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Träfflista för sökning "WFRF:(Bratland E) srt2:(2020-2024)"

Search: WFRF:(Bratland E) > (2020-2024)

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  • Goldfarb, Y, et al. (author)
  • Mechanistic dissection of dominant AIRE mutations in mouse models reveals AIRE autoregulation
  • 2021
  • In: The Journal of experimental medicine. - : Rockefeller University Press. - 1540-9538 .- 0022-1007. ; 218:11
  • Journal article (peer-reviewed)abstract
    • The autoimmune regulator (AIRE) is essential for the establishment of central tolerance and prevention of autoimmunity. Interestingly, different AIRE mutations cause autoimmunity in either recessive or dominant-negative manners. Using engineered mouse models, we establish that some monoallelic mutants, including C311Y and C446G, cause breakdown of central tolerance. By using RNAseq, ATACseq, ChIPseq, and protein analyses, we dissect the underlying mechanisms for their dominancy. Specifically, we show that recessive mutations result in a lack of AIRE protein expression, while the dominant mutations in both PHD domains augment the expression of dysfunctional AIRE with altered capacity to bind chromatin and induce gene expression. Finally, we demonstrate that enhanced AIRE expression is partially due to increased chromatin accessibility of the AIRE proximal enhancer, which serves as a docking site for AIRE binding. Therefore, our data not only elucidate why some AIRE mutations are recessive while others dominant, but also identify an autoregulatory mechanism by which AIRE negatively modulates its own expression.
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  • Sundgot-Borgen, Christine, et al. (author)
  • The Norwegian healthy body image intervention promotes positive embodiment through improved self-esteem
  • 2020
  • In: Body image. - : Elsevier. - 1740-1445 .- 1873-6807. ; 35, s. 84-95
  • Journal article (peer-reviewed)abstract
    • We examined both direct and indirect effects of the Healthy Body Image (HBI) intervention on positive embodiment among Norwegian high school students. In total, 2446 12th grade boys (43 %) and girls (mean age 16.8 years) from 30 schools participated in a cluster-randomized controlled study with the HBI intervention and a control condition as the study arms. We tested mediation models using path analysis and found that among several hypothesized mediators, only self-esteem mediated a positive intervention effect on positive embodiment for both boys and girls. A direct effect of the intervention on positive embodiment was only found in girls. The study provides novel findings indicating that health promotion interventions to address a positive embodiment should focus on enhancing adolescent's selfesteem. Serial mediation modeling might reveal more complex explanations of change mechanisms and could further evolve current knowledge.
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