| 1. |
- Uronis, Hope E, et al.
(author)
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Oxygen for relief of dyspnoea in people with chronic obstructive pulmonary disease who would not qualify for home oxygen: a systematic review and meta-analysis.
- 2015
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In: Thorax. - : BMJ. - 1468-3296 .- 0040-6376. ; 70:5, s. 492-494
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Journal article (peer-reviewed)abstract
- We searched MEDLINE, EMBASE and the Cochrane Controlled Trials Register to determine whether oxygen relieves dyspnoea in mildly or non-hypoxemic COPD and included 18 randomised controlled trials (431 participants) in the meta-analysis using Cochrane methodology. Oxygen therapy reduced dyspnoea when compared with medical air; standardised mean difference -0.37 (95% CI -0.50 to -0.24; I(2)=14%). In a priori subgroup and sensitivity analyses, dyspnoea was reduced by continuous oxygen during exertion but not short-burst oxygen therapy. Continuous exertional oxygen can relieve dyspnoea in mildly or non-hypoxemic COPD, but evidence from larger clinical trials is needed.
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| 2. |
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| 3. |
- Currow, David C, et al.
(author)
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Can variability in the effect of opioids on refractory breathlessness be explained by genetic factors?
- 2015
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In: BMJ Open. - : BMJ. - 2044-6055. ; 5:5
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Journal article (peer-reviewed)abstract
- Opioids modulate the perception of breathlessness with a considerable variation in response, with poor correlation between the required opioid dose and symptom severity. The objective of this hypothesis-generating, secondary analysis was to identify candidate single nucleotide polymorphisms (SNP) from those associated with opioid receptors, signalling or pain modulation to identify any related to intensity of breathlessness while on opioids. This can help to inform prospective studies and potentially lead to better tailoring of opioid therapy for refractory breathlessness.
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| 5. |
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| 6. |
- Ekström, Magnus, et al.
(author)
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Outcome measurement of refractory breathlessness: endpoints and important differences.
- 2015
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In: Current Opinion in Supportive and Palliative Care. - 1751-4266.
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Journal article (peer-reviewed)abstract
- Standardized measurement of self-rated breathlessness using appropriate tools is essential for research and clinical care. The purpose was to review recent advances in the measurement of breathlessness and the minimal clinically important differences (MCIDs) in intensity of chronic breathlessness.
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