| 1. |
- Al-Abbadi, Mousa A., et al.
(author)
-
A Proposal for the Performance, Classification, and Reporting of Lymph Node Fine-Needle Aspiration Cytopathology : The Sydney System
- 2020
-
In: Acta Cytologica. - : S. Karger AG. - 0001-5547 .- 1938-2650. ; 64:4, s. 306-322
-
Journal article (peer-reviewed)abstract
- BACKGROUND: The evaluation of lymph nodes (LN) by fine-needle aspiration cytology (FNAC) is routinely used in many institutions but it is not uniformly accepted mainly because of the lack of guidelines and a cytopathological diagnostic classification. A committee of cytopathologists has developed a system of performance, classification, and reporting for LN-FNAC. METHODS: The committee members prepared a document that has circulated among them five times; the final text has been approved by all the participants. It is based on a review of the international literature and on the expertise of the members. The system integrates clinical and imaging data with cytopathological features and ancillary techniques. The project has received the endorsement and patronage of the International Academy of Cytology and the European Federation of the Cytology Societies. RESULTS: Clinical, imaging, and serological data of lymphadenopathies, indications for LN-FNAC, technical procedures, and ancillary techniques are evaluated with specific recommendations. The reporting system includes two diagnostic levels. The first should provide basic diagnostic information and includes five categories: inadequate/insufficient, benign, atypical lymphoid cells of undetermined/uncertain significance, suspicious, and malignant. For each category, specific recommendations are provided. The second diagnostic level, when achievable, should produce the identification of specific benign or malignant entities and additional information by utilizing ancillary testing. CONCLUSION: The authors believe that the introduction of this system for performing and reporting LN-FNAC may improve the quality of the procedure, the report, and the communication between cytopathologists and the clinicians. This system may lead to a greater acceptance and utilization of LN-FNAC and to a better interdisciplinary understanding of the results of this procedure.
|
|
| 2. |
|
|
| 3. |
- Araujo, Nathalia, et al.
(author)
-
Tumor Suppressor Par-4 Regulates Complement Factor C3 and Obesity
- 2022
-
In: Frontiers in Oncology. - : Frontiers Media SA. - 2234-943X. ; 12
-
Journal article (peer-reviewed)abstract
- Prostate apoptosis response-4 (Par-4) is a tumor suppressor that induces apoptosis in cancer cells. However, the physiological function of Par-4 remains unknown. Here we show that conventional Par-4 knockout (Par-4-/-) mice and adipocyte-specific Par-4 knockout (AKO) mice, but not hepatocyte-specific Par-4 knockout mice, are obese with standard chow diet. Par-4-/- and AKO mice exhibit increased absorption and storage of fat in adipocytes. Mechanistically, Par-4 loss is associated with mdm2 downregulation and activation of p53. We identified complement factor c3 as a p53-regulated gene linked to fat storage in adipocytes. Par-4 re-expression in adipocytes or c3 deletion reversed the obese mouse phenotype. Moreover, obese human subjects showed lower expression of Par-4 relative to lean subjects, and in longitudinal studies, low baseline Par-4 levels denoted an increased risk of developing obesity later in life. These findings indicate that Par-4 suppresses p53 and its target c3 to regulate obesity.
|
|
| 4. |
- Benatar, Michael, et al.
(author)
-
Safety and efficacy of arimoclomol in patients with early amyotrophic lateral sclerosis (ORARIALS-01) : a randomised, double-blind, placebo-controlled, multicentre, phase 3 trial
- 2024
-
In: Lancet Neurology. - : Elsevier. - 1474-4422 .- 1474-4465. ; 23:7, s. 687-699
-
Journal article (peer-reviewed)abstract
- Background: Amyotrophic lateral sclerosis is a progressive neurodegenerative disorder leading to muscle weakness and respiratory failure. Arimoclomol, a heat-shock protein-70 (HSP70) co-inducer, is neuroprotective in animal models of amyotrophic lateral sclerosis, with multiple mechanisms of action, including clearance of protein aggregates, a pathological hallmark of sporadic and familial amyotrophic lateral sclerosis. We aimed to evaluate the safety and efficacy of arimoclomol in patients with amyotrophic lateral sclerosis.Methods: ORARIALS-01 was a multinational, randomised, double-blind, placebo-controlled, parallel-group trial done at 29 centres in 12 countries in Europe and North America. Patients were eligible if they were aged 18 years or older and met El Escorial criteria for clinically possible, probable, probable laboratory-supported, definite, or familial amyotrophic lateral sclerosis; had an ALS Functional Rating Scale-Revised score of 35 or more; and had slow vital capacity at 70% or more of the value predicted on the basis of the participant's age, height, and sex. Patients were randomly assigned (2:1) in blocks of 6, stratified by use of a stable dose of riluzole or no riluzole use, to receive oral arimoclomol citrate 1200 mg/day (400 mg three times per day) or placebo. The Randomisation sequence was computer generated centrally. Investigators, study personnel, and study participants were masked to treatment allocation. The primary outcome was the Combined Assessment of Function and Survival (CAFS) rank score over 76 weeks of treatment. The primary outcome and safety were analysed in the modified intention-to-treat population. This trial is registered with ClinicalTrials.gov, NCT03491462, and is completed.Findings: Between July 31, 2018, and July 17, 2019, 287 patients were screened, 245 of whom were enrolled in the trial and randomly assigned. The modified intention-to-treat population comprised 239 patients (160 in the arimoclomol group and 79 in the placebo group): 151 (63%) were male and 88 (37%) were female; mean age was 57·6 years (SD 10·9). CAFS score over 76 weeks did not differ between groups (mean 0·51 [SD 0·29] in the arimoclomol group vs 0·49 [0·28] in the placebo group; p=0·62). Cliff's delta comparing the two groups was 0·039 (95% CI –0·116 to 0·194). Proportions of participants who died were similar between the treatment groups: 29 (18%) of 160 patients in the arimoclomol group and 18 (23%) of 79 patients in the placebo group. Most deaths were due to disease progression. The most common adverse events were gastrointestinal. Adverse events were more often deemed treatment-related in the arimoclomol group (104 [65%]) than in the placebo group (41 [52%]) and more often led to treatment discontinuation in the arimoclomol group (26 [16%]) than in the placebo group (four [5%]).Interpretation: Arimoclomol did not improve efficacy outcomes compared with placebo. Although available biomarker data are insufficient to preclude future strategies that target the HSP response, safety data suggest that a higher dose of arimoclomol would not have been tolerated.Funding: Orphazyme.
|
|
| 5. |
- Blondin, Stéphane, et al.
(author)
-
StaNdaRT : a repository of standardised test models and outputs for supernova radiative transfer
- 2022
-
In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 668
-
Journal article (peer-reviewed)abstract
- We present the first results of a comprehensive supernova (SN) radiative-transfer (RT) code-comparison initiative (StaNdaRT), where the emission from the same set of standardised test models is simulated by currently used RT codes. We ran a total of ten codes on a set of four benchmark ejecta models of Type Ia SNe. We consider two sub-Chandrasekhar-mass (Mtot = 1.0 M⊙) toy models with analytic density and composition profiles and two Chandrasekhar-mass delayed-detonation models that are outcomes of hydrodynamical simulations. We adopt spherical symmetry for all four models. The results of the different codes, including the light curves, spectra, and the evolution of several physical properties as a function of radius and time are provided in electronic form in a standard format via a public repository. We also include the detailed test model profiles and several Python scripts for accessing and presenting the input and output files. We also provide the code used to generate the toy models studied here. In this paper, we describe the test models, radiative-transfer codes, and output formats in detail, and provide access to the repository. We present example results of several key diagnostic features.
|
|
| 6. |
- Caputo, Alessandro, et al.
(author)
-
Digital Examination of LYmph node CYtopathology Using the Sydney system (DELYCYUS). An international, multi-institutional study
- 2023
-
In: Cancer Cytopathology. - 1934-662X. ; 131:11, s. 679-692
-
Journal article (peer-reviewed)abstract
- Background: After a series of standardized reporting systems in cytopathology, the Sydney system was recently introduced to address the need for reproducibility and standardization in lymph node cytopathology. Since then, the risk of malignancy for the categories of the Sydney system has been explored by several studies, but no studies have yet examined the interobserver reproducibility of the Sydney system. Methods: The authors assessed interobserver reproducibility of the Sydney system on 85 lymph node fine-needle aspiration cytology cases reviewed by 15 cytopathologists from 12 institutions in eight different countries, resulting in 1275 diagnoses. In total, 186 slides stained with Diff-Quik, Papanicolaou, and immunocytochemistry were scanned. A subset of the cases included clinical data and results from ultrasound examinations, flow cytometry immunophenotyping, and fluorescence in situ hybridization analysis. The study participants assessed the cases digitally using whole-slide images. Results: Overall, the authors observed an almost perfect agreement of cytopathologists with the ground truth (median weighted Cohen κ = 0.887; interquartile range, κ = 0.210) and moderate overall interobserver concordance (Fleiss κ = 0.476). There was substantial agreement for the inadequate and malignant categories (κ = 0.794 and κ = 0.729, respectively), moderate agreement for the benign category (κ = 0.490), and very slight agreement for the suspicious (κ = 0.104) and atypical (κ = 0.075) categories. Conclusions: The Sydney system for reporting lymph node cytopathology shows adequate interobserver concordance. Digital microscopy is an adequate means to assess lymph node cytopathology specimens.
|
|
| 7. |
- Chen, Ping, et al.
(author)
-
A 12.4-day periodicity in a close binary system after a supernova
- 2024
-
In: Nature. - 0028-0836 .- 1476-4687. ; 625:7994, s. 253-258
-
Journal article (peer-reviewed)abstract
- Neutron stars and stellar-mass black holes are the remnants of massive star explosions1. Most massive stars reside in close binary systems2, and the interplay between the companion star and the newly formed compact object has been theoretically explored3, but signatures for binarity or evidence for the formation of a compact object during a supernova explosion are still lacking. Here we report a stripped-envelope supernova, SN 2022jli, which shows 12.4-day periodic undulations during the declining light curve. Narrow Hα emission is detected in late-time spectra with concordant periodic velocity shifts, probably arising from hydrogen gas stripped from a companion and accreted onto the compact remnant. A new Fermi-LAT γ-ray source is temporally and positionally consistent with SN 2022jli. The observed properties of SN 2022jli, including periodic undulations in the optical light curve, coherent Hα emission shifting and evidence for association with a γ-ray source, point to the explosion of a massive star in a binary system leaving behind a bound compact remnant. Mass accretion from the companion star onto the compact object powers the light curve of the supernova and generates the γ-ray emission.
|
|
| 8. |
- Lundell, Björn, et al.
(author)
-
Addressing Lock-in Effects in the Public Sector : How Can Organisations Deploy a SaaS SolutionWhile Maintaining Control of Their Digital Assets?
- 2020
-
In: Proceedings of Ongoing Research, Practitioners, Posters, Workshops, and Projects at EGOV-CeDEM-ePart 2020co-located with the IFIP WG 8.5 International Conference EGOV-CeDEM-ePart 2020. - Aachen : CEUR. ; , s. 289-296
-
Conference paper (peer-reviewed)abstract
- As software as a service (SaaS) adoption increases in both the public and private sectors, so does dependency on specific providers and technologies and the consequent danger of lock-in. This paper reports on how public sector organisations (PSOs) can, and should, avoid lock-in throughout the lifecycle (commissioning, deployment and decommissioning) of their deployment of the Microsoft Office 365 SaaS product (O365). We investigate how 33 PSOs address different lock-in effects, focussing on the City of Gothenburg, and show that none of the PSOs determined possible lock-in effects prior to implementation or were able to provide documented evidence that they would be able to independently access, process and maintain the digital assets processed by the SaaS solution after decommissioning. We also report on jurisdictional and data processing issues, with consequent impact on digital sovereignty.
|
|
| 9. |
- Lundell, Björn, et al.
(author)
-
Avoiding lock-in effects through obtaining all necessary licences before use of a SaaS solution in a public sector organisation
- 2023
-
In: European Journal of Law and Technology. - 2042-115X. ; 14:1
-
Journal article (peer-reviewed)abstract
- With increased adoption and use of cloud-based software-as-a-service (SaaS) solutions from international providers many public sector organisations expose themselves to a dependency on specific providers and a range of different lock-in effects. The article reports from a case study which investigated how a large Swedish public sector organisation addressed licensing issues and lock-in effects during adoption and use of a SaaS solution (Microsoft 365). The study identifies problematic licensing issues and presents a legal analysis related to the organisational implementation of the SaaS solution in the specific organisation. Findings show that the organisation has failed to successfully obtain all necessary licences and all necessary rights which would allow for long-term maintenance of all its digital assets independently of the SaaS solution currently in use.
|
|
| 10. |
- Lundell, Björn, et al.
(author)
-
Data processing and maintenance in different jurisdictions when using a SaaS solution in a public sector organisation
- 2022
-
In: eJournal of eDemocracy & Open Government. - Krems : Department for E-Governance and Administration, Danube University Krems. - 2075-9517. ; 14:2, s. 214-234
-
Journal article (peer-reviewed)abstract
- Many public sector organisations (PSO) use SaaS solutions from dominant global providers. Implementation of these solutions may raise issues concerning both lawful data processing, and the obligations that those PSOs have to maintain their digital assets. One example is a large Swedish PSO which addressed these issues as part of the adoption and implementation of Microsoft 365. The study identifies challenges and presents an analysis of the organisational implementation of that SaaS solution, exposing legal issues that arose in that context. Findings show an absence of a documented risk analysis related to the PSO's use of that SaaS solution, covering data processing and maintenance of its digital assets. Recommendations are presented to facilitate a PSO's procurement and implementation of such a SaaS solution to address issues around data processing and the processing of digital assets.
|
|
| 11. |
- Lundell, Björn, et al.
(author)
-
Effective Strategies for Using Open Source Software and Open Standards in Organizational Contexts : Experiences From the Primary and Secondary Software Sectors
- 2022
-
In: IEEE Software. - : IEEE. - 0740-7459 .- 1937-4194. ; 39:1, s. 84-92
-
Journal article (peer-reviewed)abstract
- Open source software (OSS) and open standards have become increasingly important for addressing challenges related to lock-in, interoperability and long-term maintenance of systems and associated digital assets. OSS projects operate under different conditions and many projects and organisations consider successful governance and strategic involvement with projects to constitute major challenges. Today, many companies seek to establish work practices which facilitate strategic engagement with OSS projects. Based on findings from collaborative research which draws from rich insights and extensive experiences from practice, the paper presents seven actionable strategies for organisations that seek to leverage long-term involvement with OSS projects.
|
|
| 12. |
- Lundell, Björn, et al.
(author)
-
Half a step behind – bulk disclosure of confidential data in third-party GenAI solutions under the Swedish Public Access to Information and Secrecy Act
- 2024
-
In: Digital Government: Research and Practice. - : ACM Digital Library. - 2691-199X .- 2639-0175.
-
Journal article (peer-reviewed)abstract
- Technological progress poses unique challenges for the public sector. New technology should be adopted, but it must always be done within the framework of good administration. It follows laws governing public administration must be continuously adapted. Sweden recently amended its secrecy legislation to facilitate the use of third-party cloud solutions by public authorities. When the amendment was enacted, most public sector organisations had already been using external cloud solutions for a long time. Today, there is as much pressure on authorities to implement AI technology as there ever was to move administration into the cloud. This paper uses traditional legal methodology to investigate if the Swedish secrecy legislation adequately enables the use of cloud-based GenAI solutions. Findings indicate that the recent amendment is likely insufficient and that there are significant practical hurdles for the application of the law, particularly with services from global cloud providers. The paper contributes to the understanding of Swedish law, and of the difficulties that can occur anywhere when policy makers and legislators do not move in tandem.
|
|
| 13. |
- Lundell, Björn, et al.
(author)
-
Implementing the HEVC standard in software : Challenges and Recommendations for organisations planning development and deployment of software
- 2023
-
In: Journal of Standardisation. - Delft : TU Delft OPEN. - 2772-9249. ; 2
-
Journal article (peer-reviewed)abstract
- Implementation and use of an IT standard in software involves legal, technical and societal challenges. This paper addresses how an organisation can, and should, determine the conditions for implementation and use of the HEVC standard in software. The investigation considers the availability of the standard’s complete technical specification and the extent to which an organisation can access the information necessary to assess the licence conditions for standard essential patents impinging on the standard. Through an action case study approach the investigation analyses declarations in patent databases relevant to the standard and seeks to obtain patent licences from each declarant permitting implementation of the standard in software, where that software is to be provided under one (or several) of three specific open source software licences, and alternatively to be provided as an online service. Our analysis of legal and licensing conditions for use of the standard shows significant obstacles. We find that it is impossible to obtain licences from patent holders that would allow for implementation and use of the standard in open source software. The paper illuminates significant challenges related to conditions for use of the standard under (F)RAND terms and identifies that references to the standard in public procurement projects lead to anti-competitive effects.
|
|
| 14. |
- Lundell, Björn, et al.
(author)
-
On Challenges for Implementing ISO Standards in Software : Can Both Open and Closed Standards Be Implemented in Open Source Software?
- 2021
-
In: Research Anthology on Usage and Development of Open Source Software. - : IGI Global. - 9781799891598 - 9781799891581 - 1799891585 ; , s. 63-95
-
Book chapter (peer-reviewed)abstract
- Over the years, the importance of open standards has been acknowledged in EU and national policies. Formal (e.g., ISO) standards are often referred to in software development and procurement. Use of formal (ISO) standards and to what extent ISO standards can be implemented in open source software is considered, with particular reference to patent licensing. It is shown that not all formal standards are open standards and that FRAND commitments may impose major challenges for use of such standards. Further policies and procedures set by standards setting organisations (SSOs) regarding the notification of standards-essential patents (SEPs) present challenges for organisations wishing to implement standards in software. This chapter elaborates implications and suggests ways of addressing the challenges identified. Use of formal standards may create barriers for implementation in open source software and inhibit an open and inclusive business-friendly ecosystem.
|
|
| 15. |
- Lundell, Björn, et al.
(author)
-
Perceived and Actual Lock-in Effects Amongst Swedish Public Sector Organisations when Using a SaaS Solution
- 2021
-
In: Electronic Government. - Cham : Springer. - 9783030847883 - 9783030847890 ; , s. 59-72
-
Conference paper (peer-reviewed)abstract
- When a public sector organisation (PSO) uses a software as a service (SaaS) solution from a global provider this imposes risks for different types of lock-in effects. In turn, use of such solutions by PSOs may prevent full control of digital assets that need to be created, processed, maintained, and archived for use and reuse over long life-cycles. This paper addresses perceived and actual lock-in effects related to use of SaaS solutions in the public sector. We review perceptions of lock-in amongst government agencies and investigate how 46 PSOs have addressed challenges related to obtaining licences and an effective exit plan related to use of the Microsoft Office 365 SaaS solution. Through a review of responses to a survey conducted by the Swedish Government Offices we find significant misconceptions concerning lock-in effects. We find that every one of the 46 PSOs investigated neither obtained necessary licences nor established an effective exit strategy to allow the PSO to independently access, process and maintain digital assets processed by the SaaS solution after decommissioning. We present recommendations for any PSO considering use of a SaaS solution.
|
|
| 16. |
- Lundell, Björn, et al.
(author)
-
Use of Commercial SaaS Solutions in Swedish Public Sector Organisations under Unknown Contract Terms
- 2022
-
In: Electronic Government. - Cham : Springer Nature Switzerland AG. - 9783031150869 - 9783031150852 ; , s. 73-92
-
Conference paper (peer-reviewed)abstract
- Lawful and appropriate use of cloud-based globally provided Software-as-a-Service (SaaS) solutions by a public sector organisation (PSO) for data processing and maintenance of digital assets presupposes an investigation of all relevant contract terms. Having obtained, analysed, and filed all relevant contract terms when using a SaaS solution is a prerequisite for good administration. Identifying and obtaining all relevant contract terms for a SaaS solution involves significant obstacles which in practice may be impossible to overcome for each PSO. This paper addresses how PSOs investigate contract terms prior to adoption, and why PSOs use a globally provided SaaS solution without having identified and obtained all relevant contract terms. Through a review of responses to questions and public documents from Swedish PSOs we analysed how each PSO had investigated contract terms and licences for the Microsoft 365 (M365) solution prior to adoption and use of the solution in each PSO. We find that no PSO had investigated all relevant contract terms prior to use of M365, which implies that each PSO uses M365 under unknown contract terms. Further, we find that all PSOs use M365 for data processing of its digital assets under unknown contract terms and that each PSO has significant dependence and trust in its supplier.
|
|
| 17. |
- Peters, Ruth, et al.
(author)
-
An investigation of antihypertensive class, dementia, and cognitive decline: A meta-analysis.
- 2020
-
In: Neurology. - 1526-632X. ; 94:3
-
Journal article (peer-reviewed)abstract
- High blood pressure is one of the main modifiable risk factors for dementia. However, there is conflicting evidence regarding the best antihypertensive class for optimizing cognition. Our objective was to determine whether any particular antihypertensive class was associated with a reduced risk of cognitive decline or dementia using comprehensive meta-analysis including reanalysis of original participant data.To identify suitable studies, MEDLINE, Embase, and PsycINFO and preexisting study consortia were searched from inception to December 2017. Authors of prospective longitudinal human studies or trials of antihypertensives were contacted for data sharing and collaboration. Outcome measures were incident dementia or incident cognitive decline (classified using the reliable change index method). Data were separated into mid and late-life (>65 years) and each antihypertensive class was compared to no treatment and to treatment with other antihypertensives. Meta-analysis was used to synthesize data.Over 50,000 participants from 27 studies were included. Among those aged >65 years, with the exception of diuretics, we found no relationship by class with incident cognitive decline or dementia. Diuretic use was suggestive of benefit in some analyses but results were not consistent across follow-up time, comparator group, and outcome. Limited data precluded meaningful analyses in those ≤65 years of age.Our findings, drawn from the current evidence base, support clinical freedom in the selection of antihypertensive regimens to achieve blood pressure goals.The review was registered with the international prospective register of systematic reviews (PROSPERO), registration number CRD42016045454.
|
|
| 18. |
- Wilkinson, Jack, et al.
(author)
-
Protocol for the development of a tool (INSPECT-SR) to identify problematic randomised controlled trials in systematic reviews of health interventions
- 2024
-
In: BMJ Open. - : BMJ Publishing Group Ltd. - 2044-6055. ; 14:3
-
Journal article (peer-reviewed)abstract
- Introduction Randomised controlled trials (RCTs) inform healthcare decisions. It is now apparent that some published RCTs contain false data and some appear to have been entirely fabricated. Systematic reviews are performed to identify and synthesise all RCTs that have been conducted on a given topic. While it is usual to assess methodological features of the RCTs in the process of undertaking a systematic review, it is not usual to consider whether the RCTs contain false data. Studies containing false data therefore go unnoticed and contribute to systematic review conclusions. The INveStigating ProblEmatic Clinical Trials in Systematic Reviews (INSPECT-SR) project will develop a tool to assess the trustworthiness of RCTs in systematic reviews of healthcare-related interventions.Methods and analysis The INSPECT-SR tool will be developed using expert consensus in combination with empirical evidence, over five stages: (1) a survey of experts to assemble a comprehensive list of checks for detecting problematic RCTs, (2) an evaluation of the feasibility and impact of applying the checks to systematic reviews, (3) a Delphi survey to determine which of the checks are supported by expert consensus, culminating in, (4) a consensus meeting to select checks to be included in a draft tool and to determine its format and (5) prospective testing of the draft tool in the production of new health systematic reviews, to allow refinement based on user feedback. We anticipate that the INSPECT-SR tool will help researchers to identify problematic studies and will help patients by protecting them from the influence of false data on their healthcare.Ethics and dissemination The University of Manchester ethics decision tool was used, and this returned the result that ethical approval was not required for this project (30 September 2022), which incorporates secondary research and surveys of professionals about subjects relating to their expertise. Informed consent will be obtained from all survey participants. All results will be published as open-access articles. The final tool will be made freely available.
|
|
| 19. |
- Zeppa, Pio, et al.
(author)
-
Announcement : The International System for Reporting Lymph Node Cytopathology
- 2020
-
In: Acta Cytologica. - : S. Karger AG. - 0001-5547 .- 1938-2650. ; 64:4, s. 299-305
-
Research review (peer-reviewed)abstract
- Fine needle aspiration biopsy cytopathology (FNAC) of lymph nodes is a very common, inexpensive, and rapid diagnostic procedure and can lead to the accurate and timely diagnosis of one of the wide range of pathological processes that involve lymph nodes. These diagnoses include specific reactive processes, specific infections such as tuberculosis, metastatic carcinomas and melanomas, and some lymphomas. The FNAC effectively triages the lymph node material, but the initial diagnosis often requires ancillary testing as a second diagnostic step to make a specific diagnosis, such as the particular infectious agent, the type of lymphoma or Hodgkin lymphoma, or the specific type of metastatic malignancy. An international group of cytopathologists have begun the process of developing a system for the standardized reporting of lymph node FNAC. The group is addressing the pre-analytical issues related to the FNAC, including the role of clinical information and the use of ultrasound, and developing a structure of reporting categories based on the cytopathological findings linked to management recommendations. The basis of the system is the integration of the FNAC with the clinical setting, imaging, and ancillary tests that utilize the FNAC material, to produce a final report that will enhance patient care.
|
|
