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- Chen, Zhixuan, et al.
(author)
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Effects of Zinc, Magnesium, and Iron Ions on Bone Tissue Engineering
- 2022
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In: ACS Biomaterials Science & Engineering. - : American Chemical Society (ACS). - 2373-9878. ; 8:6, s. 2321-2335
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Research review (peer-reviewed)abstract
- Large-sized bone defects are a great challenge in clinics and considerably impair the quality of patients' daily life. Tissue engineering strategies using cells, scaffolds, and bioactive molecules to regulate the microenvironment in bone regeneration is a promising approach. Zinc, magnesium, and iron ions are natural elements in bone tissue and participate in many physiological processes of bone metabolism and therefore have great potential for bone tissue engineering and regeneration. In this review, we performed a systematic analysis on the effects of zinc, magnesium, and iron ions in bone tissue engineering. We focus on the role of these ions in properties of scaffolds (mechanical strength, degradation, osteogenesis, antibacterial properties, etc.). We hope that our summary of the current research achievements and our notifications of potential strategies to improve the effects of zinc, magnesium, and iron ions in scaffolds for bone repair and regeneration will find new inspiration and breakthroughs to inspire future research.
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| 3. |
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| 4. |
- Lu, Yung Hsiang, et al.
(author)
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Temporally Controlled Photouncaged Epidermal Growth Factor Influences Cell Fate in Hydrogels
- 2022
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In: ACS Biomaterials Science & Engineering. - : American Chemical Society (ACS). - 2373-9878. ; 8:1, s. 185-195
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Journal article (peer-reviewed)abstract
- Hydrogels are powerful materials that more accurately mimic the cellular microenvironment over static two-dimensional culture. Photochemical strategies enable dynamic complexity to be achieved within hydrogels to better mimic the extracellular matrix; however, many photochemical systems to pattern proteins within hydrogels are complicated by long reaction times to immobilize these proteins wherein the protein can lose activity. As proof-of-concept, we demonstrate an elegant method where photocaged proteins are immobilized in hydrogels and then directly photoactivated. Specifically, we immobilized streptavidin-ortho-nitrobenzyl-modified epidermal growth factor (EGF) to cross-linked hyaluronan hydrogels and cultured two EGF-responsive cancer cells of breast and lung therein. We used light to temporally uncage and control EGF activation, thereby inducing cell death in breast cancer cells and proliferation in lung cancer cells. These results show how temporal, photochemical, protein activation influences cellular response and lays the foundation for further advances in manipulating the in vitro environment to control cell fate.
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| 5. |
- Rogal, J, et al.
(author)
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Developer's Guide to an Organ-on-Chip Model
- 2022
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In: ACS biomaterials science & engineering. - : American Chemical Society (ACS). - 2373-9878. ; 8:11, s. 4643-4647
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Journal article (peer-reviewed)
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