| 1. |
- Falster, Daniel, et al.
(author)
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AusTraits, a curated plant trait database for the Australian flora
- 2021
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In: Scientific Data. - : Nature Portfolio. - 2052-4463. ; 8:1
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Journal article (peer-reviewed)abstract
- We introduce the AusTraits database - a compilation of values of plant traits for taxa in the Australian flora (hereafter AusTraits). AusTraits synthesises data on 448 traits across 28,640 taxa from field campaigns, published literature, taxonomic monographs, and individual taxon descriptions. Traits vary in scope from physiological measures of performance (e.g. photosynthetic gas exchange, water-use efficiency) to morphological attributes (e.g. leaf area, seed mass, plant height) which link to aspects of ecological variation. AusTraits contains curated and harmonised individual- and species-level measurements coupled to, where available, contextual information on site properties and experimental conditions. This article provides information on version 3.0.2 of AusTraits which contains data for 997,808 trait-by-taxon combinations. We envision AusTraits as an ongoing collaborative initiative for easily archiving and sharing trait data, which also provides a template for other national or regional initiatives globally to fill persistent gaps in trait knowledge.
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| 2. |
- Gross, Sean M., et al.
(author)
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A multi-omic analysis of MCF10A cells provides a resource for integrative assessment of ligand-mediated molecular and phenotypic responses
- 2022
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In: Communications Biology. - : Springer Nature. - 2399-3642. ; 5:1
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Journal article (peer-reviewed)abstract
- The phenotype of a cell and its underlying molecular state is strongly influenced by extracellular signals, including growth factors, hormones, and extracellular matrix proteins. While these signals are normally tightly controlled, their dysregulation leads to phenotypic and molecular states associated with diverse diseases. To develop a detailed understanding of the linkage between molecular and phenotypic changes, we generated a comprehensive dataset that catalogs the transcriptional, proteomic, epigenomic and phenotypic responses of MCF10A mammary epithelial cells after exposure to the ligands EGF, HGF, OSM, IFNG, TGFB and BMP2. Systematic assessment of the molecular and cellular phenotypes induced by these ligands comprise the LINCS Microenvironment (ME) perturbation dataset, which has been curated and made publicly available for community-wide analysis and development of novel computational methods ( synapse.org/LINCS_MCF10A ). In illustrative analyses, we demonstrate how this dataset can be used to discover functionally related molecular features linked to specific cellular phenotypes. Beyond these analyses, this dataset will serve as a resource for the broader scientific community to mine for biological insights, to compare signals carried across distinct molecular modalities, and to develop new computational methods for integrative data analysis.
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| 3. |
- Jiang, Zhe, et al.
(author)
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A high-resilience imprecise computing architecture for mixed-criticality systems
- 2023
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In: IEEE Transactions on Computers. - : IEEE. - 0018-9340 .- 1557-9956. ; 72:1, s. 29-42
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Journal article (peer-reviewed)abstract
- Conventional mixed-criticality systems (MCS)s are designed to terminate the execution of less critical tasks in exceptional situations so that the timing properties of more critical tasks can be preserved. Such a strategy can be controversial and has proven difficult to implement in practice, as it can lead to hazards and reduced functionality due to the absence of the discarded tasks. To mitigate this issue, the imprecise mixed-critically system model (IMCS) has been proposed. In such a model, instead of completely dropping less-critical tasks, these tasks are executed as much as possible through the use of decreased computation precision. Although IMCS could effectively improve the survivability of the less-critical tasks, it also introduces three key drawbacks - run-time computation errors, real-time performance degradation, and lack of flexibility. In this paper, we present a novel IMCS framework, which can (i) mitigate the computation errors caused by imprecise computation; (ii) achieve real-time performance near to that of a conventional MCS; (iii) enhance system-level throughput; and (iv) provide flexibility for run-time configuration. We describe the design details of HIART-MCS, and then present the corresponding theoretical analysis and optimisation method for its run-time configuration. Finally, HIART-MCS is evaluated against other MCS frameworks using a variety of experimental metrics.
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| 4. |
- Jiang, Zhe, et al.
(author)
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NPRC-I/O: a NoC-based real-time I/O system with reduced contention and enhanced predictability
- 2023
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In: IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems. - : IEEE. - 0278-0070 .- 1937-4151. ; , s. 1-1
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Journal article (peer-reviewed)abstract
- All systems rely on inputs and outputs (I/Os) to perceive and interact with their surroundings. In safety-critical systems, it is important to guarantee both the performance and time-predictability of I/O operations. However, with the continued growth of architectural complexity in modern safety-critical systems, satisfying such real-time requirements has become increasingly challenging due to complex I/O transaction paths and extensive hardware contention. In this paper, we present a new NoC-based Predictable I/O system framework (NPRC-I/O) which reduces this contention and ensures the performance and timepredictability of I/O operations. Specifically, NPRC-I/O contains a programmable I/O command controller (NPRC-CC) and a runtime reconfigurable NoC (RNoC), which provides the capability to adjust I/O transaction paths at run-time. Using this flexibility, we construct an end-to-end transmission latency analysis and an optimisation engine that produces configurations for NPRCI/ O and the I/O traffic in a given system. The constructed analysis and optimisation engine guarantee the timing of all hard realtime traffic while reducing the deadline misses of soft real-time traffic and overall transmission latency.
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| 5. |
- Waldschläger, Kryss, et al.
(author)
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Microplastics: What Can We Learn from Clastic Sediments?
- 2023
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In: Springer Water. - : Springer Nature. - 2364-6934 .- 2364-8198. ; , s. 105-116
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Book chapter (other academic/artistic)abstract
- Microplastics research has gained momentum in the 21st century but lags behind the long-standing research on clastic sediment.An interdisciplinary review paper was conducted, comparing microplastics with natural sediments in terms of particle properties, transport processes, sampling techniques, and ecotoxicology. The paper identifies seven research goals to enhance our understanding of microplastics in freshwater environments while learning from sediment research. This extended abstract presents the core message of the review paper, emphasizing the need to improve descriptions of microplastic particles, understand their transport processes, develop standardized sampling methods, and study their ecotoxicological effects. The research goals outline specific tasks to achieve these objectives and emphasize the importance of comparing microplastics to sediments to gain insights into their toxicity. Addressing these research goals will contribute to a comprehensive understanding of microplastics and their impact on freshwater ecosystems. For detailed insights, the original paper should be consulted.
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