| 1. |
- Locke, Adam E, et al.
(author)
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Genetic studies of body mass index yield new insights for obesity biology.
- 2015
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In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 518:7538, s. 197-401
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Journal article (peer-reviewed)abstract
- Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.
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| 2. |
- Shungin, Dmitry, et al.
(author)
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New genetic loci link adipose and insulin biology to body fat distribution.
- 2015
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In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 518:7538, s. 187-378
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Journal article (peer-reviewed)abstract
- Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.
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| 3. |
- Rose, Linda M, 1963-, et al.
(author)
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RAMP - A new tool for MSD risk management in manualhandling
- 2017
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In: Conference Proceedings 48th Annual Conference of the Association of Canadian Ergonomists & 12th International Symposium on Human Factors in Organizational Design and Management "Organizing for High Performance ".
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Conference paper (peer-reviewed)abstract
- Summative Statement: In this conference contribution RAMP (Risk Assessment and Management tool for Manual Handling - Proactively) will be presented. It is developed for managing MSD risks in manual handling jobs. The presentation will include a demonstration of the digitalised tool and information about upcoming Massive Open Online Courses about it.Problem statement: Manual handling work is regarded as one of the main causes to increased risks of developing Musculoskeletal disorders (MSDs). Several MSD risk assessment tools have been developed, but have been found to have insufficiencies in managing MSD risks in manual handling. The insufficiencies include that tools only assess certain body parts or certain types of work, are not freely accessible, assess exposure but not risks, and don´t support the whole risk management process. In 2009 there was a call from a global company, which had identified a need for a scientifically based, freely accessible, risk assessment and risk management tool. The tool should support systematic risk management of MSD risks in manual handling jobs and be able to be used by companies themselves. To meet this call the development of the RAMP tool (Risk Assessment and Management tool for Manual Handling – Proactively) was started. It has been developed in a research and development (R&D) project in close co-operation between researchers and practitioners at companies.Research Objective: The objective of this conference contribution is to present the results of a seven year long R&D project: to describe the RAMP tool and its development, present the digitalised version, share some experiences from its use, and inform about upcoming RAMP Massive Open Online Courses (MOOCs), aimed at educating and training users in the RAMP tool.Methodology: RAMP is scientifically based and was developed with a participative R&D methodology. The participating organisations as well as the methodology, including the base for the development, ranging from scientific publications and legislation to user testing and feed-back, will be described in the presentation.Results: The RAMP tool consists of four parts: RAMP I, RAMP II, The Results module and the Action module. At the conference, these will be presented and the digitalised version of RAMP will be demonstrated. In addition, information about three Massive Open Online Courses (MOOCs) about the RAMP tool which are being developed will be presented and user experiences from applying RAMP will be shared. In addition to the oral presentation a workshop on RAMP is planned to be held at the conference.Discussion: The discussion focuses on how methods like RAMP, which are freely accessible, can be spread after the R&D project is finished. Another question is how to secure updates in the future for methods which do not bring any profit for the developers/owners.Conclusions: It is concluded that RAMP, a scientifically based new tool for risk management of MSD risks in manual handling, is freely available via KTH’s homepage and that a MOOC-package for disseminating knowledge and training on how to use the tool will be accessible from the autumn 2017.
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| 5. |
- Rose, Linda M., 1963-, et al.
(author)
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The RAMP Tool for Risk Management in Manual Handling : A Seven Year R&D Project
- 2017
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In: NES2017 Conference Proceedings.
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Conference paper (peer-reviewed)abstract
- Background and purposeIn 2010 a research and development (R&D) project started after an initiative from a large global company. They needed a free, systematic musculoskeletal disorder (MSD) risk assessment and management tool, focused on manual handling. The development of the RAMP tool (Risk Assessment and Management tool for Manual Handling – Proactively) was therefore initiated, and the progress has since then been presented at several NES-conferences. The objective of this paper is to present the result of this 7 year R&D project: the digitalized RAMP tool and courses on the tool. MethodologyA participative methodology in close co-operation between researchers and practitioners at companies has been used. The participating companies and the methodology, including the base for the development, ranging from scientific papers to user feedback, and evaluations will be described at NES 2017. ResultsThe R&D project has resulted in the freely accessible RAMP tool consisting of four parts: RAMP I, RAMP II, the Action module and the Results module. A broad range of MSD risks are assessed, the results from assessments are visualized in a novel way and risk reducing actions for risk management are supported. The digitalised version has recently been released. Further, three massive open online courses (MOOCs) for professionals on the RAMP tool are under development, and will also be presented. Discussion The discussion focuses on the need of and dissemination of freely accessible methods such as RAMP, and how to enable users to acquire sufficient knowledge to use them. ConclusionsIn conclusion: The project has resulted in a new tool for MSD risk management in manual handling jobs, the RAMP tool. Evaluations of the tool show that it is regarded as usable from different usability aspects. It is argued that the upcoming online MOCCs may contribute to provide adequate knowledge for proper use of the tool. Keywords. musculoskeletal disorders, risk assessment, risk reducing measures, risk communication, digital tool.
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| 6. |
- Rose, Linda M, 1963-, et al.
(author)
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Workshop: learn how to use the ramp tool for risk assessment and risk management of msd risks in manual handling
- 2017
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Conference paper (other academic/artistic)abstract
- BackgroundManual handling work is regarded as one of the main causes to increased risks of developing Musculoskeletal disorders (MSDs). Several MSD risk assessment tools have been developed, but have been found to have insufficiencies for managing MSD risks in manual handling. The RAMP tool (Risk Assessment and Management tool for Manual Handling – Proactively), was developed to support the whole process of risk management of MSD risks in manual handling: from identification and assessment of risks to developing risk reducing suggestions and systematic risk management. What will you learn?In this workshop you will learn how to use the RAMP tool by participating in applying the tool on an example. RAMP consists of four parts:- The checklist based RAMP I for screening of MSD risks in manual handling,- RAMP II for a more in depth analysis of such risks,- The Action module to support development of risk reducing measures and support systematic risk management, and- The Results module, for communicating the results. It enables presentation of the results at different level of detail and scope, ranging from a work station to the whole company. In the workshop you will get experience from using the four parts of the RAMP tool, based on a film-based example. Bring your laptop to download and use the RAMP tool on your computer!
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