| 1. |
- Berndt, Sonja I., et al.
(author)
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Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
- 2013
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 45:5, s. 501-U69
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Journal article (peer-reviewed)abstract
- Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influencing height detected in the distribution tails and 7 new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3 and ZZZ3) for clinical classes of obesity. Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups.
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- Gustafsson, Henrik, 1974-, et al.
(author)
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The mediational role of perceived stress in the relation between optimism and burnout in competitive athletes
- 2012
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In: Anxiety, Stress, and Coping. - Oxon, United Kingdom : Taylor & Francis. - 1061-5806 .- 1477-2205. ; 25:2, s. 183-199
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Journal article (peer-reviewed)abstract
- Burnout has been highlighted as an important issue, not only in occupational settings but also among athletes. Optimists appear to be more resistant to burnout, which might be partly explained by lower levels of stress. The purpose of this study was to investigate the relationship between optimism and burnout symptoms in 217 athletes (139 males and 78 females, aged 16 to 19 years), while also examining stress as a mediator in this relationship. The results showed that optimism had a significant negative relationship with both stress and burnout. Mediation analyses indicated that perceived stress fully mediated the links between optimism and two symptoms of burnout, emotional/physical exhaustion and sport devaluation, and partly mediated the link between optimism and a third symptom, reduced sense of accomplishment. The findings indicate that individual factors, such as optimism, may play an important role in the development of burnout by virtue of their association with stress. Future research should, therefore, investigate the longitudinal effects of optimism on stress and burnout.
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- Gustafsson, Jenny K, 1981, et al.
(author)
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Dynamic changes in mucus thickness and ion secretion during Citrobacter rodentium infection and clearance.
- 2013
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In: PloS one. - : Public Library of Science (PLoS). - 1932-6203. ; 8:12
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Journal article (peer-reviewed)abstract
- Citrobacter rodentium is an attaching and effacing pathogen used as a murine model for enteropathogenic Escherichia coli. The mucus layers are a complex matrix of molecules, and mucus swelling, hydration and permeability are affected by many factors, including ion composition. Here, we used the C. rodentium model to investigate mucus dynamics during infection. By measuring the mucus layer thickness in tissue explants during infection, we demonstrated that the thickness changes dynamically during the course of infection and that its thickest stage coincides with the start of a decrease of bacterial density at day 14 after infection. Although quantitative PCR analysis demonstrated that mucin mRNA increases during early infection, the increased mucus layer thickness late in infection was not explained by increased mRNA levels. Proteomic analysis of mucus did not demonstrate the appearance of additional mucins, but revealed an increased number of proteins involved in defense responses. Ussing chamber-based electrical measurements demonstrated that ion secretion was dynamically altered during the infection phases. Furthermore, the bicarbonate ion channel Bestrophin-2 mRNA nominally increased, whereas the Cftr mRNA decreased during the late infection clearance phase. Microscopy of Muc2 immunostained tissues suggested that the inner striated mucus layer present in the healthy colon was scarce during the time point of most severe infection (10 days post infection), but then expanded, albeit with a less structured appearance, during the expulsion phase. Together with previously published literature, the data implies a model for clearance where a change in secretion allows reformation of the mucus layer, displacing the pathogen to the outer mucus layer, where it is then outcompeted by the returning commensal flora. In conclusion, mucus and ion secretion are dynamically altered during the C. rodentium infection cycle.
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- Kenttä, Göran, et al.
(author)
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From working life to sporting life
- 2013
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In: <em>the 13<sup>th</sup> European Congress of Psychology, Stockholm 9-12 July. </em>.
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Conference paper (peer-reviewed)
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| 14. |
- Lundkvist, Erik, 1978-, et al.
(author)
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An interpretative phenomenological analysis of burnout and recovery in elite soccer coaches
- 2012
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In: Qualitative Research in Sport, Exercise and Health. - Oxon, United Kingdom : Routledge. - 2159-676X .- 2159-6778. ; 4:3, s. 400-419
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Journal article (peer-reviewed)abstract
- Knowledge about the personal experience of burnout in elite coaches is sparse. We therefore studied subjective experiences associated with burnout in a group of elite soccer coaches; specifically how they describe perceived causes of burnout, symptoms and the subsequent recovery process. A qualitative approach was used, because our aim was to study the coaches ’ personal experiences of burnout. We conducted semi-structured interviews and used interpretative phenomenological analysis to analyse the data. We interviewed eight Swedish elite soccer coaches who had previously reported high levels of burnout. We found two burnout profiles that matched the coaches’ perceived causes of burnout. The first was associated with problems in handling the performance culture itself and the second had to do with the overall situation, including workload, family and health. Our findings describe coach burnout as stemming from a combination of issues, related to both home and work. When combined with work overload, coaches who have problems handling the performance culture in elite sports, and who lack the tools to enhance recovery, are particularly vulnerable to burnout.
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| 15. |
- Lundkvist, Erik, 1978-, et al.
(author)
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How to measure coach burnout : an evaluation of three burnout measures
- 2014
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In: Measurement in Physical Education and Exercise Science. - : Taylor & Francis Group. - 1091-367X .- 1532-7841. ; 18:3, s. 209-226
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Journal article (peer-reviewed)abstract
- Although coach burnout has been studied for 30 years, what measure to use in this context has not yet been problematized. This study focuses on evaluating convergent and discriminant validity of three coach burnout measures by using multi-trait/multi-method analysis (CT-C[M-1]) model. We choose Maslach Burnout Inventory (MBI), the two dimensional Oldenburg Burnout Inventory (OLBI), and a coach version of Athlete Burnout Questionnaire (CBQ). Our analysis shows that MBI and OLBI cover similar definitions of exhaustion and depersonalization/disengagement and that CBQ measures somewhat different dimensions. A problem for OLBI is a lack of discriminant validity due to high correlations between exhaustion and disengagement. For lack of personal accomplishment/reduced sense of accomplishment CBQ measures a somewhat different construct than MBI. Although all three measures have advantages and disadvantages, we promote CBQ since it discriminates between dimensions and covers important aspects of burnout in a sports context that the other two do not cover.
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