| 1. |
- Sjöberg, Per-Olof, et al.
(author)
-
Sverige i halvledarvärlden – analys och förslag till strategi
- 2022
-
Reports (other academic/artistic)abstract
- Den brist på halvledare som industrin upplevt under 2021 har satt den annars tämligen anonyma halvledarindustrin i rampljuset såväl i Sverige som i Europa, USA och globalt. Hur länge denna brist kommer att bestå är en viktig fråga för industrin, som dock är svår att svara på. Enligt internationella analytiker kommer industrin att uppleva halvledarbrist fram till sommaren 2022 och eventuellt in på nästa höst eller eventuellt längre, varefter det föreligger en risk för överproduktion då lager förmodligen byggts upp bland avnämare. Erfarenheterna från tidigare halvledarbrister är att de så småningom övergår i överskott. Men den nuvarande bristen kan sannolikt kräva längre tid för detta än tidigare brister. Främsta skälet är att de halvledarfabriker som för närvarande är under uppbyggnad för att råda bot på bristen lider av samma överhettade försörjningskedjor som övrig industri, med förseningar av allt från vitala utrustningar till förbrukningsmateriel, och att det därför troligen kommer att ta längre tid än planerat att få dem i drift. Detta kan i värsta fall innebära att det rentav kan ta ett eller flera år längre tid än analytikerna förutspått innan försörjningsläget är normalt. Sverige är en del av det globala halvledarekosystemet – ett komplext ekosystem som kännetecknas av hög grad av arbetsfördelning, hög kapitalintensitet, hög kunskapsintensitet, långa produktionstider, stark internationalisering och starka inlåsningseffekter. Sverige interagerar med detta globala ekosystem på två sätt - som leverantör av produkter och tjänster i ett antal nischer där vi uppvisar global spetskompetens samt som avnämare av halvledarprodukter för industriella behov. Båda dessa sidor behöver stärkas för att a) våra SMF och stora företag ska kunna få tillgång till de halvledare och system byggda på halvledare som krävs för den produktion av produkter och tjänster som bidrar till Sveriges välstånd, b) svenska industriföretag ska kunna säkra tillgång till den kompetens och de tjänster som krävs då industrins produkter innehåller allt större mängd halvledare, och c) för att maximera möjligheterna för svenska halvledar- och elektronikinnovationer att hävda sig på världsmarknaden, och på så sätt bidra till landets välstånd. Det övergripande målet för Sverige bör vara att använda vår nationella styrka inom innovation som hävstång, och fokusera de starka specialiserade kompetenserna som finns här i landet, jämte långsiktiga investeringar i forskning inom halvledarteknik, systemdesign och halvledarmaterial, i syfte att med samlad kraft nå följande strategiska mål: 1) Etablera Sverige som ett halvledarinnovationsland genom att stärka vårt innovationssystem för halvledare och halvledarmaterial. 2) Få utväxling på de svenska investeringarna i forsknings- och innovationsinfrastruktur för design och produktion av halvledare. 3) Säkra och vidmakthåll en roll för Sverige i halvledarindustrin, inte minst genom svensk representation i de organ och församlingar som beslutar om framtida europeiska investeringar. För att nå dessa mål krävs stark samverkan mellan industri, akademi, institut och offentlig sektor, och långsiktiga såväl publika som privata investeringar i utbildning, forskningsinfrastruktur, test- och demonstrationsanläggningar och i startup- och scaleup-bolag. RISE åsikt är att Sverige därtill bör ta aktiv del i EU-initiativ som den europeiska halvledaralliansen (Alliance on Processor and Semiconductor Technologies) och European Chips Act. Påpekas bör att dessa mål är långsiktiga och kräver kontinuerligt arbete och finansiering under många år framöver. De löser inte industrins kortsiktiga behov av halvledare, och det kommer att ta tid att säkra industrins behov av halvledarkompetens. Med en väl genomförd strategi skulle dock dessa behov i högre grad kunna tillgodoses samtidigt som vårt lands bidrag till det globala halvledarekosystemet skulle växa kraftigt, till fromma för vårt gemensamma välstånd.
|
|
| 2. |
- Akbari, Saeed, et al.
(author)
-
Ceramic Additive Manufacturing Potential for Power Electronics Packaging
- 2022
-
In: IEEE Transactions on Components, Packaging, and Manufacturing Technology. - : Institute of Electrical and Electronics Engineers Inc.. - 2156-3950 .- 2156-3985. ; 12:11, s. 1857-1866
-
Journal article (peer-reviewed)abstract
- Compared with silicon-based power devices, wide band gap (WBG) semiconductor devices operate at significantly higher power densities required in applications such as electric vehicles and more electric airplanes. This necessitates development of power electronics packages with enhanced thermal characteristics that fulfil the electrical insulation requirements. The present research investigates the feasibility of using ceramic additive manufacturing (AM), also known as three-dimensional (3D) printing, to address thermal and electrical requirements in packaging gallium nitride (GaN) based high-electron-mobility transistors (HEMTs). The goal is to exploit design freedom and manufacturing flexibility provided by ceramic AM to fabricate power device packages with a lower junction-to-ambient thermal resistance (RθJA). Ceramic AM also enables incorporation of intricate 3D features into the package structure in order to control the isolation distance between the package source and drain contact pads. Moreover, AM allows to fabricate different parts of the packaging assembly as a single structure to avoid high thermal resistance interfaces. For example, the ceramic package and the ceramic heatsink can be printed as a single part without any bonding layer. Thermal simulations under different thermal loading and cooling conditions show the improvement of thermal performance of the package fabricated by ceramic AM. If assisted by an efficient cooling strategy, the proposed package has the potential to reduce RθJA by up to 48%. The results of the preliminary efforts to fabricate the ceramic package by AM are presented, and the challenges that have to be overcome for further development of this manufacturing method are recognized and discussed.
|
|
| 3. |
- Akbari, Saeed, et al.
(author)
-
Low Inductive SiC Power Electronics Module with Flexible PCB Interconnections and 3D Printed Casing
- 2022
-
In: 2022 IMAPS Nordic Conference on Microelectronics Packaging, NordPac 2022. - : Institute of Electrical and Electronics Engineers Inc.. - 9789189711396
-
Conference paper (peer-reviewed)abstract
- Silicon carbide (SiC) power devices are steadily increasing their market share in various power electronics applications. However, they require low-inductive packaging in order to realize their full potential. In this research, low-inductive layouts for half-bridge power modules, using a direct bonded copper (DBC) substrate, that are suitable for SiC power devices, were designed and tested. To reduce the negative effects of the switching transients on the gate voltage, flexible printed circuit boards (PCBs) were used to interconnect the gate and source pins of the module with the corresponding pads of the power chips. In addition, conductive springs were used as low inductive, solder-free contacts for the module power terminals. The module casing and lid were produced using additive manufacturing, also known as 3D printing, to create a compact design. It is shown that the inductance of this module is significantly lower than the commercially available modules.
|
|
| 4. |
- Akbari, Saeed, et al.
(author)
-
Packaging Induced Stresses in Embedded and Molded GaN Power Electronics Components
- 2023
-
In: Int. Conf. Therm., Mech. Multi-Phys. Simul. Exp. Microelectron. Microsyst., EuroSimE. - : Institute of Electrical and Electronics Engineers Inc..
-
Conference paper (peer-reviewed)abstract
- Residual stresses created during the packaging process can adversely affect the reliability of electronics components. We used incremental hole-drilling method, following the ASTM E 837-20 standard, to measure packaging induced residual stresses in discrete packages of power electronics components. For this purpose, we bonded a strain gauge on the surface of a Gallium Nitride (GaN) power component, drilled a hole through the thickness of the component in several incremental steps, recorded the relaxed strain data on the sample surface using the strain gauge, and finally calculated the residual stresses from the measured strain data. The recorded strains and the residual stresses are related by the compliance coefficients. For the hole drilling method in the isotropic materials, the compliance coefficients are calculated from the analytical solutions, and available in the ASTM standard. But for the orthotropic multilayered components typically found in microelectronics assemblies, numerical solutions are necessary. We developed a subroutine in ANSYS APDL to calculate the compliance coefficients of the hole drilling test in the molded and embedded power electronics components. This can extend the capability of the hole drilling method to determine residual stresses in more complex layered structures found in electronics.
|
|
| 5. |
- Andersson, Mathias, et al.
(author)
-
Management Measures to Reduce Continuous Underwater Noise from Shipping
- 2023
-
Reports (peer-reviewed)abstract
- Underwater radiated noise (URN) from commercial ships is a significant source of elevated noise levels in the oceans and can have a negative impact on marine wildlife. Noise from commercial shipping places additional stress on the oceans, but is one of the least studied environmental pollutants, and there is an urgent need to reduce the aggregate stress levels. Until recently, reduction of underwater noise has not been prioritised by ship designers, shipowners, or crews. Even within the field of marine management, noise has received limited interest. However, the International Maritime organization (IMO) has adopted global guidelines on URN reduction, which are currently being updated. Within the EU, the Marine Strategy Framework Directive (MSFD 2008/56/EC) Descriptor 11 criteria 11.2, now provides a framework for marine administrators to manage noise by establishing threshold values. Marine management focuses on the total noise load on the marine environment. Management entails several considerations before recommendations can be made. As a first step, interdisciplinary teams need to assess the aggregated noise levels and determine acceptable thresholds based on the local ecosystem, then assess which existing mandates and management tools can be used, and finally assess how effective these mandates have been in improving the environment. These activities must also be managed in a way that is acceptable to various relevant stakeholders, who would need to follow the decisions. The URN from a ship can be affected by the vessel’s design, either during its construction or during upgrades, and balances a trade-off against fuel efficiency. However, the URN can also depend on how the ship is operated. Regulating ship speed is one potential management tool, and its effectiveness needs to be assessed. Other management measures include how shipping lanes are drawn, areas to avoid, financial support, information, etc. This report focuses on possible policy measures that the Swedish authorities could adopt to lower URN by regulating the speed of ships. The report presents an interdisciplinary analysis, using a case study of an area in the southern Kattegat that covered several maritime zones, different national jurisdictions, intensive traffic, and high natural values. An important part of the work was to assess whether existing source models for ship noise could be used for the type of ships that are common in waters around Sweden. In this study, the JOMOPANS-ECHO (J-E) model was used.The J-E model was validated by comparing measurement data from a hydrophone station at Vinga on the Swedish coast that collected data from ships (254 passages) that used the port of Gothenburg. The analysis showed some deviation between the J-E model and measurement data, which could be due to differences in the length and speed of ships in waters around Sweden compared to the ships used in the development of the J-E model. However, this was likely to have negligible impact on the outcome of the case study.Analyses of ship traffic in 2021 showed that 4,511 unique vessels visited the study area at least once. Most ships followed the main routes, but no part of the study area was completely free from ship traffic. About 68% of the ships visited the study area for 1-4 days, while about 32% visited the area more regularly. The most common ship types were General Cargo Ships, Dry Bulk Ships, and Tankers. The ships that on average travelled at highest speeds were RoPax Ships, RoRo Ships, Vehicle Carriers, and Container Ships. The ships were registered in 64 countries. About two percent of the ships were registered in Sweden and about four percent in Denmark.Legal analysis showed that Sweden has the right and the responsibility to take measures to reduce underwater noise from ships to the extent that the noise can be deemed to pollute the marine environment. However, this mainly applies to Sweden’s territorial seas, which cover roughly half the area being studied for this report. In the portion that constitutes Danish territorial sea, Denmark has comparable opportunities for managing URN. In areas that are Swedish or Danish exclusive economic zones (EEZs), the ability to introduce mandatory speed limits is significantly limited. There, the most realistic option would be to request the IMO to establish speed limits, or alternatively to issue a recommendation to navigate at lower speeds, although such guidance could not be enforced on ships that do not voluntarily reduce their speed.It was estimated that lowering the ships' speeds to a hypothetical limit of 11 kn would reduce the average URN levels by 4.4 ± 2 dB, as registered by local receivers in the study area. This speed limit would affect approximately 44% of the ships in the area. A maximum speed of 13 kn would instead reduce the level by 1.9 ± 0.5 dB and would affect 11% of the ships on average. The reduction in noise levels may temporarily be much higher in the immediate vicinity of individual fast ships, and there might be a high degree of variation between different ships.The study and report make it clear that it is a complex task to assess the feasibility and benefit of introducing a specific marine management tool, in this case an enforceable local speed limit. But it is also clear that there are reliable methods to make the preliminary assessments, and that it requires interdisciplinary analyses and competence.
|
|
| 6. |
- Andersson, Susanne, et al.
(author)
-
From glass ceiling to firewalls : Detecting and changing gendered organizational norms
- 2022
-
In: NORA. - : Routledge. - 0803-8740 .- 1502-394X. ; 30:2, s. 140-153
-
Journal article (peer-reviewed)abstract
- This article is based on an empirical case study with an interactive research approach focusing on gendered norms in a Swedish truck Company. It discusses the combined value of using the metaphor of a firewall for (1) analysing how organizational constraining gendered norms are done in everyday organizational life, and (2) as a practical tool to facilitate the processes aimed at improving norm awareness. The metaphor embodies an understanding that makes it possible to visualize relational ongoing organizational processes and power dimensions. In addition, the firewall is useful for emphasizing variations and complexity. Variations and dynamics are manifested in the ways that employees need to fulfil varying “codes” in order to be accepted. The possession of certain codes (norms) that are required to pass through the first layer of the firewall (employment), and give access to some networks, does not automatically ensure acceptance and integration into more influential networks (referred to as the informal and inner layers of the firewall). The results furthermore show that the firewall metaphor is fruitful when facilitating reflection processes amongst employees to improve norma wareness and to discuss strategies for change. The conclusion is that the firewall metaphor facilitates an analysis of the relational and complex doing of constraining norms, and that it also can be used to initiate change.
|
|
| 7. |
- Balkmar, Dag, 1974-, et al.
(author)
-
Women truck drivers and (future) mobile work : Towards gender equal transport futures?
- 2021
-
In: Gender and Equality in Transport. - Dublin : TU Dublin. ; , s. 161-165
-
Conference paper (other academic/artistic)abstract
- This paper focuses gender and gender equality in contemporary and future haulage business, arguing for a need for norm-critical approaches to build more gender equal transport futures. Currently, there is a general demand for more drivers internationally and in Sweden. Following the current driver shortage in occupational road freight, transport companies in Europe and Sweden recognise the need to recruit more women chauffeurs. Part of the problem is how transport is gendered, strongly intertwined with masculine norms that prevents nonnormative bodies to identify themselves as drivers. In Sweden, a country with a world reputation as champions in gender equality, men still make up more than 90 % of the work force in the Swedish transport business. While recruiting more women would contribute to solve the urgent problem of driver shortage, women drivers typically face gendered problems, concerning their personal safety, harassments, hygiene, and work/life (im)balance. From the perspective of the haulage business, addressing these gendered problems can increase the ability hire more women drivers, but would also need to develop transport innovations that suit not only today’s male users but also those of tomorrow.Future road freight and transport innovations such as more autonomous vehicles are often imagined to ‘solve’ some of the current problems that transport companies struggle with, including driver shortage. With the advent of autonomous, electrified and connected mobilities, we may anticipate both a gendered re-segregation and that fewer drivers would be needed (Balkmar and Mellström 2018). Nevertheless, problems of road transportation and the lack of gender equality in the haulage business can’t be solved following the “old logics of a technological fix”, gendered social and cultural issues need to be part of the solution (Kröger and Weber, 2018). Against this background, the aim of this paper is to explore how normcritical perspectives can offer ways forward with regards to gender and (lack of) gender equality in the haulage business. This includes to consider how technological innovations may change what it entails to be a truck driver and open new opportunities for the profession with regards to gender equality.
|
|
| 8. |
- Boen, Rune, et al.
(author)
-
Beyond the global brain differences : intraindividual variability differences in 1q21.1 distal and 15q11.2 bp1-bp2 deletion carriers
- 2024
-
In: Biological Psychiatry. - 0006-3223 .- 1873-2402. ; 95:2, s. 147-160
-
Journal article (peer-reviewed)abstract
- Background: Carriers of the 1q21.1 distal and 15q11.2 BP1-BP2 copy number variants exhibit regional and global brain differences compared with noncarriers. However, interpreting regional differences is challenging if a global difference drives the regional brain differences. Intraindividual variability measures can be used to test for regional differences beyond global differences in brain structure.Methods: Magnetic resonance imaging data were used to obtain regional brain values for 1q21.1 distal deletion (n = 30) and duplication (n = 27) and 15q11.2 BP1-BP2 deletion (n = 170) and duplication (n = 243) carriers and matched noncarriers (n = 2350). Regional intra-deviation scores, i.e., the standardized difference between an individual's regional difference and global difference, were used to test for regional differences that diverge from the global difference.Results: For the 1q21.1 distal deletion carriers, cortical surface area for regions in the medial visual cortex, posterior cingulate, and temporal pole differed less and regions in the prefrontal and superior temporal cortex differed more than the global difference in cortical surface area. For the 15q11.2 BP1-BP2 deletion carriers, cortical thickness in regions in the medial visual cortex, auditory cortex, and temporal pole differed less and the prefrontal and somatosensory cortex differed more than the global difference in cortical thickness.Conclusions: We find evidence for regional effects beyond differences in global brain measures in 1q21.1 distal and 15q11.2 BP1-BP2 copy number variants. The results provide new insight into brain profiling of the 1q21.1 distal and 15q11.2 BP1-BP2 copy number variants, with the potential to increase understanding of the mechanisms involved in altered neurodevelopment.
|
|
| 9. |
- Bonvicini, Gillian, et al.
(author)
-
Comparing in vitro affinity measurements of antibodies to TfR1 : Surface plasmon resonance versus on-cell affinity
- 2024
-
In: Analytical Biochemistry. - : Elsevier. - 0003-2697 .- 1096-0309. ; 686
-
Journal article (peer-reviewed)abstract
- Despite years of utilizing the transferrin receptor 1 (TfR1) to transport large biomolecules into the brain, there is no consensus on how to optimally measure affinity to it. The aim of this study was to compare different methods for measuring the affinities of anti-TfR1 antibodies.Antibodies 15G11, OX26 and 8D3 are known to successfully carry large biologics across the blood-brain barrier in humans, rats, and mice, respectively. The affinity to their respective species of TfR1 was measured with different surface plasmon resonance setups in Biacore and an on-cell assay.When the antibody was captured and TfR1 was the analyte, the dissociation in Biacore was very slow. The dissociation was faster when the antibody was the analyte and TfR1 was the ligand. The Biacore setup with capture of N-terminal FLAG-tag TfR1 yielded the most similar apparent affinities as the cell assay.In conclusion, it is important to evaluate assay parameters including assay orientation, surface capture method, and antibody format when comparing binding kinetics for TfR1 antibodies. Although it seems possible to determine relative affinities of TfR1 antibodies using the methods described here, both the FLAG-tag TfR1 capture setup and cell assays likely yield apparent affinities that are most translatable in vivo.
|
|
| 10. |
- Bonvicini, Gillian, et al.
(author)
-
ImmunoPET imaging of amyloid-beta in a rat model of Alzheimer's disease with a bispecific, brain-penetrating fusion protein
- 2022
-
In: Translational Neurodegeneration. - : BioMed Central (BMC). - 2047-9158. ; 11
-
Journal article (peer-reviewed)abstract
- Background: Hijacking the transferrin receptor (TfR) is an effective strategy to transport amyloid-beta (A beta) immuno-positron emission tomography (immunoPET) ligands across the blood-brain barrier (BBB). Such ligands are more sensitive and specific than small-molecule ligands at detecting A beta pathology in mouse models of Alzheimer's disease (AD). This study aimed to determine if this strategy would be as sensitive in rats and to assess how TfR affinity affects BBB transport of bispecific immunoPET radioligands.Methods: Two affinity variants of the rat TfR antibody, OX26, were chemically conjugated to a F(ab')(2) fragment of the anti-A beta antibody, bapineuzumab (Bapi), to generate two bispecific fusion proteins: OX26(5)-F(ab')(2)-Bapi and OX26(76)-F(ab')(2)-Bapi. Pharmacokinetic analyses were performed 4 h and 70 h post-injection of radioiodinated fusion proteins in wild-type (WT) rats. [I-124]I-OX26(5)-F(ab')(2)-Bapi was administered to TgF344-AD and WT rats for in vivo PET imaging. Ex vivo distribution of injected [I-124]I-OX26(5)-F(ab')(2)-Bapi and A beta pathology were assessed.Results: More [I-125]I-OX26(5)-F(ab')(2)-Bapi was taken up into the brain 4 h post-administration than [I-124]I-OX26(76)-F(ab')(2)-Bapi. [I-124]I-OX26(5)-F(ab')(2)-Bapi PET visualized A beta pathology with significantly higher signals in the TgF344-AD rats than in the WT littermates without A beta pathology. The PET signals significantly correlated with A beta levels in AD animals.Conclusion: Affinity to TfR affects how efficiently a TfR-targeting bispecific fusion protein will cross the BBB, such that the higher-affinity bispecific fusion protein crossed the BBB more efficiently. Furthermore, bispecific immunoPET imaging of brain A beta pathology using TfR-mediated transport provides good imaging contrast between TgF344-AD and WT rats, suggesting that this immunoPET strategy has the potential to be translated to higher species.
|
|
| 11. |
- Chorey, Devashish, et al.
(author)
-
Simultaneous imaging of CH*, C*2, and temperature in flames using a DSLR camera and structured illumination
- 2023
-
In: Applied Optics. - 1559-128X .- 2155-3165. ; 62:14, s. 3737-3746
-
Journal article (peer-reviewed)abstract
- Measurement of chemical species and temperature mapping in flames is essential to understanding the combustion process. Multiple cameras are conventionally employed for measurement in such scenarios making the experi-mental setup not only cost-intensive but also challenging. To circumvent this, structured illumination (SI)-based methods are reported for multispecies chemiluminescence (CL) imaging using a single camera. In this paper, we demonstrate four-channel SI-based imaging for simultaneous snapshot CH* and C*2 CL imaging and two-color pyrometry for temperature profiles in a butane diffusion flame. We demonstrate our approach using individual species and multiple species imaging. Taking the advantage of the axisymmetric nature of the flame, the Abel trans-form is performed on the line-of-sight averaged images to obtain deconvoluted images. The deconvoluted maps of temperature are compared with the temperature data obtained by using a physical thermocouple probe. (c) 2023 Optica Publishing Group
|
|
| 12. |
- Chorey, Devashish, et al.
(author)
-
Simultaneous imaging of CH*, C*2, and temperature in flames using a DSLR camera and structured illumination
- 2023
-
In: Applied Optics. - 1559-128X. ; 62:14, s. 3737-3746
-
Journal article (peer-reviewed)abstract
- Measurement of chemical species and temperature mapping in flames is essential to understanding the combustion process. Multiple cameras are conventionally employed for measurement in such scenarios making the experi-mental setup not only cost-intensive but also challenging. To circumvent this, structured illumination (SI)-based methods are reported for multispecies chemiluminescence (CL) imaging using a single camera. In this paper, we demonstrate four-channel SI-based imaging for simultaneous snapshot CH* and C*2 CL imaging and two-color pyrometry for temperature profiles in a butane diffusion flame. We demonstrate our approach using individual species and multiple species imaging. Taking the advantage of the axisymmetric nature of the flame, the Abel trans-form is performed on the line-of-sight averaged images to obtain deconvoluted images. The deconvoluted maps of temperature are compared with the temperature data obtained by using a physical thermocouple probe. (c) 2023 Optica Publishing Group
|
|
| 13. |
- Dima, Danai, et al.
(author)
-
Subcortical volumes across the lifespan : Data from 18,605 healthy individuals aged 3-90 years.
- 2022
-
In: Human Brain Mapping. - : Wiley. - 1065-9471 .- 1097-0193. ; 43:1, s. 452-469
-
Journal article (peer-reviewed)abstract
- Age has a major effect on brain volume. However, the normative studies available are constrained by small sample sizes, restricted age coverage and significant methodological variability. These limitations introduce inconsistencies and may obscure or distort the lifespan trajectories of brain morphometry. In response, we capitalized on the resources of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to examine age-related trajectories inferred from cross-sectional measures of the ventricles, the basal ganglia (caudate, putamen, pallidum, and nucleus accumbens), the thalamus, hippocampus and amygdala using magnetic resonance imaging data obtained from 18,605 individuals aged 3-90 years. All subcortical structure volumes were at their maximum value early in life. The volume of the basal ganglia showed a monotonic negative association with age thereafter; there was no significant association between age and the volumes of the thalamus, amygdala and the hippocampus (with some degree of decline in thalamus) until the sixth decade of life after which they also showed a steep negative association with age. The lateral ventricles showed continuous enlargement throughout the lifespan. Age was positively associated with inter-individual variability in the hippocampus and amygdala and the lateral ventricles. These results were robust to potential confounders and could be used to examine the functional significance of deviations from typical age-related morphometric patterns.
|
|
| 14. |
- Eng, Mattias P., et al.
(author)
-
A Link between the Lab and the Real World-A Setup for Accelerated Aging of Power Electronics Using Mission Profiles from the Field
- 2024
-
In: <em>25th International Conference on Thermal, Mechanical and Multi-Physics Simulation and Experiments in Microelectronics and Microsystems, EuroSimE 2024</em>. - : Institute of Electrical and Electronics Engineers Inc..
-
Conference paper (peer-reviewed)abstract
- To generate data used for developing schemes and models for CM, PHM, and for estimating RUL of power electronic devices, accelerated aging experiments in the form of power cycling are often performed. In these experiments, a set current is passed through the power devices and is turned on and off in regular cycles. Due to the mismatch in CTEs of the materials in the devices, the on/off cycles will generate thermally induced stress in the various material interfaces, which is the main cause of failures. Most of the power cycling setups that are currently used can only manage a single set on-state current level and fixed on/off times (which is also the common standard for lifetime testing); a condition that is very far from most real applications. The experimental setup described here is based on a Gamry Reference 3000AEpotentiostat/galvanostat/ZRA working with a Gamry 30k Booster, which can be programmed to generate a variable load current profile and will thus enable the application of more realistic conditions for accelerated aging of power electronic devices in the lab. This will improve prognostics model development and provide excellent use cases for evaluating the capabilities of the prognostics algorithms for generalization to field conditions. The application of variable load profiles from the field, instead of the regular on/off cycles traditionally used, is not compatible with the commonly used method of using the chip itself as a temperature sensor. Instead, we here present a novel method of estimating the junction temperature using a device specific derivation of thermal parameters from the measured cooling block temperature, case temperature, and dissipated power in conjunction with simulations using the PySpice simulation package implemented in Python. The setup coupled with the new junction temperature estimation is an important step in enabling predictive maintenance of power devices that is currently missing from the power electronics community. © 2024 IEEE.
|
|
| 15. |
- Frangou, Sophia, et al.
(author)
-
Cortical thickness across the lifespan : Data from 17,075 healthy individuals aged 3-90 years
- 2022
-
In: Human Brain Mapping. - : John Wiley & Sons. - 1065-9471 .- 1097-0193. ; 43:1, s. 431-451
-
Journal article (peer-reviewed)abstract
- Delineating the association of age and cortical thickness in healthy individuals is critical given the association of cortical thickness with cognition and behavior. Previous research has shown that robust estimates of the association between age and brain morphometry require large-scale studies. In response, we used cross-sectional data from 17,075 individuals aged 3-90 years from the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to infer age-related changes in cortical thickness. We used fractional polynomial (FP) regression to quantify the association between age and cortical thickness, and we computed normalized growth centiles using the parametric Lambda, Mu, and Sigma method. Interindividual variability was estimated using meta-analysis and one-way analysis of variance. For most regions, their highest cortical thickness value was observed in childhood. Age and cortical thickness showed a negative association; the slope was steeper up to the third decade of life and more gradual thereafter; notable exceptions to this general pattern were entorhinal, temporopolar, and anterior cingulate cortices. Interindividual variability was largest in temporal and frontal regions across the lifespan. Age and its FP combinations explained up to 59% variance in cortical thickness. These results may form the basis of further investigation on normative deviation in cortical thickness and its significance for behavioral and cognitive outcomes.
|
|
| 16. |
- Fällmar, David, et al.
(author)
-
Imaging features associated with idiopathic normal pressure hydrocephalus have high specificity even when comparing with vascular dementia and atypical parkinsonism
- 2021
-
In: Fluids and Barriers of the CNS. - : BioMed Central (BMC). - 2045-8118. ; 18
-
Journal article (peer-reviewed)abstract
- Background: Vascular dementia (VaD) and atypical parkinsonism often present with symptoms that can resemble idiopathic normal pressure hydrocephalus (iNPH) and enlarged cerebral ventricles, and can be challenging differential diagnoses. The aim was to investigate frequencies of imaging features usually associated with iNPH and their radiological diagnostic accuracy in a sample containing the relevant differential diagnoses VaD, progressive supranuclear palsy (PSP), multiple system atrophy parkinsonian type (MSA-P), and healthy controls.Methods: Nine morphological imaging features usually associated with iNPH were retrospectively investigated in MR images of 55 patients with shunt-responsive iNPH, 32 patients with VaD, 30 patients with PSP, 27 patients with MSA-P, and 39 age-matched healthy controls. Logistic regression and receiver operating characteristic curves were used to assess diagnostic accuracy, sensitivity, and specificity for each imaging finding.Results: In a logistic regression model using iNPH diagnosis as a dependent variable, the following imaging features contributed significantly to the model: callosal angle (OR = 0.95 (0.92-0.99), p = 0.012), Evans' index * 100 (OR = 1.51 (1.23-1.86), p < 0.001), enlarged Sylvian fissures (OR = 6.01 (1.42-25.40), p = 0.015), and focally enlarged sulci (OR = 10.18 (1.89-55.02), p = 0.007). Imaging features with 95% specificity for iNPH were: callosal angle <= 71 degrees, temporal horns >= 7 mm, Evans' index >= 0.37, iNPH Radscale >= 9, and presence of DESH, bilateral ventricular roof bulgings or focally enlarged sulci. A simplified version of the iNPH Radscale with only four features resulted in equally high diagnostic accuracy as the original iNPH Radscale.Conclusions: There is a notable overlap between some of the commonly used imaging markers regarding iNPH, VaD and atypical parkinsonism, such as PSP. However, this study shows that the specificity of imaging markers usually associated with iNPH was high even when comparing with these challenging differential diagnoses. The callosal angle was the single imaging feature with highest diagnostic accuracy to discriminate iNPH from its mimics. A simplified rating scale using only a few selected features could be used with retained specificity.
|
|
| 17. |
- Genell, Anders, 1974-, et al.
(author)
-
Common sources of under water and air borne noise from ships
- 2023
-
In: Proceedings of the 10<sup>th </sup>Convention of the European Acoustics Association Forum Acusticum 2023. - : European Acoustics Association (EAA). - 9788888942674 ; , s. 6083-6086
-
Conference paper (other academic/artistic)abstract
- The project Silent@Sea, funded by the Swedish Transport Administration, aims to investigate levels of noise radiated from ships into the marine environment as well as on board from diesel engines, from LNG engines and from electric propulsion. The current paper presents results from measurements of on board noise and vibrations, external under water noise and external air borne noise from a hybrid battery/diesel shuttle ferry. On board vibration measurements provided information about sources such as engine mounts and thruster mounts that potentially radiate noise into the water. The most important of these sources were then confirmed by narrow band analysis of corresponding under water noise measurement results. Finally, results from air borne noise measurements were similarly analysed to find sources that contribute to both under and over water marine environment noise exposure. The analyses show that the vessel emit comparatively low levels of noise regardless of propulsion mode, and that when using electric propulsion the noise is further reduced both on board and under as well as over the water.
|
|
| 18. |
- Genell, Anders, 1974-, et al.
(author)
-
Ship noise in coastal regions : final report of the SHIPNOISE project
- 2024
-
Reports (other academic/artistic)abstract
- Ships carry cargo and passengers around our planet. In coastal regions, complaints about ship noise have been raised from nearby residents. Ships are also the dominant source of continuous underwater noise in the seas. In the SHIPNOISE project, we investigate levels of ship noise in coastal regions using a custom measurement station for both airborne and underwater noise from ships underway. The measurement station is developed using embedded microprocessors for low power consumption. The station is deployed at Böttö at the inlet to Gothenburg harbor, and then at Lurö in Lake Vänern.These sites are close to shipping lanes of different traffic intensity. The measured airborne noise levels indicate that there is a risk to exceed recommended indoor low-frequency noise limits for dwellings positioned up to several hundred meters from the passing ships, although the effect on public health is uncertain. The underwater noise recorded at 200-300 m range at the SHIPNOISE measurement locations during ship passages is strong enough to exceed levels for environmental impact previously demonstrated on local marine mammals, fish and possibly invertebrates. For example, harbor porpoises, herring and salmon are likely to avoid or escape the area when a loud ship passes.
|
|
| 19. |
- Genell, Anders, et al.
(author)
-
Ship noise in coastal regions - final report of the SHIPNOISE project
- 2024
-
Reports (other academic/artistic)abstract
- Ships carry cargo and passengers around our planet. In coastal regions, complaintsabout ship noise have been raised from nearby residents. Ships are also thedominant source of continuous underwater noise in the seas.In the SHIPNOISEproject, we investigate levels of ship noise in coastal regions using a custommeasurement station for both airborne and underwater noise from shipsunderway. The measurement station is developed using embeddedmicroprocessors for low power consumption. The station is deployed at Böttö atthe inlet to Gothenburg harbor, and then at Lurö in Lake Vänern.These sites areclose to shipping lanes of different traffic intensity. The measured airborne noiselevels indicate that there is a risk to exceed recommended indoor low-frequencynoise limits for dwellings positioned up to several hundred meters from thepassing ships, although the effect on public health is uncertain.The underwaternoise recorded at 200-300 m range at the SHIPNOISE measurement locationsduring ship passages is strong enough to exceed levels for environmental impactpreviously demonstrated on local marine mammals, fish and possiblyinvertebrates. For example, harbor porpoises, herring and salmon are likely toavoid or escape the area when a loud ship passes.
|
|
| 20. |
- Gustafsson, Finn, et al.
(author)
-
Everolimus Initiation With Early Calcineurin Inhibitor Withdrawal in De Novo Heart Transplant Recipients : Long-term Follow-up From the Randomized SCHEDULE Study
- 2020
-
In: Transplantation. - : LIPPINCOTT WILLIAMS & WILKINS. - 1534-6080 .- 0041-1337. ; 104:1, s. 154-164
-
Journal article (peer-reviewed)abstract
- BACKGROUND: A calcineurin inhibitor (CNI)-free immunosuppressive regimen has been demonstrated to improve renal function early after heart transplantation, but long-term outcome of such a strategy has not been well described. METHODS: In the randomized SCHEDULE trial, de novo heart transplant recipients received (1) everolimus with reduced-exposure CNI (cyclosporine) followed by CNI withdrawal at week 7-11 posttransplant or (2) standard-exposure cyclosporine, both with mycophenolate mofetil and corticosteroids; 95/115 randomized patients were followed up at 5-7 years posttransplant. RESULTS: Mean measured glomerular filtration rate was 74.7 mL/min and 62.4 mL/min with everolimus and CNI, respectively. The mean difference was in favor of everolimus by 11.8 mL/min in the intent-to-treat population (P = 0.004) and 17.2 mL/min in the per protocol population (n = 75; P < 0.001). From transplantation to last follow-up, the incidence of biopsy-proven acute rejection (BPAR) was 77% (37/48) and 66% (31/47) (P = 0.23) with treated BPAR in 50% and 23% (P < 0.01) in the everolimus and CNI groups, respectively; no episode led to hemodynamic compromise. Coronary allograft vasculopathy (CAV) assessed by coronary intravascular ultrasound was present in 53% (19/36) and 74% (26/35) of everolimus- and CNI-treated patients, respectively (P = 0.037). Graft dimensions and function were similar between the groups. Late adverse events were comparable. CONCLUSIONS: These results suggest that de novo heart transplant patients randomized to everolimus and low-dose CNI followed by CNI-free therapy maintain significantly better long-term renal function as well as significantly reduced CAV than patients randomized to standard CNI treatment. Increased BPAR in the everolimus group during year 1 did not impair long-term graft function.
|
|
| 21. |
- Gustavsson, Tobias, et al.
(author)
-
Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer's disease
- 2023
-
In: Alzheimer's Research & Therapy. - : BioMed Central (BMC). - 1758-9193. ; 15:1
-
Journal article (peer-reviewed)abstract
- BackgroundBrain-directed immunotherapy is a promising strategy to target amyloid-β (Aβ) deposits in Alzheimer’s disease (AD). In the present study, we compared the therapeutic efficacy of the Aβ protofibril targeting antibody RmAb158 with its bispecific variant RmAb158-scFv8D3, which enters the brain by transferrin receptor-mediated transcytosis.MethodsAppNL−G−F knock-in mice received RmAb158, RmAb158-scFv8D3, or PBS in three treatment regimens. First, to assess the acute therapeutic effect, a single antibody dose was given to 5 months old AppNL−G−F mice, with evaluation after 3 days. Second, to assess the antibodies’ ability to halt the progression of Aβ pathology, 3 months old AppNL−G−F mice received three doses during a week, with evaluation after 2 months. Reduction of RmAb158-scFv8D3 immunogenicity was explored by introducing mutations in the antibody or by depletion of CD4+ T cells. Third, to study the effects of chronic treatment, 7-month-old AppNL−G−F mice were CD4+ T cell depleted and treated with weekly antibody injections for 8 weeks, including a final diagnostic dose of [125I]RmAb158-scFv8D3, to determine its brain uptake ex vivo. Soluble Aβ aggregates and total Aβ42 were quantified with ELISA and immunostaining.ResultsNeither RmAb158-scFv8D3 nor RmAb158 reduced soluble Aβ protofibrils or insoluble Aβ1-42 after a single injection treatment. After three successive injections, Aβ1-42 was reduced in mice treated with RmAb158, with a similar trend in RmAb158-scFv8D3-treated mice. Bispecific antibody immunogenicity was somewhat reduced by directed mutations, but CD4+ T cell depletion was used for long-term therapy. CD4+ T cell-depleted mice, chronically treated with RmAb158-scFv8D3, showed a dose-dependent increase in blood concentration of the diagnostic [125I]RmAb158-scFv8D3, while concentration was low in plasma and brain. Chronic treatment did not affect soluble Aβ aggregates, but a reduction in total Aβ42 was seen in the cortex of mice treated with both antibodies.ConclusionsBoth RmAb158 and its bispecific variant RmAb158-scFv8D3 achieved positive effects of long-term treatment. Despite its ability to efficiently enter the brain, the benefit of using the bispecific antibody in chronic treatment was limited by its reduced plasma exposure, which may be a result of interactions with TfR or the immune system. Future research will focus in new antibody formats to further improve Aβ immunotherapy.
|
|
| 22. |
- Holmgren, Simon, et al.
(author)
-
Neuropsychiatric Symptoms in Dementia : Considering a Clinical Role for Electroencephalography
- 2022
-
In: The Journal of Neuropsychiatry and Clinical Neurosciences. - : American Psychiatric Association Publishing, Inc.. - 0895-0172 .- 1545-7222. ; 34:3, s. 214-223
-
Journal article (peer-reviewed)abstract
- OBJECTIVE: Degenerative dementia is characterized by progressive cognitive decline and neuropsychiatric symptoms. People with Alzheimer's disease (AD), the most common cause of dementia, show synaptic loss and disruption of functional brain networks along with neuritic plaques and neurofibrillary tangles. Electroencephalography (EEG) directly reflects synaptic activity, and among patients with AD it is associated with slowing of background activity. The purpose of this study was to identify associations between neuropsychiatric symptoms and EEG in patients with dementia and to determine whether EEG parameters could be used for clinical assessment of pharmacological treatment of neuropsychiatric symptoms in dementia (NPSD) with galantamine or risperidone.METHODS: Seventy-two patients with EEG recordings and a score ≥10 on the Neuropsychiatric Inventory (NPI) were included. Clinical assessments included administration of the NPI, the Mini-Mental State Examination (MMSE), and the Cohen-Mansfield Agitation Inventory (CMAI). Patients underwent EEG examinations at baseline and after 12 weeks of treatment with galantamine or risperidone. EEG frequency analysis was performed. Correlations between EEG and assessment scale scores were statistically examined, as were EEG changes from baseline to the week 12 visit and the relationship with NPI, CMAI, and MMSE scores.RESULTS: Significant correlations were found between NPI agitation and delta EEG frequencies at baseline and week 12. No other consistent and significant relationships were observed between NPSD and EEG at baseline, after NPSD treatment, or in the change in EEG from baseline to follow-up.CONCLUSIONS: The limited informative findings in this study suggest that there exists a complex relationship between NPSD and EEG; hence, it is difficult to evaluate and use EEG for clinical assessment of pharmacological NPSD treatment.
|
|
| 23. |
- Jensen Wolfhechel, Ola, 1965-, et al.
(author)
-
Norrlands vattenanknutna kulturmiljöer – en förstudie : rapport från ett FoU-projekt
- 2022
-
Reports (other academic/artistic)abstract
- Syftet med föreliggande förstudie har varit att ta fram ett underlag inför ett kommande tvärvetenskapligt forsknings- och digitaliseringsprojekt. Bakgrunden är att Riksantikvarieämbetet under 1940-1980-talen genomförde omfattande arkeologiska, men även naturvetenskapliga och etnologiska, undersökningar vid Norrlands älvar och sjöar som ett led i vattenkraftsutbyggnaden. Materialet kom under 1960-1980-talen att bearbetas tillsammans med Stockholms universitet inom ramen för det tvärvetenskapliga projektet Norrlands Tidiga Bebyggelse. Insatserna resulterade i ett rikt material som idag förvaras i Riksantikvarieämbetets arkiv. Då stora delar av Norrland alltjämt är antikvariskt eftersatta utgör det ett mycket viktigt källmaterial för både forskning och förvaltning av dess kulturmiljöer.Det långsiktiga målet med förstudien och det kommande projektet är att skapa ett kunskapsunderlag för forskning och redskap för landskapsanalyser som leder till ett hållbart bevarande och förvaltning av Norrlands vattenanknutna kulturmiljöer. Inom förstudien har en rad viktiga forsknings- och förvaltningsområden identifierats. För att ta fram ett adekvat underlag inför ansökan har den bland annat mynnat ut i olika förslag på strategier för det kommande projektets genomförande och finansiering, en fördjupning av frågor som rör förvaltning av vattenanknutna kulturmiljöer, utvecklat tvärvetenskapliga forskningsfrågor, tagit fram en digitaliseringsstrategi, formaliserat ett nätverk och en referensgrupp, genomfört en behovsanalys samt en inventering för att identifiera relevant arkivmaterial inom projektdeltagarnas respektive institutioner. Med förstudien har vi således lagt grunden till ett tvärvetenskapligt forsknings- och digitaliseringsprojekt som inkluderar kulturmiljöförvaltning, arkeologi, etnologi, sociologi och naturveten-skapliga ämnen, däribland miljö- och klimatforskning.
|
|
| 24. |
- Lodin, Karin, et al.
(author)
-
Patient global assessment and inflammatory markers in patients with idiopathic inflammatory myopathies : A longitudinal study
- 2024
-
In: Seminars in Arthritis & Rheumatism. - : Elsevier. - 0049-0172 .- 1532-866X. ; 65
-
Journal article (peer-reviewed)abstract
- AimTo explore if patient global assessment (PGA) is associated with inflammation over time and if associations are explained by other measures of disease activity and function in patients with idiopathic inflammatory myopathies (IIM).MethodsPGA and systemic inflammatory markers prospectively collected over five years were retrieved from the International MyoNet registry for 1200 patients with IIM. Associations between PGA, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and creatine kinase (CK) were analyzed using mixed models. Mediation analysis was used to test if the association between PGA and inflammatory markers during the first year of observation could be explained by measures of disease activity and function.ResultsPGA improved, and inflammatory markers decreased during the first year of observation. In the mixed models, high levels of inflammatory markers were associated with worse PGA in both men and women across time points during five years of observation. In men, but not in women, the association between elevated ESR, CRP and poorer PGA was explained by measures of function and disease activity. With a few exceptions, the association between improved PGA and reduced inflammatory markers was partially mediated by improvements in all measures of function and disease activity.ConclusionIncreased levels of systemic inflammation are associated with poorer PGA in patients with IIM. In addition to known benefits of lowered inflammation, these findings emphasize the need to reduce systemic inflammation to improve subjective health in patients with IIM. Furthermore, the results demonstrate the importance of incorporating PGA as an outcome measure in clinical practice and clinical trials.
|
|
| 25. |
- Lundtoft, Christian, et al.
(author)
-
Complement C4 Copy Number Variation is Linked to SSA/Ro and SSB/La Autoantibodies in Systemic Inflammatory Autoimmune Diseases
- 2022
-
In: Arthritis & Rheumatology. - : Wiley. - 2326-5191 .- 2326-5205. ; 74:8, s. 1440-1450
-
Journal article (peer-reviewed)abstract
- Objective Copy number variation of the C4 complement components, C4A and C4B, has been associated with systemic inflammatory autoimmune diseases. This study was undertaken to investigate whether C4 copy number variation is connected to the autoimmune repertoire in systemic lupus erythematosus (SLE), primary Sjogrens syndrome (SS), or myositis. Methods Using targeted DNA sequencing, we determined the copy number and genetic variants of C4 in 2,290 well-characterized Scandinavian patients with SLE, primary SS, or myositis and 1,251 healthy controls. Results A prominent relationship was observed between C4A copy number and the presence of SSA/SSB autoantibodies, which was shared between the 3 diseases. The strongest association was detected in patients with autoantibodies against both SSA and SSB and 0 C4A copies when compared to healthy controls (odds ratio [OR] 18.0 [95% confidence interval (95% CI) 10.2-33.3]), whereas a weaker association was seen in patients without SSA/SSB autoantibodies (OR 3.1 [95% CI 1.7-5.5]). The copy number of C4 correlated positively with C4 plasma levels. Further, a common loss-of-function variant in C4A leading to reduced plasma C4 was more prevalent in SLE patients with a low copy number of C4A. Functionally, we showed that absence of C4A reduced the individuals capacity to deposit C4b on immune complexes. Conclusion We show that a low C4A copy number is more strongly associated with the autoantibody repertoire than with the clinically defined disease entities. These findings may have implications for understanding the etiopathogenetic mechanisms of systemic inflammatory autoimmune diseases and for patient stratification when taking the genetic profile into account.
|
|
| 26. |
- Martin, David, et al.
(author)
-
Defining Major Surgery: A Delphi Consensus Among European Surgical Association (ESA) Members
- 2020
-
In: World Journal of Surgery. - : Springer Science and Business Media LLC. - 0364-2313 .- 1432-2323. ; 44:7, s. 2211-2219
-
Journal article (peer-reviewed)abstract
- © 2020, Société Internationale de Chirurgie. Background: Major surgery is a term frequently used but poorly defined. The aim of the present study was to reach a consensus in the definition of major surgery within a panel of expert surgeons from the European Surgical Association (ESA). Methods: A 3-round Delphi process was performed. All ESA members were invited to participate in the expert panel. In round 1, experts were inquired by open- and closed-ended questions on potential criteria to define major surgery. Results were analyzed and presented back anonymously to the panel within next rounds. Closed-ended questions in round 2 and 3 were either binary or statements to be rated on a Likert scale ranging from 1 (strong disagreement) to 5 (strong agreement). Participants were sent 3 reminders at 2-week intervals for each round. 70% of agreement was considered to indicate consensus. Results: Out of 305 ESA members, 67 (22%) answered all the 3 rounds. Significant comorbidities were the only preoperative factor retained to define major surgery (78%). Vascular clampage or organ ischemia (92%), high intraoperative blood loss (90%), high noradrenalin requirements (77%), long operative time (73%) and perioperative blood transfusion (70%) were procedure-related factors that reached consensus. Regarding postoperative factors, systemic inflammatory response (76%) and the need for intensive or intermediate care (88%) reached consensus. Consequences of major surgery were high morbidity (>30% overall) and mortality (>2%). Conclusion: ESA experts defined major surgery according to extent and complexity of the procedure, its pathophysiological consequences and consecutive clinical outcomes.
|
|
| 27. |
- Schlein, Eva, et al.
(author)
-
Reducing neonatal Fc receptor binding enhances clearance and brain-to-blood ratio of TfR-delivered bispecific amyloid-β antibody
- 2024
-
In: mAbs. - : Taylor & Francis. - 1942-0862 .- 1942-0870. ; 16:1
-
Journal article (peer-reviewed)abstract
- Recent development of amyloid-β (Aβ)-targeted immunotherapies for Alzheimer’s disease (AD) have highlighted the need for accurate diagnostic methods. Antibody-based positron emission tomography (PET) ligands are well suited for this purpose as they can be directed toward the same target as the therapeutic antibody. Bispecific, brain-penetrating antibodies can achieve sufficient brain concentrations, but their slow blood clearance remains a challenge, since it prolongs the time required to achieve a target-specific PET signal. Here, two antibodies were designed based on the Aβ antibody bapineuzumab (Bapi) – one monospecific IgG (Bapi) and one bispecific antibody with an antigen binding fragment (Fab) of the transferrin receptor (TfR) antibody 8D3 fused to one of the heavy chains (Bapi-Fab8D3) for active, TfR-mediated transport into the brain. A variant of each antibody was designed to harbor a mutation to the neonatal Fc receptor (FcRn) binding domain, to increase clearance. Blood and brain pharmacokinetics of radiolabeled antibodies were studied in wildtype (WT) and AD mice (AppNL-G-F). The FcRn mutation substantially reduced blood half-life of both Bapi and Bapi-Fab8D3. Bapi-Fab8D3 showed high brain uptake and the brain-to-blood ratio of its FcRn mutated form was significantly higher in AppNL-G-F mice than in WT mice 12 h after injection and increased further up to 168 h. Ex vivo autoradiography showed specific antibody retention in areas with abundant Aβ pathology. Taken together, these results suggest that reducing FcRn binding of a full-sized bispecific antibody increases the systemic elimination and could thereby drastically reduce the time from injection to in vivo imaging.
|
|
| 28. |
- Trabaldo, Edoardo, 1990, et al.
(author)
-
Properties of grooved Dayem bridge based YBa2Cu3 O 7 - δ superconducting quantum interference devices and magnetometers
- 2020
-
In: Applied Physics Letters. - : AIP Publishing. - 0003-6951 .- 1077-3118. ; 116:13
-
Journal article (peer-reviewed)abstract
- The transport properties of a YBa2Cu3 O 7 - δ superconducting quantum interference device (SQUID) based on grooved Dayem bridge weak links are studied as a function of temperature: at high temperatures (60 K < T < T c = 89 K), the weak links show properties similar to superconductor-normal conductor-superconductor junctions, while at temperatures below 60 K, the weak links behave like short Dayem bridges. Using these devices, we have fabricated SQUID magnetometers with galvanically coupled in-plane pickup loops: at T = 77 K, magnetic field white noise levels as low as 63 fT/ Hz have been achieved. © 2020 Author(s).
|
|
| 29. |
- Trabaldo, Edoardo, 1990, et al.
(author)
-
SQUID magnetometer based on Grooved Dayem nanobridges and a flux transformer
- 2020
-
In: IEEE Transactions on Applied Superconductivity. - 1558-2515 .- 1051-8223. ; 30:7
-
Journal article (peer-reviewed)abstract
- We report noise measurements performed on a superconducting quantum interference devices (SQUID) magnetometer implementing YBa2Cu3O7-δ grooved Dayem nanobridges as weak links. The magnetometer is realized by coupling the SQUID to a flux transformer with a two-level coupling scheme using a flip-chip approach to improve the effective area of the SQUID. The measured magnetic flux noise of the SQUID is as low as 10 μ Φ0/√Hz, which corresponds to an equivalent magnetic field white noise of 60 fT/√Hz above 100 Hz at T=77 K.
|
|
