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Träfflista för sökning "WFRF:(Kehler M.) srt2:(2015-2019)"

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1.	Adam, A, et al. (author) Abstracts from Hydrocephalus 2016. 2017 In: Fluids and Barriers of the CNS. - : Springer Science and Business Media LLC. - 2045-8118. ; 14:Suppl 1 Journal article (peer-reviewed)
2.	Schuette, Moritz, et al. (author) Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors 2017 In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 8 Journal article (peer-reviewed)abstract Colorectal carcinoma represents a heterogeneous entity, with only a fraction of the tumours responding to available therapies, requiring a better molecular understanding of the disease in precision oncology. To address this challenge, the OncoTrack consortium recruited 106 CRC patients (stages I-IV) and developed a pre-clinical platform generating a compendium of drug sensitivity data totalling 44,000 assays testing 16 clinical drugs on patient-derived in vivo and in vitro models. This large biobank of 106 tumours, 35 organoids and 59 xenografts, with extensive omics data comparing donor tumours and derived models provides a resource for advancing our understanding of CRC. Models recapitulate many of the genetic and transcriptomic features of the donors, but defined less complex molecular sub-groups because of the loss of human stroma. Linking molecular profiles with drug sensitivity patterns identifies novel biomarkers, including a signature outperforming RAS/RAF mutations in predicting sensitivity to the EGFR inhibitor cetuximab.

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Type of publication: journal article (2)

Type of content: peer-reviewed (2)

Author/Editor: Garcia, C. (1); Martin, B. (1); Schmidt, E. (1); Yamamoto, K. (1); Shin, T. (1); Cheng, S. (1); show more...; Lu, J. (1); Yamada, S. (1); Thompson, D. (1); Foley, S. (1); Modesto, P. (1); Williams, M (1); Asgari, M. (1); Nilsson, Mats (1); Xu, J (1); Landegren, Ulf (1); Alafuzoff, Irina (1); Rodriguez, S. (1); Adam, A. (1); Robison, J (1); Jose, R (1); Badran, N (1); Vivas-Buitrago, T (1); Rigamonti, D (1); Sattar, A (1); Omoush, O (1); Hammad, M (1); Dawood, M (1); Maghaslah, M (1); Belcher, T (1); Carson, K (1); Hoffberger, J (1); Jusué Torres, I (1); Yasar, S (1); Thai, Q A (1); Wemmer, J (1); Klinge, P (1); Al-Mutawa, L (1); Al-Ghamdi, H (1); Carson, K A (1); de Zélicourt, D (1); Kurtcuoglu, V (1); Garnotel, S (1); Salmon, S (1); Balédent, O (1); Lokossou, A (1); Page, G (1); Balardy, L (1); Czosnyka, Z (1); Payoux, P (1); show less...

University: Uppsala University (2); Stockholm University (1)

Language: English (2)

Research subject (UKÄ/SCB): Medical and Health Sciences (2); Natural sciences (1)

Year: 2017 (2)

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