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- Gadea, A, et al.
(author)
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Magnetic rotation in the Sn-105 nucleus
- 1997
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In: PHYSICAL REVIEW C-NUCLEAR PHYSICS. - : AMER INST PHYSICS. ; 55:1, s. R1-R4
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Journal article (other academic/artistic)abstract
- The structure of Sn-105 has been investigated through the Cr-50(Ni-58,2pn) reaction at a beam energy of 210 MeV. In addition to an extension of the spherical level scheme a regular sequence of dipole transitions has been found. The states of the dipole ba
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| 9. |
- Gadea, A, et al.
(author)
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Shears band in the Sn-105 nucleus
- 1997
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In: ZEITSCHRIFT FUR PHYSIK A-HADRONS AND NUCLEI. - : SPRINGER VERLAG. ; 358:2, s. 193-194
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Journal article (other academic/artistic)abstract
- The structure of Sn-105 has been investigated through the Cr-50(Ni-58, 2pn) reaction at a beam energy of 210 MeV. In addition to an extension of the spherical level scheme, a regular sequence of dipole transitions has been found. The experimental results
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- Gunnelin, K, et al.
(author)
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Bond-length-dependent core hole localization observed in simple hydrocarbons
- 1999
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In: Physical Review Letters. - 0031-9007. ; 83:7, s. 1315-1318
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Journal article (peer-reviewed)abstract
- Soft x-ray-emission spectroscopy is applied to measure the amount of dynamic symmetry breaking in core-excited acetylene, ethylene, and ethane. Large variations are observed between the molecules and are rationalized in terms of the different C-C bond lengths: Shorter bond lengths give smaller symmetry breaking. The results also indicate that asymmetric modes are important for all the systems studied, in contradiction to previous assumptions in literature.
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| 12. |
- Gunnelin, K, et al.
(author)
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Bond-length-dependent core hole localization observed in simple hydrocarbons
- 1999
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In: PHYSICAL REVIEW LETTERS. - : AMERICAN PHYSICAL SOC. - 0031-9007. ; 83:7, s. 1315-1318
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Journal article (other academic/artistic)abstract
- Soft x-ray-emission spectroscopy is applied to measure the amount of dynamic symmetry breaking in core-excited acetylene, ethylene, and ethane. Large variations are observed between the molecules and are rationalized in terms of the different C-C bond len
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- Larsson, LI, et al.
(author)
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Retinopathy in diabetic patients aged 15-50 years in the county of Umea, Sweden
- 1999
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In: ACTA OPHTHALMOLOGICA SCANDINAVICA. - : SCRIPTOR PUBLISHER. - 1395-3907. ; 77:4, s. 430-436
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Journal article (other academic/artistic)abstract
- Purpose: To examine the prevalence of diabetic retinopathy and its relation to certain risk factors (glycosylated hemoglobin, blood pressure, serum creatinine, proteinuria, smoking) in a population-based study on a specific age-group of patients with diab
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| 33. |
- Tamás, Markus J., 1970, et al.
(author)
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Fps1p controls the accumulation and release of the compatible solute glycerol in yeast osmoregulation.
- 1999
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In: Molecular microbiology. - 0950-382X .- 1365-2958. ; 4, s. 1087-104
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Journal article (peer-reviewed)abstract
- The accumulation of compatible solutes, such as glycerol, in the yeast Saccharomyces cerevisiae, is a ubiquitous mechanism in cellular osmoregulation. Here, we demonstrate that yeast cells control glycerol accumulation in part via a regulated, Fps1p-mediated export of glycerol. Fps1p is a member of the MIP family of channel proteins most closely related to the bacterial glycerol facilitators. The protein is localized in the plasma membrane. The physiological role of Fps1p appears to be glycerol export rather than uptake. Fps1 delta mutants are sensitive to hypo-osmotic shock, demonstrating that osmolyte export is required for recovery from a sudden drop in external osmolarity. In wild-type cells, the glycerol transport rate is decreased by hyperosmotic shock and increased by hypo-osmotic shock on a subminute time scale. This regulation seems to be independent of the known yeast osmosensing HOG and PKC signalling pathways. Mutants lacking the unique hydrophilic N-terminal domain of Fps1p, or certain parts thereof, fail to reduce the glycerol transport rate after a hyperosmotic shock. Yeast cells carrying these constructs constitutively release glycerol and show a dominant hyperosmosensitivity, but compensate for glycerol loss after prolonged incubation by glycerol overproduction. Fps1p may be an example of a more widespread class of regulators of osmoadaptation, which control the cellular content and release of compatible solutes.
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| 37. |
- Zhang, B, et al.
(author)
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Discovery of a small molecule insulin mimetic with antidiabetic activity in mice
- 1999
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In: Science (New York, N.Y.). - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 284:5416, s. 974-977
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Journal article (peer-reviewed)abstract
- Insulin elicits a spectrum of biological responses by binding to its cell surface receptor. In a screen for small molecules that activate the human insulin receptor tyrosine kinase, a nonpeptidyl fungal metabolite (L-783,281) was identified that acted as an insulin mimetic in several biochemical and cellular assays. The compound was selective for insulin receptor versus insulin-like growth factor I (IGFI) receptor and other receptor tyrosine kinases. Oral administration of L-783,281 to two mouse models of diabetes resulted in significant lowering in blood glucose levels. These results demonstrate the feasibility of discovering novel insulin receptor activators that may lead to new therapies for diabetes.
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