SwePub - search: WFRF:(Hellström Björn)

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1.	Abarkan, Abdellah, et al. (author) Corona hotar förvärra svenska bostadskrisen. 108 forskare: Sveriges regering och kommuner måste förhindra en katastrof. 2020 In: Aftonbladet. - 1103-9000. Journal article (pop. science, debate, etc.)abstract Debattartikel och Öppet brev publicerad i tidningen Aftonbladet. 29.3. 2020.
2.	Abarkan, Abdellah, et al. (author) Lyssna på forskningen : Den visar på avregleringens problem 2019 In: Dagens nyheter. - Stockholm : Dagens nyheter. - 1101-2447. ; :10/21/2019 Journal article (pop. science, debate, etc.)
3.	Lundqvist, Pia, et al. (author) Development and psychometric properties of the Swedish ALPS-Neo pain and stress assessment scale for newborn infants 2014 In: Acta Paediatrica. - : Wiley-Blackwell. - 0803-5253 .- 1651-2227. ; 103:8, s. 833-839 Journal article (peer-reviewed)abstract AIM: To validate and evaluate the psychometric properties of the ALPS-Neo, a new pain assessment scale created for the continuous evaluation of pain and stress in preterm and sick term infants.METHODS: A unidimensional scale for continuous pain, Astrid Lindgren Children's Hospital Pain Scale (ALPS 1), was developed further to assess continuous pain and stress in infants treated in the neonatal intensive care unit (NICU). The pain scale includes observations of five behaviours. A manual was created, clarifying the scoring criteria. An internal and an external panel assessed face validity. Psychometric properties were evaluated in three different steps. Inter-rater reliability was estimated from video-based assessments (n = 625) using weighted kappa statistics (test I). Inter-rater reliability was further evaluated in test II (n = 125) and test III (n = 96) by real-time assessments using the intraclass correlation coefficient (ICC) and Cronbach's alpha.RESULTS: The final inter-rater reliability (test III) was assessed as good with ICC 0.91 for the total score and 0.62-0.81 for the five items. Cronbach's alpha showed 0.95 for the total score.CONCLUSION: ALPS-Neo is a new assessment tool for optimising the management of pain and stress in newborn infants in the NICU. It has proved easy to implement and user-friendly, permitting fast, reliable observations with high inter-rater reliability.
4.	Nilsson, Erling, et al. (author) Room acoustical measures for open plan spaces 2008 In: Acoustics '08 Paris. ; , s. 543-549 Conference paper (peer-reviewed)abstract Room acoustical measures for open plan spaces
5.	Abdellah, Tebani, et al. (author) Integration of molecular profiles in a longitudinal wellness profiling cohort. 2020 In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11:1 Journal article (peer-reviewed)abstract An important aspect of precision medicine is to probe the stability in molecular profiles among healthy individuals over time. Here, we sample a longitudinal wellness cohort with 100 healthy individuals and analyze blood molecular profiles including proteomics, transcriptomics, lipidomics, metabolomics, autoantibodies andimmune cell profiling, complementedwith gut microbiota composition and routine clinical chemistry. Overall, our results show high variation between individuals across different molecular readouts, while the intra-individual baseline variation is low. The analyses show that each individual has a unique and stable plasma protein profile throughout the study period and that many individuals also show distinct profiles with regards to the other omics datasets, with strong underlying connections between the blood proteome and the clinical chemistry parameters. In conclusion, the results support an individual-based definition of health and show that comprehensive omics profiling in a longitudinal manner is a path forward for precision medicine.
6.	Adsten, Monika, et al. (author) Comparison of the optical efficiency of a wide and a narrow absorber fin in an asymmetric concentrating collector. 2002 Conference paper (peer-reviewed)
7.	Adsten, Monika, et al. (author) Comparison of the optical efficiency of a wide and a narrow absorber fin in an asymmetric concentrating collector Other publication (pop. science, debate, etc.)
8.	Adsten, Monika, et al. (author) Comparison of the optical efficiency of a wide and narrow absorber fin in an asymmetrically truncated concentrating collector 2002 In: Proceedings of EuroSun 2002, Bologna, Italy. Conference paper (peer-reviewed)
9.	Adsten, Monika, et al. (author) Measurement of radiation distribution on the absorber in an asymmetric CPC collector 2001 In: . Prodeedings ISES Solar World Conference, Adelaide, Australia.. Conference paper (other academic/artistic)
10.	Aksyutina, Yu, et al. (author) Lithium isotopes beyond the drip line 2008 In: Physics Letters B. - : Elsevier BV. - 0370-2693. ; 666:5, s. 430-434 Journal article (peer-reviewed)abstract The unbound isotopes 10Li, 12Li and 13Li have been observed after nucleon-knockout reactions at relativistic energies with 11Li and 14Be beams impinging on a liquid hydrogen target. The channels , and were analysed in the ALADIN-LAND setup at GSI. The 10Li data confirm earlier findings, while the 12Li and 13Li nuclei were observed for the first time. The relative-energy spectrum shows that the ground state of 12Li can be described as a virtual s-state with a scattering length of -13.7(1.6) fm. A broad energy spectrum was found for the channel. Based on the assumption that the relative-energy spectrum is dominated by a correlated background presumably stemming from initial correlations in the 14Be ground-state, evidence for a 13Li resonance at 1.47(31) MeV above the threshold with a width around 2 MeV has been found.
11.	Axelsson, Östen, et al. (author) A field experiment on the impact of sounds from a jet-and-basin fountain on soundscape quality in an urban park 2014 In: Landscape and Urban Planning. - : Elsevier BV. - 0169-2046 .- 1872-6062. ; 123, s. 49-60 Journal article (peer-reviewed)abstract A field experiment was conducted to explore whether water sounds from a fountain had a positive impact on soundscape quality in a downtown park. In total, 405 visitors were recruited to answer a questionnaire on how they perceived the park, including its acoustic environment. Meanwhile the fountain was turned on or off, at irregular hours. Water sounds from the fountain were not directly associated with ratings of soundscape quality. Rather, the predictors of soundscape quality were the variables Road-traffic noise and Other natural sounds. The former had a negative and the latter a positive impact. However, water sounds may have had an indirect impact on soundscape quality by affecting the audibility of road-traffic and natural sounds. The present results, obtained in situ, agree with previous results in soundscape research that the sounds perceived particularly roadtraffic and natural sounds explain soundscape quality. They also agree with the results from laboratory studies that water sounds may mask roadtraffic sounds, but that this is not simple and straight forward. Thus sound should be brought into the design scheme when introducing water features in urban open spaces, and their environmental impact must be thoroughly assessed empirically.
12.	Barrenäs, Marie-Louise, et al. (author) High risk of sensorineural hearing loss in men born small for gestational age with and without obesity or height catch-up growth : a prospective longitudinal register study on birth size in 245,000 Swedish conscripts. 2005 In: J Clin Endocrinol Metab. - 0021-972X. ; 90:8, s. 4452-6 Journal article (peer-reviewed)
13.	Benson, Mikael, et al. (author) Interleukin (IL)-6 and IL-8 in children with febrile urinary tract infection and asymptomatic bacteriuria 1996 In: Journal of Infectious Diseases. - : Oxford University Press (OUP). - 0022-1899 .- 1537-6613. ; 174:5, s. 1080-1084 Journal article (peer-reviewed)abstract Urine and serum interleukin (IL)-6 and IL-8 responses were higher in children with febrile urinary tract infection (n = 61) than in those with asymptomatic bacteriuria (n = 39). By univariate analysis, cytokine levels were related to age, sex, reflux, renal scarring, urine leukocytes, C- reactive protein (CRP), erythrocyte sedimentation rate (ESR), and bacterial properties (P fimbriae but not hemolysin). Multivariate modeling showed that urine IL-6 responds were higher in girls than boys, increased with age, and were positively associated with CRP, ESR, serum IL-6, and urine leukocyte counts. The urine IL-8 response was not influenced by age, but it was influenced by P fimbriae and was associated with ESR, CRP, urine leukocytes, and female sex. The results show that cytokine responses to urinary tract infection vary with the severity of infection and that cytokine activation is influenced by a variety of host and bacterial variables.
14.	Bergkvist, Mikael, et al. (author) Radical improvements of large collector fields 1992 In: North Sun. - Trondheim, Norge. Conference paper (other academic/artistic)
15.	Björn, Hellström (author) Universell utformning i den kommunala samhällsbyggnadsprocessen : Om konsten att bygga en organisation med spelrum för reflektion, kreativitet och professionellt omdöme 2022 In: Jämlik livsmiljö. - Stockholm : Kungliga tekniska högskolan. ; , s. 17-46 Book chapter (other academic/artistic)abstract Avsikten med universell utformning är att behovsägare med olika individuella krav ska göras delaktiga i samhällsstyrningen så tidigt som möjligt och genom hela förloppet via designlösningar i form av tjänster och produkter som svarar mot behoven. Syftet med den här studien är att utreda Uppsala kommuns arbete med tillgänglighetsfrågor, med särskilt fokus på universell utformning. Det handlar framför allt om att belysa universella utmaningsmöjligheter och -svårheter som kan hänföras till kommunal processtyrning med fokus på följande centrala faktorer:BegreppspreciseringOrganisationSamverkanPlaneringStyrning Studien utgår från närläsning av fjorton kommunala styrdokument som hanterar frågor om tillgänglighet och universell utformning, upprättade i Uppsala under perioden 2015–2020. Därutöver har elva tjänstepersoner i Uppsala kommun och Uppsala Funktionsrätt djupintervjuats.Ambitionen är inte att precisera explicita råd, kravkriterier, indikatorer, checklistor, standardiserade metoder och andra former av styrmedel. Utgångspunkten är att precisera frågor – inte genom förenklingar och generaliseringar – utan med hänsyn till komplexa förutsättningar i relation till omvärldsfaktorer som stöd för att komma närmare en förståelse för universell utformning som processdrivet angreppssätt. Därutöver innefattar studien en uppsättning öppet formulerade rekommendationer, med ambitionen att bidra med kunskap om hur universell utformning skulle kunna genomsyra den kommunala samhällsbyggnadsprocessens olika skeden.I studien ställs följande fråga: Hur kan man bygga en organisation med spelrum för reflektion, kreativitet och professionellt omdöme? Många organisationer hämmar detta spelrum genom att skapa ledningssystem med regler och rutiner som har motverkande effekt. Studiens genomgående tema handlar därför om hur angreppssättet universell utformning kan tillämpas i samhällsbyggnadsprocessen som medger spelrum för den kreativa byråkraten.
16.	Buervenich, Silvia, et al. (author) A rare truncating mutation in ADH1C (G78Stop) shows significant association with Parkinson disease in a large international sample. 2005 In: Archives of neurology. - : American Medical Association (AMA). - 0003-9942. ; 62:1, s. 74-8 Journal article (peer-reviewed)abstract BACKGROUND: Alcohol dehydrogenases (ADHs) may be involved in the pathogenesis of neurodegenerative disorders because of their multiple roles in detoxification pathways and retinoic acid synthesis. In a previous study, significant association of an ADH class IV allele with Parkinson disease (PD) was found in a Swedish sample. PATIENTS: The previously associated single-nucleotide polymorphism plus 12 further polymorphisms in the ADH cluster on human chromosome 4q23 were screened for association in an extension of the original sample that now included 123 Swedish PD patients and 127 geographically matched control subjects. A rare nonsense single-nucleotide polymorphism in ADH1C (G78stop, rs283413) was identified in 3 of these patients but in no controls. To obtain sufficient power to detect a possible association of this rare variant with disease, we screened a large international sample of 1076 PD patients of European ancestry and 940 matched controls. RESULTS: The previously identified association with an ADH class IV allele remained significant (P<.02) in the extended Swedish study. Furthermore, in the international collaboration, the G78stop mutation in ADH1C was found in 22 (2.0%) of the PD patients but only in 6 controls (0.6%). This association was statistically significant (chi(2)(1) = 7.5; 2-sided P = .007; odds ratio, 3.25 [95% confidence interval, 1.31-8.05]). In addition, the G78stop mutation was identified in 4 (10.0%) of 40 Caucasian index cases with PD with mainly hereditary forms of the disorder. CONCLUSION: Findings presented herein provide further evidence for mutations in genes encoding ADHs as genetic risk factors for PD.
17.	Dyrssen, Catharina, 1949, et al. (author) Buller kan inte byggas bort 2005 In: Arkitekten. - Stockholm : Arkitektförbundet. - 0347-058X. ; 2005:3, s. 52-:4, s. 52-52 Journal article (other academic/artistic)
18.	Dyrssen, Catharina, 1949, et al. (author) Bullerbyn - en tvångströja. 2004 In: Arkitekten. ; 2004:12, s. 42-43 Journal article (other academic/artistic)
19.	Dyrssen, Catharina, 1949, et al. (author) The Sound Labyrinth Project: Catalyst for Creative Activity 2012 In: Interference: A Journal of Audioculture. - 2009-3578 .- 2009-3578. ; 2012:2 Journal article (peer-reviewed)abstract Two large sound installations, developed by transdisciplinary sound art and research group Urban Sound Institute, created a meeting place for one year of artistic and pedagogic activity in a Swedish regional museum. The project involved a historic sound archive, a string quartet, a local radio station, pedagogic workshops, several schools, children’s groups and musical education programs. The installations created a complexity of interior spaces, and acted as huge musical instruments to be ‘played’ by professional musicians, dancers and visitors. Through advanced computer programming and careful composition, modeling and distribution of sounds as words, narratives, music, space, bodily experiences and memory, the Sound Labyrinth allowed for great variations, durability over time, and different forms of interaction. The article describes the project, and discusses the exhibition as a platform for collective, multiple interaction; as an expanded musical-architectonic composition; and as a contribution to artistic research methodologies relevant for sound spaces within so-called sound-making disciplines.
20.	Dyrssen, Catharina, 1949, et al. (author) Transmission. Urban experiments in sound art and sonic space 2007 In: Landskab og landskabsarkitektur, Nordisk Arkitekturforskning, Århus, 19-21 April 2007. Conference paper (peer-reviewed)
21.	Hadrévi, Jenny, 1977-, et al. (author) Comparative metabolomics of muscle interstitium fluid in human trapezius myalgia: an in vivo microdialysis study 2013 In: European Journal of Applied Physiology. - : Springer Verlag (Germany). - 1439-6319 .- 1439-6327. ; 113:12, s. 2977-2989 Journal article (peer-reviewed)abstract The mechanisms behind trapezius myalgia are unclear. Many hypotheses have been presented suggesting an altered metabolism in the muscle. Here, muscle microdialysate from healthy and myalgic muscle is analysed using metabolomics. Metabolomics analyse a vast number of metabolites, enabling a comprehensive explorative screening of the cellular processes in the muscle. less thanbrgreater than less thanbrgreater thanMicrodialysate samples were obtained from the shoulder muscle of healthy and myalgic subjects that performed a work and stress test. Samples from the baseline period and from the recovery period were analysed using gas chromatography-mass spectrometry (GC-MS) together with multivariate analysis to detect differences in extracellular content of metabolites between groups. Systematic differences in metabolites between groups were identified using multivariate analysis and orthogonal partial least square discriminate analysis (OPLS-DA). A complementary Mann-Whitney U test of group difference in individual metabolites was also performed. less thanbrgreater than less thanbrgreater thanA large number of metabolites were detected and identified in this screening study. At baseline, no systematic differences between groups were observed according to the OPLS-DA. However, two metabolites, l-leucine and pyroglutamic acid, were significantly more abundant in the myalgic muscle compared to the healthy muscle. In the recovery period, systematic difference in metabolites between the groups was observed according to the OPLS-DA. The groups differed in amino acids, fatty acids and carbohydrates. Myristic acid and putrescine were significantly more abundant and beta-d-glucopyranose was significantly less abundant in the myalgic muscle. less thanbrgreater than less thanbrgreater thanThis study provides important information regarding the metabolite content, thereby presenting new clues regarding the pathophysiology of the myalgic muscle.
22.	Hadrevi, Jenny, et al. (author) Comprehensive analysis of the painful trapezius muscle using a proteomic method (Poster) 2010 In: Proceedings of the Premus 2010 conference (Seventh International Conference on Prevention of Work-Related Musculoskeletal Disorders) August 29-September 2. Conference paper (peer-reviewed)
23.	Hadrévi, Jenny, 1977-, et al. (author) Multivariate Modeling of Proteins Related to Trapezius Myalgia, a Comparative Study of Female Cleaners with or without Pain 2013 In: PLOS ONE. - : Public Library of Science. - 1932-6203. ; 8:9, s. e73285- Journal article (peer-reviewed)abstract The prevalence of chronic trapezius myalgia is high in women with high exposure to awkward working positions, repetitive movements and movements with high precision demands. The mechanisms behind chronic trapezius myalgia are not fully understood. The purpose of this study was to explore the differences in protein content between healthy and myalgic trapezius muscle using proteomics. Muscle biopsies from 12 female cleaners with work-related trapezius myalgia and 12 pain free female cleaners were obtained from the descending part of the trapezius. Proteins were separated with two-dimensional differential gel electrophoresis (2D-DIGE) and selected proteins were identified with mass spectrometry. In order to discriminate the two groups, quantified proteins were fitted to a multivariate analysis: partial least square discriminate analysis. The model separated 28 unique proteins which were related to glycolysis, the tricaboxylic acid cycle, to the contractile apparatus, the cytoskeleton and to acute response proteins. The results suggest altered metabolism, a higher abundance of proteins related to inflammation in myalgic cleaners compared to healthy, and a possible alteration of the contractile apparatus. This explorative proteomic screening of proteins related to chronic pain in the trapezius muscle provides new important aspects of the pathophysiology behind chronic trapezius myalgia.
24.	Hadrevi, Jenny, et al. (author) Myosin light chain and calcium regulating protein differences in chronic musculoskeletal neck and shoulder pain 2016 In: Journal of Integrated Omnics. - : Proteomass Scientific Society. - 2182-0287. ; 6:1, s. 1-8 Journal article (peer-reviewed)abstract Proteomic screening analysis has detected myosin light chain (MLC) as a protein implied to be involved in chronic musculoskeletal neck and shoulder pain. Several analyses of MLC proteins have stated a difference in phosphorylation being the determining factor for protein activation hence altered contrability of the muscle in i.e. senescence. In continuation of a previous publication, this study is an attempt to analyze the different MLC isoforms by mass spectrometry and immune-analyses in myalgic and healthy trapezius muscle. In the present study no differences in phosphorylation level between the corresponding individual proteins were detected using LC-MSMS and immunoblotting; instead we assigned different isoforms of regulatory MLCs. To further elucidate the contrability: calcium (Ca2+) regulatory proteins, sarco(endo)plasmic reticulum Ca2+ ATPase 1 (SERCA-1) and calsequestrine (CSQ) were analyzed by western blot. The analysis revealed a significantly increased abundance of SERCA-1 protein in the myalgic muscle and a significantly increased abundance of CSQ in healthy muscle. Myalgic muscle contraction patterns have in previous studies shown to differ from healthy muscle which may be connected to the Ca2+ availability in the muscle. Here we present the proteomic characterization of differences in Ca2+ regulating proteins and particularly regulatory MLCs in trapezius muscle of women with chronic musculoskeletal neck and shoulder pain.
25.	Helander, Björn, et al. (author) Rapportering från undersökning av trofinivå hos havsörn - stabila isotoper och miljögifter : Överenskommelse Nr 2213-13-029 2016 Reports (other academic/artistic)abstract Höga koncentrationer av PCB och DDE har konstaterats i ägg från fem havsörnshonor vid Norrlands-kusten. Möjliga förklaringar kan vara regional förorening, eller att vissa örnar lever på en högre nivå i en näringskedja där koncentrationerna ökar i varje steg. Denna rapport redovisar resultat från analyser av PCB, DDE, HCB och stabila isotoper (SI) (δ15N, δ13C) i muskel från fiskar (fyra lokaler), skarvar (tre lokaler), ägg från skarv (tre lokaler) och havsörn (två lokaler) i Västernorrlands län, och SI i ägg och fjädrar från havsörn i olika biotoper vid Östersjökusten. PCB, DDE, HCB i fiskar visade inte påtagligt högre koncentrationer än vad som rapporterats från Norrlandskusten i övrigt, men hade högre värden för PCB och HCB än vid Kvädöfjärden, Holmöarna och Örefjärden, som används som referenslokaler längs Östersjökusten inom den nationella miljöövervakningen. Koncentrationerna i muskel från skarvungar jämfört med muskel från abborre på lipidbasis var ca 3-7 ggr högre för DDE och upp till två resp. tre ggr högre för HCB och PCB (CB-153). I skarvägg jämfört med abborre var förhöjningen av koncentrationer 30-400 ggr för DDE, 30-140 ggr för PCB och 7-30 ggr för HCB. Koncentrationer av DDE och PCB (CB-153) i de högbelastade havsörnsäggen från Västernorrland var 20 respektive 40 ggr högre än i skarväggen. Hos havsörn ses en tydlig trend för både ägg och fjädrar för δ13C, som blir tyngre ju mer marin fyndplatsen antagits vara, men ingen trend för δ15N. En stegvis ökning ses för δ15N i muskelprover från olika fiskar till skarvungar och skarvägg, dock inte vidare till havsörnsägg, men däremot till havsörnsfjädrar. Avsaknaden av skillnad i δ15N mellan skarv- och havsörnsägg indikerar att de inte är jämförbara med avseende på trofiska nivåer. Statistiskt signifikanta men relativt svaga samband ses mellan koncentrationer av DDE och PCB och δ15N i hela materialet av havsörnsägg. Havsörn är på högre trofisk nivå än skarv men δ15N i örnäggen som läggs redan i mars avspeglar troligen ett inslag av däggdjurskadaver under vintern, medan fjädrarna avspeglar sommarfödan (mest fisk och fågel). Möjligheten kvarstår att högre miljögiftshalter i äggen hos vissa havsörnar kan bero på högre trofisk nivå men detta bör undersökas på fjädrar.
26.	Helander, Björn, et al. (author) Rapportering från undersökning av trofinivå hos havsörn - stabila isotoper och miljögifter 2015 Reports (other academic/artistic)abstract Höga koncentrationer av PCB och DDE har konstaterats i ägg från fem havsörnshonor vid Norrlands-kusten. Möjliga förklaringar kan vara regional förorening, eller att vissa örnar lever på en högre nivå i en näringskedja där koncentrationerna ökar i varje steg. Denna rapport redovisar resultat från analyser av PCB, DDE, HCB och stabila isotoper (SI) (δ15N, δ13C) i muskel från fiskar (fyra lokaler), skarvar (tre lokaler), ägg från skarv (tre lokaler) och havsörn (två lokaler) i Västernorrlands län, och SI i ägg och fjädrar från havsörn i olika biotoper vid Östersjökusten. PCB, DDE, HCB i fiskar visade inte påtagligt högre koncentrationer än vad som rapporterats från Norrlandskusten i övrigt, men hade högre värden för PCB och HCB än vid Kvädöfjärden, Holmöarna och Örefjärden, som används som referenslokaler längs Östersjökusten inom den nationella miljöövervakningen. Koncentrationerna i muskel från skarvungar jämfört med muskel från abborre på lipidbasis var ca 3-7 ggr högre för DDE och upp till två resp. tre ggr högre för HCB och PCB (CB-153). I skarvägg jämfört med abborre var förhöjningen av koncentrationer 30-400 ggr för DDE, 30-140 ggr för PCB och 7-30 ggr för HCB. Koncentrationer av DDE och PCB (CB-153) i de högbelastade havsörnsäggen från Västernorrland var 20 respektive 40 ggr högre än i skarväggen. Hos havsön ses en tydlig trend fö båe äg och fjärar fö δ13C, som blir tyngre ju mer marin fyndplatsen antagits vara, men ingen trend fö δ15N. En stegvis öning ses fö δ15N i muskelprover från olika fiskar till skarvungar och skarvägg, dock inte vidare till havsörnsägg, men däremot till havsörnsfjädrar. Avsaknaden av skillnad i δ15N mellan skarv- och havsörnsägg indikerar att de inte är jämförbara med avseende på trofiska nivåer. Statistiskt signifikanta men relativt svaga samband ses mellan koncentrationer av DDE och PCB och δ15N i hela materialet av havsönsäg. Havsön ä påhöre trofisk nivåä skarv men δ15N i örnäggen som läggs redan i mars avspeglar troligen ett inslag av däggdjurskadaver under vintern, medan fjädrarna avspeglar sommarfödan (mest fisk och fågel). Möjligheten kvarstår att högre miljögiftshalter i äggen hos vissa havsörnar kan bero på högre trofisk nivå men detta bör undersökas på fjädrar.
27.	Hellsmark, Hans, 1974, et al. (author) Teknologiska innovationssystem inom energiområdet: En praktisk vägledning till identifiering av systemsvagheter som motiverar särskilda politiska åtaganden 2014 Reports (other academic/artistic)abstract Syftet med denna rapport är att illustrera hur ett praktiskt inriktat ramverk, tekno- logiska innovationssystem (TIS), kan användas av analytiker och beslutsfattare vid departement och myndigheter för att analysera strategiskt viktiga teknikområden ?????????????????????????????????????????????????????????????????????????????I rapporten analyseras fem TIS centrerade kring havsbaserad vindkraft, marin energi, ????????????????????????????????????????????????????????????????????????????????????? systemsvagheter som bromsar områdets vidare utveckling, vilka som kan åtgärdas av systemets aktörer och vilka som motiverar särskilda politiska åtaganden. Rapporten utgör därmed ett underlag för att formulera åtgärder för att åstadkomma ökad innova- tion, teknikspridning och industrialisering inom ovan nämnda teknikområden.Studien har även möjliggjort en jämförande analys av likheter och skillnader ???????????????????????????????????????????????????????????????????????????????? ?????????????????????????????????????????????????????????????????????????????????????? mellan områdena – de är starka respektive svaga av olika orsaker. Detta visar att ???????????????????????????????????????????????????????????????????????Samtidigt har områdena gemensamma drag. Systemets aktörer, där även politiska ???????????????????????????????????????????????????????????????????????????????????? ?????????????????????????????????????????????????????????????????????????????- skapsnätverk. Men de har varit sämre på att skapa tidiga nischmarknader som ger utrymme för fortsatt lärande och kostnadsreduktion. Sådana nischer kan ibland skapas av marknadens aktörer, men ofta krävs politiska styrmedel. De behövs för att investeringar i kunskapsutveckling ska kunna nyttiggöras och för att en bred industriell utveckling inom nya områden skall göras möjlig i Sverige.Vidare presenteras lärdomar kring vad en aktiv teknikpolitik innebär. Två huvud- ??????????????????????????????????????????????????????????????????????????????- hällsbygget och därför bör vara ett politikområde bland många samt att den skarpa ??????????????????????????????????????????????????????????????????????????????- ?????????????????????????????????????????????????????????????????????????????????? ?????????????????????????????????????????????????????????????????????????????????? olika faser av innovationssystemets utveckling.För att lyckas med en aktiv teknikpolitik behövs en hög grad av koordinering ??????????????????????????????????????????????????????????????????????? teknikområden så att ”rätt” typ av åtgärder kan sättas in vid ”rätt” tidpunkt av ”rätt” aktör. TIS-ramverket lyfts här fram som en metod för att skapa ett sådant underlag. Slutligen presenteras en metod för projektbedömningar som syftar till att stötta handläggare i utvärderingar av projekt inom nya teknikområden.Rapporten i sin helhet riktar sig särskilt till beslutsfattare och handläggare vid myndigheter, departement och politiker, men även andra organisationer och indi- vider med intresse av att högt ställda klimatmål ska kunna nås samtidigt som en positiv näringslivsutveckling möjliggörs.
28.	Hellström, Anders R., et al. (author) Inactivation of Pmel Alters Melanosome Shape But Has Only a Subtle Effect on Visible Pigmentation 2011 In: PLoS Genetics. - : Public Library of Science (PLoS). - 1553-7390 .- 1553-7404. ; 7:9, s. e1002285- Journal article (peer-reviewed)abstract PMEL is an amyloidogenic protein that appears to be exclusively expressed in pigment cells and forms intralumenal fibrils within early stage melanosomes upon which eumelanins deposit in later stages. PMEL is well conserved among vertebrates, and allelic variants in several species are associated with reduced levels of eumelanin in epidermal tissues. However, in most of these cases it is not clear whether the allelic variants reflect gain-of-function or loss-of-function, and no complete PMEL loss-of-function has been reported in a mammal. Here, we have created a mouse line in which the Pmel gene has been inactivated (Pmel(-/-)). These mice are fully viable, fertile, and display no obvious developmental defects. Melanosomes within Pmel(-/-) melanocytes are spherical in contrast to the oblong shape present in wild-type animals. This feature was documented in primary cultures of skin-derived melanocytes as well as in retinal pigment epithelium cells and in uveal melanocytes. Inactivation of Pmel has only a mild effect on the coat color phenotype in four different genetic backgrounds, with the clearest effect in mice also carrying the brown/Tyrp1 mutation. This phenotype, which is similar to that observed with the spontaneous silver mutation in mice, strongly suggests that other previously described alleles in vertebrates with more striking effects on pigmentation are dominant-negative mutations. Despite a mild effect on visible pigmentation, inactivation of Pmel led to a substantial reduction in eumelanin content in hair, which demonstrates that PMEL has a critical role for maintaining efficient epidermal pigmentation.
29.	Hellström, Björn, 1959-, et al. (author) Acoustic Design Artifacts and Methods for Urban Soundscapes 2008 In: The 15th International Congress on Sound and Vibration In: International Journal of Acoustics & Vibration. ; , s. 52-52 Conference paper (peer-reviewed)abstract The research question is: “How to develop and apply acoustic artifacts and design methodologies for improving soundscapes in urban outdoor spaces?” In the project, this research question is limited to two specific types of urban outdoor spaces – city-park and city-square – and to two types of acoustic design artifacts. These are: I. Dynamic promotion of qualitative site specific sounds (e.g., the overall site specific sonic atmosphere, sounds from human activities, birds and fountains), which creates an improved soundscape. II. Sound-art installations, that creates delimited auditory sub-spaces within the park/square. The purpose and method is: 1. To provide two case-studies of artistic soundscape improvement, one in a noise polluted city-park and one in a city-square. The case-studies will serve as models for future applications of the new acoustic design artifacts. 2. To create and validate an innovative acoustic design methodology based on state-of-the-art real-time acoustic simulation tools integrated into the design process. The methodology will be validated in psychoacoustic listening experiments and field studies. 3. To determine the potential of the two acoustic design artifacts (I Dynamic promotion of qualitative site specific sounds, and II Sound-art installations) for providing pleasant and restorative soundscapes, in order to strengthening the social interaction as well as the spatial and aesthetical qualities in noise polluted city parks/squares. The present project beats a new track by combining acoustic design with sound art research, integrating methodologies based on real-time acoustic simulation and application of psychoacoustic methodology for validating simulations and for evaluating perceptual, emotional and behavioural effects on visitors to public open spaces. The ongoing research project, financed by the Swedish Research Council, is executed by the University College of Arts, Crafts and Design (Konstfack), Gösta Ekman Laboratory – Stockholm University and Karolinska Institutet and the Interactive Institute, all in Stockholm, Sweden.
30.	Hellström, Björn, 1959- (author) Acoustic Design Artifacts and Methods for Urban Soundscapes : A Case Study on the Qualitative Dimensions of Sounds 2012 In: Proceedings of Inter-noise 2012 "Quieting the world's cities".. - New York, USA : Institute of Noise Control Engineering. ; , s. 1-12 Conference paper (peer-reviewed)abstract Noise is steadily on the rise in urban settings, creating a potential health hazard as well as being a nuisance. In major European cities, noise levels are so high that the majority of urban parks can no longer truly serve as recreational environments, a problem the WHO and the EU are attempting to address. This study explores various strategies that promotethe sustainable development of urban soundscapes at locations meant for rest, recreation, and social interaction. How are people affected by the combined effects of traffic and nature sounds in urban parks? To this end, we adopted a new track – the use of interdisciplinarymethodology – bringing together architectural analysis and artistic experiments, along with psychoacoustic methodology to evaluate aesthetic, emotional, perceptual, and spatial effects. A large-scale case study was conducted at a city park to explore if and how subjects are affected by purposely distributed sounds. The working hypothesis was that it is possible to cancel out traffic noise by affecting aural perceptions using a process known as informational masking. Our long-term objective is to create a scientific foundation for action plans, both pre-emptive and trouble-shooting, targeting parks and other similar public spaces that provide a relaxing environment.
31.	Hellström, Björn, 1959-, et al. (author) Acoustic Design Artifacts and Methods for Urban Soundscapes : A case study on the qualitative dimensions of sounds 2014 In: Journal of Architectural and Planning Research. - 0738-0895. ; 31:1, s. 57-71 Journal article (peer-reviewed)
32.	Hellström, Björn, 1959- (author) Acoustic design Artifacts and Methods for Urban Soundscapes 2009 In: Proceedings of a meeting held 5-9 July 2009, Krakow, Poland.. - : International Institute of Acoustics and Vibration (IIAV). - 9781615677368 ; , s. 1-8 Conference paper (peer-reviewed)abstract The research question is: "How to develop and apply acoustic artefacts and design method-ologies for improving soundscapes in urban outdoor spaces?" In the project, this research question is limited to one specific type of urban outdoor space – city-park – and to two types of acoustic design artefacts. These are: I. Dynamic promotion of qualitative site specific sounds (e.g., the overall site specific sonic atmosphere, sounds from activities, birds and fountains), which creates an improved soundscape. II. Sound-art installations, that creates de-limited auditory sub-spaces within the park/square.
33.	Hellström, Björn, et al. (author) Acoustic design artifacts and methods for urban soundscapes : A case study on the qualitative dimensions of sounds 2014 In: Journal of Architectural and Planning Research. - 0738-0895. ; 31:1, s. 57-71 Journal article (peer-reviewed)abstract The amount of noise in urban settings is steadily on the rise, creating a potential health hazard and causing a general nuisance. In major European cities, noise levels are so high that the majority of urban parks can no longer truly serve as recreational environments, a problem the World Health Organization and the European Union are attempting to address. This study explores various strategies that promote the sustainable development of urban soundscapes at locations meant for rest, recreation, and social interaction. Further, we look at how people are affected by the combined effects of traffic and nature sounds in parks and other outdoor settings. To this end, we adopted a new track the use of interdisciplinary methodology that brings together architectural analysis, artistic experiments, and psychoacoustic methodology to evaluate the aesthetic, emotional, perceptual, and spatial effects of noise on subjects spending time in public open-air spaces. We conducted a large-scale case study at a city park to explore whether subjects were affected by purposely distributed sounds and, if so, how The working hypothesis was that it is possible to cancel out or mute traffic noise by affecting individuals' aural perceptions using a process known as informational masking. Our long-term objective is to create a scientific foundation for action plans, both preemptive and troubleshooting, targeting noise reduction in parks' and similar public spaces that are meant to provide a relaxing environment.
34.	Hellström, Björn, 1959- (author) Acoustic design in Commercial Space 2006 In: ICSV13 Proceedings. Conference paper (peer-reviewed)abstract The starting point for this paper is to discuss and challenge the visual dominance in architectural thinking, and to raise competence among architects and planners on sound and sound environment issues. To promote a sustainable urban environment,sounds must be integrated in the complexity of urban design and development. Therefore,it is especially important to integrate acoustic and architectural analysis.The paper focuses on urban public space as well as indoor public pathways, communication space and semi-public commercial space, e.g. shopping malls, wherereliability on sonic orientation may be crucial. For these kinds of collective spaces, I argue, it is especially important to integrate acoustic and architectural analysis. Their sonic conditions are often loud, blurred, and confusing, with little correspondence between visual and aural perception, and with weak articulations of spatial dimension, distance, borders, and orientation. If not cared for, the result may be increasing sound disturbance, lack of people’s moving through the areas, dangerous differences between day and night use, disorientation for several user groups, and segregation.The paper is integrated in the ongoing research project, Transmission, executed by Urban Sound Institute (USIT), financed by Swedish Research Council. Results will hopefully deliver good examples and operative methods to be used by architects, planners and acousticians. The paper is also a result of ongoing projects and research at the acoustic consultancy company Ingemansson Technology AB, Sweden
35.	Hellström, Björn, 1959- (author) Akustisk design : spola snacket om buller - prata om istället om ljudkvalitet 2007 In: V-byggaren. - Stockholm : Svenska väg- och vattenbyggares riksförbund. - 0283-5363. ; :2, s. 39-43 Journal article (pop. science, debate, etc.)
36.	Hellström, Björn, 1959-, et al. (author) Akustisk design i Citybanan 2005 In: Bygg och Teknik. - Stockholm : Förlags AB Bygg & teknik. - 0281-658X .- 2002-8350. ; :3, s. 12-14; 16 - 17 Journal article (pop. science, debate, etc.)
37.	Hellström, Björn, 1959- (author) Akustisk design och hållbar stadsutveckling 2011 In: Ljudmiljö, hälsa och stadsbyggnad. - Lund : Ljudmiljöcentrum vid Lunds universitet. ; , s. 26-36 Book chapter (other academic/artistic)
38.	Hellström, Björn, 1959- (author) Akustisk design och hållbar utveckling 2010 In: Bygg och Teknik. - Stockholm : Förlags AB Bygg & teknik. - 0281-658X .- 2002-8350. ; :3, s. 24-27 Journal article (pop. science, debate, etc.)
39.	Hellström, Björn, 1959- (author) Akustiska stadsplanerare efterlyses 2010 In: Svenska dagbladet. - Stockholm : Svenska dagbladet. - 1101-2412. ; :2010-01-09 Journal article (pop. science, debate, etc.)
40.	Hellström, Björn, 1959- (author) Akustiskt designlaboratorium 2006 Reports (pop. science, debate, etc.)abstract Projektets målsättning är att etablera ett Akustiskt Designlabb på Konstfack som ska omfatta utbildning och forskning, och även fungera som mötesplattform för representanter från näringslivet och från universitetssfären. Idag finns audioteknisk utrustning utspridd på Konstfacks olika institutioner. Tanken är att skapa ett interdisciplinärt labb genom att samla teknik och specialistkompetenser under ett och samma tak. Personalen kommer att bestå av ett team av personer med kunskaper om ljudredigeringsteknik, ljudkonstinstallationer, ljuddesign, rumsakustik, konst, arkitektur, musik och pedagogik mm. Teknik och kompetens ska vara tillgänglig för forskningsprojekt och för lärare och studenter vid de olika institutionerna, och även för skolans utställningsverksamheter. Det finns idag inget motsvarande ”laboratorium” i Sverige, utan det här skulle bli unikt för Konstfack.
41.	Hellström, Björn, 1959- (author) Buller kan lösas med design 2013 In: Arkitekten. - Stockholm : Arkitektförbundet. - 0347-058X. ; :10, s. 20-20 Journal article (pop. science, debate, etc.)
42.	Hellström, Björn, 1959- (author) Konstfack satsar på akustisk design 2006 In: Bygg och Teknik. - Stockholm : Förlags AB Bygg & teknik. - 0281-658X .- 2002-8350. ; :3, s. 46-48 Journal article (pop. science, debate, etc.)
43.	Hellström, Björn, 1959- (author) Kritiken missar målet 2010 In: Svenska dagbladet. - Stockholm : Svenska dagbladet. - 1101-2412. ; :2010-08-29 Journal article (pop. science, debate, etc.)
44.	Hellström, Björn, et al. (author) Lagningsmetoder 1978 Reports (peer-reviewed)
45.	Hellström, Björn, 1959, et al. (author) Modelling the shopping soundscape 2011 In: Journal of Sonic Studies. - Leiden : Leiden University Press. - 2212-6252. ; 1 Journal article (peer-reviewed)abstract This article’s pivotal theme is: “How to compose a site-specific sound-art installation for a commercial space in order to improve conditions, while taking perceptual, social, aesthetical, temporal and spatial criteria into account” The interdisciplinary, art-based research approach is derived from the concept of acousmatics, i.e. the process of apprehending any sound, the source of which is invisible. Acousmatic perception concerns the everyday identification process; when lacking visual contact with the sound source, we automatically seek references, such as social (what produces the sound and what is my relation to it?), aesthetical, spatial and temporal (e.g. orientation and demarcation). The acousmatic concept identifies phenomena based on individually, culturally and spatially conditioned experiences. Today, a shopping culture dominates urban space. Indoor malls expose us to all types of acousmatically perceived sounds: jingles, signals, music and muzak from public loudspeakers, mobile devices, etc. In this respect, one could claim that the soundscape of the shopping culture embodies an acousmatic environment. In 2009, the research and sound-art group Urban Sound Institute (USIT) created a permanent sound installation in a shopping mall (Gallerian) located in downtown Stockholm. This installation serves as a case study for the present paper. The artistic assignment involved the creation of a meeting place without material devices as well as the enhancement of the overall atmosphere. The research objective was to elucidate different qualities of the sound installation in regard to the acousmatics of the shopping mall, promoting discussions on the articulation of sound-space configurations in relation to time and site-specific context, issues on musical-architectural qualities as well as objective, subjective and inter-subjective interrelationships between the experience of the sound-art installation and the experience of the shopping mall soundscape. Other applied, interrelated concepts are metabolic environment and masking- and cutting effects.
46.	Hellström, Björn, 1959- (author) Noise design : Architectural Modelling and the Aesthetics of Urban Acoustic Spase 2003 Doctoral thesis (other academic/artistic)abstract Noise Design takes up a structural approach to sound issuesin general and more particularly to urban acoustic space. Whilemost recent research efforts in the field adopt a defensiveattitude by seeking to protect people from sounds, this bookcelebrates our constructive and creative relations with thesound world and develops methods to manage sounds as mediatorsof qualitative information. The title is chosen to oppose thecommon meaning of noise, as‘unwanted sound’, whichimplies a denial of all its immanent qualities as well as itscontexts and uses. The thesis explores the concept oftransparent and fluid space as a central principle forarchitectural conception. Urban acoustic space is seen astransient and immaterial, making public and private spaces lesspredictable, less monotonous.The thesis comprises a Prologue, which provides an overviewof the subject, and three essays: On Sound Design, On SoundEffect and On Sound Identity. The first essay derives mainlyfrom the fieldof music, and discusses the internal,morphological properties of sound as well as aspects ofperception and notation. The second and third essays originatefrom theories and methods that are developed at the CressonInstitute in Grenoble, focusing on the external properties ofsounds, mainly regarding spatial, social and perceptualcriteria. Each essay comprises a descriptive and operativesection, whereby the former emphasises the exploration andqualification of conceptual tools, while the latter examinesthe concepts in different types of models. Thus, the essays arebased upon a research-by-design methodology, revealing theclose connection between analysis and creation towards design,and including, for example, the sound art installations Tiksand Tiger, which are presented in the text body and on theattached CD.Keywords:architecture, music, aesthetics, sound art,acoustic space, sound design, sound effect, sound identity,sound morphology, graphic notation, diagram, sampling culture,acousmatics, sound-object, metabolic effect, ubiquity,synecdoche, schizophonia, gesture,listening-hearing-attending-understanding, Cresson,Jean-François Augoyard, Pascal Amphoux, Tiks, Tiger.
47.	Hellström, Björn, 1959- (author) Noise design - ett sidoskott från soundscaperörelsen. 2007 In: Nutida Musik. - Stockholm : Nutida musik. - 1652-6082. ; :1, s. 72-80 Journal article (pop. science, debate, etc.)
48.	Hellström, Björn, 1959- (author) Om Kontorslandskapens Akustik & Arkitektur - vad örat hör men ögat inte ser. 2012 Book (pop. science, debate, etc.)
49.	Hellström, Björn, 1959-, et al. (author) Redesign of One Atmosphere : What do you want to hear? 2008 In: Faire une ambiance / Creating an atomsphere. Conference paper (peer-reviewed)abstract In an ongoing research project the design of acoustical atmospheres in large indoor spaces are investigated. The research question is: “How to redesign one sonic atmosphere into a variation of sub-atmospheres in large indoor spaces?” This question is especially valid for spaces such as semi-public commercial spaces (e.g. shopping malls), libraries, airports and communication spaces. The sonic atmosphere in these collective spaces is often loud, blurred and confusing, with little correspondence between visual and aural perception, and with weak articulations of spatial dimension, distance, borders and orientation. Together the different sound sources within these spaces generate a sonic hubbub. Even though such spaces comprise of several types of activities, the sonic atmosphere is the same all over the place.Hence, this research project focuses on design of sonic variations of the atmosphere; i.e., site specific sounds that deal with qualities such as communication, comfort, orientation, identity and privacy. The objective is to develop and test an interdisciplinary design methodology, which comprises a number of co-related methods; e.g. acoustic measurements, architectural site analysis, as well as virtual modeling and representation (visual and acoustic) of the space. The main part of the project is the virtual modeling and representation. It connects software that handles architectural 3D-modelling (SketchUp) with the Catt-Acoustic software, used for prediction and auralization.The research project also includes a case-study, which comprises proposals for redesign of a congress centre (Scandic Infra City), situated north of Stockholm. The proposals –consisting of architectural elements, sound installations (additions of sounds) as well as acoustical measures – will be demonstrated in a virtual model. The presumed effect is a differentiation in terms of a variety of sonic sub-atmospheres within the congress centre. The methodology developed in the project is intended to function as a tool for design measures of large indoor spaces. It is an interdisciplinary tool in that it supports acousticians as well as architects. The case-study may serve as a pilot model for future applications of redesign of the sonic atmosphere in large indoor spaces.This paper is a result of a research project, executed by the acoustic consultancy company ÅF-Ingemansson and the University College of Arts, Crafts & Design (Konstfack), Stockholm. The project has funding from the White’s Foundation for research and ARKUS, a Swedish foundation for the improvement of qualifications within architecture.
50.	Hellström, Björn, 1959-, et al. (author) Room acoustic design in open-plan offices 2009 In: Proceedings of the Institute of Acoustics Volume 31 Pt.3. - St. Albans, United Kingdom : Institute of Acoustics. - 9781615676804 ; , s. 2954-2959 Conference paper (peer-reviewed)abstract In a Nordic cooperation project the acoustical conditions in open-plan offices was investigated. Measurements have been carried out in five open plan offices accompanied with an inquiry gathering the subjective judgments by the staff. A program for the acoustical measurements was designed specifying how to perform the measurements and which type of parameters to measure. The acoustical parameters included in the measurements are Reverberation time T20, Early Decay Time (EDT), Clarity (C50), Speech transmission index (STI), Speech intelligibility index (SII), Privacy Index (PI), Rate of spatial decay of sound pressure levels per distance doubling (DL2 ), Excess of sound pressure level with respect to a reference curve (DLf), background noise levels in occupied and unoccupied offices. In two of the offices are furbishment program was carried out. Measurements as well as questionnaire were accomplished after refurbishment. The effect on room acoustic parameters DL2 and DLf and on subjective judgments by the staff will be presented in this paper.

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