| 1. |
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| 2. |
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| 3. |
- Soares, Rodrigo P., et al.
(author)
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Highlights of the São Paulo ISEV workshop on extracellular vesicles in cross-kingdom communication
- 2017
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In: Journal of Extracellular Vesicles. - : Wiley. - 2001-3078. ; 6:1
-
Journal article (peer-reviewed)abstract
- In the past years, extracellular vesicles (EVs) have become an important field of research since EVs have been found to play a central role in biological processes. In pathogens, EVs are involved in several events during the host–pathogen interaction, including invasion, immunomodulation, and pathology as well as parasite–parasite communication. In this report, we summarised the role of EVs in infections caused by viruses, bacteria, fungi, protozoa, and helminths based on the talks and discussions carried out during the International Society for Extracellular Vesicles (ISEV) workshop held in São Paulo (November, 2016), Brazil, entitled Cross-organism Communication by Extracellular Vesicles: Hosts, Microbes and Parasites.
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| 4. |
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| 5. |
- Almqvist, Gustaf, et al.
(author)
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Report of the Benchmark Workshop on Baltic Cod Stocks (WKBALTCOD)
- 2015
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Reports (other academic/artistic)abstract
- The ICES Benchmark Workshop on Baltic Cod Stocks (WKBALTCOD), chaired by External Chair Jean-Jacques Maguire, Canada and ICES Chair Marie Storr-Paulsen, Denmark, and attended by two invited external experts Verena Trenkel, France and Meaghan Bryan, USA met in Rostock, Germany, 2–6 March 2015 with 39 participants and six countries represented. The objective of WKBALTCOD was to evaluate the appropriateness of data and methods to determine stock status and investigate meth-ods appropriate to use in the single-stock assessment for the cod stock in SD 22–24 and cod in SD 25–32 in the Baltic. Participants in the workshop were a large group with diverse backgrounds representing the industry, fisheries, NGOs, managers and scientists.The single-stock analytic assessment of the eastern Baltic stock was not accepted by the assessment working group (WGBFAS) in 2014 due to severe problems with the input data. The advice for the eastern Baltic cod was, therefore, based on the ICES approach for data-limited stocks. As an outcome ICES decided to establish a bench-mark for both cod stocks and to scope an integrated assessment for the Baltic cod stocks. The first meeting (WKSIBCA) was therefore meant to introduce the interces-sional work conducted since the assessment working group in April 2014, and to reach some conclusions on how to proceed both in the short term (Benchmark in March 2015) and longer term (2–3 years) and was seen as a data compilation work-shop, there is produced a separate report from this workshop. The WKBALTCOD was the 2nd meeting in the benchmark process and was intended to come up with a final stock assessment method, stock annex and input data for both stocks. As it was not possible to reach conclusive decision on the final model to be used for the east Baltic cod stock during the benchmark meeting and as more work on the preferable models was needed, it was decided by the ACOM leadership to prolong the bench-mark process until the assessment working group meeting in April 2015. This deci-sion has led to a relatively long process partly mixed with the assessment working group WGBFAS.It became clear during the benchmark process that although large effort has been put into explaining the underlying processes leading to the changes in the Baltic ecosys-tem, there is still some lack of understanding of the present situation in the eastern Baltic cod stock. Therefore, it was not possible to reach firm conclusions on the final model to be used and therefore not possible to set reference points. It was decided to continue to explore the most promising models and to continue to improve the input data until the assessment working group started in April.The main challenges still to be solved for the Eastern Baltic cod stock is the quantifi-cation of increased natural mortality and decrease in growth. Through several presentations during the workshop (both WKSIBCA and WKBALTCOD) it became clear that natural mortality very likely has increased in later years, due to decreased condition and increased parasite infection. A decrease in growth also seems plausible duo to a decrease in condition and/or selectivity-induced mortality of the largest in-dividuals. However, as none of these parameters are easily estimated, especially with the severe ageing problems, different model assumptions made the output very shaky.For the western Baltic cod, stock identification issues were examined in area SD 24, the intermediate area: based on otolith characteristics and genetics. Due to the results showing a large proportion of east cod in this area, it was decided to split the catch2 | ICES WKBALTCOD REPORT 2015and survey from SD 24 into either the western or eastern Baltic cod stock. It was pos-sible to derive proportions of eastern and western cod in SD 24 back to the mid-1990s.For the western Baltic cod stock a modelled survey indices was included in the as-sessment covering the western part of SD 24 and Area 22+23 and based on a smoothed ALK.Both cod stocks have in the past used commercial tuning fleet to have a better cov-ered of older age groups. It was decided to abound this time-series duo quality issues such as a limited coverage and problems with technical creeping.WKBALTCOD was not able to explore and define reference points for the Western Baltic cod stock during the meeting due to time constraints, but these were calculated and decided by correspondence after the meeting. The recent protocols on estimation procedures developed by WKMSYREF3 for stocks with a full analytical assessment and for data-limited stocks served as objective guidelines to obtain reference point estimates.
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| 6. |
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| 7. |
- Bjelke, Ulf, et al.
(author)
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Rödlistade arter och naturvård i sand- och grustäkter
- 2012
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Reports (other academic/artistic)abstract
- Naturligt störningspräglade sandmarker hyser en artrik och konkurrenskänslig flora och fauna. Sådana livsmiljöer har minskat drastiskt under 1900-talet. Under samma period ökade antalet sand- och grustäkter. Trots att täkterna ofta innebär stora ingrepp i naturen kan de utgöra viktiga ersättningshabitat för arter knutna till sandiga miljöer. Sedan några decennier så minskar även sand- och grustäkter starkt, beroende på att samhället vill bevara naturliga sand- och grusresurser. Produktionen har medvetet flyttats till bergkrossanläggningar och det ges idag mycket få tillstånd för utökad verksamhet eller nya sandtäkter. Från fler än 5 000 aktiva täkter på 1990-talet har antalet sjunkit till färre än 1 000. Täkter som avslutas har ofta föreskrifter om att planas ut och övertäckas vilket gör att deras naturvärden spolieras. Drygt 300 rödlistade arter har gynnats av sandtäkter när ursprungshabitaten minskat. Steklar och skalbaggar utgör de största grupperna med närmare två tredjedelar av arterna. Södra Sverige hyser störst rikedom av dessa arter men såväl täkter som arternas mer naturliga miljöer är bristfälligt undersökta, särskilt i glest befolkade delar av landet. För att bevara dessa täktlevande arter krävs att naturvården arbetar för att förhindra att avslutade täkter planas ut eller täcks över. Det är av stor betydelse att naturvårdande myndigheter ges tillräckliga styrmedel och ekonomiska resurser att arbeta med täkter. Genom enkla åtgärder kan de skapade livsmiljöerna i täkter bevaras till en låg kostnad jämfört med andra alternativa biotopvårdande åtgärder. Rapporten belyser artsamhällena som kan finnas i täkter samt viktiga strategier och åtgärder för naturvård i dessa miljöer. Rapporten har finansierats av Naturvårdsverket och av SLU:s medel för fortlöpande miljöanalys.
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| 8. |
- Dietz, Benedikt, et al.
(author)
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Detection of diabetes from whole-body MRI using deep learning
- 2021
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In: JCI Insight. - : American Society for Clinical Investigation. - 2379-3708. ; 6:21
-
Journal article (peer-reviewed)abstract
- Obesity is one of the main drivers of type 2 diabetes, but it is not uniformly associated with the disease. The location of fat accumulation is critical for metabolic health. Specific patterns of body fat distribution, such as visceral fat, are closely related to insulin resistance. There might be further, hitherto unknown, features of body fat distribution that could additionally contribute to the disease. We used machine learning with dense convolutional neural networks to detect diabetes-related variables from 2371 T1-weighted whole-body MRI data sets. MRI was performed in participants undergoing metabolic screening with oral glucose tolerance tests. Models were trained for sex, age, BMI, insulin sensitivity, HbA1c, and prediabetes or incident diabetes. The results were compared with those of conventional models. The area under the receiver operating characteristic curve was 87% for the type 2 diabetes discrimination and 68% for prediabetes, both superior to conventional models. Mean absolute regression errors were comparable to those of conventional models. Heatmaps showed that lower visceral abdominal regions were critical in diabetes classification. Subphenotyping revealed a group with high future diabetes and microalbuminuria risk. Our results show that diabetes is detectable from whole-body MRI without additional data. Our technique of heatmap visualization identifies plausible anatomical regions and highlights the leading role of fat accumulation in the lower abdomen in diabetes pathogenesis.
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| 9. |
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| 10. |
- Elsik, Christine G., et al.
(author)
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The Genome Sequence of Taurine Cattle : A Window to Ruminant Biology and Evolution
- 2009
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In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 324:5926, s. 522-528
-
Journal article (peer-reviewed)abstract
- To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome sequence thus provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production.
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| 11. |
- Enmark, Martin, 1984-, et al.
(author)
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Investigation of factors influencing the separation of diastereomers of phosphorothioated oligonucleotides
- 2019
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In: Analytical and Bioanalytical Chemistry. - : Springer. - 1618-2642 .- 1618-2650. ; 411:15, s. 3383-3394
-
Journal article (peer-reviewed)abstract
- This study presents a systematic investigation of factors influencing the chromatographic separation of diastereomers of phosphorothioated pentameric oligonucleotides as model solutes. Separation was carried out under ion-pairing conditions using an XBridge C18 column. For oligonucleotides with a single sulfur substitution, the diastereomer selectivity was found to increase with decreasing carbon chain length of the tertiary alkylamine used as an ion-pair reagent. Using an ion-pair reagent with high selectivity for diastereomers, triethylammonium, it was found the selectivity increased with decreased ion-pair concentration and shallower gradient slope. Selectivity was also demonstrated to be dependent on the position of the modified linkage. Substitutions at the center of the pentamer resulted in higher diastereomer selectivity compared to substitutions at either end. For mono-substituted oligonucleotides, the retention order and stereo configuration were consistently found to be correlated, with Rp followed by Sp, regardless of which linkage was modified. The type of nucleobase greatly affects the observed selectivity. A pentamer of cytosine has about twice the diastereomer selectivity of that of thymine. When investigating the retention of various oligonucleotides eluted using tributylammonium as the ion-pairing reagent, no diastereomer selectivity could be observed. However, retention was found to be dependent on both the degree and position of sulfur substitution as well as on the nucleobase. When analyzing fractions collected in the front and tail of overloaded injections, a significant difference was found in the ratio between Rp and Sp diastereomers, indicating that the peak broadening observed when using tributylammonium could be explained by partial diastereomer separation.
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| 12. |
- Fischer, Hubertus, et al.
(author)
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Palaeoclimate constraints on the impact of 2 °C anthropogenic warming and beyond
- 2018
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In: Nature Geoscience. - : Springer Science and Business Media LLC. - 1752-0894 .- 1752-0908. ; 11:7, s. 474-485
-
Journal article (peer-reviewed)abstract
- Over the past 3.5 million years, there have been several intervals when climate conditions were warmer than during the pre-industrial Holocene. Although past intervals of warming were forced differently than future anthropogenic change, such periods can provide insights into potential future climate impacts and ecosystem feedbacks, especially over centennial-to-millennial timescales that are often not covered by climate model simulations. Our observation-based synthesis of the understanding of past intervals with temperatures within the range of projected future warming suggests that there is a low risk of runaway greenhouse gas feedbacks for global warming of no more than 2 °C. However, substantial regional environmental impacts can occur. A global average warming of 1–2 °C with strong polar amplification has, in the past, been accompanied by significant shifts in climate zones and the spatial distribution of land and ocean ecosystems. Sustained warming at this level has also led to substantial reductions of the Greenland and Antarctic ice sheets, with sea-level increases of at least several metres on millennial timescales. Comparison of palaeo observations with climate model results suggests that, due to the lack of certain feedback processes, model-based climate projections may underestimate long-term warming in response to future radiative forcing by as much as a factor of two, and thus may also underestimate centennial-to-millennial-scale sea-level rise.
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| 13. |
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| 14. |
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| 15. |
- Fritz, Martin, et al.
(author)
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Economic Development and Prosperity Patterns Around the World: Structural Challenges for a Global Steady-State Economy
- 2016
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In: Global Environmental Change. - 0959-3780. ; 38:May, s. 41-48
-
Journal article (peer-reviewed)abstract
- Taking a global perspective this paper sets out to theoretically and empirically identify prosperity patterns for four groups of countries at different levels of economic development. It conceptualizes ‘prosperity’ in terms of ecological sustainability, social inclusion, and the quality of life and contextualizes this definition in global perspective. Subsequently, it operationalizes and measures these dimensions on the basis of data from sources such as the World Bank, the Global Footprint Network and the OECD for 138 countries and by applying dual multiple factor analysis. Building on earlier research that suggested that higher development levels in terms of GDP per capita are capable of providing social and individual prosperity but at the expense of environmental sustainability, we ask whether other interrelations between prosperity indicators exist on other levels of economic development. Empirically distinguishing between ‘rich’, ‘emerging’, ‘developing’ and ‘poor countries’ the paper finds that social and individual prosperity indicators largely increase with economic development while ecological sustainability indicators worsen. Our analyses further reveal that ‘social cohesion’ can be established under different economic and institutional conditions, that subjective wellbeing increases with income rises at all levels of economic development and that a decoupling of carbon emissions from the provision of prosperity is,in principle, achievable, while a reduction of the global matter and energy throughput poses a much greater challenge. The paper concludes by highlighting the repercussions of these findings for the trajectories that countries at different levels of economic development would need to undertake.
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| 16. |
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| 17. |
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| 18. |
- Fritz, Martin, 1937
(author)
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Framtida utmaningar och möjligheter
- 2011
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In: Bergsbruk : gruvor och metallframställning. - Stockholm : Norstedts. - 9789187760587 ; , s. 202-205
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Book chapter (other academic/artistic)
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| 19. |
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| 20. |
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| 21. |
- Fritz, Martin, et al.
(author)
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Habitus and climate change: Exploring support and resistance to sustainable welfare and social–ecological transformations in Sweden
- 2021
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In: British Journal of Sociology. - : Wiley. - 0007-1315 .- 1468-4446. ; 72:4, s. 874-890
-
Journal article (peer-reviewed)abstract
- We explore peoples' dispositions and practices with regard to social–ecological transformations based on a sustainable welfare policy strategy in Sweden. We draw on Bourdieu's concept of habitus to highlight the relations between social positions, dispositions, and position-takings. Using data from an own survey, we identify habitus types and place these in the space of social positions. We apply principal component analysis to a large set of questions about social, ecological, and climate change related topics and identify eight underlying eco–social dispositions. These are used for cluster analyses that find typical constellations of eco–social dispositions within the Swedish population: variants of eco–social habitus. We find seven habitus types and describe their social characteristics, political preferences, and practices. Finally, the seven habitus are plotted onto the map of social positions, the Bourdieusian social space, highlighting their relations—proximities, tensions, and contestations—to each other. We find evidence that political struggles around social–ecological transformations reproduce existing social structures but are also connected to new “eco–social” divisions that appear between groups in similar positions. In the conclusion we discuss the implications for social–ecological transformations based on sustainable welfare.
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| 22. |
- Fritz, Martin, 1937
(author)
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Industriledaren
- 2008
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In: Oscar Ekman - en portalgestalt. - Göteborg : University of Gothenburg. ; , s. 21-30
-
Book chapter (other academic/artistic)abstract
- I artikeln belyses Oscar Ekmans roll som industriledare i Göteborg, främst som mångårig, dominerande chef för det Carnegieska sockerbruket vid Klippan.
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| 23. |
- Fritz, Martin, et al.
(author)
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Introduction to the special issue: Tackling inequality and providing sustainable welfare through eco-social policies
- 2023
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In: European Journal of Social Security (EJSS). - 1388-2627 .- 2399-2948. ; 25:4, s. 315-327
-
Journal article (other academic/artistic)abstract
- We are increasingly witnessing the social and ecological crises of our time becoming entangled and amplifying each other. The current policy responses from national states and international governance bodies remain within the dominant framework of economic growth-centred strategies. In this editorial, we argue that a new paradigm of sustainable welfare is needed, which includes eco-social policies addressing social and ecological sustainability concerns in integrated ways. We first demonstrate how social and ecological problems are interconnected and why green growth approaches fail to tackle them. As an alternative, and as a pointer to a social security system that can help people navigate the dire straits of increasing eco-social risks, we present the foundations and principles of sustainable welfare, and discuss how this, according to Kuhn, can be understood as a new social policy paradigm. In the second part of this editorial, we introduce the papers brought together in this special issue. The cutting-edge research of the contributing authors includes theoretical and conceptual advances, empirical case studies from different European countries, and transnational studies. Each paper discusses the implications of its findings for European social security systems.
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| 24. |
- Fritz, Martin, 1937
(author)
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Kris och förnyelse, 1900-talets första hälft
- 2011
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In: Bergsbruk : gruvor och metallframställning. - Stockholm : Norstedts. - 9789187760587 ; , s. 126-145
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Book chapter (other academic/artistic)
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| 25. |
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| 26. |
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| 27. |
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| 28. |
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| 29. |
- Fritz, Martin, et al.
(author)
-
Potentials for prosperity without growth: Ecological sustainability, social inclusion and the quality of life in 38 countries
- 2014
-
In: Ecological Economics. - : Elsevier BV. - 0921-8009. ; 108, s. 191-199
-
Journal article (peer-reviewed)abstract
- Recent contributions to ecological economics and related social sciences indicate that issues such as climate change, resource depletion and environmental degradation cannot be effectively addressed under conditions of continued economic growth. This paper aims at empirically identifying structural potentials and policy challenges for prosperity at scaleswhere economic development remainswithin ecological carrying capacities. Building on the growing literature that interprets prosperity ‘beyond’ economic growth, the paper presents a threedimensional concept to operationalise prosperity in terms of ecological sustainability, social inclusion, and the quality of life. These dimensions are measured using data from sources such as TheWorld Bank, the Global Footprint Network and the OECD. The results of cluster and correspondence analyses indicate the existence of five ‘prosperity regimes’ and demonstrate that all aspects of prosperity – including (unsatisfactory) ecological performance – are linked to economic development. However, our findings also indicate that in order to achieve a decent minimum of prosperity moderate levels of the material living standard are sufficient. Further increases in the material living standard do not lead to significant additional prosperity; instead they cause greater environmental harms. The paper concludes by highlighting potentials for prosperity for each of the ‘prosperity regimes’ and corresponding policy challenges.
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| 30. |
- Fritz, Martin, et al.
(author)
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Public Support for Sustainable Welfare Compared: Links between Attitudes towards Climate and Welfare Policies
- 2019
-
In: Sustainability. - : MDPI AG. - 2071-1050. ; 11:15
-
Journal article (peer-reviewed)abstract
- The emerging concept of sustainable welfare attempts to integrate environmental sustainability and social welfare research. Oriented at a mid-term re-embedding of Western production and consumption norms into planetary limits, it suggests the development of “eco-social” policies in the rich countries. In this theoretical context, this article empirically investigates the relationships between attitudes towards welfare and climate policy in 23 countries. Using 2016 data from the European Social Survey, we explored patterns of synergy between both kinds of policies as well as effects of crowding-out, where support for one kind of policy involves refusing the other. Since previous research addressed the role of welfare states and their institutional foundations in establishing environmentally sustainable societies, we studied how attitudes towards welfare and climate policies differ according to welfare regime affiliation. Additionally, we examined how a range of socio-demographic and political factors such as class, education, income, and political position shape people’s views on welfare and climate policy goals. The results of a multiple correspondence analysis indicate that the simultaneous support of welfare and climate policies follows welfare regime lines in that this support is the highest among social-democratic countries. However, also some conservative and Mediterranean countries score high in this regard. At the individual level, people with a higher education, employees in socio-cultural professions, and voters of moderate left and green parties display the highest mutual support for welfare and climate policies.
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| 31. |
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| 32. |
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| 33. |
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| 34. |
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| 35. |
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| 36. |
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| 37. |
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| 38. |
- Fritz, Martin, 1937
(author)
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Sveriges industrialisering och släkten Keiller
- 2008
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Book (other academic/artistic)abstract
- Medlemmar av familjen Keiller spelade en viktig roll för Göteborgs indutrialisering under 1800-talet. So ägaqre till Keillers Mekaniska Verkstad vid Skeppsbron - föregångare till Götaverken - levererade de mekanisk utrustning till andra industrier och medverkade till uppbyggnaden av en modern infrastruktur, gasverk, broar, järnvägsmateriel. Familjen engagerade sig också i gruvbrytning och koppartiillverkning i Bregslagen
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| 39. |
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| 40. |
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| 41. |
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| 42. |
- Fritz, Martin, et al.
(author)
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The 'good life' of nations : A global perspective
- 2017
-
In: The good life beyond growth : New perspectives - New perspectives. - 9781138687882 - 9781134885176 ; , s. 215-228
-
Book chapter (peer-reviewed)abstract
- Major socio-ecological issues such as climate change have a global character. For the atmosphere it does not matter from which point in the world greenhouse gases are emitted. The structural preconditions for any ‘good life’ likewise have global reach. In this chapter, we theorise and operationalise the individual, social and ecological dimensions for prosperity and the ‘good life’ at national level and empirically explore patterns of prosperity at the global scale. How are prosperity patterns structured in various parts of the world? Are there any country clusters that manage to develop (elements of) the ‘good life’ within ecological limits? And what are the future prospects for the different clusters and particularly for the Western world en route to achieving a surplus in prosperity?
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| 43. |
- Fritz, Martin, 1937
(author)
-
World War I Sweden in World War I - Iron ore mining, iron and steel industry
- 2016
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In: Stahl und Eisen. - 0340-4803. ; 136:11, s. 160-166
-
Journal article (peer-reviewed)abstract
- Investments in iron ore mining and iron works as well as running business in this range of operations are long-term activities characterized by limited flexibility. This article therefore, as a background, starts with a description of the conditions before World War I for these very important trades in Swedish economy. This overview also provides an insight into the dimensions of the effects of World War I on a small neutral nation with long traditions within these industrial fields. How did these industries develop under the new conditions caused by the war?.
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| 44. |
- Gauld, Jethro G., et al.
(author)
-
Hotspots in the grid : Avian sensitivity and vulnerability to collision risk from energy infrastructure interactions in Europe and North Africa
- 2022
-
In: Journal of Applied Ecology. - : John Wiley & Sons. - 0021-8901 .- 1365-2664. ; 59:6, s. 1496-1512
-
Journal article (peer-reviewed)abstract
- Wind turbines and power lines can cause bird mortality due to collision or electrocution. The biodiversity impacts of energy infrastructure (EI) can be minimised through effective landscape-scale planning and mitigation. The identification of high-vulnerability areas is urgently needed to assess potential cumulative impacts of EI while supporting the transition to zero carbon energy. We collected GPS location data from 1,454 birds from 27 species susceptible to collision within Europe and North Africa and identified areas where tracked birds are most at risk of colliding with existing EI. Sensitivity to EI development was estimated for wind turbines and power lines by calculating the proportion of GPS flight locations at heights where birds were at risk of collision and accounting for species' specific susceptibility to collision. We mapped the maximum collision sensitivity value obtained across all species, in each 5 x 5 km grid cell, across Europe and North Africa. Vulnerability to collision was obtained by overlaying the sensitivity surfaces with density of wind turbines and transmission power lines. Results: Exposure to risk varied across the 27 species, with some species flying consistently at heights where they risk collision. For areas with sufficient tracking data within Europe and North Africa, 13.6% of the area was classified as high sensitivity to wind turbines and 9.4% was classified as high sensitivity to transmission power lines. Sensitive areas were concentrated within important migratory corridors and along coastlines. Hotspots of vulnerability to collision with wind turbines and transmission power lines (2018 data) were scattered across the study region with highest concentrations occurring in central Europe, near the strait of Gibraltar and the Bosporus in Turkey. Synthesis and applications. We identify the areas of Europe and North Africa that are most sensitive for the specific populations of birds for which sufficient GPS tracking data at high spatial resolution were available. We also map vulnerability hotspots where mitigation at existing EI should be prioritised to reduce collision risks. As tracking data availability improves our method could be applied to more species and areas to help reduce bird-EI conflicts.
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| 45. |
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| 46. |
- Grandoch, Maria, et al.
(author)
-
4-Methylumbelliferone improves the thermogenic capacity of brown adipose tissue
- 2019
-
In: Nature Metabolism. - : Springer Science and Business Media LLC. - 2522-5812. ; 1:5, s. 546-559
-
Journal article (peer-reviewed)abstract
- Therapeutic increase in brown adipose tissue (BAT) thermogenesis is of great interest, as BAT activation counteracts obesity and insulin resistance. Hyaluronan (HA) is a glycosaminoglycan, found in the extracellular matrix, that is synthesized by HA synthases (HAS1, HAS2, and HAS3) from sugar precursors and accumulates in diabetic conditions. Its synthesis can be inhibited by the small molecule 4-methylumbelliferone (4-MU). Here we show that inhibition of HA synthesis by 4-MU or genetic deletion of Has2 and Has3 improves the thermogenic capacity of BAT, reduces body-weight gain, and improves glucose homeostasis independently of adrenergic stimulation in mice on a diabetogenic diet. In this context, we validated a novel magnetic resonce T2 mapping approach for in vivo visualization of BAT activation. Inhibition of HA synthesis increases glycolysis, BAT respiration, and uncoupling protein 1 (UCP1) expression. In addition, we show that 4-MU increases BAT capacity without inducing chronic stimulation and propose that 4-MU, a clinically approved, prescription-free drug, could be repurposed to treat obesity and diabetes.
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| 47. |
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| 48. |
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| 49. |
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| 50. |
- Hardwick, Martin, et al.
(author)
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A roadmap for STEP-NC-enabled interoperable manufacturing
- 2013
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In: The International Journal of Advanced Manufacturing Technology. - : Springer Science and Business Media LLC. - 0268-3768 .- 1433-3015. ; 68:5-8, s. 1023-1037
-
Journal article (peer-reviewed)abstract
- The STEP-NC-AP 238 and ISO 14649 standard is the result of a 10-year international effort to replace the RS274D (ISO 6983) G and M code standard with a modern associative language that connects the CAD design data used to determine the machining requirements for an operation with the CAM process data that is used in creating a machining solution to satisfy these requirements. STEP-NC builds on the previous 10 years effort to develop the STEP neutral data standard for CAD data, and uses the modern geometric constructs in that standard to specify device independent tool paths, and CAM independent volume removal features. STEP-Manufacturing, Team 24 in Working Group 3 (WG3) of ISO TC184/SC4, is developing and validating the STEP-NC standard in liaison with Working Group (WG7) of ISO TC184/SC1 who provides the domain-specific input (ISO 14649) used within the standard. This paper reviews the demonstrations carried out by STEP-Manufacturing over the past 10 years. These demonstrations have been international collaborations between industry, academia, and research agencies. Each demonstration focused on extending the STEP-NC data model for a different application.
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