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1.	Albertsson, Eva, 1979, et al. (author) Marin fiskodling på den svenska västkusten: Biologiska förutsättningar : Rapport nummer 1 från Vattenbrukscentrum Väst, Göteborgs universitet 2013 Reports (other academic/artistic)abstract I den av regeringen beställda utredningen ”Det växande Vattenbrukslandet” föreslås att ”Göteborgs universitet (GU) tillförs resurser för att fortsätta att utveckla vattenbruksrelaterad forskning när det gäller musslor, ostron och marina fiskarter”. Därför tog under 2011 företrädare inom den odlingsrelaterade fiskforskningen vid Gö- teborgs universitet initiativet till denna studie om förutsättningarna för marin fiskodling. Studien har syftet att utreda de odlingsbiologiska förutsättningarna för etablering av vattenbruk av marina fiskarter på den svenska västkusten. Målet är att den ska kunna användas som kunskapsunderlag för en framtida handlingsplan för fiskodling på västkusten, och främja kunskapsutbytet mellan den fiskodlingsrelaterade forskningen, beslutsfat- tande organ och privata entreprenörer för att utveckla konkurrenskraftiga innovationer inom vattenbruket. En central fråga för sammanhanget är vilka fiskarter det finns potential för att odla på den svenska västkusten. Vattenbruket måste vara ekonomiskt bärkraftigt och en urvalsmodell baserad på svenska marina fiskarters kg- pris i förhållande till en minsta tänkbara produktionskostnad användes därför i denna studie. Vidare bedöm- des arterna utifrån kunskapsläge och odlingspotential. Arterna hälleflundra, tunga, piggvar, havskatt (vanlig och fläckig) samt lyrtorsk och torsk bedömdes att vara ”kandidatarter” för framtida odling i Sverige. För dessa arter gjordes omfattande studier för att vidare utreda behov och möjligheter. Det gjordes även en analys av de abiotiska faktorerna (vattentemperatur, syrgas- och salthalt) på den svenska västkusten. I en sista del av studien kombinerades kunskapen om kandidatarternas biologiska förutsättningar med västkustens abiotiska faktorer. De abiotiska förhållandena på den svenska västkusten är inte odlingsbiologiskt optimala för traditionell nät- kasseodling för någon av de framtagna kandidatarterna, då för höga sommartemperaturer skapar problem för kallvattensarterna medan varmvattensarterna hämmas av de låga vintertemperaturerna. En av de huvudsak- liga slutsatserna i denna rapport är därför att året-runt-bedriven fiskodling i öppna system, såsom i kustnära nätkassar, knappast är praktiskt genomförbart på den svenska västkusten för de arter som i denna studie i övrigt ansågs ha hög odlingspotential. För etablering av framgångsrika odlingssystem behövs speciella tekniska lösningar, som möjliggör reglering av abiotiska faktorer såsom syrgashalter och temperatur. För att Sverige skall kunna bli ett växande vattenbruksland krävs samordnade insatser mellan forskare från flera discipliner, privata aktörer och andra intressenter. Dessutom krävs satsningar på forskning och utredning av de mera tekniskt avancerade odlingssystem som den svenska västkusten kommer behöva. Med tanke på miljöbelastningsproblematiken kring öppna havsbaserade system för fiskodling samt de abiotiska faktorerna längs västkusten som inte är optimala för någon av kandidatarterna i utredningen, så är slutsatsen att man bör undersöka, alternativa odlingssystem till traditionella öppna nätkassar för fiskodling, där man kan kontrollera faktorer som temperatur, salthalt och syrenivåer och minimera utsläppen. Nästa steg som föreslås är att göra en teknisk/ekonomisk utredning kring hållbara havs- eller landbaserade system för marin fiskodling. Utred- ningen bör innehålla fall-studier för en eller två fiskarter och ett kräftdjur och inkludera en myndighetspröv- ning för de framtagna koncepten. Ytterligare en förutsättning för att vattenbruket skall kunna utvecklas är satsningar på nödvändig infrastruktur, som ett marint kläckeri för forskning och utvecklingsarbete.
2.	Bejerot, Susanne, 1955-, et al. (author) The extreme male brain revisited: gender coherence in adults with autism spectrum disorder 2012 In: British Journal of Psychiatry. - London, United Kingdom : Royal College of Psychiatrists. - 0007-1250 .- 1472-1465. ; 201:2, s. 116-123 Journal article (peer-reviewed)abstract Background The 'extreme male brain' theory suggests that autism spectrum disorder (ASD) is an extreme variant of male intelligence. However, somewhat paradoxically, many individuals with ASD display androgynous physical features regardless of gender. Aims To assess physical measures, supposedly related to androgen influence, in adults with and without ASD. Method Serum hormone levels, anthropometry, the ratio of 2nd to 4th digit length (2D:4D) and psychiatric symptomatology were measured in 50 adults with high-functioning ASD and age- and gender-matched neurotypical controls. Photographs of face and body, as well as voice recordings, were obtained and assessed with respect to gender coherence, blindly and independently, by eight assessors. Results Women with ASD had higher total and bioactive testosterone levels, less feminine facial features and a larger head circumference than female controls. Men in the ASD group were assessed as having less masculine body characteristics and voice quality, and displayed higher (i.e. less masculine) 2D:4D ratios, but similar testosterone levels to controls. Androgynous facial features correlated strongly and positively with autistic traits measured with the Autism-Spectrum Quotient in the total sample. In males and females with ASD dehydroepiandrosterone sulfate did not decrease with age, in contrast to the control group. Conclusions Women with ASD had elevated testosterone levels and several masculinised characteristics compared with controls, whereas men with ASD displayed several feminised characteristics. Our findings suggest that ASD, rather than being characterised by masculinisation in both genders, may constitute a gender defiant disorder.
3.	Eriksson, Susanne P., et al. (author) Stress biology and immunology in Nephrops norvegicus 2013 In: The ecology and biology of <em>Nephrops norvegicus</em>. - Amsterdam : Academic Press. - 9780124104662 ; , s. 149-200 Book chapter (peer-reviewed)abstract The Norway lobster Nephrops norvegicus lives at low-light depths, in muddy substrata of high organic content where water salinities are high and fluctuations in temperature are moderate. In this environment, the lobsters are naturally exposed to a number of potential stressors, many of them as a result of the surficial breakdown of organic material in the sediment. This process (early diagenesis) creates a heterogeneous environment with temporal and spatial fluctuations in a number of compounds such as oxygen, ammonia, metals, and hydrogen sulphide. In addition to this, there are anthropogenically generated stressors, such as human-induced climate change (resulting in elevated temperature and ocean acidification), pollution and fishing. The lobsters are thus exposed to several stressors, which are strongly linked to the habitat in which the animals live. Here, the capacity of Nephrops to deal with these stressors is summarised. Eutrophication-induced hypoxia and subsequent metal remobilisation from the sediment is a well-documented effect found in some wild Nephrops populations. Compared to many other crustacean species, Nephrops is well adapted to tolerate periods of hypoxia, but prolonged or severe hypoxia, beyond their tolerance level, is common in some areas. When the oxygen concentration in the environment decreases, the bioavailability of redox-sensitive metals such as manganese increases. Manganese is an essential metal, which, taken up in excess, has a toxic effect on several internal systems such as chemosensitivity, nerve transmission and immune defence. Since sediment contains high concentrations of metals in comparison to sea water, lobsters may accumulate both essential and non-essential metals. Different metals have different target tissues, though the hepatopancreas, in general, accumulates high concentrations of most metals. The future scenario of increasing anthropogenic influences on Nephrops habitats may have adverse effects on the fitness of the animals.
4.	Eriksson, Susanne P., 1964, et al. (author) Stress Biology and Immunology in Nephrops norvegicus 2013 In: Advances in Marine Biology. - : Elsevier. - 0065-2881. ; 64, s. 149-200 Journal article (peer-reviewed)abstract The Norway lobster Nephrops norvegicus lives at low-light depths, in muddy substrata of high organic content where water salinities are high and fluctuations in temperature are moderate. In this environment, the lobsters are naturally exposed to a number of potential stressors, many of them as a result of the surficial breakdown of organic material in the sediment. This process (early diagenesis) creates a heterogeneous environment with temporal and spatial fluctuations in a number of compounds such as oxygen, ammonia, metals, and hydrogen sulphide. In addition to this, there are anthropogenically generated stressors, such as human-induced climate change (resulting in elevated temperature and ocean acidification), pollution and fishing. The lobsters are thus exposed to several stressors, which are strongly linked to the habitat in which the animals live. Here, the capacity of Nephrops to deal with these stressors is summarised. Eutrophication-induced hypoxia and subsequent metal remobilisation from the sediment is a well-documented effect found in some wild Nephrops populations. Compared to many other crustacean species, Nephrops is well adapted to tolerate periods of hypoxia, but prolonged or severe hypoxia, beyond their tolerance level, is common in some areas. When the oxygen concentration in the environment decreases, the bioavailability of redox-sensitive metals such as manganese increases. Manganese is an essential metal, which, taken up in excess, has a toxic effect on several internal systems such as chemosensitivity, nerve transmission and immune defence. Since sediment contains high concentrations of metals in comparison to sea water, lobsters may accumulate both essential and non-essential metals. Different metals have different target tissues, though the hepatopancreas, in general, accumulates high concentrations of most metals. The future scenario of increasing anthropogenic influences on Nephrops habitats may have adverse effects on the fitness of the animals.
5.	Eriksson, Susanne P., et al. (author) Stress biology and immunology in Nephrops norvegicus 2013 In: The ecology and biology of Nephrops norvegicus. - Amsterdam : Academic Press. ; , s. 149-200 Book chapter (pop. science, debate, etc.)abstract The Norway lobster Nephrops norvegicus lives at low-light depths, in muddy substrata of high organic content where water salinities are high and fluctuations in temperature are moderate. In this environment, the lobsters are naturally exposed to a number of potential stressors, many of them as a result of the surficial breakdown of organic material in the sediment. This process (early diagenesis) creates a heterogeneous environment with temporal and spatial fluctuations in a number of compounds such as oxygen, ammonia, metals, and hydrogen sulphide. In addition to this, there are anthropogenically generated stressors, such as human-induced climate change (resulting in elevated temperature and ocean acidification), pollution and fishing. The lobsters are thus exposed to several stressors, which are strongly linked to the habitat in which the animals live. Here, the capacity of Nephrops to deal with these stressors is summarised. Eutrophication-induced hypoxia and subsequent metal remobilisation from the sediment is a well-documented effect found in some wild Nephrops populations. Compared to many other crustacean species, Nephrops is well adapted to tolerate periods of hypoxia, but prolonged or severe hypoxia, beyond their tolerance level, is common in some areas. When the oxygen concentration in the environment decreases, the bioavailability of redox-sensitive metals such as manganese increases. Manganese is an essential metal, which, taken up in excess, has a toxic effect on several internal systems such as chemosensitivity, nerve transmission and immune defence. Since sediment contains high concentrations of metals in comparison to sea water, lobsters may accumulate both essential and non-essential metals. Different metals have different target tissues, though the hepatopancreas, in general, accumulates high concentrations of most metals. The future scenario of increasing anthropogenic influences on Nephrops habitats may have adverse effects on the fitness of the animals.
6.	Adermark, Louise, 1974, et al. (author) Region-specific depression of striatal activity in Wistar rat by modest ethanol consumption over a ten-month period 2013 In: Alcohol. - : Elsevier BV. - 0741-8329. ; 47:4, s. 289-298 Journal article (peer-reviewed)abstract The nucleus accumbens (nAc) is the primary target for the mesolimbic dopamine system and a key brain region for the reinforcing effects displayed by drugs of abuse, including ethanol. During the. transition from recreational to compulsive consumption of reinforcing drugs, however, the dorsal striatum seems to be recruited. Understanding how synaptic activity is altered in a sub-region specific manner in the striatum during the course of long-term drug consumption thus could be essential for understanding the long-lasting changes produced by addictive substances, including ethanol. Here we evaluated synaptic activity in the dorsolateral striatum (DLS) and ventral Striatum (nucleus accumbens, nAc) of single-housed Wistar rats consuming water, or water and ethanol, for up to 10 months. Even though ethanol intake was moderate, it was sufficient to decrease input/output function in response to stimulation intensity in the DLS, while recorded population spike (PS) amplitudes in the nAc were unaffected. Striatal disinhibition induced by the GABA(A) receptor antagonist bicuculline had a slower onset in rats that had consumed ethanol for 2 months, and was significantly depressed in slices from rats that had Consumed ethanol for 4 months. Bicuculline-induced disinhibition in the nAc, on the other hand, was not significantly altered by long-term ethanol intake. Changes in PS amplitude induced by taurine or the glycine receptor antagonist strychnine were not significantly altered by ethanol in any brain region. Even though input/output function was not significantly affected by age, there was a significant decline in antagonist-induced disinhibition in brain slices from aged rats. The data presented here suggest that even modest consumption of ethanol is sufficient to alter neurotransmission in the striatum, while synaptic activity appears to be relatively well-preserved in the nAc during the course of long-term ethanol consumption. (C) 2013 Elsevier Inc. All rights reserved.
7.	Albertsdottir, Elsa, et al. (author) A simulation study of bias in variance component estimation due to ignoring environmental correlation between “test-status” and a continuous trait in culled data 2010 In: Annual meeting of the European Association for Animal Production. - 1382-6077. ; 16, s. 85-85 Conference paper (other academic/artistic)
8.	Albertsdottir, Elsa, et al. (author) Comparison of models for genetic evaluation of Icelandic horses 2011 In: Annual meeting of the European Association for Animal Production. - 1382-6077. ; 17, s. 135-135 Conference paper (other academic/artistic)
9.	Albertsdottir, Elsa, et al. (author) Estimation of genetic parameters and response to selection for a continuous trait subject to culling before testing 2012 In: Journal of Animal Breeding and Genetics. - : Wiley. - 0931-2668 .- 1439-0388. ; 129, s. 50-59 Journal article (peer-reviewed)
10.	Alexanderson, Camilla, 1978, et al. (author) Influence of having a male twin on body mass index and risk for dyslipidemia in middle-aged and old women. 2011 In: International Journal of Obesity. - : Springer Science and Business Media LLC. - 0307-0565 .- 1476-5497. ; 35, s. 1466-1469 Journal article (peer-reviewed)abstract Background:Animal experiments suggest that exposure to elevated levels of androgens during development by means of so-called hormonal programming causes metabolic aberrations at adulthood. An indirect strategy to address the possible importance of such an influence also in humans would be to study female dizygotic twins, presuming that those with a twin brother-due to diffusion of testosterone-have been exposed to higher androgen levels prenatally.Design:We have compared 8409 women with a male twin with 9166 women with a dizygotic female twin with respect to self-reported indices of anthropometry and metabolic aberrations at age 42 or older.Results:Body mass index (BMI), body weight and rate of dyslipidemia were moderately, but significantly, higher in women from opposite-sexed (OS) twin pairs; splitting for age revealed this difference to be present in those 60 years of age only.Conclusion:The results (i) support the notion that comparisons of women with a twin brother with women from same-sexed twin pairs may be used to shed light on possible long-term effects of interindividual variations in early androgen exposure, and (ii) suggest that the effects of early androgen exposure on metabolism previously observed in animal experiments are of relevance also for humans.International Journal of Obesity advance online publication, 8 March 2011; doi:10.1038/ijo.2011.18.
11.	Andersson, Lisa, et al. (author) Genome Wide Association Study of Equine Insect Bite Hypersensitivity 2010 Other publication (peer-reviewed)
12.	Andersson, Lisa, et al. (author) The same ELA class II risk factors confer equine insect bite hypersensitivity in two distinct populations 2012 In: Immunogenetics. - : Springer Science and Business Media LLC. - 0093-7711 .- 1432-1211. ; 64:3, s. 201-208 Journal article (peer-reviewed)abstract Insect bite hypersensitivity (IBH) is a chronic allergic dermatitis common in horses. Affected horses mainly react against antigens present in the saliva from the biting midges, Culicoides ssp, and occasionally black flies, Simulium ssp. Because of this insect dependency, the disease is clearly seasonal and prevalence varies between geographical locations. For two distinct horse breeds, we genotyped four microsatellite markers positioned within the MHC class II region and sequenced the highly polymorphic exons two from DRA and DRB3, respectively. Initially, 94 IBH-affected and 93 unaffected Swedish born Icelandic horses were tested for genetic association. These horses had previously been genotyped on the Illumina Equine SNP50 BeadChip, which made it possible to ensure that our study did not suffer from the effects of stratification. The second population consisted of 106 unaffected and 80 IBH-affected Exmoor ponies. We show that variants in the MHC class II region are associated with disease susceptibility (p(raw)=2.34x10(-5)), with the same allele (COR112:274) associated in two separate populations. In addition, we combined microsatellite and sequencing data in order to investigate the pattern of homozygosity and show that homozygosity across the entire MHC class II region is associated with a higher risk of developing IBH (p=0.0013). To our knowledge this is the first time in any atopic dermatitis suffering species, including man, where the same risk allele has been identified in two distinct populations.
13.	Andersson, Lisa, et al. (author) Variants in the MHC-II Gene Cluster Influence Susceptibility to Equine Insect Bite Hypersensitivity 2011 Conference paper (other academic/artistic)
14.	Antonsson, Helen, et al. (author) First-line managers’ experiences of alternative modes of funding in elderly care in Sweden 2012 In: Journal of Nursing Management. - : Hindawi Limited. - 0966-0429 .- 1365-2834. ; 20:6, s. 737-747 Journal article (peer-reviewed)abstract Aim: The aim of this study was to describe first-line managers’ experiences of alternative modes of funding elderly care in two communities in western Sweden. Background: A growing elderly population demands alternative modes of funding elderly care for better outcomes for patients and better efficiency as it is publicly funded through taxation. Methods: The study comprised a total of eight semi-structured interviews with first-line managers working within elderly care. The interviews were analysed using manifest qualitative content analysis. Respect for the individuals was a main concern in the study. Results: One category, quality improvement, and four subcategories freedom of choice, organisational structure, quality awareness and market forces effects were identified to describe first-line managers’ experiences of the operation of elderly care. Conclusions: Quality improvement was an important factor to deal with when elderly care was operated in different organisational perspectives, either private or public. The first-line manager is a key person for developing a learning organisation that encourages both staff, clients and their relatives to improve the organisation. Moreover, person-centred care strengthens the client’s role in the organisation, which is in line with the government’s goal for the quality improvement of elderly care. However, further research is needed on how quality improvement could be developed when different caregivers operate in the same market in order to improve care from the elderly perspective.Implications for nursing management: This study highlights alternative modes of funding elderly care. The economical perspectives should not dominate without taking care of quality improvement when the operation of elderly care is planned and implemented. Strategies such as a learning organisational structure built on person-centred care could create quality improvement in elderly care.
15.	Ashelford, Kevin, et al. (author) Full genome re-sequencing reveals a novel circadian clock mutationin Arabidopsis 2011 In: Genome Biology. - : Springer Science and Business Media LLC. - 1465-6906 .- 1474-760X. ; 12, s. R28- Journal article (peer-reviewed)abstract Background: Map based cloning in Arabidopsis thaliana can be a difficult and time-consuming process,specifically if the phenotype is subtle and scoring labour intensive. An alternative to map basedcloning would be to directly sequence the whole genome of a mutant to uncover the mutationresponsible for the phenotype. Results: Here, we have re-sequenced the 120 Mb genome of a novel Arabidopsis clock mutant earlybird (ebi-1), using massively parallel sequencing by ligation. This process was further complicated by the fact that ebi-1 is in Wassilewskija (Ws-2), not the reference accession ofArabidopsis. The approach reveals evidence of DNA strand bias in the ethyl methanesulfonate(EMS) mutation process. We have demonstrated the utility of sequencing a backcrossed line andusing gene expression data to limit the number of SNP considered. Using new SNP informationwe have excluded a previously identified clock gene, PRR7. Finally, we have identified a SNPin the gene AtNFXL-2 as the likely cause of the ebi-1 phenotype and validated this bycharacterising a further allele. Conclusion: In Arabidopsis, as in other organisms, the (EMS) mutation load can be high. Here wedescribe how sequencing a backcrossed line, using functional genomics and analysing new SNPinformation can be used to reduce the number EMS mutations for consideration. Moreover, theapproach we describe here does not require out-crossing and scoring F2 mapping populations, anapproach which can be compromised by background effects. The strategy has broad utility andwill be an extremely useful tool to identify causative SNP in other organisms.
16.	Backe, Susanne, et al. (author) Markanvändningsbetingade vegetationsförändringar inom öppen myr 1987-2000 i Norrbottens län- Satellitbaserad övervakning 2012 Reports (other academic/artistic)abstract Miljöövervakning av våtmarker bedrivs inom Naturvårdsverkets programområde våtmark med syfte att långsiktigt följa utvecklingen av våtmarkernas tillstånd vad gäller hydrologiskorördhet och biologisk mångfald. För ett av delprogrammen används en satellitbaserad metodik för att upptäcka markanvändningsbetingade vegetationsförändringar i öppna myrar. Metoden baseras på antagandet att spektralt och vegetationsmässigt homogena myrtyper uppträder likartat med avseende på normal variation i fenologi och väder. Detta innebär att om grupper av homogena myrtyper avgränsas vid tidpunkt 1 så kan spektralt avvikande myrar, dvs förändrade myrar, sökas genom riktad förändringsanalys inom grupperna vid tidpunkt 2. Förändringsriktningen som analyserats är ökad biomassa/igenväxning. Förändringarna redovisas i två klasser; säker och potentiell. Analysen kommer att genomföras i hela landet nedanför fjällen från norr till söder med ett omdrev på tio år.Under 2008 utfördes denna förändringsanalys i Norrbottens län. Satellitscenerna som har använts är för tidpunkt 1 från 1984, 1987 samt 1990 och för tidpunkt 2 från 2000. Analysen har resulterat i en mängd ytor inom öppen myr där indikationer på förändring finns. De förändrade ytorna omfattar ca 16 800 ha, vilket motsvarar 1,22 % av arealen öppen myr i undersökningsområdet, dvs hela Norrbottens län med undantag av fjällenVid en utvärdering av resultatet från förändringsanalysen ingick totalt 300 ytor varav 250 förändrade ytor och 50 referensytor. Referensytorna slumpades ut inom den oförändrade delen av den öppna myrmasken. Utvärderingen utfördes mha flygbilder och fältbesök för att verifera förändringar. Utvärderingen visade att säkerheten i förändringsanalysen var mellan 48-91 %. I 48 % av ytorna kunde förändring verifieras. I ytterligare 43 % av fallen var det svårt att bedöma om en förändring skett, men möjlighet fanns att biomassa kan ha ökat under aktuell tidsperiod, dvs säkerheten i analysen kan vara upp till 91%. Förändringsytorna skiljde sig från referensytorna genom att de i högre grad låg i anslutning till vattendrag, sjöar och dråg samt hade fler ingrepp i omgivningen. Vanligast förekommande ingrepp inom 100 m från de förändrade ytorna var dikningar, ungskogar och upphörd myrslåtter. I de östra delarna kunde förändringarna i högre grad verifieras jämfört med i de västra delarna. I väster fanns fler svårbedömda fall. Med andra ord kan man säga att förändringsanalysen har en högre säkerhet och i högre grad kan kopplas till markanvändning i de östra jämfört med de västra delarna. En möjlig orsak till denna skillnad kan vara att fenologiska effekter påverkar analysresultatet i mer höglänta områden med kortare vegetationsperiod.Markanvändning i anslutning till de förändrade myrarna har analyserats med hjälp av flygbildstolkning av de förändrade ytornas tillrinningsområde. Flygbilderna som användes var från tre olika tidsperioder : 1960-, 1980- och 2000-tal. Markanvändningen i anslutning till de förändrade ytorna hade ökat i högre grad jämfört med referensytor. Ökningen har framförallt skett under perioden 1980 till 2000. Diken för skogsbruk stod för den största delen av ökningen.Kring ytor med säker förändringsindikation fanns en större andel skogsdiken jämfört med ytor som hade potentiell förändringsindikation. Det fanns fler rester av lador och hässjor sedan myrslåtterepoken kring de förändrade ytorna jämfört med referensytorna. Markanvändningsanalysen gav oss ytterligare en bekräftelse på att resultatet från förändringsanalysen fångat upp ytor där snabba förändringar i form av igenväxning skett pga ingrepp.Ett förslag på indikator för att följa miljökvalitetsmålet för Myllrande våtmarker har tagits fram baserat på resultatet från förändringsanalysen. Förslaget är att man använder måttet andel förändrad öppen myr av den totala arealen öppen myr som indikator på snabba förändringar.Vi föreslår att indikatorn används dels på länsnivå och dels på kommunnivå.
17.	Bah Rösman, Jessica, 1975, et al. (author) Further exploration of the possible influence of polymorphisms in HTR2C and 5HTT on body weight. 2010 In: Metabolism. - : Elsevier BV. - 0026-0495. ; 59:8, s. 1156-1163 Journal article (peer-reviewed)abstract Receptors of the 5-HT2C subtype are of importance for the influence of serotonin on food intake, and 2 single nucleotide polymorphisms in this gene (HTR2C)-Cys23Ser (rs6318) and -759C>T (rs3813929)-have been reported to be associated with weight and/or antipsychotic-induced weight gain. The present study aimed to replicate these associations; in addition, the 5-HTTLPR polymorphism in the promoter region of the serotonin transporter gene (SLC6A4) was assessed. The polymorphisms were genotyped in subjects recruited from the normal population (n = 510), and possible associations between genotype and body mass index (BMI) were assessed. The Ser23 allele was more common in underweight subjects (BMI <20) than in normal- and overweight (BMI >/=20) subjects (P = .006). The T allele of the -759C/T polymorphism was less common in the overweight group (BMI >/=25) (P = .007). Homozygosity for the short allele of 5-HTTLPR was more frequent in underweight subjects (P = .015). Our results are in agreement with previous studies, suggesting polymorphisms in HTR2C to be associated with body weight, particularly in women; and they also suggest that 5-HTTLPR may influence this phenotype. Further studies on the importance of the investigated genes for eating disorders and drug-induced weight gain are warranted.
18.	Bejerot, Susanne, 1955-, et al. (author) Sexuality and gender role in autism spectrum disorder : a case control study 2014 In: PLOS ONE. - San Francisco, USA : Public Library Science. - 1932-6203. ; 9:1 Journal article (peer-reviewed)abstract The 'extreme male brain theory of autism' describes an extreme male pattern of cognitive traits defined as strong systemising abilities paired with empathising weaknesses in autism spectrum disorder. However, beyond these cognitive traits, clinical observations have suggested an ambiguous gender-typed pattern regarding several sexually dimorphic traits. The aim of the present study was to investigate if patterns of non-cognitive sexually dimorphic traits differed between the autism spectrum disorder and control groups. Fifty adults with autism spectrum disorder and intelligence within the normal range, and 53 neurotypical controls responded to questions on gender role, self-perceived gender typicality and gender identity, as well as sexuality. Measures used were a Swedish modification of the Bem Sex Role Inventory and questions on sexuality and gender designed for the purpose of this study. Our results showed that one common gender role emerged in the autism spectrum disorder group. Masculinity (e.g. assertiveness, leadership and competitiveness) was weaker in the autism spectrum disorder group than in the controls, across men and women. Self-perceived gender typicality did not differ between the groups but tomboyism and bisexuality were overrepresented amongst women with autism spectrum disorder. Lower libido was reported amongst both male and female participants with autism spectrum disorder compared with controls. We conclude that the extreme male patterns of cognitive functions in the autistic brain do not seem to extend to gender role and sexuality. A gender-atypical pattern for these types of characteristics is suggested in autism spectrum disorder.
19.	Bergman, Olle, 1978, et al. (author) Association between amygdala reactivity and a dopamine transporter gene polymorphism. 2014 In: Translational psychiatry. - : Springer Science and Business Media LLC. - 2158-3188. ; 4 Journal article (peer-reviewed)abstract Essential for detection of relevant external stimuli and for fear processing, the amygdala is under modulatory influence of dopamine (DA). The DA transporter (DAT) is of fundamental importance for the regulation of DA transmission by mediating reuptake inactivation of extracellular DA. This study examined if a common functional variable number tandem repeat polymorphism in the 3' untranslated region of the DAT gene (SLC6A3) influences amygdala function during the processing of aversive emotional stimuli. Amygdala reactivity was examined by comparing regional cerebral blood flow, measured with positron emission tomography and [(15)O]water, during exposure to angry and neutral faces, respectively, in a Swedish sample comprising 32 patients with social anxiety disorder and 17 healthy volunteers. In a separate US sample, comprising 85 healthy volunteers studied with blood oxygen level-dependent functional magnetic resonance imaging, amygdala reactivity was assessed by comparing the activity during exposure to threatening faces and neutral geometric shapes, respectively. In both the Swedish and the US sample, 9-repeat carriers displayed higher amygdala reactivity than 10-repeat homozygotes. The results suggest that this polymorphism contributes to individual variability in amygdala reactivity.
20.	Bergstrom, Aileen L., et al. (author) Perceived occupational gaps one year after stroke : An explorative study 2012 In: Journal of Rehabilitation Medicine. - Uppsala : Medical Journals Sweden AB. - 1650-1977 .- 1651-2081. ; 44:1, s. 36-42 Journal article (peer-reviewed)abstract Objective: To explore and describe factors associated with occupational gaps and to identify factors at 3 months that predict occupational gaps one year post-stroke. A gap, a restriction in participation, is considered to be present when there is a discrepancy between what the individual wants to do and what they actually do in everyday life. Design: Prospective longitudinal study. Subjects: Two hundred persons with stroke. Methods: Data from the Occupational Gaps Questionnaire, one year post-stroke, was used as the dependent variable in 3- and 12-month regression analyses. Domains of the Stroke Impact Scale, global life satisfaction, demographic and medical factors were used as independent variables. Results: At 3 months, activities of daily living abilities, social participation and not being born in Sweden predicted occupational gaps at 12 months. Stroke severity and not being born in Sweden and 3 factors at 12 months: social participation, self-rated recovery, and global life satisfaction were associated with occupational gaps. Conclusion: Activities of daily living ability at 3 months predicted occupational gaps after stroke. Thus, it is possible to identify early on, and provide interventions for, those that risk participation restrictions. Not being born in the country might be an indicator of a risk for participation restrictions.
21.	Bertilsson, Ann-Sofie, et al. (author) A client-centred ADL intervention: three-month follow-up of a randomized controlled trial 2014 In: Scandinavian Journal of Occupational Therapy. - : Informa UK Limited. - 1103-8128 .- 1651-2014. ; 21, s. 377-391 Journal article (peer-reviewed)abstract Objective: The aim was to study a client-centred activities of daily living (ADL) intervention (CADL) compared with the usualADL intervention (UADL) in people with stroke regarding: independence in ADL, perceived participation, life satisfaction,use of home-help service, and satisfaction with training and, in their significant others, regarding: caregiver burden, lifesatisfaction, and informal care. Methods: In this multicentre study, 16 rehabilitation units were randomly assigned to deliverCADL or UADL. The occupational therapists who provided the CADL were specifically trained. Eligible for inclusion werepeople with stroke treated in a stroke unit £3 months after stroke, dependent in ‡two ADL, not diagnosed with dementia, andable to understand instructions. Data were collected at inclusion and three months thereafter. To detect a significant differencebetween the groups in the Stroke Impact Scale (SIS) domain “participation”, 280 participants were required. Intention-totreatanalysis was applied. Results: At three months, there was no difference in the outcomes between the CADL group(n = 129) and the UADL group (n = 151), or their significant others (n = 87/n = 93) except in the SIS domain “emotion” infavour of CADL (p = 0.04). Conclusion: The CADL does not appear to bring about short-term differences in outcomes andlonger follow-ups are required.
22.	Bladh, Sara, 1974- (author) Dynamical atmospheres and winds of M-type AGB stars 2014 Doctoral thesis (other academic/artistic)abstract Mass loss, in the form of slow stellar winds, is a decisive factor for the evolution of cool luminous giants, eventually turning them into white dwarfs. These dense outflows are also a key factor in the enrichment of the interstellar medium with newly produced elements from the interior of these stars. There are strong indications that these winds are accelerated by radiation pressure on dust grains, but the actual grain species responsible for driving the outflows in M-type Asymptotic Giant Branch stars are still a matter of debate. Observations of dust features in the circumstellar environment of these stars suggest that magnesium-iron silicates are possible wind-drivers. However, the optical properties of these silicate grains are strongly influenced by the Fe-content. Fe-bearing condensates heat up strongly when interacting with the radiation field and therefore cannot form close enough to the star to trigger outflows. Fe-free condensates, on the other hand, have a low absorption cross-section at near-IR wavelengths where AGB stars emit most of their flux. To solve this conundrum, it has been suggested that winds of M-type AGB stars may be driven by photon scattering on Fe-free silicate grains with sizes comparable to the wavelength of the flux maximum, rather than by true absorption. In this thesis we investigate dynamical models of M-type AGB stars, using Fe-free silicates as the wind-driving dust species. According to our findings these models produce both dynamic and photometric properties consistent with observations. Especially noteworthy are the large photometric variations in the visual band during a pulsation cycle, seen both in the observed and synthetic fluxes. A closer examination of the models reveals that these variations are caused by changes in the molecular layers, and not by changes in the dust. This is a strong indication that stellar winds of M-type AGB stars are driven by dust materials that are very transparent in the visual and near-infrared wavelength regions, otherwise these molecular effects would not be visible.
23.	Bladh, Sara, et al. (author) Exploring wind-driving dust species in cool luminous giants II. Constraints from photometry of M-type AGB stars 2013 In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 553, s. A20- Journal article (peer-reviewed)abstract Context. The heavy mass loss observed in evolved asymptotic giant branch (AGB) stars is usually attributed to a two-stage process: atmospheric levitation by pulsation-induced shock waves, followed by radiative acceleration of newly formed dust grains. The dust transfers momentum to the surrounding gas through collisions and thereby triggers a general outflow. Radiation-hydrodynamical models of M-type AGB stars suggest that these winds can be driven by photon scattering - in contrast to absorption - on Fe-free silicate grains of sizes 0.1-1 mu m. Aims. In this paper we study photometric constraints for wind-driving dust species in M-type AGB stars, as part of an ongoing effort to identify likely candidates among the grain materials observed in circumstellar envelopes. Methods. To investigate the scenario of stellar winds driven by photon scattering on dust, and to explore how different optical and chemical properties of wind-driving dust species affect photometry we focus on two sets of dynamical models atmospheres: (i) models using a detailed description for the growth of Mg2SiO4 grains, taking into account both scattering and absorption cross-sections when calculating the radiative acceleration; and (ii) models using a parameterized dust description, constructed to represent different chemical and optical dust properties. By comparing synthetic photometry from these two sets of models to observations of M-type AGB stars we can provide constraints on the properties of wind-driving dust species. Results. Photometry from wind models with a detailed description for the growth of Mg2SiO4 grains reproduces well both the values and the time-dependent behavior of observations of M-type AGB stars, providing further support for the scenario of winds driven by photon scattering on dust. The photometry from the models with a parameterized dust description suggests that wind-drivers need to have a low absorption cross-section in the visual and near-IR to reproduce the time-dependent behavior, i. e. small variations in (J-K) and spanning a larger range in (V-K). This places constraints on the optical and chemical properties of the wind-driving dust species. Conclusions. To reproduce the observed photometric variations in (V-K) and (J-K) both detailed and parameterized models suggest that the wind-driving dust materials have to be quite transparent in the visual and near-IR. Consequently, strong candidates for outflows driven by photon scattering on dust grains are Mg2SiO4, MgSiO3, and potentially SiO2.
24.	Egeblad, Louise, et al. (author) Structural and functional studies of the human phosphoribosyltransferase domain containing protein 1 2010 In: The FEBS Journal. - : Wiley. - 1742-464X .- 1742-4658. ; 277:23, s. 4920-30 Journal article (peer-reviewed)abstract Human hypoxanthine-guanine phosphoribosyltransferase (HPRT) (EC 2.4.2.8) catalyzes the conversion of hypoxanthine and guanine to their respective nucleoside monophosphates. Human HPRT deficiency as a result of genetic mutations is linked to both Lesch-Nyhan disease and gout. In the present study, we have characterized phosphoribosyltransferase domain containing protein 1 (PRTFDC1), a human HPRT homolog of unknown function. The PRTFDC1 structure has been determined at 1.7 Å resolution with bound GMP. The overall structure and GMP binding mode are very similar to that observed for HPRT. Using a thermal-melt assay, a nucleotide metabolome library was screened against PRTFDC1 and revealed that hypoxanthine and guanine specifically interacted with the enzyme. It was subsequently confirmed that PRTFDC1 could convert these two bases into their corresponding nucleoside monophosphate. However, the catalytic efficiency (k(cat)/K(m)) of PRTFDC1 towards hypoxanthine and guanine was only 0.26% and 0.09%, respectively, of that of HPRT. This low activity could be explained by the fact that PRTFDC1 has a Gly in the position of the proposed catalytic Asp of HPRT. In PRTFDC1, a water molecule at the position of the aspartic acid side chain position in HPRT might be responsible for the low activity observed by acting as a weak base. The data obtained in the present study indicate that PRTFDC1 does not have a direct catalytic role in the nucleotide salvage pathway.
25.	Eriksson, Gunilla, et al. (author) Occupational gaps in everyday life one year after stroke : association with life satisfaction and impact of stroke 2012 In: Topics in Stroke Rehabilitation. - Birmingham, USA : Thomas Land Publishers Inc. - 1074-9357 .- 1945-5119. ; 19:3, s. 244-255 Journal article (peer-reviewed)abstract Purpose: To examine the presence, frequency, and distribution of occupational gaps and to explore whether there are associations between occupational gaps and life satisfaction, self-rated recovery, and functioning and participation in activities of daily living (ADLs) 1 year after stroke.Method: Data were collected at onset and at 12 months after stroke from 161 patients admitted to a stroke unit in central Sweden by using Occupational Gaps Questionnaire, LiSat-11, Stroke Impact Scale, Katz ADL Index, and Barthel Index. Spearman rank correlation and Mann Whitney U test were used in the analyses.Results: Occupational gaps were reported by 87% of the participants. The number of occupational gaps was moderately associated with participation and self-rated recovery. There was a significant difference in the number of occupational gaps between the participants who were independent in ADLs and those who were not, both at baseline and at 12 months after stroke. There was, however, no significant association between occupational gaps and life satisfaction.Conclusions: Occupational gaps 1 year after stroke are very common, particularly among individuals experiencing difficulties in ADLs. Increased efforts are vital to enable individuals to do the activities that are important to them, irrespective of whether these are instrumental ADLs or leisure or social activities. Occupational gaps could be reduced by developing rehabilitation interventions that enable desired activities in different contexts that are crucial for individual patients.
26.	Eriksson, Jonna M., et al. (author) RAADS-14 Screen : validity of a screening tool for autism spectrum disorder in an adult psychiatric population 2013 In: Molecular Autism. - London, United Kingdom : BioMed Central. - 2040-2392. ; 4:1 Journal article (peer-reviewed)abstract Background: Autism spectrum disorder (ASD) can be difficult to distinguish from other psychiatric disorders. The clinical assessment of ASD is lengthy, and has to be performed by a specialized clinician. Therefore, a screening instrument to aid in the identification of patients who may have undiagnosed ASD should be useful. The purpose of this study was to develop such a screening instrument.Methods: Based on the 80 item Ritvo Autism and Asperger Diagnostic Scale-Revised (RAADS-R), we developed a 14 item self-evaluation questionnaire, the RAADS-14 Screen. In total, 135 adults with ASD and 508 psychiatric controls completed the abridged version of the RAADS-R.Results The RAADS-14 Screen score was significantly higher in the ASD group than in the control samples, with a median score of 32 for ASD, 15 for attention deficit hyperactivity disorder, and 11 for other psychiatric disorders (P < 0.001). A cut-off score of 14 or above reached a sensitivity of 97% and a specificity of 46 to 64%. A factor analysis identified three factors consistent with mentalizing deficits, social anxiety, and sensory reactivity relevant for the diagnosis of ASD. The psychometric properties of RAADS-14 Screen were shown to be satisfactory.Conclusions: The results of this study indicate that RAADS-14 Screen is a promising measure in screening for ASD in adult psychiatric outpatients.
27.	Eriksson, Kjell, et al. (author) Synthetic Colors for Dynamic C-Star Models 2011 In: Why Galaxies Care about AGB Stars II. Conference paper (peer-reviewed)abstract Dust is formed in the outer atmospheres and winds of AGB stars and severely affects their observed spectra and colours. Synthetic JHK colours from a grid of time-dependent C-star models are presented and compared to observed colours. The combined effects of pulsation and dust are significant, especially for the coolest and most luminous models. We are now extending the calculations with respect to effective temperature, luminosity, stellar mass, and pulsation amplitude, as well as the carbon excess.
28.	Eriksson, Kjell, et al. (author) Synthetic photometry for carbon-rich giants IV : An extensive grid of dynamic atmosphere and wind models 2014 In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 566, s. A95- Journal article (peer-reviewed)abstract Context. The evolution and spectral properties of stars on the asymptotic giant branch (AGB) are significantly affected by mass loss through dusty stellar winds. Dynamic atmosphere and wind models are an essential tool for studying these evolved stars, both individually and as members of stellar populations, to understand their contribution to the integrated light and chemical evolution of galaxies. Aims. This paper is part of a series with the purpose of testing state-of-the-art atmosphere and wind models of C-type AGB stars against observations, and making them available to the community for use in various theoretical and observational studies. Methods. We have computed low-resolution spectra and photometry (in the wavelength range 0.35-25 mu m) for a grid of 540 dynamic models with stellar parameters typical of solar-metallicity C-rich AGB stars and with a range of pulsation amplitudes. The models cover the dynamic atmosphere and dusty outflow (if present), assuming spherical symmetry, and taking opacities of gas-phase species and dust grains consistently into account. To characterize the time-dependent dynamic and photometric behaviour of the models in a concise way we defined a number of classes for models with and without winds. Results. Comparisons with observed data in general show a quite satisfactory agreement for example regarding mass-loss rates vs. (J - K) colours or K magnitudes vs. (J - K) colours. Some exceptions from the good overall agreement, however, are found and attributed to the range of input parameters (e.g. relatively high carbon excesses) or intrinsic model assumptions (e.g. small particle limit for grain opacities). Conclusions. While current results indicate that some changes in model assumptions and parameter ranges should be made in the future to bring certain synthetic observables into better agreement with observations, it seems unlikely that these pending improvements will significantly affect the mass-loss rates of the models.
29.	Eriksson, Susanne, et al. (author) Effects of integrated genetic evaluations for Icelandic horses on predictive ability, accuracy and selection bias 2012 In: Journal of Animal Breeding and Genetics. - : Wiley. - 0931-2668 .- 1439-0388. ; 129, s. 41-49 Journal article (peer-reviewed)
30.	Eriksson, Susanne, et al. (author) Factors influencing stallion reproductive success in Swedish warmblood riding horses and trotters 2012 In: Annual meeting of the European Association for Animal Production. - 1382-6077. ; 18, s. 256- Conference paper (other academic/artistic)
31.	Eriksson, Susanne, 1965, et al. (author) Food choice is reflected in serum markers and anthropometric measures in healthy 8-yr old. 2010 In: e-SPEN, the European e-Journal of Clinical Nutrition and Metabolism. - : Elsevier BV. - 1751-4991. ; 5:3 Journal article (peer-reviewed)abstract Background: In healthy 4-yr-olds 17% were overweight/obese and high fat intake was associated with lower body weight and BMI. Aim: The objective was to analyse food intake and the relationship to anthropometry at the age of 8 yrs. Design: One-hundred and fourteen 8-yr-olds were investigated. Questionnaires were used for lifestyle, health and food choice combined with a 24-h dietary recall. Serum concentrations of vitamin D (25(OH)D) and phospholipid fatty acid concentrations were measured in 97 children. Results: Percentage of overweight/obesity was similar to 4-yr-olds. Saturated fat intake was higher than recommended. Consumption of full fat milk was negatively associated to BMI, like protein and fat intake per kg body weight. A moderate intake of fat fish was associated with higher serum concentrations of omega-3 fatty acids. Serum 25(OH)D levels were correlated to the intake. Junk food was mainly restricted to weekends and associated to higher energy, fat and sucrose intake, without association to anthropometry. Conclusion: Food pattern was similar to that at 4 yrs of age suggesting that food habits were established at an early age. High saturated fat intake was not negatively influencing anthropometry. Serum markers reflected the intake of fish, milk and vitamin D.
32.	Eriksson, Susanne (author) Forskning om fruktsamhet hos svenska hästar 2012 In: Nyheter från ASVH. ; , s. 3- Other publication (pop. science, debate, etc.)
33.	Eriksson, Susanne (author) Forskning på gång om fruktsamheten hos svenska travhästar 2012 Other publication (pop. science, debate, etc.)
34.	Eriksson, Susanne (author) Genetic analysis of 'breeding field test status' in Icelandic horses 2011 In: Journal of Animal Breeding and Genetics. - : Wiley. - 0931-2668 .- 1439-0388. ; 128, s. 124-132 Journal article (peer-reviewed)abstract P>Genetic evaluation of Icelandic horses is currently based on results from breeding field tests where riding ability and conformation of the horses are evaluated over the course of 1-2 days. Only a small part of registered horses attend these field tests, and it can be assumed that these are not a random sample of the population. In this study, the trait test status was introduced, describing whether a horse was assessed in a breeding field test. This trait was analysed to find out whether it has a genetic variation and how it correlates genetically to other traits in the breeding goal. Breeding field test data included 39 443 mares born in Iceland in 1990-2001, of which 7431 were assessed in the period 1994-2007. The trait was defined in relation to age, gender and stud of horses. Variance and covariance components were estimated using the Markov Chain Monte Carlo method by applying the Gibbs sampler procedure in the DMU program. Three multivariate analyses were performed where the test status trait was analysed with breeding field test traits. Animal models and sire models were applied. Based on estimated heritabilities (0.51-0.67) and genetic correlations (0.00-0.87), the test status trait showed significant genetic variation and was strongly correlated to some traits. The test status trait reflects preselection in the breeding field test traits and should be included in the genetic evaluation to enhance the procedure, reduce selection bias and increase accuracy of the estimation.
35.	Eriksson, Susanne, et al. (author) Genetic analysis of cryptorchidism in Swedish born Icelandic horses 2013 In: Annual meeting of the European Association for Animal Production. - 1382-6077. ; 19, s. p. 129- Other publication (other academic/artistic)
36.	Eriksson, Susanne, et al. (author) Genetic trends for fertility in Swedish Red cattle using different models 2013 In: Annual meeting of the European Association for Animal Production. - 1382-6077. ; 19, s. 525-525 Conference paper (other academic/artistic)
37.	Eriksson, Susanne Ledin, et al. (author) Obstetric care requires direct access to intensive care : Förlossningsvård kräver direct tillgång till intensivvård. 2014 In: Läkartidningen. - 0023-7205. ; 111:46, s. 2043-4 Journal article (other academic/artistic)
38.	Eriksson, Susanne (author) Mer om kryptorkism hos islandshäst 2013 In: Islandshästen. - 0284-9607. ; , s. s. 14- Journal article (pop. science, debate, etc.)abstract Kryptorkism är en medfödd defekt hos handjur som innebär att den ena eller båda testiklarna inte kommer ner i pungen som de ska. Problemet togs upp i Islandshästen under 2012. Ny forskning om kryptorkism hos svenskfödda islandshästar tyder på att kryptorkism är relativt vanligt och ärftligt.
39.	Eriksson, Susanne, 1965, et al. (author) Metabolic profiles of fat and glucose differ by gender in healthy 8-year-olds. 2010 In: Acta paediatrica. - : Wiley. - 1651-2227 .- 0803-5253. ; 99:1, s. 78-82 Journal article (peer-reviewed)abstract OBJECTIVE: The aim was to investigate if metabolic markers were associated with anthropometry and weight increase in healthy 8-year-olds. METHODS: Ninety-seven healthy children, 66 of whom had been examined at the age of 4 years, were investigated. Dual energy X-ray absorptiometry was performed to determine fat (FM) and lean body mass (LBM). Plasma glucose and serum levels of insulin, cholesterol, triglycerides, adiponectin and leptin were analysed and HOMA-indices were calculated. RESULTS: Despite similar anthropometry, metabolic markers differed by gender. Sixteen % of the children were overweight or obese. Body mass index (BMI) was strongly correlated to FM. Anthropometric measures except LBM correlated to metabolic markers in the girls. Boys had higher concentrations of plasma glucose than girls. In overweight children, insulin was negatively associated with LBM. Leptin and the ratio between leptin and adiponectin, but not adiponectin, were significantly associated with HOMA-IR and body composition. CONCLUSION: The metabolic profile of plasma glucose, serum leptin, fasting insulin and related HOMA indices differed by gender, despite no difference in BMI or FM. LBM, but not FM correlated to the insulin concentration in the overweight children. Leptin was the best marker of overweight.
40.	Eriksson, Staffan, et al. (author) Modell för förebyggande hembesök i kommunal verksamhet: Utveckling och prövning av en struktur för intervjuer i Helsingborgs stad. 2010 Reports (pop. science, debate, etc.)
41.	Eriksson, Susanne (author) Varför insemineras inte fler islandshästston? 2013 In: Islandshästen. - 0284-9607. ; , s. s. 34- Journal article (pop. science, debate, etc.)
42.	Eriksson, Susanne, 1965, et al. (author) Vitamin D-status hos friska barn i Sverige ännu tillfredsställande : [Vitamin D status in healthy children in Sweden still satisfactory. Changed supplementation and new knowledge motivation for further studies]. 2010 In: Läkartidningen. - 0023-7205. ; 107:41, s. 2474-2477 Journal article (peer-reviewed)abstract Trots att intaget av vitamin D är lågt hos många grupper hade svenska 4- och 8-åringar på gruppnivå tillfredsställande serumkoncentrationer (medelvärden 76 respektive 68 nmol/l). Tre gånger fler hade otillfredsställande koncentrationer vid 8 år än vid 4 år, och 62 respektive 45 procent hade serumkoncentrationer <75 nmol/l. Överviktiga barn och barn till kvinnor födda utomlands hade lägre nivåer, och 8-åriga flickor hade lägre nivåer än jämnåriga pojkar. Serumkoncentrationen var negativt korrelerad med nivåerna av fasteinsulin och parathormon. De undersökta barnen hade rekommenderats supplementering till 5 års ålder, vilket skulle kunna förklara att de hade bättre serumkoncentrationer än barn i andra länder.
43.	Fransson, Susanne, 1975, et al. (author) p37δ is a new isoform of PI3K p110δ that increases cell proliferation and is overexpressed in tumors 2012 In: Oncogene. - : Nature Publishing Group. - 0950-9232 .- 1476-5594. ; 31:27, s. 3277-3286 Journal article (peer-reviewed)abstract The phosphatidylinositol 3-kinases (PI3Ks) regulate cell growth, proliferation and survival, and are frequently affected in human cancer. PI3K is composed of a catalytic subunit, p110, and a regulatory subunit, p85. The PI3K catalytic subunit p110δ is encoded by PIK3CD and contains p85- and RAS-binding domains, and a kinase domain. Here we present an alternatively spliced PIK3CD transcript encoding a previously unknown protein, p37δ, and demonstrate that this protein is expressed in human ovarian and colorectal tumors. p37δ retains the p85-binding domain and a fraction of the RAS-binding domain, lacks the catalytic domain, and has a unique carboxyl-terminal region. In contrast to p110δ, which stabilizes p85, p37δ promoted p85 sequestering. Despite the truncated RAS-binding domain, p37δ bound to RAS and we found a strong positive correlation between the protein levels of p37δ and RAS. Overexpressing p37δ, but not p110δ, increased the proliferation and invasive properties of HEK-293 cells and mouse embryonic fibroblasts. Cells overexpressing p37δ showed a quicker phosphorylation response of AKT and ERK1/2 following serum stimulation. Ubiquitous expression of human p37δ in the fruit fly increased body size, DNA content and phosphorylated ERK1/2 levels. Thus, p37δ appears to be a new tumor-specific isoform of p110δ with growth-promoting properties.
44.	Gallo, Valentina, et al. (author) Social Inequalities and Mortality in Europe - Results from a Large Multi-National Cohort 2012 In: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 7:7 Journal article (peer-reviewed)abstract Background: Socio-economic inequalities in mortality are observed at the country level in both North America and Europe. The purpose of this work is to investigate the contribution of specific risk factors to social inequalities in cause-specific mortality using a large multi-country cohort of Europeans. Methods: A total of 3,456,689 person/years follow-up of the European Prospective Investigation into Cancer and Nutrition (EPIC) was analysed. Educational level of subjects coming from 9 European countries was recorded as proxy for socioeconomic status (SES). Cox proportional hazard model's with a step-wise inclusion of explanatory variables were used to explore the association between SES and mortality; a Relative Index of Inequality (RII) was calculated as measure of relative inequality. Results: Total mortality among men with the highest education level is reduced by 43% compared to men with the lowest (HR 0.57, 95% C.I. 0.52-0.61); among women by 29% (HR 0.71, 95% C.I. 0.64-0.78). The risk reduction was attenuated by 7% in men and 3% in women by the introduction of smoking and to a lesser extent (2% in men and 3% in women) by introducing body mass index and additional explanatory variables (alcohol consumption, leisure physical activity, fruit and vegetable intake) (3% in men and 5% in women). Social inequalities were highly statistically significant for all causes of death examined in men. In women, social inequalities were less strong, but statistically significant for all causes of death except for cancer-related mortality and injuries. Discussion: In this European study, substantial social inequalities in mortality among European men and women which cannot be fully explained away by accounting for known common risk factors for chronic diseases are reported.
45.	Guidetti, Susanne, et al. (author) Changes in the impact of stroke between 3 and 12 months post-stroke, assessed with the Stroke Impact Scale 2014 In: Journal of Rehabilitation Medicine. - : Medical Journals Sweden AB. - 1650-1977 .- 1651-2081. ; 46:10, s. 963-968 Journal article (peer-reviewed)abstract Objective: To examine data collected using the Stroke Impact Scale 3.0 (SIS) at 3 and 12 months post-stroke, and to explore any clinically meaningful changes in everyday life in relation to age, gender and stroke severity. Design: Prospective longitudinal study. Methods: A total of 204 persons were assessed using the SIS at 3 and 12 months after onset of stroke. Changes in domain scores were calculated over time and in relation to age, gender and stroke severity. Results: The Strength, Hand Function and Participation domains had the highest perceived impact at 3 and 12 months, indicating problems in everyday life. Stroke recovery was perceived to be significantly higher at 12 than at 3 months irrespective of stroke severity, age or gender. The impact on the Strength and Emotion domains was significantly lower at 12 months than at 3 months. Most clinically meaningful changes, both positive and negative ( 15 points), were seen in the Participation domain and in Stroke recovery. Few changes were associated with age, gender or stroke severity. Conclusion: Both positive and negative clinically meaningful changes related to impact of stroke were found between 3 and 12 months post-stroke. Therefore it is important to pay close attention to patients' perceptions of their everyday life situation during rehabilitation and at discharge.
46.	Gustafsson, Anders, et al. (author) Handbok för beställare och projektörer av flervånings bostadshus i trä 2012 Reports (peer-reviewed)
47.	Gustafsson, Susanne, 1961-, et al. (author) Ljudvarningar vid vägarbetsplatser för att uppnå sänkta hastigheter : Kartläggning och praktisk utvärdering 2014 Reports (other academic/artistic)abstract Ett projekt har genomförts i syfte att hitta metoder som effektivt sänker förbipasserande trafikanters hastigheter vid vägarbetsområden genom att i realtid varna med hjälp av ljud. Projektet har bestått av två delar. Först genomfördes en kartläggning av befintliga studier. Resultaten visar att de egenskaper i en ljudvarning som ger större effekt är att den har kvinnoröst, är direkt och informativ, samverkar mellan semantik och akustik, ökar i intensitet och medför nedtoning av andra ljuddistraktioner. Med bas i resultaten från kartläggningen gjordes en praktisk utvärdering av potentiell användning av ljudvarningar vid vägarbetsplatser i VTI:s simulator Sim III. Tjugotvå personbilsförare körde 25 kilometer på en motorväg där två vägarbeten fanns utplacerade i vägrenen. Hälften av försökspersonerna fick en ljudvarning före det första vägarbetet och den andra hälften före det andra vägarbetet. Ljudvarningen bestod av ett "pling" följt av en kvinnoröst som sa ”Varning! Vägarbete om 500 meter. Anpassa hastigheten!”. Meddelandet sändes via bilens interna högtalarsystem. Resultaten visar bland annat en signifikant hastighetsreducerande effekt av ljudvarningen. Den genomsnittliga sänkningen skattas till 9–17 km/h större med ljudvarning än utan. Vidare fanns en liten effekt (0,5–3,3 km/h) kvar av ljudvarningen även efter vägarbetet. Fler resultat presenteras tillsammans med förarnas subjektiva upplevelser av försöket.
48.	Hansen-Axelsson, Helen, et al. (author) Selection of bull dams for production and functional traits in an open nucleus herd 2011 In: Journal of Dairy Science. - : American Dairy Science Association. - 0022-0302 .- 1525-3198. ; 94, s. 2592-2600 Journal article (peer-reviewed)
49.	Jäderkvist Fegraeus, Kim, et al. (author) The DMRT3 'Gait keeper' mutation affects performance of Nordic and Standardbred trotters 2014 In: Journal of Animal Science. - : Oxford University Press (OUP). - 0021-8812 .- 1525-3163. ; 92:10, s. 4279-4286 Journal article (peer-reviewed)abstract In a previous study it was shown that a nonsense mutation in the DMRT3 gene alters the pattern of locomotion in horses and that this mutation has a strong positive impact on trotting performance of Standardbreds. One aim of this study was to test if racing performance and trotting technique in the Nordic (Coldblood) trotters are also influenced by the DMRT3 genotype. Another aim was to further investigate the effect of the mutation on performance in Standardbreds, by using a within-family analysis and genotype-phenotype correlations in a larger horse material than in the previous study. We genotyped 427 Nordic trotters and 621 Standardbreds for the DMRT3 nonsense mutation and a SNP in strong linkage disequilibrium with it. In Nordic trotters, we show that horses homozygous for the DMRT3 mutation (A) had significantly higher EBV for trotting performance traits than heterozygous (CA) or homozygous wild-type (CC) horses (P = 0.001). Furthermore, AA homozygotes had a higher proportion of victories and top 3 placings than horses heterozygous or homozygous wild-type, when analyzing performance data for the period 3 to 6 yr of age (P = 0.06 and P = 0.05, respectively). Another finding in the Nordic trotters was that the DMRT3 mutation influenced trotting technique (P = 2.1 x 10(-8)). Standardbred horses homozygous AA had significantly higher EBV for all traits than horses with at least 1 wild-type allele (CA and CC; P = 1.6 x 10(-16)). In a within-family analysis of Standardbreds, we found significant differences in several traits (e. g., earnings, P = 0.002; number of entered races, P = 0.004; and fraction of offspring that entered races, P = 0.002) among paternal half-sibs with genotype AA or CA sired by a CA stallion. For most traits, we found significant differences at young ages. For Nordic trotters, most of the results were significant at 3 yr of age but not for the older ages, and for the Standardbreds most of the results for the ages 3 to 5 were significant. For Nordic trotters, the proportion of victories and placings were the only traits that were significant for other ages than 3 yr.
50.	Keen, Christina, et al. (author) Supplementation With Fatty Acids Influences the Airway Nitric Oxide and Inflammatory Markers in Patients With Cystic Fibrosis 2010 In: Journal of Pediatric Gastroenterology and Nutrition - JPGN. - 0277-2116 .- 1536-4801. ; 50:5, s. 537-544 Journal article (peer-reviewed)abstract Objectives: To obtain a balance in the fatty acid (FA) metabolism is important for the inflammatory response and of special importance in cystic fibrosis (CF), which is characterized by impaired FA metabolism, chronic inflammation, and infection in the airways. Nitric oxide (NO) has antimicrobial properties and low nasal (nNO) and exhaled NO (FENO), commonly reported in CF that may affect bacterial status. The present study investigates the effect of different FA blends on nNO and FENO and immunological markers in patients with CF. Patients and Methods: Forty-three patients with CF and "severe" mutations were consecutively enrolled in a randomized double-blind placebo-controlled study with 3 FA blends containing mainly n-3 or n-6 FA or saturated FA acting as placebo. FENO, nNO, serum phospholipid concentrations of FA, and biomarkers of inflammation were measured before and after 3 months of supplementation. Results: Thirty-five patients in clinically stable condition completed the study. The serum phospholipid FA pattern changed significantly in all 3 groups. An increase of the n-6FA, arachidonic acid, was associated with a decrease of FENO and nNO. The inflammatory biomarkers, erythrocyte sedimentation rate, and interleukin-8 decreased after supplementation with n-3 FA and erythrocyte sedimentation rate increased after supplementation with n-6 FA. Conclusions: This small pilot study indicated that the composition of dietary n-3 and n-6 FA influenced the inflammatory markers in CF. FENO and nNO were influenced by changes in the arachidonic acid concentration, supporting previous studies suggesting that both the lipid abnormality and the colonization with Pseudomonas influenced NO in the airways.

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