| 1. |
- Ilbäck, Nils-Gunnar, et al.
(author)
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Do surface-active lipids in food increase the intestinal permeability to toxic substances and allergenic agents?
- 2004
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In: Medical Hypotheses. - : Elsevier BV. - 0306-9877 .- 1532-2777. ; 63:4, s. 724-30
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Journal article (other academic/artistic)abstract
- The incidence of many common diseases has increased during the last decades. High fat intake is a risk factor for many diseases. We propose that some of the negative effects of fat are caused by lipid-induced damage of the gastrointestinal epithelium, thus compromising the epithelial function as a barrier for passage of toxic substances and allergenic agents to the circulatory system. Monoglycerides (MGs), phospholipids and fatty acids (FAs) are surface-active molecules that in pharmaceutical studies act as permeability enhancers for hydrophilic drugs with low absorption. Three possible mechanisms were proposed: (a) lipid-induced alterations in intracellular events may cause destabilization of tight junctions between the GI epithelial cells, (b) lipids may destabilize cell membranes, (c) lipids cause intestinal cell damage, which increase the permeability of the GI epithelium. These "side effects" of lipids may partly explain the association between fat intake and disease observed in epidemiological studies.
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| 2. |
- Yin, D
(author)
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Is carbonyl detoxification an important anti-aging process during sleep?
- 2000
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In: Medical Hypotheses. - : Elsevier BV. - 0306-9877 .- 1532-2777. ; 54:4, s. 519-522
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Journal article (peer-reviewed)abstract
- Organisms living on the earth may undergo inevitable toxification by biological 'garbage', a variety of biometabolites. Such garbage includes a particularly large number of toxic carbonyls, such as a,▀-unsaturated carbonyls created by free radicals, glycation, and other post-translational side-reactions during various stresses and diseases. The accumulation of these toxic substances and their crosslinking products leads to the formation of different age pigments, such as lipofuscin, lens cataracts, and crosslinked collagen. The diurnal fluctuation in the concentration of the pineal gland hormone, melatonin, may be responsible for the 'cleaning activities' that reverse the covalently-bound semi-toxified proteins and nucleic acids. This toxification-cleaning cycle may explain the biochemical necessity for sleep of human and animals during aging. (C) 2000 Harcourt Publishers Ltd.
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| 3. |
- Zhang, Z., et al.
(author)
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Transdifferentiation of neoplastic cells
- 2001
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In: Medical Hypotheses. - : Elsevier BV. - 0306-9877 .- 1532-2777. ; 57:5, s. 655-666
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Journal article (peer-reviewed)abstract
- Transdifferentiation is a process in which a stable cell's phenotype changes to that of a distinctly different cell type. It occurs during certain physiological processes and leads to transition of tumor cell phenotypes. The latter process includes neoplastic epithelial-epithelial transition, neoplastic epithelial-mesenchymal transition, neoplastic mesenchymal-epithelial transition and transition between non-neural and neural neoplastic cell. This phonomenon is exemplified in some origin-debated tumors, such as carcinosarcoma, pleomorphic adenoma, synovial sarcoma, Ewing's/pPNET, and malignant fibrohistiocytoma. We propose that differentiation disturbance of cancer cells should include not only undifferentiation and dedifferentiation, but also transdifferentiation as well. Tumor cell transdifferentiation may be influenced or determined by cellular genetic instabilities, proliferation and apoptosis, as well as by extracellular matrix and growth factors. © 2001 Harcourt Publishers Ltd.
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