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- Ekholm, M, et al.
(author)
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Long-term angiotensin-converting enzyme inhibition with ramipril reduces thrombin generation in human hypertension
- 2002
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In: Clinical science (London, England : 1979). - : Portland Press Ltd.. - 0143-5221 .- 1470-8736. ; 103:2, s. 151-155
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Journal article (peer-reviewed)abstract
- Antihypertensive treatment reduces the risk of thromboembolic events in hypertension. The aim of this study was to examine the influence of angiotensin-converting enzyme inhibition on blood coagulation in subjects with mild-to-moderate essential hypertension. Fibrinogen, thrombin–antithrombin complex (TAT) and Factor VII were determined in plasma at rest and after a mental stress test following placebo for 6 weeks, or ramipril for 6 weeks or 6 months. Ramipril reduced resting TAT, and tended to reduce fibrinogen; Factor VII remained unchanged. Mental stress increased fibrinogen, but did not alter TAT or Factor VII activity. The reduced thrombin generation in patients taking ramipril may explain in part why angiotensin-converting enzyme inhibitors reduce thromboembolic complications in patients with cardiovascular disease.
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| 6. |
- Lorant, T., et al.
(author)
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Oral administration of xenogeneic erythrocytes induces production of antibodies that are capable of inducing hyperacute rejection of concordant vascularized xenografts
- 2004
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In: Transplantation. - 0041-1337. ; 77:7, s. 1100-3
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Journal article (peer-reviewed)abstract
- Oral tolerance induction has proven to be an effective approach for inducing antigen-specific unresponsiveness in several models for allogeneic transplantation and autoimmune diseases. The authors' preliminary studies, however, indicated that xenospecific antibodies are produced when rats are given mouse erythrocytes orally. This response was further examined. Mouse erythrocytes were administered to rats orally or intravenously during one or two episodes, and sera were obtained on day 9 or day 29, respectively. Rat sera containing a positive hemagglutinating titer against mouse antigens were injected into rats that had recently undergone xenotransplantation to study graft survival. Oral administration of xenogeneic cells induced a powerful antibody response consisting mainly of xenospecific immunoglobulin (Ig) M and IgG. This antibody response also induced hyperacute rejection as powerfully as sera from intravenously immunized rats. The authors' study thus indicates that oral administration of xenogeneic cells is a powerful immunization pathway that induces an antibody response capable of rejecting concordant vascularized xenografts.
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| 9. |
- Sundström, L. Fredrik, 1972, et al.
(author)
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Hatchery selection promotes boldness in newly hatched brown trout (Salmo trutta): implications for dominance
- 2004
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In: Behavioral Ecology. - : Oxford University Press (OUP). - 1045-2249 .- 1465-7279. ; 15:2, s. 192-198
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Journal article (peer-reviewed)abstract
- By using newly hatched (approximately 2 weeks old) brown trout (Salmo trutta) from six families of wild and six families of sea-ranched origin (seventh generation), we tested the hypotheses that (1) the hatchery environment selects for increased boldness, and (2) boldness predicts dominance status. Sea-ranched trout spend their first 2 years in the hatchery before being released into the wild at the onset of seaward migration. Trout were presented with a novel object (tack) and with food (brine shrimp), and their responses were measured and scored in terms of boldness. Siblings with increasing difference in boldness were then paired in dyadic contests. Fish of sea-ranged origin were on average bolder than were fish of wild origin, and bolder individuals were more likely to become dominant regardless of origin. Boldness was not related to RNA levels, indicating that bold behavior was not a consequence of higher metabolism or growth rate. Neither was size a predictor of bold behavior or the outcome of dyadic contests. These results are consistent with studies on older life stages showing increased boldness toward predators in hatchery-selected fish, which suggests that behavioral consequences of hatchery selection are manifested very early in life. The concordance between boldness and dominance may suggest that these behaviors are linked in a risk prone-aggressive phenotype, which may be promoted by hatchery selection. However, we also found significant variation in behavioral and growth-related traits among families, suggesting that heritable variation has not been exhausted by sea-ranching procedures.
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| 11. |
- Zhao, Zhe, 1973-, et al.
(author)
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Grain-size effects on the ferroelectric behavior of dense nanocrystalline BaTiO3 ceramics
- 2004
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In: Physical Review B. Condensed Matter and Materials Physics. - : American Institute of Physics (AIP). - 1098-0121 .- 1550-235X. ; 70:2
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Journal article (peer-reviewed)abstract
- A progressive reduction of tetragonal distortion, heat of transition, Curie temperature, and relative dielectric constant has been observed on dense BaTiO3 ceramics with grain size decreasing from 1200 to 50 nm. The correlations between grain size, extent of tetragonal distortion, and ferroelectric properties strongly support the existence of an intrinsic size effect. From the experimental trends the critical size for disappearance of ferroelectricity has been evaluated to be 10-30 nm. The strong depression of the relative permittivity observed for the nanocrystalline ceramics can be ascribed to the combination of the intrinsic size effect and of the size-dependent "dilution" effect of a grain boundary "dead" layer.
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| 12. |
- Zilling, T, et al.
(author)
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Anastomotic diameters and strictures following esophagectomy and total gastrectomy in 256 patients
- 2000
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In: World Journal of Surgery. - 0364-2313. ; 24:1, s. 5-84
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Journal article (peer-reviewed)abstract
- The prevalence of anastomotic strictures in esophageal anastomoses provides us with limited information about the anastomotic healing process. This prospective study evaluates the exact esophageal anastomotic diameters in 256 patients who underwent esophagectomy and esophagogastrostomy without pyloroplasty (n = 107) or total gastrectomy and Roux reconstruction (n = 149). No perioperative chemoradiotherapy was given. Anastomotic strictures and diameters were assessed during endoscopy by a separately inserted (inflated to the anastomotic width) balloon catheter. The anastomotic diameters increased significantly during the first postoperative year in the esophagectomy (p = 0.001) and gastrectomy (p < 0.001) groups. The anastomoses in the gastrectomy group were significantly wider than those in the esophagectomy group 3 (25.7 versus 19.9 mm), 6 (28.5 versus 22.0 mm), and 12 (30.5 versus 23.3 mm) months after surgery (p < 0.001). Neither the anastomotic site (neck or chest) in the esophagectomy group (p = 0.176) nor that in the gastrectomy group (abdomen or chest) (p = 0.577) influenced the anastomotic diameter. Benign anastomotic strictures were most frequently found after 3 months and after esophagectomy. Esophagojejunostomies performed with 2 linear stapling devices or cartridge size 28 mm showed the widest anastomoses with only 1 stricture. Esophagogastric anastomoses following esophagectomy are narrower and develop more strictures than esophagojejunal anastomoses after total gastrectomy, but both dilate during the first year.
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