| 1. |
- Stroth, U., et al.
(author)
-
Progress from ASDEX Upgrade experiments in preparing the physics basis of ITER operation and DEMO scenario development
- 2022
-
In: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 62:4
-
Journal article (peer-reviewed)abstract
- An overview of recent results obtained at the tokamak ASDEX Upgrade (AUG) is given. A work flow for predictive profile modelling of AUG discharges was established which is able to reproduce experimental H-mode plasma profiles based on engineering parameters only. In the plasma center, theoretical predictions on plasma current redistribution by a dynamo effect were confirmed experimentally. For core transport, the stabilizing effect of fast ion distributions on turbulent transport is shown to be important to explain the core isotope effect and improves the description of hollow low-Z impurity profiles. The L-H power threshold of hydrogen plasmas is not affected by small helium admixtures and it increases continuously from the deuterium to the hydrogen level when the hydrogen concentration is raised from 0 to 100%. One focus of recent campaigns was the search for a fusion relevant integrated plasma scenario without large edge localised modes (ELMs). Results from six different ELM-free confinement regimes are compared with respect to reactor relevance: ELM suppression by magnetic perturbation coils could be attributed to toroidally asymmetric turbulent fluctuations in the vicinity of the separatrix. Stable improved confinement mode plasma phases with a detached inner divertor were obtained using a feedback control of the plasma β. The enhanced D α H-mode regime was extended to higher heating power by feedback controlled radiative cooling with argon. The quasi-coherent exhaust regime was developed into an integrated scenario at high heating power and energy confinement, with a detached divertor and without large ELMs. Small ELMs close to the separatrix lead to peeling-ballooning stability and quasi continuous power exhaust. Helium beam density fluctuation measurements confirm that transport close to the separatrix is important to achieve the different ELM-free regimes. Based on separatrix plasma parameters and interchange-drift-Alfvén turbulence, an analytic model was derived that reproduces the experimentally found important operational boundaries of the density limit and between L- and H-mode confinement. Feedback control for the X-point radiator (XPR) position was established as an important element for divertor detachment control. Stable and detached ELM-free phases with H-mode confinement quality were obtained when the XPR was moved 10 cm above the X-point. Investigations of the plasma in the future flexible snow-flake divertor of AUG by means of first SOLPS-ITER simulations with drifts activated predict beneficial detachment properties and the activation of an additional strike point by the drifts.
|
|
| 2. |
- Shupe, M. D., et al.
(author)
-
Overview of the MOSAiC expedition : Atmosphere
- 2022
-
In: Elementa. - : University of California Press. - 2325-1026. ; 10:1
-
Journal article (peer-reviewed)abstract
- With the Arctic rapidly changing, the needs to observe, understand, and model the changes are essential. To support these needs, an annual cycle of observations of atmospheric properties, processes, and interactions were made while drifting with the sea ice across the central Arctic during the Multidisciplinary drifting Observatory for the Study of Arctic Climate (MOSAiC) expedition from October 2019 to September 2020. An international team designed and implemented the comprehensive program to document and characterize all aspects of the Arctic atmospheric system in unprecedented detail, using a variety of approaches, and across multiple scales. These measurements were coordinated with other observational teams to explore crosscutting and coupled interactions with the Arctic Ocean, sea ice, and ecosystem through a variety of physical and biogeochemical processes. This overview outlines the breadth and complexity of the atmospheric research program, which was organized into 4 subgroups: atmospheric state, clouds and precipitation, gases and aerosols, and energy budgets. Atmospheric variability over the annual cycle revealed important influences from a persistent large-scale winter circulation pattern, leading to some storms with pressure and winds that were outside the interquartile range of past conditions suggested by long-term reanalysis. Similarly, the MOSAiC location was warmer and wetter in summer than the reanalysis climatology, in part due to its close proximity to the sea ice edge. The comprehensiveness of the observational program for characterizing and analyzing atmospheric phenomena is demonstrated via a winter case study examining air mass transitions and a summer case study examining vertical atmospheric evolution. Overall, the MOSAiC atmospheric program successfully met its objectives and was the most comprehensive atmospheric measurement program to date conducted over the Arctic sea ice. The obtained data will support a broad range of coupled-system scientific research and provide an important foundation for advancing multiscale modeling capabilities in the Arctic.
|
|
| 3. |
- Klonoff, D. C., et al.
(author)
-
A Glycemia Risk Index (GRI) of Hypoglycemia and Hyperglycemia for Continuous Glucose Monitoring Validated by Clinician Ratings
- 2022
-
In: Journal of Diabetes Science and Technology. - : SAGE Publications. - 1932-2968.
-
Journal article (peer-reviewed)abstract
- Background: A composite metric for the quality of glycemia from continuous glucose monitor (CGM) tracings could be useful for assisting with basic clinical interpretation of CGM data. Methods: We assembled a data set of 14-day CGM tracings from 225 insulin-treated adults with diabetes. Using a balanced incomplete block design, 330 clinicians who were highly experienced with CGM analysis and interpretation ranked the CGM tracings from best to worst quality of glycemia. We used principal component analysis and multiple regressions to develop a model to predict the clinician ranking based on seven standard metrics in an Ambulatory Glucose Profile: very low–glucose and low-glucose hypoglycemia; very high–glucose and high-glucose hyperglycemia; time in range; mean glucose; and coefficient of variation. Results: The analysis showed that clinician rankings depend on two components, one related to hypoglycemia that gives more weight to very low-glucose than to low-glucose and the other related to hyperglycemia that likewise gives greater weight to very high-glucose than to high-glucose. These two components should be calculated and displayed separately, but they can also be combined into a single Glycemia Risk Index (GRI) that corresponds closely to the clinician rankings of the overall quality of glycemia (r = 0.95). The GRI can be displayed graphically on a GRI Grid with the hypoglycemia component on the horizontal axis and the hyperglycemia component on the vertical axis. Diagonal lines divide the graph into five zones (quintiles) corresponding to the best (0th to 20th percentile) to worst (81st to 100th percentile) overall quality of glycemia. The GRI Grid enables users to track sequential changes within an individual over time and compare groups of individuals. Conclusion: The GRI is a single-number summary of the quality of glycemia. Its hypoglycemia and hyperglycemia components provide actionable scores and a graphical display (the GRI Grid) that can be used by clinicians and researchers to determine the glycemic effects of prescribed and investigational treatments.
|
|
| 4. |
- Abramowicz, H., et al.
(author)
-
Conceptual design report for the LUXE experiment
- 2021
-
In: European Physical Journal-Special Topics. - : Springer Science and Business Media LLC. - 1951-6355 .- 1951-6401. ; 230:11, s. 2445-2560
-
Journal article (peer-reviewed)abstract
- This Conceptual Design Report describes LUXE (Laser Und XFEL Experiment), an experimental campaign that aims to combine the high-quality and high-energy electron beam of the European XFEL with a powerful laser to explore the uncharted terrain of quantum electrodynamics characterised by both high energy and high intensity. We will reach this hitherto inaccessible regime of quantum physics by analysing high-energy electron-photon and photon-photon interactions in the extreme environment provided by an intense laser focus. The physics background and its relevance are presented in the science case which in turn leads to, and justifies, the ensuing plan for all aspects of the experiment: Our choice of experimental parameters allows (i) field strengths to be probed where the coupling to charges becomes non-perturbative and (ii) a precision to be achieved that permits a detailed comparison of the measured data with calculations. In addition, the high photon flux predicted will enable a sensitive search for new physics beyond the Standard Model. The initial phase of the experiment will employ an existing 40 TW laser, whereas the second phase will utilise an upgraded laser power of 350 TW. All expectations regarding the performance of the experimental set-up as well as the expected physics results are based on detailed numerical simulations throughout.
|
|
| 5. |
- Alexander, Stephen P. H., et al.
(author)
-
The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors
- 2023
-
In: BRITISH JOURNAL OF PHARMACOLOGY. - : British pharmacological society. - 0007-1188 .- 1476-5381. ; 180
-
Journal article (peer-reviewed)abstract
- The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes almost 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at . G protein-coupled receptors are one of the six major pharmacological targets into which the Guide is divided, with the others being: ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2023, and supersedes data presented in the 2021/22, 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.
|
|
| 6. |
- Bai, Z., et al.
(author)
-
New physics searches with an optical dump at LUXE
- 2022
-
In: Physical Review D. - 2470-0010. ; 106:11
-
Journal article (peer-reviewed)abstract
- We propose a novel way to search for feebly interacting massive particles, exploiting two properties of systems involving collisions between high energy electrons and intense laser pulses. The first property is that the electron-laser collision results in a large flux of hard photons, as the laser behaves effectively as a thick medium. The second property is that the emitted photons free-stream inside the laser and thus for them the laser behaves effectively as a very thin medium. Combining these two features implies that the electron-intense-laser collision is an apparatus, which can efficiently convert O(10 GeV) electrons to a large flux of hard, collinear photons. The photons are directed onto a solid dump in which feebly interacting massive particles may be produced. With the much smaller backgrounds induced by the photon beam compared to those expected in electron- or proton-beam dump experiments and combined with a relatively shorter dump used here, the sensitivity to short lifetimes is unparalleled. We denote this novel apparatus as "optical dump"or NPOD (new physics search with optical dump). The proposed LUXE experiment at the European XFEL has all the basic required ingredients to realize this experimental concept for the first time. Moreover, the NPOD extension of LUXE is essentially parasitic to the main experiment and thus, practically it does not have any bearing on its main program. We discuss how the NPOD concept can be realized in practice by adding a detector after the last physical dump of the experiment to reconstruct the two-photon decay of a new spin-0 particle. We show that even with a relatively short dump, the search can still be background-free. Remarkably, even with a few days of data taking with a 40 TW laser corresponding to its initial run, LUXE-NPOD will be able to probe an uncharted territory of models with pseudoscalars and scalars. Furthermore, with a 350 TW laser of the main run, LUXE-NPOD will have a unique reach for these models. In particular it can probe natural scalar theories for masses above 100 MeV. We note that the new NPOD concept may be ported to other existing or future facilities worldwide, including, e.g., future lepton colliders.
|
|
| 7. |
- Christopoulos, Arthur, et al.
(author)
-
THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors.
- 2021
-
In: British journal of pharmacology. - : Wiley. - 1476-5381 .- 0007-1188. ; 178 Suppl 1
-
Research review (peer-reviewed)abstract
- The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes over 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/bph.15538. G protein-coupled receptors are one of the six major pharmacological targets into which the Guide is divided, with the others being: ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2021, and supersedes data presented in the 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.
|
|
| 8. |
|
|
| 9. |
|
|
| 10. |
- Becker, K, et al.
(author)
-
Real world data on symptomology and diagnostic approaches of 27,840 women living with endometriosis
- 2021
-
In: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 11:1, s. 20404-
-
Journal article (peer-reviewed)abstract
- Endometriosis is a chronic disease that requires a suitable, lifelong treatment. To our knowledge, the Visanne Post-approval Observational Study (VIPOS) is to date the largest real-world, non-interventional study investigating hormonal management of endometriosis. We describe women’s experiences of endometriosis in the real world by considering their symptoms and the diagnostic process in their healthcare setting. Overall, 27,840 women were enrolled from six European countries via networks of gynecologists or specialized centers. Of these, 87.8% of women were diagnosed based on clinical symptoms; the greatest and lowest proportions of women were in Russia (94.1%) and Germany (61.9%), respectively. Most women (82.8%) experienced at least one of the triad of endometriosis-associated pain symptoms: pelvic pain, pain after/during sexual intercourse, and painful menstrual periods. The most frequently reported endometriosis-associated symptoms were painful periods (61.8%), heavy/irregular bleeding (50.8%), and pelvic pain (37.2%). Women reported that endometriosis impacted their mood; 55.6% reported feeling “down”, depressed, or hopeless, and 53.2% reported feeling like a failure or having let down family/friends. VIPOS broadens our understanding of endometriosis based on real-world data by exploring the heterogeneity of symptoms women with endometriosis experience and the differences in diagnostic approaches between European countries.Trial registration: ClinicalTrials.gov, NCT01266421; registered 24 December 2010. Registered in the European Union electronic Register of Post-Authorisation Studies as number 1613.
|
|
| 11. |
- Capitanio, L., et al.
(author)
-
EREBUS: the EuRopean Extinction BUmp Survey
- 2020
-
In: Experimental astronomy. - : Springer. - 0922-6435 .- 1572-9508. ; 50:1, s. 145-158
-
Journal article (peer-reviewed)abstract
- Dust in the Interstellar Medium (ISM) is intimately linked to the life cycle of stars. Despite being of such fundamental importance to galaxy evolution, the dynamic behaviour and composition of the ISM are not yet fully understood. Observations of reddened Milky Way OB stars have revealed a strong UV extinction feature around 2175 Å and a precipitous extinction rise to the far UV along the lines of sight. Whilst the carrier(s) for this are at present still being debated, multiple laboratory studies suggest carbonate grains to be the key constituent. EREBUS is a mission concept being developed to study the composition of the ISM in both the Milky Way and Local Group Galaxies, primarily by mapping the spatial distribution of the UV extinction features. As these features are sensitive to the dust composition along the line of sight, EREBUS will provide a wealth of information about the spatial distribution and dynamic behaviour of the carrier(s). The mission proposes to deploy a satellite observatory equipped with a coarse UV spectrograph to map the extinction curve variability in the Milky Way in 3 dimensions and in the Local Group in 2 dimensions. In this paper, we discuss the scientific goals for the project, discuss a proposed observation strategy using an iterative process to develop a hierarchical map, and finally outline the instrument requirements and preliminary spacecraft architecture.
|
|
| 12. |
|
|
| 13. |
|
|
| 14. |
|
|
| 15. |
|
|
| 16. |
- Schwab, M. B., et al.
(author)
-
Visualization of relativistic laser pulses in underdense plasma
- 2020
-
In: Physical Review Accelerators and Beams. - 2469-9888. ; 23:2
-
Journal article (peer-reviewed)abstract
- We present experimental evidence of relativistic electron-cyclotron resonances (RECRs) in the vicinity of the relativistically intense pump laser of a laser wakefield accelerator (LWFA). The effects of the RECRs are visualized by imaging the driven plasma wave with a few-cycle, optical probe in transverse geometry. The probe experiences strong, spectrally dependent and relativistically modified birefringence in the vicinity of the pump that arises due to the plasma electrons' relativistic motion in the pump's electromagnetic fields. The spectral birefringence is strongly dependent on the local magnetic field distribution of the pump laser. Analysis and comparison to both 2D and 3D particle-in-cell simulations confirm the origin of the RECR effect and its appearance in experimental and simulated shadowgrams of the laser-plasma interaction. The RECR effect is relevant for any relativistic, magnetized plasma and in the case of LWFA could provide a nondestructive, in situ diagnostic for tracking the evolution of the pump's intensity distribution with propagation through tenuous plasma.
|
|
| 17. |
|
|
| 18. |
|
|
| 19. |
- Wang, Xinjiao, et al.
(author)
-
Paramagnetic iron-containing ionic liquid crystals
- 2020
-
In: Journal of Molecular Liquids. - : Elsevier BV. - 0167-7322 .- 1873-3166. ; 304
-
Journal article (peer-reviewed)abstract
- Iron-containing ionic liquid crystals of N,N'-dialkylimidazolium salts ([(CnH2n+1)(2)IM](3)[Fe(CN)(6)], with n = 12 (1), 14 (2), 16 (3), 18 (4), IM = imidazolium) were prepared and their structures and properties were characterized. Differential scanning calorimetry (DSC), polarizing optical microscopy (POM) as well as powder X-ray diffraction (PXRD) analysis reveal for all compounds thermotropic liquid crystalline behavior. The observed textures point to smectic A and smectic X phases. The crystal structure of the solvate [C12C12IM](3)[Fe(CN)(6)].2 DMSO (DMSO = dimethylsulfoxide) was examined by single crystal X-ray diffraction analysis which reveals two crystallographically independent [ C12C12IM](+) cations with different conformation, U-shape and rod-shape, together with a nearly ideal octahedral [Fe(CN)(6)](3-) anion and two DMSO solvent molecules. The crystal packing is characterized by alternating bilayers of almost linearly arranged imidazolium cations with the U-shaped cations being arranged in a head-to-head fashion and the cations' hydrophobic dodecyl chains being interdigitated. Magnetic measurements for compounds 1-4 show paramagnetic moments, mu(eff), of similar to 1.7 mu(B), which are close to the theoretically expected value for a d(5) low-spin Fe3+ spin-only S = 1/2 system (mu(s.o.)(eff) = 1.73 mu(B)). It was possible to obtain an Fe3+ containing ILC material that combines liquid crystalline behavior over a large mesophase window (from 33 degrees C to 170 degrees C) with high magnetic susceptibility by mixing compound 3 with [C16C16IM][FeCl4] (5), which contains the d(5) high-spin Fe3+ ion (S = 5/2). All compounds are highly hydrophobic and stable in the atmosphere indicating a great potential of applications as functional materials.
|
|
| 20. |
- Werdan, K., et al.
(author)
-
Curriculum Kardiologie 2., aktualisierte Auflage
- 2020
-
In: KARDIOLOGE. - : SPRINGER HEIDELBERG. - 1864-9718 .- 1864-9726. ; 14:6, s. 505-536
-
Journal article (peer-reviewed)abstract
- The updated second edition of the "Curriculum cardiology", first edition 2013, aims to show which competences a cardiologist should nowadays master. It is very pleasing that in this second edition representatives of the Young German Cardiac Society (Young DGK) have contributed as authors. The increasing specialization within cardiology should, however, only represent one side of the coin: there must also still be a common foundation of cardiology, embedded in the discipline "internal medicine". This foundation includes the basis of theoretical knowledge, practical skills (competence levels I-III) and an occupational and professional attitude of the (prospective) cardiologist. New additions to the advanced training since the first edition of the curriculum in 2013 are, for example a chapter on digital cardiology, the further training in psychocardiology, which was newly introduced into the model further training regulations and finally also the explicit formulation of shared decision making in the interests of cardiac patients. The curriculum should give the prospective cardiologist the possibility to structure the further training as efficiently as possible and ultimately to retain and expand that which has been learned in the sense of a "professional lifelong" qualification. The curriculum also aims to reach the trainers and the Medical Councils and demonstrate which contents and skills should be mediated in the further training to become a cardiologist from the perspective of the German Cardiac Society (DGK).
|
|
