| 1. |
- Nardella, F A, et al.
(author)
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Fc epitopes for human rheumatoid factors and the relationships of rheumatoid factors to the Fc binding proteins of microorganisms
- 1988
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In: Scandinavian Journal of Rheumatology. Supplement. - : Informa UK Limited. - 1502-7740 .- 0300-9742 .- 1502-7732. ; 17:Suppl. 75, s. 190-198
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Journal article (peer-reviewed)abstract
- Work from our laboratories has shown that the major antigenic determinants for rheumatoid factors (RFs) are in the C gamma 2-C gamma 3 interface region of IgG in the same area that binds staphylococcal protein A (SPA). Furthermore, the Fc binding proteins of groups A, C and G streptococci as well as the Fc binding proteins induced on cell surfaces by herpes simplex virus type I also bind to the same area of IgG. These binding site similarities between RFs and the microbial Fc binding proteins suggested conformational similarities between the RF antigen combining regions and the Fc binding regions of the microbial proteins. This hypothesis was supported by the observation that antibodies to SPA bind to the antigen combining regions of most RFs as well as to the Fc binding region of the T15 group A streptococcal Fc binding protein. These findings indicate that RFs bear the conformational internal image of these microbial proteins and suggest that RFs could arise as antibodies to the idiotypic determinants on antibodies to microbial Fc binding proteins. Alternatively, microbial Fc binding proteins could present IgG to the immune system in a way that renders specific areas of the C gamma 2-C gamma 3 interface region immunogenic. These relationships between RFs and microbial Fc binding proteins may prove to be important for our understanding of the generation of RFs in rheumatoid arthritis.
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| 2. |
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| 3. |
- Dahlqvist, Solbritt Rantapää, et al.
(author)
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Acetylator phenotypes in rheumatoid-arthritis patients with or without adverse drug-reactions to sodium-aurothiomalate or d-penicillamine
- 1987
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In: Scandinavian Journal of Rheumatology. - : Informa UK Limited. - 0300-9742 .- 1502-7732. ; 16:4, s. 235-239
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Journal article (peer-reviewed)abstract
- The acetylator phenotype was determined in 59 patients with classical, seropositive and erosive rheumatoid arthritis (RA) treated with sodium-aurothiomalate or d-penicillamine. Patients with adverse drug reactions (ADR) leading to drug withdrawal (n=29) were compared with a group of patients without ADR (n=30). The frequency of slow acetylators was significantly (p< 0.05) increased in all RA patients, irrespective of the presence of ADR, particularly in the male patients, compared with a control population. No association was found between acetylator phenotype and clinical data or secondary Sjögrens's syndrome (SS).
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| 4. |
- Dahlqvist, Solbritt Rantapää, et al.
(author)
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Clinical symptoms and HLA antigens in a family with reiters disease
- 1985
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In: Scandinavian Journal of Rheumatology. - 0300-9742 .- 1502-7732. ; 14:2, s. 149-158
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Journal article (peer-reviewed)abstract
- A clinical and immunogenetic study was performed on a three-generation family with Reiter's disease (RD). Twelve of 56 members of the family (33 clinically examined) including one in-law, had symptoms of arthritis, urethritis, conjunctivitis, uveitis, and/or mucocutaneous manifestations, but only one had the complete triad of Reiter's syndrome (RS). Radiographic sacro-iliitis was found in 7 individuals, and monoarticular onset was reported in 5 out of 7 with peripheral arthritis. HLA B27 was found in 26 of the 37 family members who were tissue typed (including one in-law). All individuals with RD were B27-positive. Seven different B27 phenotypes were identified. This finding suggests that RD is associated with the B27 antigen itself, and not to a gene closely linked to B27. From a pedigree analysis of this family an autosomal dominant inheritance with incomplete penetrance or multifactorial inheritance seemed the most probable alternatives. The family history is a useful adjunct in the diagnosis of RD.
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| 5. |
- Dahlqvist, Solbritt Rantapää
(author)
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Genetic-markers in rheumatoid-arthritis
- 1986
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In: Scandinavian Journal of Rheumatology. - 0300-9742 .- 1502-7732. ; 15:Suppl. 58, s. 1-29
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Journal article (peer-reviewed)
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| 6. |
- Dahlqvist, Solbritt Rantapää, et al.
(author)
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HLA antigens in rheumatoid-arthritis patients with and without a family history of polyarthritis
- 1985
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In: Scandinavian Journal of Rheumatology. - 0300-9742 .- 1502-7732. ; 14:4, s. 375-380
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Journal article (peer-reviewed)abstract
- The HLA antigens, A, B and DR, were studied in 141 patients with erosive, seropositive rheumatoid arthritis (RA). The frequency of the B27 antigen was significantly increased among patients with a family history of symmetrical polyarthritis compared with blood donor controls (p<0.001) and with patients without a family history of polyarthritis (p<0.005). The frequency of DR4 was significantly (p<0.001) increased among the RA patients, but there was no significant association between DR4 and a family history of polyarthritis.
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| 7. |
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| 8. |
- Mogensen, Brynjolfur, et al.
(author)
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Surface replacement of the hip in juvenile chronic arthritis
- 1981
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In: Scandinavian Journal of Rheumatology. - : Informa UK Limited. - 0300-9742 .- 1502-7732. ; 10:4, s. 269-272
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Journal article (peer-reviewed)abstract
- Seventeen resurfacing arthroplasties undertaken in 13 patients with severe hip arthritis are described. The youngest patient was 14 years and the mean age 23 years. The average follow-up time is 2 years. In one patient, pain-free for 7 months, the femoral cup slipped and revision into total hip replacement was easily performed. The remaining patients are pain-free, have increased motion, a better walking capacity and can enjoy sex life. The tremendous improvement in quality of life for these young patients justifies operation even if all may have to be converted into total hip replacement within a couple of years, although there is nothing to indicate that in this early follow-up.
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| 9. |
- Redlund-Johnell, Inga, et al.
(author)
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Backward tilting of the posterior atlantal arch in rheumatoid arthritis
- 1989
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In: Scandinavian Journal of Rheumatology. - : Informa UK Limited. - 1502-7732 .- 0300-9742. ; 18:5, s. 261-263
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Journal article (peer-reviewed)abstract
- In a retrospective survey of 450 patients with rheumatoid arthritis on whom cervical spine radiography was performed, one patient was found with a backward tilting of the posterior arch of the atlas. With preserved relations anteriorly, the posterior arch was rotated downward in front of the spinous process of the axis, encroaching on the space of the spinal canal.
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| 10. |
- Redlund-Johnell, Inga
(author)
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Posterior atlanto-axial dislocation in rheumatoid arthritis
- 1984
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In: Scandinavian Journal of Rheumatology. - : Informa UK Limited. - 1502-7732 .- 0300-9742. ; 13:4, s. 337-341
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Journal article (peer-reviewed)abstract
- Seven patients with rheumatoid arthritis and posterior atlanto-axial dislocation are presented. The patients were elderly women who had suffered with the disease a long time. In all cases earlier cervical radiographs were available, excluding any predisposing congenital anomaly. Fracture and arthritic destruction of the dens, of parts of the body of the axis, or of the anterior arch of the atlas proved to be predisposing factors of the lesion.
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| 11. |
- Redlund-Johnell, Inga
(author)
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Radiographic measurements of severe temporomandibular joint destruction at cervical radiography. Designed for evaluation in rheumatoid arthritis
- 1987
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In: Scandinavian Journal of Rheumatology. - : Informa UK Limited. - 1502-7732 .- 0300-9742. ; 16:5, s. 355-359
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Journal article (peer-reviewed)abstract
- Radiological examinations of the temporomandibular joints are not so often performed in patients with rheumatoid arthritis (RA). However, greater abnormalities of the mandibular head and neck may be evaluated at cervical radiography. With a new method, where the perpendicular distance from the palato-occipital line to the mandibular angle was measured, normal values of the distance or of ramal height were found to be above 27.5 mm in women and 33 mm in men. A significantly diminished ramal height was found in a patient material with RA compared with a normal material. Minor changes of the temporomandibular joints cannot be detected with this method, but severe arthritic destruction of the mandibular head or neck will give subnormal values.
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| 12. |
- Redlund-Johnell, Inga
(author)
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Severe rheumatoid arthritis of the temporomandibular joints and its coincidence with severe rheumatoid arthritis of the cervical spine
- 1987
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In: Scandinavian Journal of Rheumatology. - : Informa UK Limited. - 1502-7732 .- 0300-9742. ; 16:5, s. 347-353
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Journal article (peer-reviewed)abstract
- The degree of arthritis of the cervical spine was retrospectively studied in cervical spine radiographs from 400 patients with rheumatoid arthritis. In the same cervical radiographs the arthritic destruction of the temporomandibular joints was measured as diminished ramal height from the mandibular angle to the palato-occipital line. Reduced ramal height was found in 76 patients, 69 women and 7 men, and in 33 patients the reduction in height was severe enough to be compatible with a total destruction of the mandibular head. An arthritic destruction of the temporomandibular joints occurred significantly more often in patients with a severe cervical arthritis than in those without cervical affection, and vice versa. Of the 76 patients with a reduced ramal height, 66% had a severe arthritis of the cervical spine and of the 100 patients with severe arthritic changes of the cervical spine, 50% had severe destructive arthritis of the temporomandibular joints.
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| 13. |
- Redlund-Johnell, Inga, et al.
(author)
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Subaxial antero-posterior dislocation of the cervical spine in rheumatoid arthritis
- 1985
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In: Scandinavian Journal of Rheumatology. - : Informa UK Limited. - 1502-7732 .- 0300-9742. ; 14:4, s. 355-363
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Journal article (peer-reviewed)abstract
- A subaxial (below C2) antero-posterior dislocation of the cervical spine was present in 18% of 407 patients with rheumatoid arthritis. The dislocation was as common at only one level as at two more levels and was more severe if the height of the spinous process was reduced. Most of these same patients also had an atlanto-axial dislocation. At follow-up examinations, the frequency of a subaxial dislocation was the same in patients with a severe atlanto-axial dislocation who were receiving conservative treatment as in patients with a cervico-occipital fusion. Neurological symptoms occurred more frequently in patients with an encroached spinal canal and in patients with a reduced height of the entire cervical spine.
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| 14. |
- Redlund-Johnell, Inga
(author)
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Upper airway obstruction in patients with rheumatoid arthritis and temporomandibular joint destruction
- 1988
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In: Scandinavian Journal of Rheumatology. - : Informa UK Limited. - 1502-7732 .- 0300-9742. ; 17:4, s. 273-279
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Journal article (peer-reviewed)abstract
- Among 400 patients with rheumatoid arthritis and measurable ramus height there were 76 patients with mutilating arthritis of the temporomandibular joints. In 30 of these 400 patients, episodes of upper airway obstruction had occurred, mostly when the patient lay supine. Laryngoscopy had been performed in only 7 patients, and in 3 of those a laryngeal arthritis was detected. Upper airway obstruction had occurred significantly more often in patients with arthritis of the temporomandibular joints than in those with normal joints. In 70% of the patients with a severe arthritic destruction of the temporomandibular joints, episodes of airway obstruction had occurred. Upper airway obstruction is assumed to occur in those patients due to a pharyngeal obstruction, as in other patients with micrognathia or sleep apnea syndrome.
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| 15. |
- Thomsen, P, et al.
(author)
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Acute synovitis induced by preformed immune complexes
- 1986
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In: Scandinavian Journal of Rheumatology. - : Informa UK Limited. - 1502-7732 .- 0300-9742. ; 15:2, s. 134-142
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Journal article (peer-reviewed)abstract
- The morphology of acute immune complex (IC) elicited synovitis in rabbit knee joints was studied, as well as IC-induced leukocyte activation in vivo and in vitro. Acute synovitis was induced by intra-articular injection of in vitro preformed, complement activating bovine serum albumin (BSA)-anti-BSA IC. Within 30 min, migration of polymorphonuclear granulocytes (PMNGs) was observed. Scanning electron microscopy showed that adhering, apparently activated leukocytes were attached to the synovial lining, often forming clusters. Phagocytosis of IC was evident, as immunoglobulins were detected within the leukocyte cytoplasm by the direct immunofluorescence technique. At the peak accumulation of PMNGs, focal erosions of the synovial lining were observed. Later, monocytes and macrophages appeared and degenerated PMNGs were found, sometimes within the cytoplasm of large macrophages. Chemiluminescence experiments showed a maximum in vitro activation of leukocytes by complement activating IC formed near optimal precipitation proportions and in slight antigen excess, whereas IC in large antigen excess gave a smaller and later response.
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| 16. |
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| 17. |
- Löfkvist, U-B, et al.
(author)
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Individually adapted lightweight walking aids with moulded handles for patients with severely deforming chronic arthritis
- 1988
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In: Scandinavian Journal of Rheumatology. - 1502-7732. ; 17:3, s. 167-173
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Journal article (peer-reviewed)abstract
- Patients with severely deforming rheumatoid arthritis and impaired function of the upper extremity are often unable to use conventional walking aids. This report describes 42 such patients who were equipped with altogether 75 individually manufactured, lightweight walking aids (12 crutches, 12 forearm-crutches, 39 crutch-sticks and 12 sticks). A plaster cast of the patient's grip as well as analysis of the integrated function of the shoulder-elbow-wrist was used when preparing the walking aid. It was thereby possible to produce suitable walking aids for all but one patient. At follow-up after 12-18 months, of use, most patients belonging to functional classes II and III were satisfied with their walking aid(s) and 22 considered it/them indispensable. However, in 4 patients, progressive disease with increased disease activity/deteriorating hand function and in 3 patients increasing shoulder pain reduced their usability. Lack of motivation was one reason for low use intensity. Follow-up demonstrated that most patients were able to use these walking aids without detectable negative effects on the upper extremity. The durability of the walking aid was satisfactory. Thus an individually moulded handle on an adapted lightweight walking aid is important helping patients with severely deforming arthritis to maintain independent ambulation, and should be made more widely obtainable.
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| 18. |
- Sjöblom, K G, et al.
(author)
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Factors related to the progression of joint destruction in rheumatoid arthritis.
- 1984
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In: Scandinavian Journal of Rheumatology. - 1502-7732. ; 13:1, s. 21-27
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Journal article (peer-reviewed)abstract
- In 103 (M=25, F=78) of 150 consecutive RA patients, values of the following variables were obtained at the start and end of a 2-year follow-up period: radiographic destruction score of hands and feet according to Larsen (Larsen index), Ritchie index, B-hemoglobin, ESR and plasma proteins (α1-antitrypsin, ceruloplasmin, CRP, fibrinogen, haptoglobin, orosomucoid, IgA, IgG, IgM, C3 and C4). 60% of the values of ΔLI (final minus initial value of Larsen index) were significantly larger than zero (11-44 units, p<0.05). ΔLI was larger in females than in males (p=0.11). Comparing women with duration of disease (DoD) 1-6 years versus 7-52 years, ΔLI was larger in the former group (p=0.005). Comparing women with the largest ΔLI (19-44 units) with the remainder ones (ΔLI=-9-18 units), CRP and haptoglobin was higher and IgM lower in the former group (p=0.03, 0.02 and 0.03 respectively). In women with DoD 1-6 years (and only in this interval) significant linear relationships were found between ALI and hemoglobin (r-0.52, p<0.01) Ritchie index, haptoglobin, CRP (r=0.41-0.46, p<0.05) and IgM (r=-0.43, p<0.05). The mean of repeated hemoglobin values correlated even more strongly with ΔLI (r=0.70, p<0.001). ΔLI was predicted quite well by an expression linear in hemoglobin, fibrinogen and IgM (R=0.84). Similar results were obtained when male patients were included. © 1984 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted
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| 19. |
- Wadenvik, Hans, 1955, et al.
(author)
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Splenic platelet kinetics in systemic lupus erythematosus (SLE).
- 1987
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In: Scandinavian journal of rheumatology. - 0300-9742. ; 16:3, s. 193-8
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Journal article (peer-reviewed)abstract
- The splenic blood flow, intrasplenic platelet kinetics and spleen size were determined in 8 females with systemic lupus erythematosus (SLE), all without signs of active disease, by using gamma-camera scintigraphy with 111In-labelled platelets and 99mTc-stannous colloid. The results for splenic blood flow, intrasplenic platelet transit time and splenic platelet pool size, obtained by compartmental analysis of the initial distribution of radiolabelled platelets between blood and spleen, did not differ from those of a control group. In all SLE patients the spleen size was within normal limits. There was a significant relationship between the spleen volume and the splenic platelet pool size (r = 0.75; p less than 0.05), and between the spleen volume and splenic blood flow (r = 0.76; p less than 0.05). A borderline, inverse correlation was present between an estimate of splenic perfusion and intrasplenic platelet transit time (r = 0.62; p = 0.1). It is concluded that the splenic function, measured as splenic blood flow and intrasplenic platelet kinetics, is not disturbed in SLE patients without active disease.
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