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- Blomberg, Mats, et al.
(author)
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Word recognition using synthesized templates
- 1988
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In: STL-QPSR. ; 29:2-3, s. 069-081
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Journal article (peer-reviewed)abstract
- With the ultimate aim of creating a knowledge based speech understanding system, we have set up a conceptual framework named NEBULA. In this paper we briefly describe some of the components of this framework and also report on some experiments where we use a production component for generating reference data for the recognition. The production component in the form of a speech synthesis system will ideally make the collection of training data unnecessary. Preliminary results of an isolated word recognition experiment will be presented and discussed. Several methods of interfacing the production component to the recognition/evaluation component have been pursued.
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- Dohlsten, M, et al.
(author)
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Lymphocyte subpopulations and lymphokine production in children with constitutional aplastic anemia
- 1988
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In: Pediatric Hematology & Oncology. - : Informa UK Limited. - 1521-0669 .- 0888-0018. ; 5:2, s. 143-151
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Journal article (peer-reviewed)abstract
- The expression of lymphocyte surface markers as well as the production of interleukin-2 (IL-2) and interferon-gamma (IFN) by mitogen-stimulated peripheral blood mononuclear cells (MNC) have been studied in five children with constitutional aplastic anemia. A significantly reduced T4/T8 ratio was found and two of five patients also had a reduced percentage of B cells. One patient had a high percentage of HLA-DR positive T8+ cells, very suggestive of a high degree of circulating activated T suppressor/cytotoxic cells. IL-2 production was reduced in two patients, whereas IFN production was only reduced in one of these. The abnormalities found correlate with the duration of the bone marrow failure. The patients with the longest duration of bone marrow failure also exhibited the lowest T4/T8 ratio. No spontaneous IFN production was detected in any of the patients. There was no clinical benefit or reversal of the immune abnormalities during and following treatment with cimetidine and cyclosporine A in two patients.
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- Hedlund, G, et al.
(author)
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Maximal interferon-gamma production and early synthesis of interleukin-2 by CD4+ CDw29- CD45R- p80- human T lymphocytes.
- 1989
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In: Immunology. - 0019-2805. ; 66:1, s. 49-53
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Journal article (peer-reviewed)abstract
- Functionally distinct subsets within the T-helper (CD4+) cell population have been described in man, rat and mouse. We have shown previously that the CD4+ 45R- human lymphocytes are producers of IL-2 within 24 hr of polyclonal stimulation and are the major interferon (IFN) producers. The mAbs 4B4 (CDw29) and Leu 8 (p80) are here used together with Leu-18 (CD45R) to characterize the subpopulations of the CD4+ human lymphocytes in more detail. The majority of the CD45R+ cells were CDw29- and the majority of the CDw29+ cells were CD45R-. Most of the CD45R+ cells (78%) were also p80+. A significant number of cells (12%) were CDw29- CD45R-. The predominant subpopulations were defined to be CDw29- CD45R+ p80+ (31%), CDw29+ CD45R- p80- (24%) and CDW29+ CD45R- p80+ (18%). Within the CD4+ CD45R- subpopulation different subsets vary in their capacities to produce IFN and to produce IL-2 within 24 hr after activation. CD4+ CDw29- CD45R- p80- T lymphocytes produced the largest quantities of IFN and IL-2.
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