| 1. |
- Lossow, Stefan, 1977, et al.
(author)
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The SPARC water vapour assessment II: Profile-to-profile comparisons of stratospheric and lower mesospheric water vapour data sets obtained from satellites
- 2019
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In: Atmospheric Measurement Techniques. - : Copernicus GmbH. - 1867-1381 .- 1867-8548. ; 12:5, s. 2693-2732
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Journal article (peer-reviewed)abstract
- This work is distributed under the Creative Commons Attribution 4.0 License. Within the framework of the second SPARC (Stratosphere-troposphere Processes And their Role in Climate) water vapour assessment (WAVAS-II), profile-to-profile comparisons of stratospheric and lower mesospheric water vapour were performed by considering 33 data sets derived from satellite observations of 15 different instruments. These comparisons aimed to provide a picture of the typical biases and drifts in the observational database and to identify data-set-specific problems. The observational database typically exhibits the largest biases below 70 hPa, both in absolute and relative terms. The smallest biases are often found between 50 and 5 hPa. Typically, they range from 0.25 to 0.5 ppmv (5 % to 10 %) in this altitude region, based on the 50 % percentile over the different comparison results. Higher up, the biases increase with altitude overall but this general behaviour is accompanied by considerable variations. Characteristic values vary between 0.3 and 1 ppmv (4 % to 20 %). Obvious data-set-specific bias issues are found for a number of data sets. In our work we performed a drift analysis for data sets overlapping for a period of at least 36 months. This assessment shows a wide range of drifts among the different data sets that are statistically significant at the 2 σ uncertainty level. In general, the smallest drifts are found in the altitude range between about 30 and 10 hPa. Histograms considering results from all altitudes indicate the largest occurrence for drifts between 0.05 and 0.3 ppmv decade-1. Comparisons of our drift estimates to those derived from comparisons of zonal mean time series only exhibit statistically significant differences in slightly more than 3 % of the comparisons. Hence, drift estimates from profile-to-profile and zonal mean time series comparisons are largely interchangeable. As for the biases, a number of data sets exhibit prominent drift issues. In our analyses we found that the large number of MIPAS data sets included in the assessment affects our general results as well as the bias summaries we provide for the individual data sets. This is because these data sets exhibit a relative similarity with respect to the remaining data sets, despite the fact that they are based on different measurement modes and different processors implementing different retrieval choices. Because of that, we have by default considered an aggregation of the comparison results obtained from MIPAS data sets. Results without this aggregation are provided on multiple occasions to characterise the effects due to the numerous MIPAS data sets. Among other effects, they cause a reduction of the typical biases in the observational database.
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| 2. |
- Padavala, Balabalaji, et al.
(author)
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Cubic boron phosphide epitaxy on zirconium diboride
- 2018
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In: Journal of Crystal Growth. - : ELSEVIER SCIENCE BV. - 0022-0248 .- 1873-5002. ; 483, s. 115-120
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Journal article (peer-reviewed)abstract
- Cubic boron phosphide (BP) is one of the least studied III-V compound semiconductors, in part because it is difficult to prepare in high quality form. In this study, zirconium diboride (ZrB2) was studied as a potential substrate for BP epitaxial layers, because of its advantages of a low lattice constant mismatch and high thermal stability. Two types of substrates were considered: ZrB2(0001) epitaxial films on 4H-SiC (0001) and bulk ZrB2(0001) single crystals. The optimal temperature for epitaxy on these substrates was 1100 degrees C; higher and lower temperatures resulted in polycrystalline films. The BP film/ZrB2 interface was abrupt as confirmed by cross-sectional transmission electron microscopy, attesting to the stability of ZrB2 under BP deposition conditions. The BP films were under compressive and tensile strain on ZrB2 and ZrB2/4H-SiC substrates, respectively, as determined by Raman spectroscopy, due to differences in the substrate/film coefficients of thermal expansion. This study suggests that with further optimization, ZrB2 can be an excellent substrate for BP epitaxial films. (C) 2017 Elsevier B.V. All rights reserved.
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| 3. |
- Richter, Hans, 1961-, et al.
(author)
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A Comparison of Mental and Visual Load Resulting from Semi-automated and Conventional Forest Forwarding : An Experimental Machine Simulation Study
- 2019. - 827
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In: Proceedings of the 20th Congress of the International Ergonomics Association (IEA 2018). - Cham : Springer International Publishing. - 9783319960586 - 9783319960593 ; , s. 199-208
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Conference paper (peer-reviewed)abstract
- The purpose of the present study was to extend the knowledge offunctional linkages between visual and mental load, performance, and prefrontalcortex (PFC) activity, during forestry forwarding work. Eleven healthy participants,range 21–51 years old, with a minimum of 1-year work experience,carried out the task of loading logs along a standardized path in a machinesimulator during two counterbalanced test conditions: (i) conventional cranecontrol, and; (ii) semi-automated crane control. Mental load was assessed byquantification of oxygenated hemoglobin (HbO2) concentration changes overthe right dorsolateral prefrontal cortex (dlPFC) via non-invasive functional nearinfrared spectrometry (fNIRS). Visual, autonomic, and motoric control variableswere measured and analyzed in parallel along with the individual level of performance.Linear Mixed Models (LMM) analysis indicated more mental loadduring conventional crane work. Collectively, our data suggest that fNIRS is aviable tool which can be used in neuroergonomic research to evaluate physiologicalactivity levels in PFC.
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| 4. |
- Dahm-Kähler, Pernilla, 1964, et al.
(author)
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Population-based study of survival for women with serous cancer of the ovary, fallopian tube, peritoneum or undesignated origin - on behalf of the Swedish gynecological cancer group (SweGCG)
- 2017
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In: Gynecologic Oncology. - : Elsevier BV. - 0090-8258 .- 1095-6859. ; 144:1, s. 167-173
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Journal article (peer-reviewed)abstract
- Objective. The aim of the study was to determine survival outcome in patients with serous cancer in the ovary, fallopian tube, peritoneum and of undesignated origin. Methods. Nation-wide population-based study of women 18 years with histologically verified non-uterine serous cancer, included in the Swedish Quality Registry for primary cancer of the ovary, fallopian tube and peritoneum diagnosed 2009-2013. Relative survival (RS) was estimated using the Ederer II method. Simple and multivariable analyses were estimated by Poisson regression models. Results. Of 5627 women identified, 1246 (22%) had borderline tumors and 4381 had malignant tumors. In total, 2359 women had serous cancer; 71% originated in the ovary (OC), 9% in the fallopian tube (FTC), 9% in the peritoneum (PPC) and 11% at an undesignated primary site (UPS). Estimated RS at 5-years was 37%; for FTC 54%, 40% for OC, 34% for PPC and 13% for UPS. In multivariable regression analyses restricted to women who had undergone primary or interval debulldng surgery for OC, FTC and PPC, site of origin was not independently associated with survival. Significant associations with worse survival were found for advanced stages (RR 2.63, P<0.001), moderate (RR 1.90, P<0.047) and poor differentiation (RR 2.20, P<0.009), neoadjuvant chemotherapy (RR1.33, P<0.022), residual tumor (RR 2.65, P<0.001) and platinum single (2.34, P<0.001) compared to platinum combination chemotherapy. Conclusion. Survival was poorer for serous cancer at UPS than for ovarian, fallopian tube and peritoneal cancer. Serous cancer at UPS needs to be addressed when reporting and comparing survival rates of ovarian cancer. (C) 2016 Elsevier Inc. All rights reserved.
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| 5. |
- Högberg, D., et al.
(author)
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Liquid-crystalline dye-sensitized solar cells : Design of two-dimensional molecular assemblies for efficient ion transport and thermal stability
- 2016
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In: Chemistry of Materials. - : American Chemical Society (ACS). - 0897-4756 .- 1520-5002. ; 28:18, s. 6493-6500
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Journal article (peer-reviewed)abstract
- Nanostructured liquid-crystalline (LC) electrolytes have been developed for efficient and stable quasi-solid-state dye-sensitized solar cells (DSSCs). Two types of ionic LC assemblies for electrolytes have been designed: (i) noncovalent assemblies of two-component mixtures consisting of I2-doped imidazolium ionic liquids and carbonate-terminated mesogenic compounds (noncovalent type) and (ii) single-component mesogenic compounds covalently bonding an imidazolium moiety doped with I2 (covalent type). These mesogenic compounds are designed with flexible oligooxyethylene spacers connecting the mesogenic and the polar moieties. The oligooxyethylene-based material design inhibits crystallization and leads to enhanced ion transport as compared to alkyl-linked analogues due to the higher flexibility of the oligooxyethylene spacer. The noncovalent type mixtures exhibit a more than 10 times higher I3- diffusion coefficient compared to the covalent type assemblies. DSSCs containing the noncovalent type liquid crystals show power conversion efficiencies (PCEs) of up to 5.8 ± 0.2% at 30 °C and 0.9 ± 0.1% at 120 °C. In contrast, solar cells containing the covalent type electrolytes show significant increase in PCE up to 2.4 ± 0.1% at 120 °C and show superior performance to the noncovalent type-based devices at temperature above 90 °C. Furthermore, the LC-DSSCs exhibit excellent long-term stability over 1000 h. These novel electrolyte designs open unexplored paths for the development of DSSCs capable of efficient conversion of light to electricity in a wide range of temperatures.
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| 7. |
- Myléus, Anna, MD PhD, et al.
(author)
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Questionnaire showed that Swedish paediatric clinics complied well with the revised European guidelines for diagnosing coeliac disease
- 2019
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In: Acta Paediatrica. - : John Wiley & Sons. - 0803-5253 .- 1651-2227. ; 108:6, s. 1140-1143
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Journal article (peer-reviewed)abstract
- Aim: In 2012, revised criteria for diagnosing childhood coeliac disease were published by the European Society for Paediatric Gastroenterology, Hepatology and Nutrition and incorporated into the revised Swedish guidelines the same year. These made it possible, in certain cases, to diagnose coeliac disease without taking small bowel biopsies. This survey assessed the extent to which the new guidelines were implemented by Swedish paediatric clinics two years after their introduction.Methods: In October 2014, we distributed a paper questionnaire including five questions on diagnostic routines to the 40 paediatric clinics in university or regional hospitals in Sweden that perform small bowel biopsies.Results: All 36 (90%) clinics that responded used anti-tissue transglutaminase antibodies as the initial diagnostic test and some also used serological markers. Most clinics (81%) used endoscopy and took multiple duodenal biopsies, whereas only a few (19%) occasionally employed a suction capsule. Almost all clinics (86%) omitted taking small bowel biopsies in symptomatic children with repeatedly high coeliac serology and positive genotyping, thereby avoiding the need for invasive endoscopy under anaesthesia.Conclusion: The 2012 Swedish Paediatric Coeliac Disease Diagnostic Guidelines had been widely accepted and implemented in routine health care two years after their introduction.
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| 8. |
- Nardo, D., et al.
(author)
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Neurobiology of sleep disturbances in PTSD patients and traumatized controls: MRI and SPECT findings
- 2015
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In: Frontiers in Psychiatry. - : Frontiers Media SA. - 1664-0640. ; 6:SEP
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Journal article (peer-reviewed)abstract
- Objective: Sleep disturbances such as insomnia and nightmares are core components of post-traumatic stress disorder (PTSD), yet their neurobiological relationship is still largely unknown. We investigated brain alterations related to sleep disturbances in PTSD patients and controls by using both structural and functional neuroimaging techniques. Method: Thirty-nine subjects either developing (n = 21) or not developing (n = 18) PTSD underwent magnetic resonance imaging and a symptom-provocation protocol followed by the injection of 99mTc-hexamethylpropyleneamineoxime. Subjects were also tested with diagnostic and self-rating scales on the basis of which a Sleep Disturbances Score (SDS; i.e., amount of insomnia/nightmares) was computed. Results: Correlations between SDS and gray matter volume (GMV)/regional cerebral blood flow (rCBF) were computed in the whole sample and separately in the PTSD and control groups. In the whole sample, higher sleep disturbances were associated with significantly reduced GMV in amygdala, hippocampus, anterior cingulate, and insula; increased rCBF in midbrain, precuneus, and insula; and decreased rCBF in anterior cingulate. This pattern was substantially confirmed in the PTSD group, but not in controls. Conclusion: Sleep disturbances are associated with GMV loss in anterior limbic/paralimbic, PTSD-sensitive structures and with functional alterations in regions implicated in rapid eye movement-sleep control, supporting the existence of a link between PTSD and sleep disturbance. © 2015 Nardo, Högberg, Jonsson, Jacobsson, Hällström and Pagani.
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| 9. |
- Richter, Hans, 1961-, et al.
(author)
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A comparison of mental and visual loads resulting from semi-automated and conventional forest harvesting : An experimental machine simulation study
- 2018
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In: FALF Konferens 2018: Arbetet - problem eller potential för en hållbar livsmiljö?. - Gävle : Gävle Universtiy Press. - 9789188145284 ; , s. 96-
-
Conference paper (other academic/artistic)abstract
- This study is concerned with a new method for partly automating forestry harvesting work. Work-related injuries and constant demands for a higher productivity are two of the many arguments for why forestry work must be improved. Forestry work places great mental demands on the driver because they must continuously evaluate and act on relevant parts in a heavy visual information flow. Against this background the purpose of the present study was to extend the knowledge of functional linkages between visual and mental fatigue, performance, and prefrontal cortex activity, during semi-automated and conventional forestry harvesting work. Eleven healthy participants, range 21–51 years old, with a minimum of 1-year work experience, carried out the task of loading logs along a standardized path in a machine simulator during two counterbalanced 45-min periods: (i) conventional forest harvesting, and; (ii) semi-automated forest harvesting. Equal emphasizes was put on accuracy and speed. During manual forest harvesting the driver controlled the crane arm, used to load logs into the load space of the forest vehicle (“forwarder”), by manually operating the joysticks and so guide the crane to the location of the log and then back to the load space. During semi-automatic forest harvesting the driver moved the crane with the press of a button to a pre-programmed location near the log and then, after another button press, to a pre-programmed location within the load space. The following joystick usage parameters were considered for the statistical analysis: Sequential work cycle number, work phase (1-loading in basket, 2-movement to log, 3-picking up log, 4-movement to load space), number of simultaneously used controls across samples of one phase, number of direction changes of joystick movements per phase. Mental load was assessed by quantification of oxygenated hemoglobin (HbO2) concentration changes over the right dorsolateral prefrontal cortex (dlPFC) via non-invasive functional near infrared spectrometry (fFNIRS: PortaLite mini, Artinis Medical Systems, Zetten, the Netherlands). The frequency and duration of horizontal amplitudes of eye/head/neck angles was assessed continuously with 8 SmartEye cameras and used as a measure of visual load. NASA-TLX and Borg CRS was used to assess perceived mental and physical fatigue. Linear Mixed Model will be used to test and to analyze the effect of the duration of work, joystick usage, work type (manual or semi-automated) and perceived mental and physical effort on the outcome of oxygenated hemoglobin concentration. This study contributes with new knowledge of the consequences of the current increase in automation. The 4th industrial revolution can have tremendous implications on how we perceive and organize work in the future, but little is still known about the impact on human body and brain.
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| 11. |
- Stålberg, Karin, et al.
(author)
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Risk factors for lymph node metastases in women with endometrial cancer: A population-based, nation-wide register study - On behalf of the Swedish Gynecological Cancer Group
- 2017
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In: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 140:12, s. 2693-2700
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Journal article (peer-reviewed)abstract
- The role of lymphadenectomy in the management of early endometrial cancer remains controversial. In the recent ESMO-ESGO-ESTRO guidelines, lymphadenectomy is recommended for patients with endometrioid adenocarcinoma Grade 3 with deep myometrial invasion, but complete agreement was not achieved. In Sweden, DNA aneuploidy has been included as a high-risk factor. The aim of our study was to evaluate the impact of tumor histology, FIGO grade, DNA ploidy and myometrial invasion (MI) on occurrence of lymph node metastasis (LNM) in patients with endometrial cancer. The study design is a retrospective cohort study based on prospectively recorded register data. Endometrial cancer patients registered in the Swedish Quality Registry for Gynecologic Cancer 2010-2015 with FIGO Stages I-III and verified nodal status were included. Data on DNA ploidy, histology, FIGO grade and MI were included in multivariable log-binomial regression analyses with LNM as dependent variable. 1,165 cases fulfilled the inclusion criteria. The multivariable analyses revealed increased risk of LNM in patients with tumors with MI50% (risk ratio [RR]=4.1; 95% confidence interval [CI] 3.0-5.6), nonendometrioid compared to endometrioid histology (RR 1.8; CI 1.4-2.4) and FIGO Grade 3 compared to Grade 1-2 tumors (RR 1.5; CI 1.1-2.0). No statistically significant association between DNA ploidy status and LNM was detected. This population-based, nation-wide study in women with endometrial cancer confirms a strong association between MI50%, nonendometrioid histology and FIGO Grade 3, respectively, and LNM. DNA ploidy should not be included in the preoperative decision making of removing nodes or not. What's new? Whether lymphadenectomy is beneficial for women with endometrial cancer remains uncertain. Moreover, additional studies are needed to explore factors that reliably predict lymph node metastasis (LNM). Here, multiple factors, including tumor histology, grade of differentiation and DNA aneuploidy, were evaluated for associations with LNM risk in women with endometrial cancer and verified lymph node status. Most significantly, deep myometrial invasion in tumors increased LNM risk fourfold, whereas DNA ploidy had essentially no impact on LNM risk. The findings confirm the predictive relevance of myometrial invasion, histology and grade reported in previous single-center and multicenter studies.
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