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1.	Depledge, D. P., et al. (author) High Viral Diversity and Mixed Infections in Cerebral Spinal Fluid from Cases of Varicella Zoster Virus Encephalitis 2018 In: Journal of Infectious Diseases. - : Oxford University Press (OUP). - 0022-1899 .- 1537-6613. ; 218:10, s. 1592-1601 Journal article (peer-reviewed)abstract Background. Varicella zoster virus (VZV) may cause encephalitis, both with and without rash. Here we investigate whether viruses recovered from the central nervous system (CNS; encephalitis or meningitis) differ genetically from those recovered from non-CNS samples. Methods. Enrichment-based deep sequencing of 45 VZV genomes from cerebral spinal fluid (CSF), plasma, bronchoalveolar lavage (BAL), and vesicles was carried out with samples collected from 34 patients with and without VZV infection of the CNS. Results. Viral sequences from multiple sites in the same patient were identical at the consensus level. Virus from vesicle fluid and CSF in cases of meningitis showed low-level diversity. By contrast, plasma, BAL, and encephalitis had higher numbers of variant alleles. Two CSF-encephalitis samples had high genetic diversity, with variant frequency patterns typical of mixed infections with different clades. Conclusions. Low viral genetic diversity in vesicle fluid is compatible with previous observations that VZV skin lesions arise from single or low numbers of virions. A similar result was observed in VZV from cases of VZV meningitis, a generally self-limiting infection. CSF from cases of encephalitis had higher diversity with evidence for mixed clade infections in 2 cases. We hypothesize that reactivation from multiple neurons may contribute to the pathogenesis of VZV encephalitis.
2.	Mavian, C, et al. (author) Sampling bias and incorrect rooting make phylogenetic network tracing of SARS-COV-2 infections unreliable 2020 In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 1091-6490. ; 117:23, s. 12522-12523 Journal article (other academic/artistic)

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Type of publication: journal article (2)

Type of content: other academic/artistic (1); peer-reviewed (1)

Author/Editor: Albert, J. (1); Zhang, Y. (1); Martin, D (1); Bergström, Tomas, 19 ... (1); Vandamme, AM (1); Solomon, T. (1); show more...; Kundu, S (1); Leitner, T (1); Salemi, M. (1); Prosperi, M (1); Brown, J. R. (1); Milne, R. (1); Scheuermann, RH (1); Scarpino, SV (1); Norberg, Peter, 1974 (1); Marini, S (1); Stadler, T. (1); Neher, RA (1); Goldstein, R. (1); Atkinson, C (1); Depledge, D. P. (1); Cudini, J. (1); Haque, T. (1); Houldcroft, C. J. (1); Koay, Evelyn S. (1); McGill, F. (1); Whitfield, T. (1); Tang, J. W. (1); Underhill, G. (1); Breuer, J. (1); Abecasis, A (1); Boucher, C (1); Stamatakis, A. (1); Grubaugh, ND (1); Baele, G (1); Lemey, P (1); Wilkinson, E (1); Mavian, C (1); Pond, SK (1); Magalis, BR (1); Dellicour, S (1); Houldcroft, C (1); Villabona-Arenas, J (1); Paisie, TK (1); Trovao, NS (1); Gascuel, O (1); Lam, TTY (1); Suchard, MA (1); de Oliveira, TD (1); Bento, AI (1); show less...

University: University of Gothenburg (1); Karolinska Institutet (1)

Language: English (2)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

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