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Träfflista för sökning "WFRF:(Gogos J. A.) srt2:(2012-2014)"

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1.	Giamarellos-Bourboulis, EJ, et al. (author) Risk assessment in sepsis: a new prognostication rule by APACHE II score and serum soluble urokinase plasminogen activator receptor 2012 In: Critical care (London, England). - : Springer Science and Business Media LLC. - 1466-609X .- 1364-8535. ; 16:4, s. R149- Journal article (peer-reviewed)
2.	Stubelius, Alexandra, 1983, et al. (author) Sexual dimorphisms in the immune system of catechol-O-methyltransferase knockout mice 2012 In: Immunobiology. - : Elsevier BV. - 0171-2985. ; 217:8, s. 751-760 Journal article (peer-reviewed)abstract The enzyme catechol-O-methyltransferase (COMT) is part of the metabolic pathway of 17 beta-estradiol, converting 2-hydroxyestradiol to 2-methoxyestradiol. We recently showed that administration of the COMT product 2-methoxyestradiol has anti-inflammatory and anti-osteoporotic effects. We have now investigated whether COMT affects the immune system, by immunologically phenotyping COMT deficient (COMT-/-) mice. Immunoglobulin production, T lymphocyte proliferation, NK cell cytotoxicity and oxygen radical production were assessed. In male COMT-/--mice, the total number of T-, and B-lymphocytes from spleen increased but the T-cell proliferative response decreased. The NK cell population shifted toward less mature cells, leaving cytotoxic capacity unaffected. In COMT-/--females, a higher frequency of neutrophils was found but the oxygen radical production was unaltered. In conclusion, only minor changes of the immune system were seen in COMT deficient mice, and the changes were usually seen in males. This study provides clues into how COMT activity, and hence gender differences, affects the immune system. (c) 2012 Elsevier GmbH. All rights reserved.

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Type of publication: journal article (2)

Type of content: peer-reviewed (2)

Author/Editor: Treutiger, CJ (1); Norrby-Teglund, A (1); Wilhelmson, Anna S K (1); Armaganidis, A (1); Koutelidakis, I (1); Carlsten, Hans, 1954 (1); show more...; Stubelius, Alexandra ... (1); Islander, Ulrika, 19 ... (1); Tivesten, Åsa, 1969 (1); Apostolidou, E (1); Linner, A (1); Dimopoulos, G (1); Dimopoulou, I (1); Tsangaris, I (1); Giamarellos-Bourboul ... (1); Mylona, V (1); Savva, A (1); Mouktaroudi, M (1); Raftogiannis, M (1); Georgitsi, M (1); Adamis, G (1); Antonopoulou, A (1); Chrisofos, M (1); Katsenos, C (1); Kotzampassi, K (1); Koratzanis, G (1); Koupetori, M (1); Kritselis, I (1); Lymberopoulou, K (1); Mandragos, K (1); Marioli, A (1); Sunden-Cullberg, J (1); Mega, A (1); Prekates, A (1); Routsi, C (1); Gogos, C (1); Gogos, J. A. (1); show less...

University: University of Gothenburg (1); Karolinska Institutet (1)

Language: English (2)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

Year: 2012 (2)

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