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- Barucca, G., et al.
(author)
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Study of excited Ξ baryons with the P¯ ANDA detector
- 2021
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In: European Physical Journal A. - : Springer Nature. - 1434-6001 .- 1434-601X. ; 57:4
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Journal article (peer-reviewed)abstract
- The study of baryon excitation spectra provides insight into the inner structure of baryons. So far, most of the world-wide efforts have been directed towards N∗ and Δ spectroscopy. Nevertheless, the study of the double and triple strange baryon spectrum provides independent information to the N∗ and Δ spectra. The future antiproton experiment P¯ANDA will provide direct access to final states containing a Ξ¯ Ξ pair, for which production cross sections up to μb are expected in p¯p reactions. With a luminosity of L= 10 31 cm- 2 s- 1 in the first phase of the experiment, the expected cross sections correspond to a production rate of ∼106events/day. With a nearly 4 π detector acceptance, P¯ANDA will thus be a hyperon factory. In this study, reactions of the type p¯p → Ξ¯ +Ξ∗ - as well as p¯p → Ξ¯ ∗ +Ξ- with various decay modes are investigated. For the exclusive reconstruction of the signal events a full decay tree fit is used, resulting in reconstruction efficiencies between 3 and 5%. This allows high statistics data to be collected within a few weeks of data taking.
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- Barucca, G., et al.
(author)
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The potential of Λ and Ξ- studies with PANDA at FAIR
- 2021
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In: European Physical Journal A. - : Springer Nature. - 1434-6001 .- 1434-601X. ; 57:4
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Journal article (peer-reviewed)abstract
- The antiproton experiment PANDA at FAIR is designed to bring hadron physics to a new level in terms of scope, precision and accuracy. In this work, its unique capability for studies of hyperons is outlined. We discuss ground-state hyperons as diagnostic tools to study non-perturbative aspects of the strong interaction, and fundamental symmetries. New simulation studies have been carried out for two benchmark hyperon-antihyperon production channels: p¯ p→ Λ¯ Λ and p¯ p→ Ξ¯ +Ξ-. The results, presented in detail in this paper, show that hyperon-antihyperon pairs from these reactions can be exclusively reconstructed with high efficiency and very low background contamination. In addition, the polarisation and spin correlations have been studied, exploiting the weak, self-analysing decay of hyperons and antihyperons. Two independent approaches to the finite efficiency have been applied and evaluated: one standard multidimensional efficiency correction approach, and one efficiency independent approach. The applicability of the latter was thoroughly evaluated for all channels, beam momenta and observables. The standard method yields good results in all cases, and shows that spin observables can be studied with high precision and accuracy already in the first phase of data taking with PANDA.
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- Goitom, Daniel, et al.
(author)
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Radial ICP characteristics for ICP-AES using direct injection or microconcentric nebulisation
- 2005
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In: Journal of Analytical Atomic Spectrometry. - London : Royal Society of Chemistry. - 0267-9477 .- 1364-5544. ; 20:7, s. 645-651
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Journal article (peer-reviewed)abstract
- Radial analyte signal intensities, fundamental plasma parameters, and non-spectral interference effects were characterized for inductively coupled plasma atomic emission spectrometry (ICP-AES) using a direct injection nebuliser (Vulkan DIN) or a microconcentric nebuliser (MCN) coupled to a cyclonic spray chamber for sample introduction. Radial analyte signal intensity profiles for atomic and ionic lines with energy sum (Esum) between 1.85 and 15.41 eV were used. When using the MCN system, for all lines the signal intensity profiles were parabolic with maxima at the axial centre of the plasma. For the Vulkan DIN, the shapes of the profiles were dependent on their Esum showing minimum intensities at the axial centre of the plasma for lines with high Esum values. The ionisation temperature, electron number density and magnesium ion-atom line intensity ratio determined indicated that ionisation and excitation capabilities were deteriorated at the centre of the plasma when using the Vulkan DIN compared with the MCN. This was found to be not simply a result of high aerosol load when using the Vulkan DIN, but because of poor plasma–aerosol interaction, possibly caused by the confined distribution of aerosol in the plasma and high nebuliser gas velocity. Indeed, for the Vulkan DIN, electron number density and ionisation temperature increased with liquid flow rate, which could be explained by plasma shrinkage, or the thermal pinch effect, which increased the aerosol–plasma interaction at increased liquid flow rates. As a consequence, when increasing the liquid flow rate in the range 20–90 µL min–1: (i) analyte sensitivity increased linearly; (ii) the plasma became unstable; (iii) the magnitude of matrix effects remained almost unaffected. These results are partly in contrast to observations made with other types of direct injection nebulisers and ICP instruments.
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- Gottschalk, L, et al.
(author)
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Scale aggregation - comparison of flux estimates from NOPEX
- 1999
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In: AGRICULTURAL AND FOREST METEOROLOGY. - : ELSEVIER SCIENCE BV. - 0168-1923. ; 98-9, s. 103-119
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Journal article (peer-reviewed)abstract
- The NOPEX two concentrated field efforts (CFEs) (June 1994 and April-July 1995) provide high quality data sets for the Boreal environment. The analysis of these data with traditional meteorological and hydrological approaches allow estimations of fluxes o
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- Matousek, T, et al.
(author)
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Gas flow patterns and longitudinal distribution of free selenium atoms in quartz tube atomizers for hydride generation atomic absorption spectrometry
- 2000
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In: Spectrochimica Acta Part B: Atomic Spectroscopy. ; 55:2, s. 151-63
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Journal article (peer-reviewed)abstract
- Gas flow patterns in unheated quartz tube hydride atomizers were studied by light scattering on ammonium chloride particles and by observation of iodine vapors. The flow pattern is basically laminar, with a turbulent region at the T-junction and irregularities at the tube ends. We studied the free atom distribution over the length of the atomizers optical bar under various conditions by measuring the selenium signal with the tube perpendicular to the radiation beam, through the tube walls. In the whole range of atomization conditions used (Se 60-400 g l-1, 0.8-2 l min-1 of H2 as purge gas, 0-50 ml min-1 O2,), there is a sharp maximum of free atom concentration in the tube centre, and all the free atoms disappear before they reach the tube ends. The absorption profiles are essentially the same in unheated as in flame-heated tubes, and there is no difference between heated flame-in-tube and externally heated arrangement. With decreasing purge gas flow rate, free atoms occupy a shorter part of the tube. Free atoms start to decay immediately after entering the optical tube of the atomizer. In both heated and unheated atomizers, enhanced free atom decay at higher concentrations contributes to the curvature of calibration graphs. As all free atoms disappear before reaching the ends of the tube even at relatively high purge gas flow rates, it is not possible to obtain higher sensitivities by extending the atomizer length. There is no difference in the free atom distribution in the central part of the tube if oxygen is prevented to enter the tube from the ends (by quartz windows or flames burning at the tube ends), so the free atom decay is not caused by O2 diffusing from the ambient atmosphere. With flames burning on tube ends, free Se atoms were reappearing close to the ends, proving the possibility of reatomization of species formed by free atom reactions. When no measures against O2 penetration from the tube ends of the heated atomizer are taken, signal reappearance takes place at the borders of the hot part of the atomizer, contributing substantially to the overall sensitivity. The results obtained correspond very well to the present picture of hydride atomization by H-radicals and their subsequent decay.
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- Mayes, Maureen D, et al.
(author)
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Immunochip analysis identifies multiple susceptibility Loci for systemic sclerosis.
- 2014
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In: American Journal of Human Genetics. - : Elsevier BV. - 0002-9297 .- 1537-6605. ; 94:1, s. 47-61
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Journal article (peer-reviewed)abstract
- In this study, 1,833 systemic sclerosis (SSc) cases and 3,466 controls were genotyped with the Immunochip array. Classical alleles, amino acid residues, and SNPs across the human leukocyte antigen (HLA) region were imputed and tested. These analyses resulted in a model composed of six polymorphic amino acid positions and seven SNPs that explained the observed significant associations in the region. In addition, a replication step comprising 4,017 SSc cases and 5,935 controls was carried out for several selected non-HLA variants, reaching a total of 5,850 cases and 9,401 controls of European ancestry. Following this strategy, we identified and validated three SSc risk loci, including DNASE1L3 at 3p14, the SCHIP1-IL12A locus at 3q25, and ATG5 at 6q21, as well as a suggested association of the TREH-DDX6 locus at 11q23. The associations of several previously reported SSc risk loci were validated and further refined, and the observed peak of association in PXK was related to DNASE1L3. Our study has increased the number of known genetic associations with SSc, provided further insight into the pleiotropic effects of shared autoimmune risk factors, and highlighted the power of dense mapping for detecting previously overlooked susceptibility loci.
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| 15. |
- Saketkoo, LA, et al.
(author)
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World Health Organization (WHO) International Classification of Functioning, Disability and Health (ICF) Core Set Development for Interstitial Lung Disease
- 2022
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In: Frontiers in pharmacology. - : Frontiers Media SA. - 1663-9812. ; 13, s. 979788-
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Journal article (peer-reviewed)abstract
- Background: The World Health Organization (WHO) introduced the International Classification of Functioning, Disability, and Health (ICF) as a scientific method of disability data collection comprised of >1,200 categories describing the spectrum of impairment types (functional, symptoms-based and anatomical) under the bio-psycho-social model with consideration of environmental and personal factors (pf). ICF Core Sets and ICF Checklists are streamlined disease-specific resources for clinical use, service provision, and for use in health economics and health policy. ICF can disclose strengths and weaknesses across multiple patient-reported outcome measures (PROMs) and help consolidate best-fitting question-items from multiple PROMs. Interstitial lung diseases (ILDs), are generally progressive, with restrictive physiology sometimes occurring in the context of multi-organ autoimmunity/inflammatory conditions such as connective tissue diseases (CTDs). In spite of significant associated morbidity and potential disability, ILD has yet to be linked to the ICF.Methods: Each instrument and their question-items within the consensus-recommended core sets for clinical trials in ILD were deconstructed to single concept units, and then linked per updated ICF linkage rules. Inter-linker agreement was established. Three additional subsequently validated measures were also included.Results: One-hundred-eleven ICF categories were identified for ten PROMs and three traditional objective measures that were amenable to ICF linkage. The proportion of agreement ranged from 0.79 (95% CI: 0.62, 0.91) to 0.93 (0.76, 0.99) with the overall proportion of inter-linker agreement being very high 0.86 (0.82, 0.89) for the initial instruments, with 94–100% for the three additional PROMs. Thirty-four new ‘Personal Factors’ emerged to capture disease-specific qualities not elsewhere described in ICF, e.g. ‘pf_embarrassed by cough’ or ‘pf_panic/afraid when can’t get a breath’.Conclusion: This first known effort in ICF linkage of ILD has provided important revelations on the current utility of the ICF in lung disease. Results have indicated areas for meaningful assessment of ICF descriptors for lung impairment. The mapping across PROMs provides insight into possibilities of developing more streamline and precise instrumentation. Finally, familiarity with the ICF in ILD may enable clinicians to experience a smoother transition with the imminent harmonization of ICD and ICF, ICD-11.
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