| 1. |
- Abedi Dunia, Oscar, et al.
(author)
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Visibilising hidden realities and uncertainties : the ‘post-covid’ move towards decolonized and ethical field research practices
- 2023
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In: International Journal of Social Research Methodology. - : Routledge. - 1364-5579 .- 1464-5300. ; 26:5, s. 549-564
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Journal article (peer-reviewed)abstract
- This article seeks to move beyond the Euro/North-centrism recurrent in methodological discussions on what we may learn from the COVID-19 pandemic. Such debates often centre on uncertainty and involuntary immobility – aspects which are hardly new for many researchers. In this article, we argue that the pandemic offers an opportunity to rethink research relations between what we term ‘contracting researchers’ in the Global North and ‘facilitating researchers’ in the Global South. Such relations are often marked by rampant inequalities in remuneration, working conditions, and visibility/authorship. Drawing upon experiences in DR Congo, Sierra Leone, and India, we argue that the pandemic increased the dependence on – and highlighted the invaluable contributions and skills of – facilitating researchers, in part slightly refiguring bargaining power. We also propose pathways for change, arguing for a strong collaborative approach and the need for institutional change, without discarding the responsibilities of individual researchers.
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| 2. |
- Abedi, Oscar, et al.
(author)
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The Covid-19 Opportunity: Creating More Ethical and Sustainable Research Practices
- 2020
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Other publication (other academic/artistic)abstract
- Contributing to the “Covid-19 and the Social Sciences” essay series, Oscar Abedi, Maria Eriksson Baaz, David Mwambari, Swati Parashar, Anju Oseema Maria Toppo, and James Vincent outline various paths toward reducing field research’s potential for exploitation, especially that of Global South collaborators. The pandemic has highlighted inequalities and immobility that differently affect facilitating researchers and contracting researchers. In response, the authors identify key issues that institutions, publishers, and individual researchers must reflect on in order to counteract these imbalances—and take advantage of an opportunity to fundamentally transform field research into collaborative knowledge production.
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| 3. |
- Eriksson Baaz, Maria, 1971-, et al.
(author)
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Moving Out of the Backstage : How Can We Decolonize Research?
- 2019
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Other publication (other academic/artistic)abstract
- Research here in the DRC is like the coltan and other minerals. Other countries that don’t have access to it claim it and benefit from it. It is the same with research. The research would not be possible without us. Still it is people from the outside who profit from it, get visibility, funding and are called experts. At the same time we – the ones who provide access, adapt the methodology and questions and collect the data in very precarious circumstances – get little compensation and are not acknowledged. It is sort of a continuation of colonial relations.
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| 4. |
- Mamand, Doste R., et al.
(author)
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Extracellular vesicles originating from melanoma cells promote dysregulation in haematopoiesis as a component of cancer immunoediting
- 2024
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In: Journal of Extracellular Vesicles. - : Wiley. - 2001-3078. ; 13:7
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Journal article (peer-reviewed)abstract
- Haematopoiesis dysregulation with the presence of immature myeloid and erythroid immunosuppressive cells are key characteristics of the immune escape phase of tumour development. Here, the role of in vitro generated B16F10 tumour cell-derived extracellular vesicles (tEVs) as indirect cellular communicators, participating in tumour-induced dysregulation of haematopoiesis, was explored. The isolated tEVs displayed features of small EVs with a size range of 100-200 nm, expressed the common EV markers CD63, CD9, and Alix, and had a spherical shape with a lipid bilayer membrane. Proteomic profiling revealed significant levels of angiogenic factors, particularly vascular endothelial growth factor (VEGF), osteopontin, and tissue factor, associated with the tEVs. Systemic administration of these tEVs in syngeneic mice induced splenomegaly and disrupted haematopoiesis, leading to extramedullary haematopoiesis, expansion of splenic immature erythroid progenitors, reduced bone marrow cellularity, medullary expansion of granulocytic myeloid suppressor cells, and the development of anaemia. These effects closely mirrored those observed in tumour-bearing mice and were not seen after heat inactivating the tEVs. In vitro studies demonstrated that tEVs independently induced the expansion of bone marrow granulocytic myeloid suppressor cells and B cells while reducing the frequency of cells in the erythropoietic lineage. These effects of tEVs were significantly abrogated by the blockade of VEGF or heat inactivation. Our findings underscore the important role of tEVs in dysregulating haematopoiesis during the immune escape phase of cancer immunoediting, suggesting their potential as targets for addressing immune evasion and reinstating normal hematopoietic processes.
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| 5. |
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| 6. |
- Utas, Mats, 1968-, et al.
(author)
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Introduction : setting the stage
- 2023
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In: Facilitating researchers in insecure zones. - London : Bloomsbury Academic. - 9781350265653 - 9781350265677 ; , s. 1-24, s. 1-24
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Book chapter (other academic/artistic)
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| 7. |
- Utas, Mats, 1968-, et al.
(author)
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The need of change : what, how and who?
- 2023
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In: Facilitating Researchers in Insecure Zones. - London : Bloomsbury Academic. - 9781350265653 ; , s. 157-175, s. 157-175
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Book chapter (other academic/artistic)
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| 8. |
- Wain, Louise V., et al.
(author)
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Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney
- 2017
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In: Hypertension. - 0194-911X .- 1524-4563. ; 70:3, s. e4-e19
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Journal article (peer-reviewed)abstract
- Elevated blood pressure is a major risk factor for cardiovascular disease and has a substantial genetic contribution. Genetic variation influencing blood pressure has the potential to identify new pharmacological targets for the treatment of hypertension. To discover additional novel blood pressure loci, we used 1000 Genomes Project-based imputation in 150 134 European ancestry individuals and sought significant evidence for independent replication in a further 228 245 individuals. We report 6 new signals of association in or near HSPB7, TNXB, LRP12, LOC283335, SEPT9, and AKT2, and provide new replication evidence for a further 2 signals in EBF2 and NFKBIA. Combining large whole-blood gene expression resources totaling 12 607 individuals, we investigated all novel and previously reported signals and identified 48 genes with evidence for involvement in blood pressure regulation that are significant in multiple resources. Three novel kidney-specific signals were also detected. These robustly implicated genes may provide new leads for therapeutic innovation.
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