| 1. |
- Schael, S, et al.
(författare)
-
Precision electroweak measurements on the Z resonance
- 2006
-
Ingår i: Physics Reports. - : Elsevier BV. - 0370-1573 .- 1873-6270. ; 427:5-6, s. 257-454
-
Forskningsöversikt (refereegranskat)abstract
- We report on the final electroweak measurements performed with data taken at the Z resonance by the experiments operating at the electron-positron colliders SLC and LEP. The data consist of 17 million Z decays accumulated by the ALEPH, DELPHI, L3 and OPAL experiments at LEP, and 600 thousand Z decays by the SLID experiment using a polarised beam at SLC. The measurements include cross-sections, forward-backward asymmetries and polarised asymmetries. The mass and width of the Z boson, m(Z) and Gamma(Z), and its couplings to fermions, for example the p parameter and the effective electroweak mixing angle for leptons, are precisely measured: m(Z) = 91.1875 +/- 0.0021 GeV, Gamma(Z) = 2.4952 +/- 0.0023 GeV, rho(l) = 1.0050 +/- 0.0010, sin(2)theta(eff)(lept) = 0.23153 +/- 0.00016. The number of light neutrino species is determined to be 2.9840 +/- 0.0082, in agreement with the three observed generations of fundamental fermions. The results are compared to the predictions of the Standard Model (SM). At the Z-pole, electroweak radiative corrections beyond the running of the QED and QCD coupling constants are observed with a significance of five standard deviations, and in agreement with the Standard Model. Of the many Z-pole measurements, the forward-backward asymmetry in b-quark production shows the largest difference with respect to its SM expectation, at the level of 2.8 standard deviations. Through radiative corrections evaluated in the framework of the Standard Model, the Z-pole data are also used to predict the mass of the top quark, m(t) = 173(+10)(+13) GeV, and the mass of the W boson, m(W) = 80.363 +/- 0.032 GeV. These indirect constraints are compared to the direct measurements, providing a stringent test of the SM. Using in addition the direct measurements of m(t) and m(W), the mass of the as yet unobserved SM Higgs boson is predicted with a relative uncertainty of about 50% and found to be less than 285 GeV at 95% confidence level. (c) 2006 Elsevier B.V. All rights reserved.
|
|
| 2. |
- Abdallah, J, et al.
(författare)
-
Photon events with missing energy in e(+)e(-) collisions at root s=130 to 209 GeV
- 2005
-
Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 38:4, s. 395-411
-
Tidskriftsartikel (refereegranskat)abstract
- The production of single- and multi-photon events has been studied in the reaction e(+) e(-) --> gamma(gamma) + invisible particles. The data collected with the DELPHI detector during the years 1999 and 2000 at centre-of-mass energies between 191 GeV and 209 GeV was combined with earlier data to search for phenomena beyond the Standard Model. The measured number of light neutrino families was consistent with three and the absence of an excess of events beyond that predicted by the Standard Model processes was used to set limits on new physics. Both model-independent searches and searches for new processes predicted by supersymmetric and extra-dimensional models have been made. Limits on new non-standard model interactions between neutrinos and electrons were also determined.
|
|
| 3. |
- Clark, Andrew G., et al.
(författare)
-
Evolution of genes and genomes on the Drosophila phylogeny
- 2007
-
Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 450:7167, s. 203-218
-
Tidskriftsartikel (refereegranskat)abstract
- Comparative analysis of multiple genomes in a phylogenetic framework dramatically improves the precision and sensitivity of evolutionary inference, producing more robust results than single-genome analyses can provide. The genomes of 12 Drosophila species, ten of which are presented here for the first time (sechellia, simulans, yakuba, erecta, ananassae, persimilis, willistoni, mojavensis, virilis and grimshawi), illustrate how rates and patterns of sequence divergence across taxa can illuminate evolutionary processes on a genomic scale. These genome sequences augment the formidable genetic tools that have made Drosophila melanogaster a pre-eminent model for animal genetics, and will further catalyse fundamental research on mechanisms of development, cell biology, genetics, disease, neurobiology, behaviour, physiology and evolution. Despite remarkable similarities among these Drosophila species, we identified many putatively non-neutral changes in protein-coding genes, non-coding RNA genes, and cis-regulatory regions. These may prove to underlie differences in the ecology and behaviour of these diverse species.
|
|
| 4. |
|
|
| 5. |
|
|
| 6. |
- Gebe, John A, et al.
(författare)
-
Age-dependent loss of tolerance to an immunodominant epitope of glutamic acid decarboxylase in diabetic-prone RIP-B7/DR4 mice.
- 2006
-
Ingår i: Clinical Immunology. - : Elsevier BV. - 1521-6616. ; 121:3, s. 294-304
-
Tidskriftsartikel (refereegranskat)abstract
- We have identified for the first time an age-dependent spontaneous loss of tolerance to two self-antigenic epitopes derived from putative diabetes-associated antigens glutamic acid decarboxylase (GAD65) and glial fibrillary acidic protein (GFAP) in RIP-B7/DRB1*0404 HLA transgenic mice. Diabetic and older non-diabetic mice exhibited a proliferative response to an immunodominant epitope from GAD65 (555-567) and also from GFAP (240-252) but not from an immunogenic epitope from diabetes-associated islet-specific glucose-6-phosphatase catalytic subunit-related protein. The response to both of these self-antigens is not observed in young mice but is observed in older non-diabetic mice and is accompanied by histological evidence of insulitis in the absence of overt diabetes. Islet infiltrates in older non-diabetic mice and diabetic mice contain CD4(+)/FoxP3(+) cells and suggest the presence of a regulatory mechanism prior and during diabetic disease. Diabetes penetrance in RIP-B7/DR0404 mice
|
|
| 7. |
|
|
| 8. |
- Merbold, L., et al.
(författare)
-
Precipitation as driver of carbon fluxes in 11 African ecosystems
- 2009
-
Ingår i: Biogeosciences. - 1726-4189. ; 6:6, s. 1027-1041
-
Tidskriftsartikel (refereegranskat)abstract
- This study reports carbon and water fluxes between the land surface and atmosphere in eleven different ecosystems types in Sub-Saharan Africa, as measured using eddy covariance (EC) technology in the first two years of the CarboAfrica network operation. The ecosystems for which data were available ranged in mean annual rainfall from 320 mm (Sudan) to 1150 mm (Republic of Congo) and include a spectrum of vegetation types (or land cover) (open savannas, woodlands, croplands and grasslands). Given the shortness of the record, the EC data were analysed across the network rather than longitudinally at sites, in order to understand the driving factors for ecosystem respiration and carbon assimilation, and to reveal the different water use strategies in these highly seasonal environments. Values for maximum net carbon assimilation rates (photosynthesis) ranged from -12.5 mu mol CO2 m(-2) s(-1) in a dry, open Millet cropland (C-4-plants) up to -48 mu mol CO2 m(-2) s(-1) for a tropical moist grassland. Maximum carbon assimilation rates were highly correlated with mean annual rainfall (r(2)=0.74). Maximum photosynthetic uptake rates (Fp(max)) were positively related to satellite-derived f(APAR). Ecosystem respiration was dependent on temperature at all sites, and was additionally dependent on soil water content at sites receiving less than 1000 mm of rain per year. All included ecosystems dominated by C-3-plants, showed a strong decrease in 30-min assimilation rates with increasing water vapour pressure deficit above 2.0 kPa.
|
|
| 9. |
- Olsson, C .H. B, et al.
(författare)
-
Bladmögel hotar persiljeodlingen
- 2008
-
Ingår i: Viola, Potatis och Grönsaker. ; 11, s. 18-20
-
Tidskriftsartikel (populärvet., debatt m.m.)
|
|
| 10. |
|
|
| 11. |
|
|
| 12. |
|
|
| 13. |
|
|
| 14. |
|
|
| 15. |
|
|
| 16. |
|
|
| 17. |
|
|
| 18. |
- Nordstrom, H., et al.
(författare)
-
DNA microarray technique for detection and identification of seven Flaviviruses pathogenic for man
- 2005
-
Ingår i: Journal of Medical Virology. - New York : Wiley. - 0146-6615 .- 1096-9071. ; 77:4, s. 528-540
-
Tidskriftsartikel (refereegranskat)abstract
- A flavivirus microarray was developed for detection and identification of yellow fever (YF), West Nile, Japanese encephalitis (JE), and the dengue 1-4 viruses, which are causing severe human disease all over the world. The microarray was based on 500-nucleotide probe fragments from five different parts of the seven viral genomes. A low-stringent amplification method targeting the corresponding regions of the viral genomic RNA was developed and combined with hybridization to the microarray for detection and identification. For distinction of the generated virus-specific fluorescence-patterns a fitting analysis procedure was adapted. The method was verified as functional for all seven flaviviruses and the strategy for the amplification, combined with the long probes, provided a high tolerance for smaller genetic variability, most suitable for these rapidly changing RNA viruses. A potentially high detection and identification capacity was proven on diverged strains of West Nile and dengue viruses. The lower limit for detection was equivalent, or better, when compared to routinely used RT-PCR methods. The performance of the method was verified on human patient samples containing dengue viruses, or normal human serum spiked with YF or JE viruses. The results demonstrated the ability of the flavivirus microarray to screen simultaneously a sample for several viruses in parallel, in combination with a good lower limit of detection.
|
|
| 19. |
|
|
| 20. |
|
|
| 21. |
|
|
| 22. |
- Wahlgren, J., et al.
(författare)
-
Gene segment reassortment between American and Asian lineages of avian influenza virus from waterfowl in the Beringia area
- 2008
-
Ingår i: Vector Borne and Zoonotic Diseases. - : Mary Ann Liebert Inc. - 1530-3667 .- 1557-7759. ; 8:6, s. 783-90
-
Tidskriftsartikel (refereegranskat)abstract
- Since prehistoric times, the Bering Strait area (Beringia) has served as an avenue of dispersal between the Old and the New Worlds. On a field expedition to this area, we collected fecal samples from dabbling ducks, geese, shorebirds, and gulls on the Chukchi Peninsula, Siberia, and Pt. Barrow, Alaska, and characterized the subtypes of avian influenza virus present in them. Four of 202 samples (2%) from Alaska were positive for influenza A virus RNA in two independent polymerase chain reaction (PCR)-based screening assays, while all shorebird samples from the Chukchi Peninsula were negative. Subtypes H3N8 and H6N1 were recorded once, while subtype H8N4 was found in two samples. Full-length sequences were obtained from the three unique isolates, and phylogenetic analysis with representative sequences for the Eurasian and North American lineages of influenza A virus showed that one HA gene clustered with the Eurasian rather than the North American lineage. However, the closest relative to this sequence was a North American isolate from Delaware described in 2002, indicating that a H6 spillover from Asia has established itself in North America.
|
|
| 23. |
|
|
| 24. |
|
|
| 25. |
|
|
| 26. |
- Brokelman, Walter J A, et al.
(författare)
-
Decreased peritoneal tissue plasminogen activator during prolonged laparoscopic surgery.
- 2009
-
Ingår i: The Journal of surgical research. - : Elsevier BV. - 1095-8673 .- 0022-4804. ; 151:1, s. 89-93
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Peritoneal fibrinolysis is crucial in the peritoneal healing processes and subsequent adhesion formation. During conventional surgery, the peritoneal fibrinolytic system is rapidly disturbed. Short-term laparoscopy does not seem to affect peritoneal fibrinolysis. The aim of the present study was to assess the effect of prolonged laparoscopic surgery on peritoneal fibrinolysis. METHODS: Twelve consecutive patients undergoing laparoscopic gastric bypass surgery for morbid obesity were included in the study. During the procedure, biopsies of the parietal peritoneum were taken at the start of the procedure and each 45 min afterward. Tissue samples were homogenized and tissue-type plasminogen activator (tPA) antigen, tPA activity, urokinase-type PA antigen, and plasminogen activating inhibitors type 1 antigen were measured using commercial assay techniques. RESULTS: Both tPA antigen and its activity progressively decreased during the procedure, reaching significant levels after 90 min of surgery. The levels of uPA antigen and plasminogen activating inhibitors antigen did not significantly change throughout the procedure. CONCLUSIONS: As for conventional surgery, prolonged laparoscopic surgery causes a decreased fibrinolytic activity in the peritoneum due to decreased tPA levels.
|
|
| 27. |
- Brokelman, Walter J A, et al.
(författare)
-
Peritoneal fibrinolytic response to various aspects of laparoscopic surgery: a randomized trial.
- 2006
-
Ingår i: The Journal of surgical research. - : Elsevier BV. - 0022-4804. ; 136:2, s. 309-13
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Peritoneal fibrinolysis is important in peritoneal wound healing processes and adhesion formation. The peritoneal fibrinolytic response to laparoscopy is merely unknown. In the present study we investigate the effect of short-term laparoscopy on the peritoneal fibrinolytic response and the influence of intra-abdominal pressure, light intensity and choice of dissection device on this response. METHODS: There were 50 patients scheduled for laparoscopic cholecystectomy randomized in five groups operated with various pressures, light intensities, and dissection devices. Peritoneal biopsies were taken at the beginning and the end of the procedure. Tissue concentrations of tissue-type plasminogen activator (tPA), urokinase-type plasminogen activator (uPA), plasminogen activator inhibitor type 1 (PAI-1), and the tPA-activity were measured using ELISA techniques. RESULTS: There were no differences in tPA antigen, tPA-activity, uPA antigen, or PAI-1 antigen concentrations in biopsies taken at the beginning compared to samples taken at the end of the operation. Different intra-abdominal pressures, light intensities and the choice dissection device did not affect any of the measured parameters. CONCLUSION: Short-term laparoscopy does not affect the peritoneal fibrinolytic activity. The used intra-abdominal pressure, light intensity and choice of dissection device do not affect peritoneal activity during short-term laparoscopy.
|
|
| 28. |
- Brokelman, Walter J A, et al.
(författare)
-
Peritoneal transforming growth factor beta-1 expression during laparoscopic surgery: a clinical trial.
- 2007
-
Ingår i: Surgical endoscopy. - : Springer Science and Business Media LLC. - 1432-2218 .- 0930-2794. ; 21:9, s. 1537-41
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Transforming growth factor-beta 1 (TGF-beta1) is a growth factor involved in various biologic processes, including peritoneal wound healing and dissemination of malignancies. Laparoscopic surgery is evolving rapidly, and indications are increasing. The peritoneal TGF-beta1 expression during laparoscopic surgery is unknown. METHODS: For this study, 50 patients scheduled for laparoscopic cholecystectomy were randomized into five groups, then surgically treated with various pressures, light intensities, and dissection devices. Peritoneal biopsies were taken at the beginning and end of surgery. Tissue concentrations of total and active TGF-beta1 were measured using enzyme-linked immunosorbent assay (ELISA) techniques. RESULTS: There was no significant difference in either total or active TGF-beta1 concentration between peritoneal biopsies taken at the start of surgery and samples taken at the end of the procedure. Patients who underwent surgery with the ultrasonic scalpel had significant lower levels of both active (p < 0.005) and total (p < 0.01) TGF-beta1 at the end of surgery than patients treated with electrocautery. Patients who had surgery with a high light intensity had significantly lower levels of total TGF-beta1 levels (p < 0.005) with an unchanged active part than patients who had surgery with low light intensity. CONCLUSION: The choice of dissection device and the light intensity used in laparoscopic surgery affect peritoneal TGF-beta1 concentrations, indicating that peritoneal biology can be affected by laparoscopic surgery. Because TGF-beta1 is involved in various biologic processes in the peritoneal cavity, this observation may have important clinical consequences.
|
|
| 29. |
- Carlsson, F., et al.
(författare)
-
A comparative study including Clamydomonas reinhardtii and Chlamydomonas raudensis Ettl. strains SAG 49.72 and UWO 241 focusing on phototaxis.
- 2005
-
Ingår i: Proceedings of the 6th European Workshop Biotechnology of Microalgae.
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Phototaxis is movement induced by light; this phenomenon has been detected in several solitary green algae species and generally works as a balancing force against gravitaxis, creating a system for optimum vertical placing in relation to irradiance, (energy -demands/restrictions). We study phototaxis in the mesophilic green algae, Chlamydomonas reinhardtii and C. raudensis SAG 49.72, relative to phototaxis in the from Antarctica newly isolated obligate psychrophilic strain of C. Raudensis (UWO 241) (henceforth called UWO 241). This species has some unusual movement patterns (Pocock et. al 2004) which function is yet to be revealed. Phototactic movement has not earlier been monitored in the normal conditions (high salinity, low temperature) for this strain, though when exposed to extreme temperatures (25C) the organism displays movement patterns interpreted as positive phototaxis. (Pocock et. al 2004). This behaviour should lead to a more rapid destruction of the organism due to the damaging high light (high energy input). The study shows that the three species responds different to light stimuli, when temperature is set to 12 C (culturing temperature) or the respective optimum culture temperatures. Light response curves of phototaxis in the range of 0,5 to 3000 μmol quanta m-2 s-1, shows that C. raudensis SAG 49.72 produce positive phototaxis over the entire range while C. reinhardtii mainly shows negative reactions. UWO 241 seem to be unaffected by irradiance, thus showing only nondirectional behaviour. In a second set of experiments the cells were kept in Petri dishes and exposed to 3000 μmol quanta m-2 s-1 under 40 min, in a temperature range of 5C to 25C for each sample. The results show that C. reinhardtii was negatively phototactic at 5C, switching to positive phototaxis at 25C.
|
|
| 30. |
|
|
| 31. |
|
|
| 32. |
|
|
| 33. |
- Düringer, Caroline, et al.
(författare)
-
Agonist-specific patterns of beta(2)-adrenoceptor responses in human airway cells during prolonged exposure.
- 2009
-
Ingår i: British Journal of Pharmacology. - : Wiley. - 1476-5381 .- 0007-1188. ; 158, s. 169-179
-
Tidskriftsartikel (refereegranskat)abstract
- Background and purpose: beta(2)-Adrenoceptor agonists (beta(2)-agonists) are important bronchodilators used in the treatment of asthma and chronic obstructive pulmonary disease. At the molecular level, beta(2)-adrenergic agonist stimulation induces desensitization of the beta(2)-adrenoceptor. In this study, we have examined the relationships between initial effect and subsequent reduction of responsiveness to restimulation for a panel of beta(2)-agonists in cellular and in vitro tissue models. Experimental approach: beta(2)-Adrenoceptor-induced responses and subsequent loss of receptor responsiveness were studied in primary human airway smooth muscle cells and bronchial epithelial cells by measuring cAMP production. Receptor responsiveness was compared at equi-effective concentrations, either after continuous incubation for 24 h or after a 1 h pulse exposure followed by a 23 h washout. Key findings were confirmed in guinea pig tracheal preparations in vitro. Key results: There were differences in the reduction of receptor responsiveness in human airway cells and in vitro guinea pig trachea by a panel of beta(2)-agonists. When restimulation occurred immediately after continuous incubation, loss of responsiveness correlated with initial effect for all agonists. After the 1 h pulse exposure, differences between agonists emerged, for example isoprenaline and formoterol induced the least reduction of responsiveness. High lipophilicity was, to some extent, predictive of loss of responsiveness, but other factors appeared to be involved in determining the relationships between effect and subsequent loss of responsiveness for individual agonists. Conclusions and implications: There were clear differences in the ability of different beta(2) agonists to induce loss of receptor responsiveness at equi-effective concentrations.
|
|
| 34. |
- Ederth, Thomas, et al.
(författare)
-
Interactions of Zoospores of Ulva linza with Arginine-Rich Oligopeptide Monolayers
- 2009
-
Ingår i: Langmuir. - : American Chemical Society (ACS). - 0743-7463 .- 1520-5827. ; 25:16, s. 9375-9383
-
Tidskriftsartikel (refereegranskat)abstract
- We recently reported oil the strong interactions of zoospores of the green alga, Ulva linza with all arginine-rich oligopeptide self-assembled monolayer (SAM) [Biofouling 2008, 24, 303-312], where the arginine-rich peptide induced not only high spore settlement, but also a form of abnormal settlement, or "pseudo-settlement", whereby it proportion of spores do not go through the normal process of surface exploration, adhesive exocytosis, and loss of flagella. Further. it was demonstrated that both the total number of settled spores and the fraction of pseudosettled spores were related to the surface density of the arginine-rich peptide. Here we present a further investigation of the interactions of zoospores of ulva with a set of oligomeric, de nom designed, arginine-rich peptides, specifically aimed to test the effect of peptide primary structure on the interaction. Via variations in the peptide length and by permutations in the amino acid sequences, we gain further insight into the spore-surface interactions. The interpretation of the biological assays is supported by physicochemical characterization of the SAMs using infrared spectroscopy, ellipsometry, and contact angle measurement. Results confirm the importance of arginine residues for the anomalous pseudosettlement, and we found that settlement is modulated by variations in both the total length and peptide primary structure. To elucidate the Causes of the anomalous settlement and the possible relation to peptide-membrane interactions, we also compared the settlement of the "naked" zoospores of Ulva(which present it lipoprotein membrane to the exterior without a discrete polysaccharide cell wall), with the settlement of diatoms (unicellular algae that are surrounded by it silica cell wall), onto the peptide SAMs. Cationic SAMs do not notably affect settlement (attachment), adhesion strength, or viability of diatom cells, Suggesting that the effect of the peptides on zoospores of Ulva is mediated via specific peptide-membrane interactions.
|
|
| 35. |
- Falk, A, et al.
(författare)
-
New neurons in old brains
- 2005
-
Ingår i: Annals of medicine. - : Informa UK Limited. - 0785-3890 .- 1365-2060. ; 37:7, s. 480-486
-
Tidskriftsartikel (refereegranskat)
|
|
| 36. |
|
|
| 37. |
|
|
| 38. |
|
|
| 39. |
|
|
| 40. |
- Hernandez, Victor Agmo, et al.
(författare)
-
The adhesion and spreading of thrombocyte vesicles on electrode surfaces
- 2008
-
Ingår i: Bioelectrochemistry. - : Elsevier BV. - 1567-5394 .- 1878-562X. ; 74, s. 210-216
-
Tidskriftsartikel (refereegranskat)abstract
- The interaction of thrombocyte vesicles with the surface of metal electrodes, i.e., mercury, gold and gold electrodes modified with self assembled monolayers (SAM), was studied with the help of chronoamperometry, atomic force microscopy, and quartz crystal microbalance measurements. The experimental results show that the interaction of the thrombocyte vesicles with the surface of the electrodes depends on the hydrophobicity of the latter: whereas on very hydrophobic surfaces (mercury and gold functionalized with SAM) the thrombocyte vesicles disintegrate and form a monolayer of lipids. on the less hydrophobic gold surface a bilayer is formed. The chronoamperometric measurements indicate the possibility of future applications to probe membrane properties of thrombocytes. (C) 2008 Elsevier B.V. All rights reserved.
|
|
| 41. |
|
|
| 42. |
|
|
| 43. |
- Lindblad-Toh, Kerstin, et al.
(författare)
-
Genome sequence, comparative analysis and haplotype structure of the domestic dog.
- 2005
-
Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 438:7069, s. 803-19
-
Tidskriftsartikel (refereegranskat)abstract
- Here we report a high-quality draft genome sequence of the domestic dog (Canis familiaris), together with a dense map of single nucleotide polymorphisms (SNPs) across breeds. The dog is of particular interest because it provides important evolutionary information and because existing breeds show great phenotypic diversity for morphological, physiological and behavioural traits. We use sequence comparison with the primate and rodent lineages to shed light on the structure and evolution of genomes and genes. Notably, the majority of the most highly conserved non-coding sequences in mammalian genomes are clustered near a small subset of genes with important roles in development. Analysis of SNPs reveals long-range haplotypes across the entire dog genome, and defines the nature of genetic diversity within and across breeds. The current SNP map now makes it possible for genome-wide association studies to identify genes responsible for diseases and traits, with important consequences for human and companion animal health.
|
|
| 44. |
|
|
| 45. |
- Massa, J, et al.
(författare)
-
Plasma titers of antibodies against Epstein-Barr virus BZLF1 and risk of multiple sclerosis
- 2007
-
Ingår i: Neuroepidemiology. - : S. Karger AG. - 1423-0208 .- 0251-5350. ; 28:4, s. 214-215
-
Tidskriftsartikel (refereegranskat)abstract
- <i>Background/Aims:</i> Results of recently conducted prospective studies have demonstrated that the presence of high titers of anti-EBNA-1 or anti-EBNA complex IgG antibodies in healthy individuals is a strong risk factor for multiple sclerosis (MS). Antibodies to BZLF1, the product of the homonymous early lytic gene, have been found to be related to risk of nasopharyngeal carcinoma, but have not been previously measured in MS studies. <i>Methods:</i> We examined whether high levels of anti-BZLF1 IgG antibodies also predict MS risk in a nested case-control study among women in the Nurses Health Study and Nurses Health Study II cohorts. <i>Results:</i> Results of this prospective study suggest that antibody titers to EBNAs are the strongest predictor of MS risk. <i>Conclusion:</i> Little further contribution may be provided by measuring anti-BZLF1 antibodies in regard to MS risk.
|
|
| 46. |
|
|
| 47. |
- Olsson, Christer H. B., et al.
(författare)
-
Bladmögel hotar persiljeodlingen
- 2008
-
Ingår i: Viola: Potatis och Grönsaker. ; 29 Maj 2008:11, s. 18-20
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- På senare år har flera persiljeodlingar i Sverige visat sig vara infekterade med en bladmögel- svamp. Detta, för persilja relativt nya problem, har även upptäckts i många andra europeiska länder.
|
|
| 48. |
|
|
| 49. |
- Pocock, Tessa, et al.
(författare)
-
Excitation pressure regulates the activation energy for recombination events in the photosystem II reaction centres of Chlamydomonas reinhardtii
- 2007
-
Ingår i: Biochemistry and Cell Biology. - 0829-8211 .- 1208-6002. ; 85:6, s. 721-729
-
Tidskriftsartikel (refereegranskat)abstract
- Using in vivo thermoluminescence, we examined the effects of growth irradiance and growth temperature on charge recombination events in photosystem IT reaction centres of the model green alga Chlamydomonas reinhardtii. We report that growth at increasing irradiance at either 29 or 15 degrees C resulted in comparable downward shifts in the temperature peak maxima (T-M) for S(2)Q(B)(-) charge pair recombination events, with minimal changes in S(2)Q(A)(-) recombination events. This indicates that such growth conditions decrease the activation energy required for S(2)QB(-) charge pair recombination events with no concomitant change in the activation energy for S(2)Q(A)(-) recombination events. This resulted in a decrease in the Delta T-M between S(2)Q(A)(-) and S(2)Q(B)(-) recombination events, which was reversible when shifting cells from low to high irradiance and back to low irradiance at 29 degrees C. We interpret these results to indicate that the redox potential of Q(B) was modulated independently of Q(A), which consequently narrowed the redox potential gap between Q(A) and Q(B) in photosystem II reaction centres. Since a decrease in the Delta T-M between S(2)Q(A)(-) and S(2)Q(B)(-) recombination events correlated with growth at increasing excitation pressure, we conclude that acclimation to growth under high excitation pressure narrows the redox potential gap between Q(A) and Q(B) in photosystem 11 reaction centres, enhancing the probability for reaction center quenching in C. reinhardtii. We discuss the molecular basis for the modulation of the redox state of Q(B), and suggest that the potential for reaction center quenching complements antenna quenching via the xanthophyll cycle in the photoprotection of C. reinhardtii from excess light.
|
|
| 50. |
|
|
