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- Fortner, Renée T., et al.
(author)
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Anti-Mullerian hormone and endometrial cancer : a multi-cohort study
- 2017
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In: British Journal of Cancer. - : Nature Publishing Group. - 0007-0920 .- 1532-1827. ; 117:9, s. 1412-1418
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Journal article (peer-reviewed)abstract
- Background: The Mullerian ducts are the embryological precursors of the female reproductive tract, including the uterus; anti-Mullerian hormone (AMH) has a key role in the regulation of foetal sexual differentiation. Anti-Mullerian hormone inhibits endometrial tumour growth in experimental models by stimulating apoptosis and cell cycle arrest. To date, there are no prospective epidemiologic data on circulating AMH and endometrial cancer risk. Methods: We investigated this association among women premenopausal at blood collection in a multicohort study including participants from eight studies located in the United States, Europe, and China. We identified 329 endometrial cancer cases and 339 matched controls. AntiMullerian hormone concentrations in blood were quantified using an enzyme-linked immunosorbent assay. Conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CI) across tertiles and for a doubling of AMH concentrations (ORlog2). Subgroup analyses were performed by ages at blood donation and diagnosis, oral contraceptive use, and tumour characteristics. Results: Anti-Mullerian hormone was not associated with the risk of endometrial cancer overall (ORlog(2): 1.07 (0.99-1.17)), or with any of the examined subgroups. Conclusions: Although experimental models implicate AMH in endometrial cancer growth inhibition, our findings do not support a role for circulating AMH in the aetiology of endometrial cancer.
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| 2. |
- Fortov, V., et al.
(author)
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The project 'Plasmakristall-4' (PK-4) - a new stage in investigations of dusty plasmas under microgravity conditions : first results and future plans
- 2005
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In: Plasma Physics and Controlled Fusion. - 0741-3335 .- 1361-6587. ; 47, s. B537-B549
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Journal article (peer-reviewed)abstract
- The PK-4 experiment is a continuation of the successful dusty plasma experiments PK-1, PK-2 and PK-3 conducted on board of the orbital space stations Mir and International Space Station. For all these experiments it is important to avoid the strong influence of gravity, exerting an external stress on the system. Whereas PK-3 and PK-3 Plus experiments are using a planar rf capacitive discharge, PK-4 studies complex plasmas in a long cylindrical chamber with a combined dc/rf discharge. Such a configuration of the chamber will provide a particular advantage for investigation of different dynamical phenomena in complex plasmas such as sheared laminar flow of a highly nonideal dusty liquid and its transition to the turbulent regime, nozzle flow, boundary layers and instabilities, shock waves (solitons) formation and propagation, dust particle lane formation, and space dust grain separation according to their size.
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| 3. |
- Fortugno, Federico, et al.
(author)
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Symptoms associated with victimization in patients with schizophrenia and related disorders
- 2013
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In: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 8:3, s. e58142-
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Journal article (peer-reviewed)abstract
- Background: Patients with psychoses have an increased risk of becoming victims of violence. Previous studies have suggested that higher symptom levels are associated with a raised risk of becoming a victim of physical violence. There has been, however, no evidence on the type of symptoms that are linked with an increased risk of recent victimization.Methods: Data was taken from two studies on involuntarily admitted patients, one national study in England and an international one in six other European countries. In the week following admission, trained interviewers asked patients whether they had been victims of physical violence in the year prior to admission, and assessed symptoms on the Brief Psychiatric Rating Scale (BPRS). Only patients with a diagnosis of schizophrenia or related disorders (ICD-10 F20-29) were included in the analysis which was conducted separately for the two samples. Symptom levels assessed on the BPRS subscales were tested as predictors of victimization. Univariable and multivariable logistic regression models were fitted to estimate adjusted odds ratios.Results: Data from 383 patients in the English sample and 543 patients in the European sample was analysed. Rates of victimization were 37.8% and 28.0% respectively. In multivariable models, the BPRS manic subscale was significantly associated with victimization in both samples.Conclusions: Higher levels of manic symptoms indicate a raised risk of being a victim of violence in involuntary patients with schizophrenia and related disorders. This might be explained by higher activity levels, impaired judgement or poorer self-control in patients with manic symptoms. Such symptoms should be specifically considered in risk assessments.
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