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Träfflista för sökning "L773:1079 9796 OR L773:1096 0961 srt2:(2010-2014)"

Search: L773:1079 9796 OR L773:1096 0961 > (2010-2014)

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1.	Hughes, DA, et al. (author) Early access experience with VPRIV(®): recommendations for 'core data' collection 2011 In: Blood cells, molecules & diseases. - : Elsevier BV. - 1096-0961 .- 1079-9796. ; 47:2, s. 140-142 Journal article (other academic/artistic)
2.	Micale, Lucia, et al. (author) Amplification of the G allele at SNP rs6983267 in 8q24 amplicons in myeloid malignancies as cause of the lack of MYC overexpression? 2011 In: Blood Cells, Molecules & Diseases. - : Elsevier BV. - 1096-0961 .- 1079-9796. ; 47:4, s. 259-261 Journal article (other academic/artistic)
3.	Schuster, Jens, et al. (author) Ribosomal protein S19 binds to its own mRNA with reduced affinity in Diamond-Blackfan anemia 2010 In: Blood Cells, Molecules & Diseases. - : Elsevier. - 1079-9796 .- 1096-0961. ; 45:1, s. 23-28 Journal article (peer-reviewed)abstract Heterozygous mutations in the ribosomal protein S19 (RPS19) gene are associated with Diamond-Blackfan anemia (DBA). The mechanism by which RPS19 mediates anemia are still unclear, as well as the regulation of RPS19 expression. We show herein that RPS19 binds specifically to the 5' untranslated region of its own mRNA with an equilibrium binding constant (K(D)) of 4.1+/-1.9 nM. We investigated the mRNA binding properties of two mutant RPS19 proteins (W52R and R62W) identified in DBA patients. We observed a significant increase in K(D) for both proteins (16.1+/-2.1 and 14.5+/-4.9 nM, respectively), indicating a reduced RNA binding capability (p<0.05). We suggest that the binding of RPS19 to its mRNA has a regulatory function and hypothesize that the weaker RNA binding of mutant rRPS19 may have implications for the pathophysiological mechanisms in DBA.

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Type of publication: journal article (3)

Type of content: other academic/artistic (2); peer-reviewed (1)

Author/Editor: Jones, S. (1); Johansson, Bertil (1); Al Sayed, M (1); Nilsson, Per (1); Bottcher, T. (1); Dahl, Niklas (1); show more...; Machaczka, M (1); Lund, A. (1); Badhai, Jitendra (1); Schuster, Jens (1); Fröjmark, Anne-Sophi ... (1); Virtanen, Anders (1); Macchia, Gemma (1); Belmatoug, N (1); Giraldo, P (1); Hughes, DA (1); Mengel, E (1); Pastores, GM (1); Rosenbaum, H (1); Zimran, A (1); Bodamer, O (1); Dastugue, Nicole (1); Vandenberghe, Peter (1); Cappellini, M (1); Cohen, IJ (1); Eagleton, T (1); Elstein, D (1); Kaplinsky, C (1); Sjo, M (1); Tiling, N (1); Tsaftaridis, P (1); Weinreb, N (1); Merla, Giuseppe (1); Micale, Lucia (1); Storlazzi, Clelia T (1); L’abbate, Alberto (1); Augello, Bartolomeo (1); Daniele, Giulia (1); Muehlematter, Domini ... (1); Cabrol, Christine (1); Sole, Francesc (1); Slovak, Marilyn L. (1); Lillington, Debra (1); Raynaud, Sophie (1); Lafage, Marina (1); Nacheva, Elizabeth D ... (1); show less...

University: Uppsala University (1); Lund University (1); Karolinska Institutet (1)

Language: English (3)

Research subject (UKÄ/SCB): Medical and Health Sciences (2); Natural sciences (1)

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