| 1. |
- Hillier, Ladeana W, et al.
(author)
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Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution
- 2004
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In: Nature. - 0028-0836 .- 1476-4687. ; 432:7018, s. 695-716
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Journal article (peer-reviewed)abstract
- We present here a draft genome sequence of the red jungle fowl, Gallus gallus. Because the chicken is a modern descendant of the dinosaurs and the first non-mammalian amniote to have its genome sequenced, the draft sequence of its genome--composed of approximately one billion base pairs of sequence and an estimated 20,000-23,000 genes--provides a new perspective on vertebrate genome evolution, while also improving the annotation of mammalian genomes. For example, the evolutionary distance between chicken and human provides high specificity in detecting functional elements, both non-coding and coding. Notably, many conserved non-coding sequences are far from genes and cannot be assigned to defined functional classes. In coding regions the evolutionary dynamics of protein domains and orthologous groups illustrate processes that distinguish the lineages leading to birds and mammals. The distinctive properties of avian microchromosomes, together with the inferred patterns of conserved synteny, provide additional insights into vertebrate chromosome architecture.
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| 2. |
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| 3. |
- Gennery, A. R., et al.
(author)
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Treatment of CD40 ligand deficiency by hematopoietic stem cell transplantation: a survey of the European experience, 1993-2002
- 2004
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In: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 103:3, s. 1152-7
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Journal article (peer-reviewed)abstract
- CD40 ligand (CD40L) deficiency causes recurrent sinopulmonary infection, Pneumocystis carinii pneumonia, and Cryptosporidium parvum infection. Approximately 40% to 50% of patients survive to the third decade: long-term survival is unclear. Hematopoietic stem cell transplantation (HSCT) is curative. We present a retrospective analysis of 38 European patients undergoing HSCT for CD40L deficiency in 8 European countries between 1993 and 2002. Donor stem cell source included 14 HLA-identical siblings, 22 unrelated donors, and 2 phenotypically matched parental stem cells (12 T-cell depleted). Of the patients, 34 engrafted and 26 (68%) survived; 3 had autologous reconstitution, 22 (58%) were cured, and 1 engrafted but has poor T-cell immune reconstitution. There were 18 evaluated patients who responded to vaccination. Of the patients, 12 (32%) died from infection-related complications, with severe cryptosporidiosis in 6. Grades 2 to 4 graft-versus-host disease (GvHD) associated with infection occurred in 6 of 12 fatal cases. HSCT cured 58% of patients, 72% of those without hepatic disease. Early T-cell function following whole marrow HSCT may limit cryptosporidial disease, but survival was similar after T-cell-depleted HSCT. Preexisting lung damage was the most important adverse risk factor. Further studies will determine optimal timing and type of HSCT.
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| 4. |
- Piotto, Giampaolo, et al.
(author)
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Relative Frequencies of Blue Stragglers in Galactic Globular Clusters: Constraints for the Formation Mechanisms
- 2004
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In: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 604:2, s. 109-112
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Journal article (peer-reviewed)abstract
- We discuss the main properties of the Galactic globular cluster (GC)blue straggler stars (BSSs), as inferred from our new catalog containingnearly 3000 BSSs. The catalog has been extracted from thephotometrically homogeneous V versus (B-V) color-magnitude diagrams(CMDs) of 56 GCs, based on Wide Field Planetary Camera 2 images of theircentral cores. In our analysis, we used consistent relative distancesbased on the same photometry and calibration. The number of BSSs hasbeen normalized to obtain relative frequencies (FBSS) andspecific densities (NS) using different stellar populationsextracted from the CMD. The cluster FBSS is significantlysmaller than the relative frequency of field BSSs. We find a significantanticorrelation between the BSS relative frequency in a cluster and itstotal absolute luminosity (mass). There is no statistically significanttrend between the BSS frequency and the expected collision rate. Thevalue of FBSS does not depend on other cluster parameters,apart from a mild dependence on the central density. Post-core-collapseclusters act like normal clusters as far as the BSS frequency isconcerned. We also show that the BSS luminosity function for the mostluminous clusters is significantly different, with a brighter peak andextending to brighter luminosities than in the less luminous clusters.These results imply that the efficiency of BSS production mechanisms andtheir relative importance vary with the cluster mass.Based on observations with the NASA/ESA Hubble Space Telescope, obtainedat the Space Telescope Science Institute, which is operated by theAssociation of Universities for Research in Astronomy, Inc., under NASAcontract NAS 5-26555.
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| 6. |
- Moberg, A, et al.
(author)
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Day-to-day temperature variability trends in 160-to 275-year-long European instrumental records
- 2000
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In: JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES. - : AMER GEOPHYSICAL UNION. - 0747-7309. ; 105:D18, s. 22849-22868
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Journal article (peer-reviewed)abstract
- Day-to-day temperature variability is investigated in eight European series of daily mean temperatures beginning between 1722 and 1833. Eight statistical measures of day-to-day temperature variability are compared. The intramonthly standard deviation of d
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| 7. |
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| 8. |
- Neelov, I.M., et al.
(author)
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Computer simulations of stretching and collapse of polymer molecules in solution
- 2003
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In: Macromolecular Symposia. - : Wiley. - 1022-1360 .- 1521-3900. ; 191
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Conference paper (peer-reviewed)abstract
- Computer simulations are reported for system of linear polymer molecules, diblock copolymer and dendrimer in dilute solution without and with elongational flow. The effect of fluctuating hydrodynamics interactions (HI) on the coil-stretch transition of linear polymers and dendrimers in elongational flow is studied. The process of coiling of homo- and blockcopolymer from completely extended state is also simulated.
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