| 1. |
- Akbari, Ali, et al.
(author)
-
Free and hydrogel encapsulated exosome-based therapies in regenerative medicine.
- 2020
-
In: Life sciences. - : Elsevier BV. - 1879-0631 .- 0024-3205. ; 249
-
Journal article (peer-reviewed)abstract
- Over the last few decades, mesenchymal stem cells-derived exosomes (MSCs-Ex) have attracted a lot of attention as a therapeutic tool in regenerative medicine. Exosomes are extracellular vehicles (EVs) that play important roles in cell-cell communication through various processes such as stress response, senescence, angiogenesis, and cell differentiation. Success in the field of regenerative medicine sparked exploration of the potential use of exosomes as key therapeutic effectors of MSCs to promote tissue regeneration. Various approaches including direct injection, intravenous injection, intraperitoneal injection, oral administration, and hydrogel-based encapsulation have been exploited to deliver exosomes to target tissues in different disease models. Despite significant advances in exosome therapy, it is unclear which approach is more effective for administering exosomes. Herein, we critically review the emerging progress in the applications of exosomes in the form of free or association with hydrogels as therapeutic agents for applications in regenerative medicine.
|
|
| 2. |
- Ghajarnia, Navid, et al.
(author)
-
Evaluating the Evolution of ECMWF Precipitation Products Using Observational Data for Iran : From ERA40 to ERA5
- 2022
-
In: Earth and Space Science. - : American Geophysical Union (AGU). - 2333-5084. ; 9:10
-
Journal article (peer-reviewed)abstract
- European Center for Medium-Range Weather Forecasts Reanalysis (ERA), one of the most widely used precipitation products, has evolved from ERA-40 to ERA-20CM, ERA-20C, ERA-Interim, and ERA5. Studies evaluating the performance of individual ERA products cannot adequately assess the evolution of the products. We compared the performance of all ERA precipitation products at daily, monthly, and annual data (1980-2018) using more than 2100 Iran precipitation gauges. Results indicated that ERA-40 performed worst, followed by ERA-20CM, which showed only minor improvements over ERA-40. ERA-20C considerably outperformed its predecessors, benefiting from the assimilation of observational data. Although several previous studies have reported full superiority of ERA5 over ERA-Interim, our results revealed several shortcomings in ERA5 compared with the ERA-Interim estimates. Both ERA-Interim and ERA5 performed best overall, with ERA-Interim showing better statistical and categorical skill scores, and ERA5 performing better in estimating extreme precipitations. These results suggest that the accuracy of ERA precipitation products has improved from ERA-40 to ERA-Interim, but not consistently from ERA-Interim to ERA5. This study employed a grid-grid comparison approach by first creating a gridded reference data set through the spatial aggregation of point source observations, however, the results from a point-grid approach showed no change in the overall ranking of products (despite the slight changes in the error index values). These findings are useful for model development at a global scale and for hydrological applications in Iran.
|
|
| 3. |
- Ali Akbari, Danial
(author)
-
Das Human-Kapital : Emerging Patterns in the Class Structure
- 2021
-
Doctoral thesis (other academic/artistic)abstract
- This thesis consists of three self-contained papers in theoretical and computational macroeconomics and growth theory with income inequality and human capital accumulation as common themes. The first paper investigates what level of income tax progressivity is welfare-optimal given modern patterns of income inequality in the US. The paper develops a model for endogenous income inequality that fits US evidence while comparing popular income processes. It also permits discussing the welfare effects and trade-offs of tax reforms as individuals adjust their labor supply and human capital accumulation. We extend it in an incomplete market setup solved numerically, in which individuals can both form precautionary savings and adjust their labor supply. A calibrated version suggests that the progressivity of US income taxes is below its welfare optimum by around six percentage points. The second paper develops a theoretical framework that explains the increasing and convex pattern of skill premia through diminishing aversion towards the ambiguous possibility of skill obsolescence. High-income workers are shown to invest more in education as their concern with forgone income is progressively lower than their less credentialed counterparts. As a result, high-skill (low-skill) individuals invest in their stock of human capital beyond (below) what is optimal if the true obsolescence frequency was known to them. This learning glut (deficit) subsequently pays large dividends (losses) during unexpected episodes that exhibit increased ambiguity. A calibration of the model is able to match the skill premium curve in the US economy. The third paper develops a task-based framework which incorporates decisions on human capital investment based on the concepts of the psychometric literature on skill formation. The model predicts that labor immiseration -- i.e. full automation of the economy -- is inevitable unless learning efficiency is improved through capital taxation. While such a scheme can hinder labor immiseration, job polarization, however, is shown to be perpetual and exacerbating as low-index workers are more adversely affected by automation of routine tasks. The main mechanism for these results are shown to be differences in skill profiles, cross-productivity of skills and the faster accumulation rate of physical vis-à-vis human capital due to advanced skills being more difficult to master.
|
|
| 4. |
|
|
| 5. |
- Loni, Mohammad, et al.
(author)
-
DenseDisp : Resource-Aware Disparity Map Estimation by Compressing Siamese Neural Architecture
- 2020
-
In: IEEE WORLD CONGRESS ON COMPUTATIONAL INTELLIGENCE (WCCI) 2020 IEEE WCCI. - Glasgow, United Kingdom.
-
Conference paper (peer-reviewed)abstract
- Stereo vision cameras are flexible sensors due to providing heterogeneous information such as color, luminance, disparity map (depth), and shape of the objects. Today, Convolutional Neural Networks (CNNs) present the highest accuracy for the disparity map estimation [1]. However, CNNs require considerable computing capacity to process billions of floating-point operations in a real-time fashion. Besides, commercial stereo cameras produce huge size images (e.g., 10 Megapixels [2]), which impose a new computational cost to the system. The problem will be pronounced if we target resource-limited hardware for the implementation. In this paper, we propose DenseDisp, an automatic framework that designs a Siamese neural architecture for disparity map estimation in a reasonable time. DenseDisp leverages a meta-heuristic multi-objective exploration to discover hardware-friendly architectures by considering accuracy and network FLOPS as the optimization objectives. We explore the design space with four different fitness functions to improve the accuracy-FLOPS trade-off and convergency time of the DenseDisp. According to the experimental results, DenseDisp provides up to 39.1x compression rate while losing around 5% accuracy compared to the state-of-the-art results.
|
|
| 6. |
- Patterson, Nick, et al.
(author)
-
Large-scale migration into Britain during the Middle to Late Bronze Age
- 2022
-
In: Nature. - : Nature Publishing Group. - 0028-0836 .- 1476-4687. ; , s. 588-594
-
Journal article (peer-reviewed)abstract
- Present-day people from England and Wales harbour more ancestry derived from Early European Farmers (EEF) than people of the Early Bronze Age1. To understand this, we generated genome-wide data from 793 individuals, increasing data from the Middle to Late Bronze and Iron Age in Britain by 12-fold, and Western and Central Europe by 3.5-fold. Between 1000 and 875 BC, EEF ancestry increased in southern Britain (England and Wales) but not northern Britain (Scotland) due to incorporation of migrants who arrived at this time and over previous centuries, and who were genetically most similar to ancient individuals from France. These migrants contributed about half the ancestry of Iron Age people of England and Wales, thereby creating a plausible vector for the spread of early Celtic languages into Britain. These patterns are part of a broader trend of EEF ancestry becoming more similar across central and western Europe in the Middle to Late Bronze Age, coincident with archaeological evidence of intensified cultural exchange2-6. There was comparatively less gene flow from continental Europe during the Iron Age, and Britain's independent genetic trajectory is also reflected in the rise of the allele conferring lactase persistence to ~50% by this time compared to ~7% in central Europe where it rose rapidly in frequency only a millennium later. This suggests that dairy products were used in qualitatively different ways in Britain and in central Europe over this period.
|
|
| 7. |
|
|
