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Träfflista för sökning "WFRF:(Khosravani Nina) srt2:(2007)"

Search: WFRF:(Khosravani Nina) > (2007)

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  • Khosravani, Nina, et al. (author)
  • Intraoral stimulation of salivary secretion with the cholinesterase inhibitor physostigmine as a mouth spray: A pilot study in healthy volunteers.
  • 2007
  • In: Archives of oral biology. - : Elsevier BV. - 0003-9969. ; 52:11, s. 1097-101
  • Journal article (peer-reviewed)abstract
    • Dry mouth produces a deterioration in oral health and impairs quality of life. There is a need for a novel approach to the pharmacological treatment of dry mouth. With a view to enhancing the cholinergic drive on minor salivary glands, whilst at the same time minimising adverse systemic effects, the cholinesterase inhibitor physostigmine was therefore sprayed, in a fixed volume, onto the oral mucosa of seven healthy subjects. Three concentrations (0.5%, 1% and 2%) were tested. The mean salivary output over time (0-105min) was higher than that of placebo (p<0.05), as the area under the curve increased by 61%, 91% and 66% at physostigmine 0.5%, 1% and 2%, respectively. Two subjects experienced nausea at the highest physostigmine concentration, thus reflecting systemic effects. Heart rate, blood pressure and respiration were unaffected by the physostigmine treatment.
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  • Result 1-2 of 2
Type of publication
journal article (2)
Type of content
peer-reviewed (2)
Author/Editor
Ekström, Jörgen, 194 ... (2)
Khosravani, Nina (2)
Birkhed, Dowen, 1946 (1)
Ekman, Rolf, 1938 (1)
University
University of Gothenburg (2)
Language
English (2)
Research subject (UKÄ/SCB)
Medical and Health Sciences (2)
Year
2007 (2)Undo refine

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