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Träfflista för sökning "WFRF:(Johansson Erik M) srt2:(2000-2004)"

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1.
  • Blücher, D. Bengtsson, et al. (author)
  • Scanning kelvin probe force microscopy - A useful tool for studying atmospheric corrosion of MgAl alloys in situ
  • 2004
  • In: JOURNAL OF THE ELECTROCHEMICAL SOCIETY. - : The Electrochemical Society. - 0013-4651 .- 1945-7111. ; 151:12
  • Journal article (peer-reviewed)abstract
    • Scanning Kelvin probe force microscopy (SKPFM) is used to study the initial stages of atmospheric corrosion of an AlMg alloy and of physical vapor deposition (PVD) deposited 2 μm Al dots on pure Mg. The latter system is used as a model of a two-phase AlMg alloy. The influence of CO2 was studied in situ in humid air using SKPFM. This method allows for the in situ investigation of the evolution of the Volta potential during exposure, the resolution being in the submicrometer range. The temperature was 22.0°C, and the relative humidity was 85 or 95%. The concentration of CO2 was <1 or 350 ppm. The corrosion products were analyzed by gravimetry, ion chromatography, X-ray diffraction, scanning electron microscopy, scanning Kelvin probe, and Auger electron spectroscopy. We found that the initial stages of atmospheric corrosion on magnesium are influenced by the presence of cathodic PVD-deposited aluminum. A similar effect was seen in the case of AZ91D, the aluminum-rich β-phase forming the cathodic areas. The β-phase is nobler compared to the substrate because of the higher Al content. In the absence of CO2, the corrosion attack is localized in nature whereas the presence of ambient levels of CO2 results in a more general corrosion attack. The inhibitive effect of CO2 on the atmospheric corrosion of AZ91D is explained by the formation of a passivating layer of Mg5(CO3)4(OH)2⋅5H2O. In the absence of CO2, the increase in pH originating from the cathodic reaction results in the dissolution of aluminum in the passive layer. A corrosion mechanism is proposed explaining the behavior in the two environments.
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  • Garg, Parie, et al. (author)
  • Idling by DNA polymerase delta maintains a ligatable nick during lagging-strand DNA replication.
  • 2004
  • In: Genes & Development. - : Cold Spring Harbor Laboratory. - 0890-9369 .- 1549-5477. ; 18:22, s. 2764-2773
  • Journal article (peer-reviewed)abstract
    • During each yeast cell cycle, ∼100,000 nicks are generated during lagging-strand DNA replication. Efficient nick processing during Okazaki fragment maturation requires the coordinated action of DNA polymerase δ (Pol δ) and the FLAP endonuclease FEN1. Misregulation of this process leads to the accumulation of double-stranded breaks and cell lethality. Our studies highlight a remarkably efficient mechanism for Okazaki fragment maturation in which Pol δ by default displaces 2–3 nt of any downstream RNA or DNA it encounters. In the presence of FEN1, efficient nick translation ensues, whereby a mixture of mono- and small oligonucleotides are released. If FEN1 is absent or not optimally functional, the ability of Pol δ to back up via its 3′–5′-exonuclease activity, a process called idling, maintains the polymerase at a position that is ideal either for ligation (in case of a DNA–DNA nick) or for subsequent engagement by FEN1 (in case of a DNA–RNA nick). Consistent with the hypothesis that DNA polymerase ϵ is the leading-strand enzyme, we observed no idling by this enzyme and no cooperation with FEN1 for creating a ligatable nick.
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3.
  • Hedberg, E, et al. (author)
  • Chemical and physical characterization of emissions from birch wood combustion in a wood stove
  • 2002
  • In: Atmospheric Environment. - 1352-2310. ; 36:30, s. 4823-4837
  • Journal article (peer-reviewed)abstract
    • The purpose of this study was to characterize the emissions of a large number of chemical compounds emitted from birch wood combustion in a wood stove. Birch wood is widely used as fuel in Swedish household appliances. The fuel load was held constant during six experiments. Particles < 2.5 mum diameter were collected and the size distribution of the particles was measured. The results were compared to the size distribution in road traffic emissions. It could be seen that the number distribution differed between the sources. In traffic exhaust, the number of particles maximized at 20 nm, while the number distribution from wood burning ranged from 20 to 300 nm. The ratio K/Ca on particles was found. to be significantly different in wood burning compared to road dust, range 30-330 for the former and 0.8+/-0.15 for the latter. The source profile of common elements emitted from wood-burning differed from that found on particles at a street-level site or in long-distance transported particles. The ratio toluene/benzene in this study was found to be in the range 0.2-0.7, which is much lower than the ratio 3.6+/-0.5 in traffic exhaust emissions. Formaldehyde and acetone were the most abundant compounds among the volatile ketones and aldehydes. The emission factor varied between 180-710mg/kg wood for formaldehyde and 5-1300mg/kg wood for acetone. Of the organic acids analyzed (3,4,5)-trimethoxy benzoic acid was the most abundant compound. Of the PAHs reported, fluorene, phenanthrene, anthracene, fluoranthene and pyrene contribute to more than 70% of the mass of PAH. Of the elements analyzed, K and Si were the most abundant elements, having emission factors of 27 and 9mg/kg wood, respectively. Although fluoranthene has a toxic equivalence factor of 5% of benzo(a)pyrene (B(a)P), it can be seen that the toxic potency of fluoranthene in wood burning emissions is of the same size as B(a)P. This indicates that the relative carcinogenic potency contribution of fluoranthene in wood smoke would be about 40% of B(a)P. (C) 2002 Elsevier Science Ltd. All rights reserved.
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  • Diep, Chieu B, et al. (author)
  • Genome characteristics of primary carcinomas, local recurrences, carcinomatoses, and liver metastases from colorectal cancer patients
  • 2004
  • In: Molecular Cancer. - : Springer Science and Business Media LLC. - 1476-4598. ; 3
  • Journal article (peer-reviewed)abstract
    • BACKGROUND: Colorectal cancer (CRC) is one of the most common causes of cancer-related deaths in the Western world, and despite the fact that metastases are usually the ultimate cause of deaths, the knowledge of the genetics of advanced stages of this disease is limited. In order to identify potential genetic abnormalities underlying the development of local and distant metastases in CRC patients, we have, by comparative genomic hybridization, compared the DNA copy number profiles of 10 primary carcinomas, 14 local recurrences, 7 peritoneal carcinomatoses, and 42 liver metastases from 61 CRC patients. RESULTS: The median number of aberrations among the primary carcinomas, local recurrences, carcinomatoses, and liver metastases was 10, 6, 13, and 14, respectively. Several genetic imbalances, such as gains of 7, 8q, 13q, and 20, and losses of 4q, 8p, 17p, and 18, were common in all groups. In contrast, gains of 5p and 12p were more common in the carcinomatoses than in other stages of the disease. With hierarchical cluster analysis, liver metastases could be divided into two main subgroups according to clusters of chromosome changes. CONCLUSIONS: Each stage of CRC progression is characterized by a particular genetic profile, and both carcinomatoses and liver metastases are more genetically complex than local recurrences and primary carcinomas. This is the first genome profiling of local recurrences and carcinomatoses, and gains of 5p and 12p seem to be particularly important for the spread of the CRC cells within the peritoneal cavity.
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9.
  • Eriksson, Lennart, et al. (author)
  • Three-block bi-focal PLS (3BIF-PLS) and its application in QSAR
  • 2004
  • In: SAR and QSAR in Environmental Research. - : Informa UK Limited. - 1062-936X .- 1029-046X. ; 15:5 & 6, s. 481-99
  • Journal article (peer-reviewed)abstract
    • When X and Y are multivariate, the two-block partial least squares (PLS) method is often used. In this paper, we outline an extension addressing a special case of the three-block (X/Y/Z) problem, where Z sits "under" Y. We have called this approach three-block bi-focal PLS (3BIF-PLS). It views the X/Y relationship as the dominant problem, and seeks to use the additional information in Z in order to improve the interpretation of the Y-part of the X/Y association. Two data sets are used to illustrate 3BIF-PLS. Example I relates to single point mutants of haloalkane dehalogenase from Sphingomonas paucimobilis UT26 and their ability to transform halogenated hydrocarbons, some of which are found as organic pollutants in soil. Example II deals with soil remediation capability of bacteria. Whole bacterial communities are monitored over time using "DNA-fingerprinting" technology to see how pollution affects population composition. Since the data sets are large, hierarchical multivariate modelling is invoked to compress data prior to 3BIF-PLS analysis. It is concluded that the 3BIF-PLS approach works well. The paper contains a discussion of pros and cons of the method, and hints at further developmental opportunities.
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  • Håkanson, Ulf, et al. (author)
  • Photon mapping of single quantum dots by scanning tunneling microscopy induced luminescence spectroscopy
  • 2002
  • In: 7th International Conference on Nanometer-Scale Science and Technology and 21st European Conference on Surface Science.
  • Conference paper (peer-reviewed)abstract
    • Scanning tunneling microscopy induced luminescence (STML) has been used to investigate individual self-assembled InP quantum dots overgrown with GaInP. We will present results correlating the surface morphology with the optical properties of single dots. In particular, the strain induced energy-shift of the dot emission with increasing cap layer thickness and its relation to the overgrowth will be discussed. Effects of the dots on the properties of the overgrown GaInP will also be treated. STML spectra and monochromatic photon maps are compared with results from photoluminescence and transmission electron microscopy measurements. Furthermore, a comparison with theoretical calculations is made
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  • Rodrigo Blomqvist, Sandra, 1974, et al. (author)
  • Distal renal tubular acidosis in mice that lack the forkhead transcription factor Foxi1.
  • 2004
  • In: The Journal of clinical investigation. - 0021-9738. ; 113:11, s. 1560-70
  • Journal article (peer-reviewed)abstract
    • While macro- and microscopic kidney development appear to proceed normally in mice that lack Foxi1, electron microscopy reveals an altered ultrastructure of cells lining the distal nephron. Northern blot analyses, cRNA in situ hybridizations, and immunohistochemistry demonstrate a complete loss of expression of several anion transporters, proton pumps, and anion exchange proteins expressed by intercalated cells of the collecting ducts, many of which have been implicated in hereditary forms of distal renal tubular acidosis (dRTA). In Foxi1-null mutants the normal epithelium with its two major cell types - principal and intercalated cells - has been replaced by a single cell type positive for both principal and intercalated cell markers. To test the functional consequences of these alterations, Foxi1(-/-) mice were compared with WT littermates in their response to an acidic load. This revealed an inability to acidify the urine as well as a lowered systemic buffer capacity and overt acidosis in null mutants. Thus, Foxi1(-/-) mice seem to develop dRTA due to altered cellular composition of the distal nephron epithelium, thereby denying this epithelium the proper gene expression pattern needed for maintaining adequate acid-base homeostasis.
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  • Result 1-16 of 16
Type of publication
journal article (12)
conference paper (3)
book chapter (1)
Type of content
peer-reviewed (14)
other academic/artistic (2)
Author/Editor
Johansson, Erik (9)
Kalander Blomqvist, ... (1)
Johansson, P. (1)
Dellborg, M (1)
Lothe, Ragnhild A (1)
Prakash, S (1)
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Trygg, Johan (1)
Bergström, Göran, 19 ... (1)
Samuelson, Lars (1)
Johansson, C. (1)
Johansson, M (1)
Johansson, Bertil (1)
Teixeira, Manuel R (1)
Holm, Magnus (1)
Starrin, Bengt (1)
Montelius, Lars (1)
Pistol, Mats Erik (1)
Kristensson, Adam (1)
Swietlicki, Erik (1)
Johansson, Lars-Gunn ... (1)
Persson, Jonas (1)
Kunkel, Thomas A (1)
Wallentin, Lars (1)
Persson, A. Erik G. (1)
Lindahl, Bertil (1)
Johansson, Bengt R, ... (1)
Venge, Per (1)
Enerbäck, Sven, 1958 (1)
Svensson, Jan-Erik, ... (1)
Westerholm, R (1)
Wold, Svante (1)
Eriksson, Lennart (1)
Håkanson, Ulf (1)
Hedberg, E. (1)
Sabouri, Nasim (1)
Chilkova, Olga (1)
Björklund, Erik (1)
Ohlsson, M (1)
Stratmann, M (1)
Sass, T (1)
Forsberg, Erik (1)
Ollerstam, Anna (1)
Vidarsson, Hilmar, 1 ... (1)
Blücher, D. Bengtsso ... (1)
Rohwerder, M. (1)
Wiig, Johan N. (1)
Eknæs, Mette (1)
Brown, Russell (1)
Johansson, PA (1)
Johnson, R. E. (1)
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University
Umeå University (8)
Lund University (4)
University of Gothenburg (2)
Uppsala University (1)
Chalmers University of Technology (1)
Karlstad University (1)
Language
English (16)
Research subject (UKÄ/SCB)
Natural sciences (3)
Medical and Health Sciences (2)
Engineering and Technology (1)
Social Sciences (1)
Humanities (1)

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