RbG approach, provide a catalogue of UK-based resources for such studies and present an online RbG study planner.
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2.
  • Kehoe, Laura, et al. (author)
  • Make EU trade with Brazil sustainable
  • 2019
  • In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 364:6438, s. 341-
  • Journal article (other academic/artistic)
  •  
3.
  • Shrine, Nick, et al. (author)
  • New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries
  • 2019
  • In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 51:3, s. 481-493
  • Journal article (peer-reviewed)abstract
    • Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of European ancestry, we define 279 lung function signals, 139 of which are new. In combination, these variants strongly predict COPD in independent populations. Furthermore, the combined effect of these variants showed generalizability across smokers and never smokers, and across ancestral groups. We highlight biological pathways, known and potential drug targets for COPD and, in phenome-wide association studies, autoimmune-related and other pleiotropic effects of lung function-associated variants. This new genetic evidence has potential to improve future preventive and therapeutic strategies for COPD.
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  • Result 1-4 of 4
Type of publication
journal article (4)
Type of content
peer-reviewed (3)
other academic/artistic (1)
Author/Editor
Scott, Robert A (2)
Gyllensten, Ulf B. (1)
Wareham, Nick (1)
Rothhaupt, Karl-Otto (1)
Weigend, Maximilian (1)
Lind, Lars (1)
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Raitakari, Olli T (1)
Imboden, Medea (1)
Probst-Hensch, Nicol ... (1)
Gulsvik, Amund (1)
Farrell, Katharine N ... (1)
Hansell, Anna L (1)
van Heel, David A (1)
Tan, Vanessa Y (1)
Rudan, Igor (1)
Strachan, David P (1)
Islar, Mine (1)
Krause, Torsten (1)
Uddling, Johan, 1972 (1)
Alexanderson, Helena (1)
Schneider, Christoph (1)
Battiston, Roberto (1)
Lukic, Marko (1)
Franks, Paul W. (1)
Pereira, Laura (1)
Riggi, Laura (1)
Cattaneo, Claudio (1)
Jung, Martin (1)
Andresen, Louise C. (1)
Kasimir, Åsa (1)
McCarthy, Mark I (1)
Wang-Erlandsson, Lan (1)
Langenberg, Claudia (1)
Sutherland, William ... (1)
Boonstra, Wiebren J. (1)
Surakka, Ida (1)
Enroth, Stefan, 1976 ... (1)
Vajda, Vivi (1)
Pascual, Unai (1)
Karrasch, Stefan (1)
Gieger, Christian (1)
Jarvelin, Marjo-Riit ... (1)
Schulz, Holger (1)
Tscharntke, Teja (1)
Brown, Calum (1)
Peterson, Gustaf (1)
Meyer, Carsten (1)
Seppelt, Ralf (1)
Johansson, Maria (1)
Martin, Jean Louis (1)
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University
Lund University (2)
Umeå University (1)
Royal Institute of Technology (1)
Uppsala University (1)
Luleå University of Technology (1)
Mid Sweden University (1)
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Chalmers University of Technology (1)
Swedish University of Agricultural Sciences (1)
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Language
English (4)
Research subject (UKÄ/SCB)
Engineering and Technology (2)
Medical and Health Sciences (2)
Natural sciences (1)
Social Sciences (1)

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