| 1. |
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- 2019
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Journal article (peer-reviewed)
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| 2. |
- Kattge, Jens, et al.
(author)
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TRY plant trait database - enhanced coverage and open access
- 2020
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In: Global Change Biology. - : Wiley-Blackwell. - 1354-1013 .- 1365-2486. ; 26:1, s. 119-188
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Journal article (peer-reviewed)abstract
- Plant traits-the morphological, anatomical, physiological, biochemical and phenological characteristics of plants-determine how plants respond to environmental factors, affect other trophic levels, and influence ecosystem properties and their benefits and detriments to people. Plant trait data thus represent the basis for a vast area of research spanning from evolutionary biology, community and functional ecology, to biodiversity conservation, ecosystem and landscape management, restoration, biogeography and earth system modelling. Since its foundation in 2007, the TRY database of plant traits has grown continuously. It now provides unprecedented data coverage under an open access data policy and is the main plant trait database used by the research community worldwide. Increasingly, the TRY database also supports new frontiers of trait-based plant research, including the identification of data gaps and the subsequent mobilization or measurement of new data. To support this development, in this article we evaluate the extent of the trait data compiled in TRY and analyse emerging patterns of data coverage and representativeness. Best species coverage is achieved for categorical traits-almost complete coverage for 'plant growth form'. However, most traits relevant for ecology and vegetation modelling are characterized by continuous intraspecific variation and trait-environmental relationships. These traits have to be measured on individual plants in their respective environment. Despite unprecedented data coverage, we observe a humbling lack of completeness and representativeness of these continuous traits in many aspects. We, therefore, conclude that reducing data gaps and biases in the TRY database remains a key challenge and requires a coordinated approach to data mobilization and trait measurements. This can only be achieved in collaboration with other initiatives.
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| 3. |
- Lundgren, Markus, et al.
(author)
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Analgesic antipyretic use among young children in the TEDDY study : No association with islet autoimmunity
- 2017
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In: BMC Pediatrics. - : Springer Science and Business Media LLC. - 1471-2431. ; 17:1
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Journal article (peer-reviewed)abstract
- Background: The use of analgesic antipyretics (ANAP) in children have long been a matter of controversy. Data on their practical use on an individual level has, however, been scarce. There are indications of possible effects on glucose homeostasis and immune function related to the use of ANAP. The aim of this study was to analyze patterns of analgesic antipyretic use across the clinical centers of The Environmental Determinants of Diabetes in the Young (TEDDY) prospective cohort study and test if ANAP use was a risk factor for islet autoimmunity. Methods: Data were collected for 8542 children in the first 2.5 years of life. Incidence was analyzed using logistic regression with country and first child status as independent variables. Holm's procedure was used to adjust for multiplicity of intercountry comparisons. Time to autoantibody seroconversion was analyzed using a Cox proportional hazards model with cumulative analgesic use as primary time dependent covariate of interest. For each categorization, a generalized estimating equation (GEE) approach was used. Results: Higher prevalence of ANAP use was found in the U.S. (95.7%) and Sweden (94.8%) compared to Finland (78.1%) and Germany (80.2%). First-born children were more commonly given acetaminophen (OR 1.26; 95% CI 1.07, 1.49; p = 0.007) but less commonly Non-Steroidal Anti-inflammatory Drugs (NSAID) (OR 0.86; 95% CI 0.78, 0.95; p = 0.002). Acetaminophen and NSAID use in the absence of fever and infection was more prevalent in the U.S. (40.4%; 26.3% of doses) compared to Sweden, Finland and Germany (p < 0.001). Acetaminophen or NSAID use before age 2.5 years did not predict development of islet autoimmunity by age 6 years (HR 1.02, 95% CI 0.99-1.09; p = 0.27). In a sub-analysis, acetaminophen use in children with fever weakly predicted development of islet autoimmunity by age 3 years (HR 1.05; 95% CI 1.01-1.09; p = 0.024). Conclusions: ANAP use in young children is not a risk factor for seroconversion by age 6 years. Use of ANAP is widespread in young children, and significantly higher in the U.S. compared to other study sites, where use is common also in absence of fever and infection.
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| 4. |
- Chen, Xuelong, et al.
(author)
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Investigation of Precipitation Process in the Water Vapor Channel of the Yarlung Zsangbo Grand Canyon
- 2024
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In: BULLETIN OF THE AMERICAN METEOROLOGICAL SOCIETY. - 0003-0007 .- 1520-0477. ; 105:2
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Journal article (peer-reviewed)abstract
- The Yarlung Zsangbo Grand Canyon (YGC) is an important pathway for water vapor transport from southern Asia to the Tibetan Plateau (TP). This area exhibits one of the highest frequencies of convective activity in China, and precipitation often induces natural disasters in local communities, which can dramatically affect their livelihoods. In addition, the produced precipitation gives rise to vast glaciers and large rivers around the YGC. In 2018, the Second Tibetan Plateau Scientific Expedition and Research Program tasked a research team to conduct an "investigation of the precipitation process in the water vapor channel of the Yarlung Zsangbo Grand Canyon" (INVC) in the southeastern TP. This team subsequently established a comprehensive observation system of land-air interaction, water vapor, clouds, and rainfall activity in the YGC. This paper introduces the developed observation system and summarizes the preliminary results obtained during the first two years of the project. Using this INVC observation network, herein, we focus on the development of rainfall events on the southeastern TP. This project also helps to monitor geohazards in the key area of the Sichuan-Tibet railway, which traverses the northern YGC. The observation datasets will benefit future research on mountain meteorology.
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| 5. |
- Ehlers, Todd A., et al.
(author)
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Past, present, and future geo-biosphere interactions on the Tibetan Plateau and implications for permafrost
- 2022
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In: Earth-Science Reviews. - : Elsevier BV. - 0012-8252. ; 234
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Journal article (peer-reviewed)abstract
- Interactions between the atmosphere, biosphere, cryosphere, hydrosphere, and geosphere are most active in the critical zone, a region extending from the tops of trees to the top of unweathered bedrock. Changes in one or more of these spheres can result in a cascade of changes throughout the system in ways that are often poorly understood. Here we investigate how past and present climate change have impacted permafrost, hydrology, and ecosystems on the Tibetan Plateau. We do this by compiling existing climate, hydrologic, cryosphere, biosphere, and geologic studies documenting change over decadal to glacial-interglacial timescales and longer. Our emphasis is on showing present-day trends in environmental change and how plateau ecosystems have largely flourished under warmer and wetter periods in the geologic past. We identify two future pathways that could lead to either a favorable greening or unfavorable degradation and desiccation of plateau ecosystems. Both paths are plausible given the available evidence. We contend that the key to which pathway future generations experience lies in what, if any, human intervention measures are implemented. We conclude with suggested management strategies that can be implemented to facilitate a future greening of the Tibetan Plateau.
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| 6. |
- Burlaka, Ievgeniia, et al.
(author)
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Ouabain Protects against Shiga Toxin-Triggered Apoptosis by Reversing the Imbalance between Bax and Bcl-xL
- 2013
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In: Journal of the American Society of Nephrology. - 1046-6673 .- 1533-3450. ; 24:9, s. 1413-1423
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Journal article (peer-reviewed)abstract
- Hemolytic uremic syndrome, a life-threatening disease often accompanied by acute renal failure, usually occurs after gastrointestinal infection with Shiga toxin 2 (Stx2)-producing Escherichia coli. Stx2 binds to the glycosphingolipid globotriaosylceramide receptor, expressed by renal epithelial cells, and triggers apoptosis by activating the apoptotic factor Bax. Signaling via the ouabain/Na,K-ATPase/IP3R/NF-B pathway increases expression of Bcl-xL, an inhibitor of Bax, suggesting that ouabain might protect renal cells from Stx2-triggered apoptosis. Here, exposing rat proximal tubular cells to Stx2 in vitro resulted in massive apoptosis, upregulation of the apoptotic factor Bax, increased cleaved caspase-3, and downregulation of the survival factor Bcl-xL; co-incubation with ouabain prevented all of these effects. Ouabain activated the NF-B antiapoptotic subunit p65, and the inhibition of p65 DNA binding abolished the antiapoptotic effect of ouabain in Stx2-exposed tubular cells. Furthermore, in vivo, administration of ouabain reversed the imbalance between Bax and Bcl-xL in Stx2-treated mice. Taken together, these results suggest that ouabain can protect the kidney from the apoptotic effects of Stx2.
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| 7. |
- Chaturvedi, Swasti, et al.
(author)
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Slit2 Prevents Neutrophil Recruitment and Renal Ischemia-Reperfusion Injury : english
- 2013
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In: Journal of the American Society of Nephrology. - 1046-6673. ; 24:8, s. 1274-1287
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Journal article (peer-reviewed)abstract
- Neutrophils recruited to the postischemic kidney contribute to the pathogenesis of ischemia-reperfusion injury (IRI), which is the most common cause of renal failure among hospitalized patients. The Slit family of secreted proteins inhibits chemotaxis of leukocytes by preventing activation of Rho-family GTPases, suggesting that members of this family might modulate the recruitment of neutrophils and the resulting IRI. Here, in static and microfluidic shear assays, Slit2 inhibited multiple steps required for the infiltration of neutrophils into tissue. Specifically, Slit2 blocked the capture and firm adhesion of human neutrophils to inflamed vascular endothelial barriers as well as their subsequent transmigration. To examine whether these observations were relevant to renal IRI, we administered Slit2 to mice before bilateral clamping of the renal pedicles. Assessed at 18 hours after reperfusion, Slit2 significantly inhibited renal tubular necrosis, neutrophil and macrophage infiltration, and rise in plasma creatinine. In vitro, Slit2 did not impair the protective functions of neutrophils, including phagocytosis and superoxide production, and did not inhibit neutrophils from killing the extracellular pathogen Staphylococcus aureus. In vivo, administration of Slit2 did not attenuate neutrophil recruitment or bacterial clearance in mice with ascending Escherichia coli urinary tract infections and did not increase the bacterial load in the livers of mice infected with the intracellular pathogen Listeria monocytogenes. Collectively, these results suggest that Slit2 may hold promise as a strategy to combat renal IRI without compromising the protective innate immune response.
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| 8. |
- Fortelius, Mikael, et al.
(author)
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The Origin and Early History of NOW as It Happened
- 2023
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In: Evolution of Cenozoic Land Mammal Faunas and Ecosystems: 25 years of the NOW database of fossil mammals.. - : Springer. ; , s. 7-32
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Book chapter (peer-reviewed)abstract
- The NOW database of fossil mammals came to be through a confluence of several initiatives spanning multiple decades. The first public version of NOW database was released in 1996 and the first Advisory Board was established the year after. Originally, NOW stood for Neogene of the Old World but with the gradual expansion of the database the acronym was eventually reassigned to stand for New and Old Worlds. The structure of what would become NOW was originally cloned from the ETE database of the Smithsonian Institution and the first NOW version accessible over the internet was a node of the ETE database. The first standalone, online version of NOW was launched in 2005 and the first formal steering group was established in 2009. During its existence, NOW has been funded, directly or indirectly, by several organizations but fundamentally it has always been an unfunded community effort, dependent on voluntary work by the participants.
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| 9. |
- Ghalwash, Mohamed, et al.
(author)
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Islet autoantibody screening in at-risk adolescents to predict type 1 diabetes until young adulthood : a prospective cohort study
- 2023
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In: The Lancet Child and Adolescent Health. - 2352-4642. ; 7:4, s. 261-268
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Journal article (peer-reviewed)abstract
- Background: Screening for islet autoantibodies in children and adolescents identifies individuals who will later develop type 1 diabetes, allowing patient and family education to prevent diabetic ketoacidosis at onset and to enable consideration of preventive therapies. We aimed to assess whether islet autoantibody screening is effective for predicting type 1 diabetes in adolescents aged 10−18 years with an increased risk of developing type 1 diabetes. Methods: Data were harmonised from prospective studies from Finland (the Diabetes Prediction and Prevention study), Germany (the BABYDIAB study), and the USA (Diabetes Autoimmunity Study in the Young and the Diabetes Evaluation in Washington study). Autoantibodies against insulin, glutamic acid decarboxylase, and insulinoma-associated protein 2 were measured at each follow-up visit. Children who were lost to follow-up or diagnosed with type 1 diabetes before 10 years of age were excluded. Inverse probability censoring weighting was used to include data from remaining participants. Sensitivity and the positive predictive value of these autoantibodies, tested at one or two ages, to predict type 1 diabetes by the age of 18 years were the main outcomes. Findings: Of 20 303 children with an increased type 1 diabetes risk, 8682 were included for the analysis with inverse probability censoring weighting. 1890 were followed up to 18 years of age or developed type 1 diabetes between the ages of 10 years and 18 years, and their median follow-up was 18·3 years (IQR 14·5–20·3). 442 (23·4%) of 1890 adolescents were positive for at least one islet autoantibody, and 262 (13·9%) developed type 1 diabetes. Time from seroconversion to diabetes diagnosis increased by 0·64 years (95% CI 0·34–0·95) for each 1-year increment of diagnosis age (Pearson's correlation coefficient 0·88, 95% CI 0·50–0·97, p=0·0020). The median interval between the last prediagnostic sample and diagnosis was 0·3 years (IQR 0·1–1·3) in the 227 participants who were autoantibody positive and 6·8 years (1·6–9·9) for the 35 who were autoantibody negative. Single screening at the age of 10 years was 90% (95% CI 86–95) sensitive, with a positive predictive value of 66% (60–72) for clinical diabetes. Screening at two ages (10 years and 14 years) increased sensitivity to 93% (95% CI 89–97) but lowered the positive predictive value to 55% (49–60). Interpretation: Screening of adolescents at risk for type 1 diabetes only once at 10 years of age for islet autoantibodies was highly effective to detect type 1 diabetes by the age of 18 years, which in turn could enable prevention of diabetic ketoacidosis and participation in secondary prevention trials. Funding: JDRF International.
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| 10. |
- Heyman, Jakob, 1979-, et al.
(author)
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A paleoglaciological reconstruction for Bayan Har Shan, NE Tibetan Plateau
- 2009
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Conference paper (peer-reviewed)abstract
- The paleoglaciology of the Tibetan Plateau has remained elusive because extensive areas still lack detailed scrutiny. We here present a paleoglaciological reconstruction for the Bayan Har Shan region, NE Tibetan Plateau, which could serve as a working model to investigate other poorly investigated regions. The reconstruction is primarily based on three methods for revealing the glacial history; 1) remote sensing (geomorphology), 2) field studies (stratigraphy), and 3) numerical dating techniques. Remote sensing (SRTM elevation data, Landsat ETM+ satellite imagery and Google Earth) of a 136 500 km2 area reveals an abundance of glacial landforms in the highest mountain areas and an absence of glacial landforms on intervening plateau surfaces. Stratigraphical data collected during three field seasons supplement the picture emerging from remote sensing. Glacial deposits (including erratic boulders and till) occur in the elevated mountain areas but are absent on the intervening plateau areas. Marginal moraines in central Bayan Har can be grouped to represent at least three separate glacial extents and scattered observations of glacial deposits indicate the presence of a fourth (and maximum) glacial extent. To tie the glacial geological record to a chronology we have employed terrestrial cosmogenic nuclide (TCN) exposure and optically stimulated luminescence (OSL) dating. Beryllium apparent exposure ages of 65 glacial boulders, surface cobbles/pebbles and depth profile samples yield minimum ages for the three youngest glacial extents of 40-65 ka, 60-100 ka, and 95-165 ka (with the wide age ranges due to TCN dating uncertainties). A preliminary OSL age of c. 160 ka from glacial sediments of the oldest of these glacial extents supports our interpretation based on TCN dating. The glacial extent presented here is more restricted than most previous reconstructions, most notably with very restricted glaciers over at least the last 40-65 ka. These results indicate that while continental-scale ice sheets evolved and disappeared in North America and Eurasia over the last half of the last glacial cycle, the NE corner of the Tibetan Plateau experienced relatively minor glacial fluctuations.
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| 11. |
- Heyman, Jakob, 1979-, et al.
(author)
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An evaluation of multiple working hypotheses to explain cosmogenic exposure age data from glacial deposits in the Bayan Har Shan, NE Tibetan Plateau
- 2009
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In: Proceedings.
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Conference paper (peer-reviewed)abstract
- Many questions remain unanswered regarding the Quaternary glaciations of the Tibetan Plateau. We have used terrestrial cosmogenic nuclide (TCN) exposure age dating of glacial deposits to examine the style, extent, and timing of past glaciations of the Bayan Har Shan, a mountain region on the northeastern Tibetan Plateau. This area lies within a transition zone between the dry interior of the Tibetan Plateau and the wetter eastern margin affected by the Asian monsoon. Bayan Har Shan has many glacial landforms and deposits that provide evidence for former glaciation ranging from cirque and valley glaciers to ice-fields and ice caps.In an attempt to constrain the timing of glaciations in Bayan Har Shan, we have performed TCN exposure dating on 65 samples in central Bayan Har Shan from glacial deposits. boulders (39 samples), on surface pebbles/cobbles (12 samples), and on pebbles in sediment depth profiles (14 samples from four profiles) allow us to examine the timing and extent of glaciations in this area. As is often the case, there are some challenges in interpreting the range of TCN apparent exposure ages that is found in data from several samples and sample types on a single deposit and from samples taken at various sites. Thus we evaluate multiple working hypotheses to explain apparent exposure ages on glacial deposits, which in this case range from 3 ka to 129 ka. We consider three different hypotheses; 1) some samples have erroneously old exposure ages due to inheritance, 2) samples have been preserved under cold-based, non-erosive ice, and 3) samples have experienced only post-glacial shielding. Only when we adopt a hypothesis that assumes no prior exposure, and thus that maximum apparent exposure ages constrain the minimum age of formation of a feature (working hypotheses 3), do we find broad consistency between apparent exposure ages from different sample types (erratic boulders, surface pebbles/cobbles and pebbles from depth profiles). This leads to the conclusion that all of the sites of former glaciations we examined are at least 50ka in age, and that there has been no large-scale expansion of glaciers in the central Bayan Har Shan over the last 50ka.
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| 12. |
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| 13. |
- Heyman, Jakob, et al.
(author)
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Landscape evolution of the northeastern Tibetan plateau - relict surfaces and fluvial margins
- 2007
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In: Geophysical Research Abstracts.
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Conference paper (peer-reviewed)abstract
- The actively uplifting Tibetan plateau has a profound impact on climate and displays a landscape marked by geomorphological action. This is because the uplift is counteracted by intense fluvial incision of some of the world’s largest rivers and their tributaries that drain the plateau. Glaciers and glacial landforms occur predominantly in and around the highest elevation areas. By investigating the imprints of glacial and fluvial erosion we can enhance our understanding of the long-term landscape evolution, as well as illuminate the paleoglaciology of the Tibetan plateau. We here present an investigation of the large-scale geomorphology of the northeastern Tibetan plateau and its implication for landscape evolution and paleoenvironmental reconstructions.The northeastern part of the Tibetan plateau is characterized by a plateau surface at c. 4300 m asl with higher mountain groups reaching up to 1500 m above the surrounding plateau surface. We used SRTM 90 m digital elevation model, satellite images and Google Earth imagery to map the large-scale geomorphology for an area of c. 135.000 km2 centered around the Bayan Har mountains. Our mapping reveals a clear pattern of substantial glacial erosion on the highest, central parts of the mountain areas and decreasing amounts of glacial erosion with decreasing elevation and increasing distance away from these centers of glaciation. Beyond the areas of glacial erosion, there is a low-relief fluvial landscape that typifies the rest of the plateau surface. The plateau margins are formed by steep fluvial valleys which cut backwards into the gentle sloping relict plateau surface. Thus, the overall landscape may be divided into three classes; (i) glacially eroded surfaces in the highest areas, (ii) a relict, low-relief plateau surface, and (iii) a steep, fluvial landscape juxtaposing the former two classes.The distribution of the different landscapes indicates the following temporal evolution of the landscape. The glacial landforms indicate a repeated glaciation of the mountain areas. The steep fluvial valleys consuming the relict plateau surface represent an ongoing adjustment of the river channels to the actively uplifting plateau margin. The pattern of abandoned fluvial erosion of the northern part of the study area supports the notion of a stepwise uplift. This is because progressively younger uplift of the northern parts of the area induced a piracy of originally N-flowing rivers to currently ESE-flowing rivers along major faults (such as we infer for the Huang He river). It is noteworthy that the outline of the relict landscape, that is the pronounced break in slope between the low-relief relict landscape and the young fluvial landscape, coincides almost completely with the outline of a hypothesized former ice sheet, the Huang He ice sheet. We have not been able to confirm the presence of geomorphology or stratigraphy that would support this reconstruction. If true, however, our notion of outline conformance could indicate that the Huang He ice sheet may actually have been larger than suggested and that glacial traces are being consumed by the fluvial incision triggered by plateau uplift.
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| 14. |
- Heyman, Jakob, 1979-, et al.
(author)
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Palaeoglaciation of Bayan Har Shan, northeastern Tibetan Plateau: glacial geology indicates maximum extents limited to ice cap and ice field scales
- 2009
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In: Journal of Quaternary Science. - : John Wiley & Sons. - 0267-8179 .- 1099-1417. ; 24:7, s. 710-727
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Journal article (peer-reviewed)abstract
- Key locations within an extensive area of the northeastern Tibetan Plateau, centred on Bayan Har Shan, have been mapped to distinguish glacial from non-glacial deposits. Prior work suggests palaeo-glaciers ranging from valley glaciers and local ice caps in the highest mountains to a regional or even plateau-scale ice sheet. New field data show that glacial deposits are abundant in high mountain areas in association with large-scale glacial landforms. In addition, glacial deposits are present in several locations outside areas with distinct glacial erosional landforms, indicating that the most extensive palaeo-glaciers had little geomorphological impact on the landscape towards their margins. The glacial geological record does indicate extensive maximum glaciation, with local ice caps covering entire elevated mountain areas. However, absence of glacial traces in intervening lower-lying plateau areas suggests that local ice caps did not merge to form a regional ice sheet on the northeastern Tibetan Plateau around Bayan Har Shan. No evidence exists for past ice sheet glaciation.
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| 15. |
- Hou, Liping, et al.
(author)
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Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder.
- 2016
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In: Human molecular genetics. - : Oxford University Press (OUP). - 1460-2083 .- 0964-6906. ; 25:15, s. 3383-94
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Journal article (peer-reviewed)abstract
- Bipolar disorder (BD) is a genetically complex mental illness characterized by severe oscillations of mood and behavior. Genome-wide association studies (GWAS) have identified several risk loci that together account for a small portion of the heritability. To identify additional risk loci, we performed a two-stage meta-analysis of >9 million genetic variants in 9,784 bipolar disorder patients and 30,471 controls, the largest GWAS of BD to date. In this study, to increase power we used ∼2,000 lithium-treated cases with a long-term diagnosis of BD from the Consortium on Lithium Genetics, excess controls, and analytic methods optimized for markers on the X-chromosome. In addition to four known loci, results revealed genome-wide significant associations at two novel loci: an intergenic region on 9p21.3 (rs12553324, p=5.87×10(-9); odds ratio=1.12) and markers within ERBB2 (rs2517959, p=4.53×10(-9); odds ratio=1.13). No significant X-chromosome associations were detected and X-linked markers explained very little BD heritability. The results add to a growing list of common autosomal variants involved in BD and illustrate the power of comparing well-characterized cases to an excess of controls in GWAS.
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| 16. |
- Huang, Liping, et al.
(author)
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Interim effects of salt substitution on urinary electrolytes and blood pressure in the China Salt Substitute and Stroke Study (SSaSS).
- 2020
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In: American Heart Journal. - : Elsevier BV. - 0002-8703 .- 1097-6744. ; 221, s. 136-145
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Journal article (peer-reviewed)abstract
- The Salt Substitute and Stroke Study is an ongoing 5-year large-scale cluster randomized trial investigating the effects of potassium-enriched salt substitute compared to usual salt on the risk of stroke. The study involves 600 villages and 20,996 individuals in rural China. Intermediate risk markers were measured in a random subsample of villages every 12 months over 3 years to track progress against key assumptions underlying study design. Measures of 24-hour urinary sodium, 24-hour urinary potassium, blood pressure and participants' use of salt substitute were recorded, with differences between intervention and control groups estimated using generalized linear mixed models. The primary outcome of annual event rate in the two groups combined was determined by dividing confirmed fatal and non-fatal strokes by total follow-up time in the first 2 years. The mean differences (95% CI) were -0.32 g (-0.68 to 0.05) for 24-hour urinary sodium, +0.77 g (+0.60 to +0.93) for 24-hour urinary potassium, -2.65 mmHg (-4.32 to -0.97) for systolic blood pressure and +0.30 mmHg (-0.72 to +1.32) for diastolic blood pressure. Use of salt substitute was reported by 97.5% in the intervention group versus 4.2% in the control group (P<.0001). The overall estimated annual event rate for fatal and non-fatal stroke was 3.2%. The systolic blood pressure difference and the annual stroke rate were both in line with the statistical assumptions underlying study design. The trial should be well placed to address the primary hypothesis at completion of follow-up.
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| 17. |
- Huang, Liping, et al.
(author)
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The contribution of sodium reduction and potassium increase to the blood pressure lowering observed in the Salt Substitute and Stroke Study
- 2024
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In: Journal of Human Hypertension. - : Springer Nature. - 0950-9240 .- 1476-5527. ; 38:4, s. 298-306
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Journal article (peer-reviewed)abstract
- The Salt Substitute and Stroke Study (SSaSS) demonstrated significant reductions in systolic blood pressure (SBP), and the risk of stroke, major cardiovascular events and total mortality with the use of potassium-enriched salt. The contribution of sodium reduction versus potassium increase to these effects is unknown. We identified four different data sources describing the association between sodium reduction, potassium supplementation and change in SBP. We then fitted a series of models to estimate the SBP reductions expected for the differences in sodium and potassium intake in SSaSS, derived from 24-h urine collections. The proportions of the SBP reduction separately attributable to sodium reduction and potassium supplementation were calculated. The observed SBP reduction in SSaSS was -3.3 mmHg with a corresponding mean 15.2 mmol reduction in 24-h sodium excretion and a mean 20.6 mmol increase in 24-h potassium excretion. Assuming 90% of dietary sodium intake and 70% of dietary potassium intake were excreted through urine, the models projected falls in SBP of between -1.67 (95% confidence interval: -4.06 to +0.73) mmHg and -5.33 (95% confidence interval: -8.58 to -2.08) mmHg. The estimated proportional contribution of sodium reduction to the SBP fall ranged between 12 and 39% for the different models fitted. Sensitivity analyses assuming different proportional urinary excretion of dietary sodium and potassium intake showed similar results. In every model, the majority of the SBP lowering effect in SSaSS was estimated to be attributable to the increase in dietary potassium rather than the fall in dietary sodium.
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| 18. |
- Huo, Huan, et al.
(author)
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Anomalous Region Detection on the Mobility Data
- 2015
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In: CIT/IUCC/DASC/PICOM 2015 IEEE INTERNATIONAL CONFERENCE ON COMPUTER AND INFORMATION TECHNOLOGY - UBIQUITOUS COMPUTING AND COMMUNICATIONS - DEPENDABLE, AUTONOMIC AND SECURE COMPUTING - PERVASIVE INTELLIGENCE AND COMPUTING. - : Institute of Electrical and Electronics Engineers (IEEE). - 9781509001545 ; , s. 1669-1674
-
Conference paper (peer-reviewed)abstract
- Mobility data records the change of location and time about the crowd activities, reflecting a large amount of semantic knowledge about human mobility and hot regions. From the perspective of regional semantic knowledge, mining anomalous regions of overcrowded area is essential for disaster-aware resilience system scheme. This paper studies how to discover anomalous regions of moving crowds over the mobility data. From the perspective of spatial information analysis about the location sequence of moving crowds, the paper introduces grid structure to index activity space and proposes a density calculation method of grid cells based on kernel function. By adopting Top-k sorting method, the algorithm determines the density thresholds to detect the anomalous regions. Finally, experimental results validate the feasibility and effectiveness of the above method on practical data sets.
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| 19. |
- Jiao, Xiang, et al.
(author)
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PHIP - a novel candidate breast cancer susceptibility locus on 6q14.1
- 2017
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In: Oncotarget. - : IMPACT JOURNALS LLC. - 1949-2553. ; 8:61, s. 102769-102782
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Journal article (peer-reviewed)abstract
- Most non-BRCA1/2 breast cancer families have no identified genetic cause. We used linkage and haplotype analyses in familial and sporadic breast cancer cases to identify a susceptibility locus on chromosome 6q. Two independent genome-wide linkage analysis studies suggested a 3 Mb locus on chromosome 6q and two unrelated Swedish families with a LOD > 2 together seemed to share a haplotype in 6q14.1. We hypothesized that this region harbored a rare high-risk founder allele contributing to breast cancer in these two families. Sequencing of DNA and RNA from the two families did not detect any pathogenic mutations. Finally, 29 SNPs in the region were analyzed in 44,214 cases and 43,532 controls from BCAC, and the original haplotypes in the two families were suggested as low-risk alleles for European and Swedish women specifically. There was also some support for one additional independent moderate-risk allele in Swedish familial samples. The results were consistent with our previous findings in familial breast cancer and supported a breast cancer susceptibility locus at 6q14.1 around the PHIP gene.
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| 20. |
- Kim, Joosup, et al.
(author)
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Global Stroke Statistics 2019
- 2020
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In: International Journal of Stroke. - : SAGE Publications. - 1747-4930 .- 1747-4949. ; 15:8, s. 819-838
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Research review (peer-reviewed)abstract
- Background: Data on stroke epidemiology and availability of hospital-based stroke services around the world are important for guiding policy decisions and healthcare planning. Aims: To provide the most current incidence, mortality and case–fatality data on stroke and describe current availability of stroke units around the world by country. Methods: We searched multiple databases (based on our existing search strategy) to identify new original manuscripts and review articles published between 1 June 2016 and 31 October 2018 that met the ideal criteria for data on stroke incidence and case–fatality. For data on the availability of hospital-based stroke services, we searched PubMed for all literature published up until 31 June 2018. We further screened reference lists, citation history of manuscripts and gray literature for this information. Mortality codes for International Classification of Diseases-9 and International Classification of Diseases-10 were extracted from the World Health Organization mortality database for each country providing these data. Population denominators were obtained from the World Health Organization, and when these were unavailable within a two-year period of mortality data, population denominators within a two-year period were obtained from the United Nations. Using country-specific population denominators and the most recent years of mortality data available for each country, we calculated both the crude mortality from stroke and mortality adjusted to the World Health Organization world population. Results: Since our last report in 2017, there were two countries with new incidence studies, China (n = 1) and India (n = 2) that met the ideal criteria. New data on case–fatality were found for Estonia and India. The most current mortality data were available for the year 2015 (39 countries), 2016 (43 countries), and 2017 (7 countries). No new data on mortality were available for six countries. Availability of stroke units was noted for 63 countries, and the proportion of patients treated in stroke units was reported for 35/63 countries. Conclusion: Up-to-date data on stroke incidence, case–fatality, and mortality statistics provide evidence of variation among countries and changing magnitudes of burden among high and low–middle income countries. Reporting of hospital-based stroke units remains limited and should be encouraged.
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| 21. |
- Li, Feng, et al.
(author)
-
Coating of Phosphide Catalysts on p-Silicon by a Necking Strategy for Improved Photoelectrochemical Characteristics in Alkaline Media
- 2021
-
In: ACS Applied Materials and Interfaces. - : American Chemical Society (ACS). - 1944-8244 .- 1944-8252. ; 13:17, s. 20185-20193
-
Journal article (peer-reviewed)abstract
- The methodology of coating electrocatalysts on semiconductor substrates is critical for the catalytic performance of photoelectrochemical electrodes. A weakly bound coating leads to orders of magnitude lower efficiency and reliability compared to those required to meet the commercial demand. Herein, a facile strategy based on the hydrolysis of TiCl4 is developed to solve the coating issue. Mesoporous tungsten phosphide (WP) particles were spin-coated and affixed onto TiO2-protected planar p-Si by the formation of a TiO2 necking layer between the catalyst particles and the substrates. Under 1 sun illumination, the as-prepared WP/TiO2/Si photocathode yields a saturated current density of -35 mA cm(-2) and a durability of over 110 h with a current density over -15 mA cm(-2) at 0 V versus a reversible hydrogen electrode in a 1.0 M KOH solution, which is among the state-of-the-art performances of commercial planar Si-based photocathodes. The Kelvin probe force microscopy results suggest the successive transfer of photoelectrons from Si to TiO2 and WP. The as-formed TiO2 necking layer plays the key role in ensuring the surface catalytic activity and durability. This necking strategy is also applicable for coating other transition-metal phosphides, for example, MoP and FeP, thus offering a practical approach to meet the commercial requirement of low-cost, highly efficient, and durable photoelectrodes.
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| 22. |
- Li, Jing, et al.
(author)
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Neurotensin accelerates atherosclerosis and increases circulating levels of short-chain and saturated triglycerides
-
In: Atherosclerosis. - 0021-9150.
-
Journal article (peer-reviewed)abstract
- Background and aims: Obesity and type 2 diabetes are significant risk factors for atherosclerotic cardiovascular disease (CVD) worldwide, but the underlying pathophysiological links are poorly understood. Neurotensin (NT), a 13-amino-acid hormone peptide, facilitates intestinal fat absorption and contributes to obesity in mice fed a high-fat diet. Elevated levels of pro-NT (a stable NT precursor produced in equimolar amounts relative to NT) are associated with obesity, type 2 diabetes, and CVD in humans. Whether NT is a causative factor in CVD is unknown. Methods: Nt+/+ and Nt–/– mice were either injected with adeno-associated virus encoding PCSK9 mutants or crossed with Ldlr–/– mice and fed a Western diet. Atherosclerotic plaques were analyzed by en face analysis, Oil Red O and CD68 staining. In humans, we evaluated the association between baseline pro-NT and growth of carotid bulb thickness after 16.4 years. Lipidomic profiles were analyzed. Results: Atherosclerotic plaque formation is attenuated in Nt-deficient mice through mechanisms that are independent of reductions in circulating cholesterol and triglycerides but associated with remodeling of the plasma triglyceride pool. An increasing plasma concentration of pro-NT predicts atherosclerotic events in coronary and cerebral arteries independent of all major traditional risk factors, indicating a strong link between NT and atherosclerosis. This plasma lipid profile analysis confirms the association of pro-NT with remodeling of the plasma triglyceride pool in atherosclerotic events. Conclusions: Our findings are the first to directly link NT to increased atherosclerosis and indicate the potential role for NT in preventive and therapeutic strategies for CVD.
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| 23. |
- Li, Marcella, et al.
(author)
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A Report on the International Transglutaminase Autoantibody Workshop for Celiac Disease
- 2009
-
In: American Journal of Gastroenterology. - : Ovid Technologies (Wolters Kluwer Health). - 1572-0241 .- 0002-9270. ; 104:1, s. 154-163
-
Journal article (peer-reviewed)abstract
- OBJECTIVES: Measurement of transglutaminase autoantibodies (TGAA) is considered to be the most efficient single serologic test for celiac disease (CD) by the American Gastroenterological Association Institute. We hypothesized that a large international collaborative effort toward improving and standardizing TGAA measurement is both feasible and necessary. The primary aim of this workshop is to compare TGAA assays among various research and clinical laboratories and examine assay concordance and improve (and eventually standardize) the TGAA assay. METHODS: A total of 20 laboratories (5 commercial laboratories, 15 research and clinical laboratories) participated that included enzyme-linked immunosorbent assay (ELISA) and radiobinding assays. A total of 150 serum samples were distributed to each laboratory, with each laboratory receiving an equal aliquot that was coded and blinded, composed of 100 healthy control sera and 50 CD sera. RESULTS: Laboratory sensitivity ranged from 69% to 93% and specificity ranged from 96% to 100%. By receiver operator characteristic analysis, the area under the curve (C index) ranged from 0.9488 to 0.9904. When analyzing for linear correlation, r-squared was as high as 0.8882 but as low as 0.4244 for the celiac samples between different laboratories performing ELISA. CONCLUSIONS: This transglutaminase autoantibody workshop allows for larger-scale international participation for the purposes of improving and eventually standardizing the TGAA assay with subsequent workshops.
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| 24. |
- Li, Yuling, et al.
(author)
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Distributed Neural-Network-Based Cooperation Control for Teleoperation of Multiple Mobile Manipulators Under Round-Robin Protocol
- 2021
-
In: IEEE Transactions on Neural Networks and Learning Systems. - 2162-237X.
-
Journal article (peer-reviewed)abstract
- This article addresses the distributed cooperative control design for a class of sampled-data teleoperation systems with multiple slave mobile manipulators grasping an object in the presence of communication bandwidth limitation and time delays. Discrete-time information transmission with time-varying delays is assumed, and the Round-Robin (RR) scheduling protocol is used to regulate the data transmission from the multiple slaves to the master. The control task is to guarantee the task-space position synchronization between the master and the grasped object with the mobile bases in a fixed formation. A fully distributed control strategy including neural-network-based task-space synchronization controllers and neural-network-based null-space formation controllers is proposed, where the radial basis function (RBF) neural networks with adaptive estimation of approximation errors are used to compensate the dynamical uncertainties. The stability and the synchronization/formation features of the single-master-multiple-slaves (SMMS) teleoperation system are analyzed, and the relationship among the control parameters, the upper bound of the time delays, and the maximum allowable sampling interval is established. Experiments are implemented to validate the effectiveness of the proposed control algorithm.
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| 25. |
- Liu, Jianan, et al.
(author)
-
Deep Instance Segmentation with Automotive Radar Detection Points
- 2023
-
In: IEEE Transactions on Intelligent Vehicles. - 2379-8858. ; 8:1, s. 84-94
-
Journal article (peer-reviewed)abstract
- Automotive radar provides reliable environmental perception in all-weather conditions with affordable cost, but it hardly supplies semantic and geometry information due to the sparsity of radar detection points. With the development of automotive radar technologies in recent years, instance segmentation becomes possible by using automotive radar. Its data contain contexts such as radar cross section and micro-Doppler effects, and sometimes can provide detection when the field of view is obscured. The outcome from instance segmentation could be potentially used as the input of trackers for tracking targets. The existing methods often utilize a clustering-based classification framework, which fits the need of real-time processing but has limited performance due to minimum information provided by sparse radar detection points. In this paper, we propose an efficient method based on clustering of estimated semantic information to achieve instance segmentation for the sparse radar detection points. In addition, we show that the performance of the proposed approach can be further enhanced by incorporating the visual multi-layer perceptron. The effectiveness of the proposed method is verified by experimental results on the popular RadarScenes dataset, achieving 89.53% mean coverage and 86.97% mean average precision with the IoU threshold of 0.5, which is superior to other approaches in the literature. More significantly, the consumed memory is around 1MB, and the inference time is less than 40ms, indicating that our proposed algorithm is storage and time efficient. These two criteria ensure the practicality of the proposed method in real-world systems.
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| 26. |
- Liu, Jianan, et al.
(author)
-
GNN-PMB: A Simple but Effective Online 3D Multi-Object Tracker without Bells and Whistles
- 2023
-
In: IEEE Transactions on Intelligent Vehicles. - 2379-8858. ; 8:2, s. 1176-1189
-
Journal article (peer-reviewed)abstract
- Multi-object tracking (MOT) is among crucial applications in modern advanced driver assistance systems (ADAS) and autonomous driving (AD) systems. The global nearest neighbor (GNN) filter, as the earliest random vector-based Bayesian tracking framework, has been adopted in most of state-of-the-arts trackers in the automotive industry. The development of random finite set (RFS) theory facilitates a mathematically rigorous treatment of the MOT problem, and different variants of RFS-based Bayesian filters have then been proposed. However, their effectiveness in the real ADAS and AD application is still an open problem. In this paper, it is demonstrated that the latest RFS-based Bayesian tracking framework could be superior to typical random vector-based Bayesian tracking framework via a systematic comparative study of both traditional random vector-based Bayesian filters with rule-based heuristic track maintenance and RFS-based Bayesian filters on the nuScenes validation dataset. An RFS-based tracker, namely Poisson multi-Bernoulli filter using the global nearest neighbor (GNN-PMB), is proposed to LiDAR-based MOT tasks. This GNN-PMB tracker is simple to use, and it achieves competitive results on the nuScenes dataset. Specifically, the proposed GNN-PMB tracker outperforms most state-of-the-art LiDAR-only trackers and LiDAR and camera fusion-based trackers, ranking the $3^{rd}$ among all LiDAR-only trackers on nuScenes 3D tracking challenge leader board 1 1 https://bit.ly/3bQJ2CP at the time of submission. Our code is available at https://github.com/chisyliu/GnnPmbTracker .
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| 27. |
- Liu, Min, et al.
(author)
-
Density Functional Theory Study of Influence of Oxide Thickness and Surface Alloying on Cl Migration within alpha-Al2O3
- 2021
-
In: Journal of the Electrochemical Society. - : The Electrochemical Society. - 0013-4651 .- 1945-7111. ; 168:8
-
Journal article (peer-reviewed)abstract
- Insertion and migration of chlorine atoms (Cl) in alpha-Al2O3 were studied by density functional theory calculations focusing on the influence of oxide thickness and doping by Mg, Cu and Si. Work function, electronic band gap, and insertion energy were calculated to explore thermodynamics of Cl migration. Partial density of state (PDOS) calculations revealed the role of dopants in the electronic character of metal-O and Al-Cl bonds. Work function data showed the effect of Cl insertion into the oxide film on the corrosion resistance. Cl can locate at an O vacancy (V-O) with a large exothermic insertion energy, independent of oxide thickness, but can only locate at superficial Al vacancy (V-Al) exothermically. The energy barrier for Cl migration via neighboring V-O increases with oxide thickness, and is 2 similar to 2.5 eV for thicker oxides. Cl insertion causes a work function reduction exceeding 2 eV, implying a decreased corrosion resistance. The inhibition of Cl migration by Si-doping can be explained by a more intense hybridization peak of Si-O over Al-O in the PDOS profile, while the reduction of energy barrier by Mg-/Cu-doping probably is due to the deviation of metal-s state from the Fermi energy, thus facilitating Cl movement within the oxide.
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| 28. |
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| 29. |
- Salinas, Joel, et al.
(author)
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An International Standard Set of Patient-Centered Outcome Measures After Stroke.
- 2016
-
In: Stroke: a journal of cerebral circulation. - 1524-4628. ; 47:1, s. 180-186
-
Journal article (peer-reviewed)abstract
- Value-based health care aims to bring together patients and health systems to maximize the ratio of quality over cost. To enable assessment of healthcare value in stroke management, an international standard set of patient-centered stroke outcome measures was defined for use in a variety of healthcare settings.
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| 30. |
- Stroeven, Arjen, et al.
(author)
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Landscape analysis of the Huang He headwaters, NE Tibetan Plateau — Patterns of glacial and fluvial erosion
- 2009
-
In: Geomorphology. - : Elsevier. - 0169-555X .- 1872-695X. ; 103:2, s. 212-226
-
Journal article (peer-reviewed)abstract
- The large-scale geomorphology of the Huang He (Yellow River) headwaters, centered around the Bayan Har Shan (5267 m asl) in the northeastern part of the Tibetan Plateau, is dominated by an uplifted remnant of a low-relief relict plateau with several mountain ranges. We have performed geomorphological mapping using SRTM topographic data and Landsat 7 ETM+ satellite imagery to evaluate landscape characteristics and patterns, and to investigate the relative importance of different erosional processes in the dissection of this plateau remnant. The distribution of valley morphologies indicates that the eastern and southern margins of the plateau remnant have been extensively dissected by the Huang He and Chang Jiang (Yangtze) rivers and associated tributaries, while the mountain ranges have valley morphologies with U-shaped cross-sections that indicate large impacts from glacial erosion during Quaternary glaciations. An east-west decrease in the abundance of glacial valleys in mountains above 4800 m asl suggests that the diminishing size of the mountain blocks, coupled with increased continentality, resulted in more restricted glaciations to the west. Glacial valleys in mountain blocks on the plateau remnant are wider and deeper than adjacent fluvial valleys. This indicates that, integrated over time, the glacial system has been more effective in eroding the mountains of the relict upland surface than the fluvial system. This erosion relationship is reversed, however, on the plateau margin where dramatic fluvial rejuvenation in valleys that are part of the Huang He and Chang Jiang watersheds has consumed whatever glacial morphology existed. A remarkable correspondence exists between the outline of the relict plateau remnant and the outline that has been proposed for the Huang He Ice Sheet. This coincidence could mean that the Huang He Ice Sheet was larger than originally proposed, but that evidence for this has been consumed by fluvial incision at the plateau margin. Alternatively, this coincidence could indicate that what has been described as an ice sheet border is merely the outline of a relict plateau landscape. In apparent support of the latter, the absence of large-scale glacial geomorphological evidence on the plains of the relict plateau surface is not consistent with the hypothesis of a Huang He Ice Sheet.
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| 31. |
- Stroeven, Arjen, et al.
(author)
-
Paleoglaciology of the Bayan Har Mountain area, eastern Tibetan Plateau
- 2006
-
In: Asian Conference on Permafrost.
-
Conference paper (peer-reviewed)abstract
- The glacial history of the Tibetan Plateau is a topic of considerable interest because of its significance for regional and global environmental reconstructions, and its interaction with variations in monsoon strength and plateau uplift. Published glacial reconstructions for the last glaciation range from a large ice sheet covering the entire Tibetan Plateau to extended valley glaciation forming discrete glaciated mountain blocks. Although current chronologies appear to underpin the restricted glaciation model, there appears to be enough regional variation to motivate further study, especially the glacial history predating the last glaciation. We therefore study the glacial history of a large upland section of the eastern Tibetan Plateau centered on the currently unglaciated Bayan Har Mountains (BHM), partly because chronological constraints are entirely absent, and partly because the area may once have been covered by an ice sheet of intermediate proportions. The BHM area, which houses the headwaters of the Huang He (Yellow River), contains a wide array of glacial deposits and morphologies. Moreover, it appears that superseding glaciations were ever limiting in extent and the area therefore presents optimal conditions to investigate glaciations over long time periods.We report from an on-going investigation into the extent and chronology of Quaternary glaciers in this region, manifested in glacial deposits and landforms (e.g., erratics, end moraines, tills and trough valleys). Previous studies have indicated the occurrence of two phases of mountain glaciation during the last glaciation (OIS 2-4), with mountain glaciers distributed around the highest summits, and two prior glaciations of ice sheet glaciation character (the penultimate glaciation, OIS 6, and the Huang He ice sheet, OIS 12).We mapped the glacial morphology of the area using satellite images and a DEM of 90 m resolution. Large-scale glacial landforms such as cirques, glacial troughs and U-shaped valleys indicate repeated glaciations, and so do series of moraine ridges and meltwater channels. The abundance of glacial traces detectable through remote sensing techniques diminish with decreasing elevation, and it appears that evidence for former ice sheets are based mainly on sedimentary evidence.In an introductory field work in 2005, surface boulders (including erratics) and boulders in till profiles have been sampled for dating using terrestrial cosmogenic nuclide (TCN) concentrations in quartz. Sampling was carried out along a 300 km stretch of the Qingkang highway, crossing the 80,000 km2 area of the Huang He ice sheet. We intend to present these first TCN results at the meeting.Our study will present new data for the paleoglaciology of the eastern Tibetan Plateau, and will contribute to the resolution of questions such as:• What glacial fluctuations occurred in the BHM area throughout the last glaciation?• When did glaciation pre-dating the last glaciation occur?• Was the area ever covered by an ice sheet?• What is the relation Tibetan glaciation – uplift – climate variations?These are questions of special significance also for former periglacial conditions, as reconstructed glaciers and ice sheets had a fundamental effect on regional paleoenvironmental conditions.
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| 32. |
- Tan, Liping, et al.
(author)
-
Porous fibrous bacterial cellulose/La(OH)3 membrane for superior phosphate removal from water
- 2022
-
In: Carbohydrate Polymers. - : Elsevier BV. - 0144-8617 .- 1879-1344. ; 298
-
Journal article (peer-reviewed)abstract
- Lanthanum (La)-based nanoparticles (NPs) are promising candidates for phosphate removal owing to their inherently high affinity towards phosphate. However, significant challenges remain to be addressed before their practical deployment, especially the problems associated with their aggregation. Herein, we fabricated a high-efficient sorbent for phosphate removal through in-situ synthesizing La(OH)3 NPs on a natural support, bacterial cellulose (BC), which is pre-modified with polyethyleneimine. The resultant La(OH)3 NPs-immobilized BC with different La contents (BPLa-X) exhibited a highly fibrous porous structure, in which BPLa-3 was selected for further phosphate adsorption studies. BPLa-3 demonstrated a high adsorption capacity of 125.5 mg P g−1, and high adsorption selectivity due to the large surface area and abundant exposed active adsorption sites for phosphate. Additionally, BPLa-3 also displayed high reusability and still possessed high adsorption capacity after four consecutive cycles of adsorption-desorption. Therefore, the present adsorbent is believed to be a promising candidate for practical phosphate removal.
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| 33. |
- Thayabaranathan, Tharshanah, et al.
(author)
-
Global stroke statistics 2022
- 2022
-
In: International Journal of Stroke. - : SAGE Publications. - 1747-4930 .- 1747-4949. ; 17:9, s. 946-956
-
Research review (peer-reviewed)abstract
- Background: Contemporary data on stroke epidemiology and the availability of national stroke clinical registries are important for providing evidence to improve practice and support policy decisions. Aims: To update the most current incidence, case-fatality, and mortality rates on stroke and identify national stroke clinical registries worldwide. Methods: We searched multiple databases (based on our existing search strategy) to identify new original papers, published between 1 November 2018 and 15 December 2021, that met ideal criteria for data on stroke incidence and case-fatality, and added these to the studies reported in our last review. To identify national stroke clinical registries, we updated our last search, using PubMed, from 6 February 2015 until 6 January 2022. We also screened reference lists of review papers, citation history of papers, and the gray literature. Mortality codes for International Classification of Diseases (ICD)-9 and ICD-10 were extracted from the World Health Organization (WHO) for each country providing these data. Population denominators were obtained from the United Nations (UN) or WHO (when data were unavailable in the UN database). Crude and adjusted stroke mortality rates were calculated using country-specific population denominators, and the most recent years of mortality data available for each country. Results: Since our last report in 2020, there were two countries (Chile and France) with new incidence studies meeting criteria for ideal population-based studies. New data on case-fatality were found for Chile and Kenya. The most current mortality data were available for the year 2014 (1 country), 2015 (2 countries), 2016 (11 countries), 2017 (10 countries), 2018 (19 countries), 2019 (36 countries), and 2020 (29 countries). Four countries (Libya, Solomon Islands, United Arab Emirates, and Lebanon) reported mortality data for the first time. Since our last report on registries in 2017, we identified seven more national stroke clinical registries, predominantly in high-income countries. These newly identified registries yielded limited information. Conclusions: Up-to-date data on stroke incidence, case-fatality, and mortality continue to provide evidence of disparities and the scale of burden in low- and middle-income countries. Although more national stroke clinical registries were identified, information from these newly identified registries was limited. Highlighting data scarcity or even where a country is ranked might help facilitate more research or greater policy attention in this field.
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| 34. |
- Wu, Zhenrui, et al.
(author)
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Unveiling the Mysteries: Acetonitrile's Dance with Weakly-Solvating Electrolytes in Shaping Gas Evolution and Electrochemical Performance of Zinc-ion Batteries
- 2024
-
In: Angewandte Chemie. - 1521-3773 .- 1433-7851. ; 63:19
-
Journal article (peer-reviewed)abstract
- Aqueous Zn-metal battery (AZMB) is a promising candidate for future large-scale energy storage with commendable capacity, exceptional safety characteristics, and low cost. Acetonitrile (AN) has been widely used as an effective electrolyte constituent to improve AZMBs’ performance. However, its functioning mechanisms remain unclear. In this study, we unveiled the critical roles of AN in AZMBs via comparative in situ electrochemical, gaseous, and morphological analyses. Despite its limited ability to solvate Zn ions, AN-modulated Zn-ion solvation sheath with increased anions and decreased water achieves a weakly-solvating electrolyte. As a result, the Zn||Zn cell with AN addition exhibited 63 times longer cycle life than cell without AN and achieved a 4 Ah cm−2 accumulated capacity with no H2 generation. In V2O5||Zn cells, for the first time, AN suppressing CO2 generation, elevating CO2-initiation voltage from 2→2.44 V (H2: 2.43→2.55 V) was discovered. AN-impeded transit and Zn-side deposition of dissolved vanadium ions, known as “crosstalk,” ameliorated inhomogeneous Zn deposition and dendritic Zn growth. At last, we demonstrated an AN-enabled high-areal-capacity AZMB (3.3 mAh cm−2) using high-mass-loading V2O5 cathode (26 mg cm−2). This study shed light on the strategy of constructing fast-desolvation electrolytes and offered insights for future electrolyte accommodation for high-voltage AZMB cathodes.
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| 35. |
- Yu, Amy Y.X., et al.
(author)
-
Measuring Stroke Quality : Methodological Considerations in Selecting, Defining, and Analyzing Quality Measures
- 2022
-
In: Stroke. - 0039-2499. ; 53:10, s. 3214-3221
-
Research review (peer-reviewed)abstract
- Knowledge about stroke and its management is growing rapidly and stroke systems of care must adapt to deliver evidence-based care. Quality improvement initiatives are essential for translating knowledge from clinical trials and recommendations in guidelines into routine clinical practice. This review focuses on issues central to the measurement of the quality of stroke care, including selection and definition of quality measures, identification of the eligible patient cohorts, optimization of data quality, and considerations for data analysis and interpretation.
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| 36. |
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| 37. |
- Zhang, Fan, et al.
(author)
-
Proliferative and Survival Effects of PUMA Promote Angiogenesis
- 2012
-
In: Cell Reports. - : Elsevier (Cell Press). - 2211-1247. ; 2:5, s. 1272-1285
-
Journal article (peer-reviewed)abstract
- The p53 upregulated modulator of apoptosis (PUMA) is known as an essential apoptosis inducer. Here, we report the seemingly paradoxical finding that PUMA is a proangiogenic factor critically required for the proliferation and survival of vascular and microglia cells. Strikingly, Puma deficiency by genetic deletion or small hairpin RNA knockdown inhibited developmental and pathological angiogenesis and reduced microglia numbers in vivo, whereas Puma gene delivery increased angiogenesis and cell survival. Mechanistically, we revealed that PUMA plays a critical role in regulating autophagy by modulating Erk activation and intracellular calcium level. Our findings revealed an unexpected function of PUMA in promoting angiogenesis and warrant more careful investigations into the therapeutic potential of PUMA in treating cancer and degenerative diseases.
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| 38. |
- Zhang, Liping, et al.
(author)
-
MXene-Stabilized VS2 Nanostructures for High-Performance Aqueous Zinc Ion Storage
- 2024
-
In: Advanced Science. - : WILEY. - 2198-3844.
-
Journal article (peer-reviewed)abstract
- Aqueous zinc-ion batteries (AZIBs) based on vanadium oxides or sulfides are promising candidates for large-scale rechargeable energy storage due to their ease of fabrication, low cost, and high safety. However, the commercial application of vanadium-based electrode materials has been hindered by challenging problems such as poor cyclability and low-rate performance. To this regard, sophisticated nanostructure engineering technology is used to adeptly incorporate VS2 nanosheets into the MXene interlayers to create a stable 2D heterogeneous layered structure. The MXene nanosheets exhibit stable interactions with VS2 nanosheets, while intercalation between nanosheets effectively increases the interlayer spacing, further enhancing their stability in AZIBs. Benefiting from the heterogeneous layered structure with high conductivity, excellent electron/ion transport, and abundant reactive sites, the free-standing VS2/Ti(3)C(2)Tz composite film can be used as both the cathode and the anode of AZIBs. Specifically, the VS2/Ti3C2Tz cathode presents a high specific capacity of 285 mAh g(-1) at 0.2 A g(-1). Furthermore, the flexible Zn-metal free in-plane VS2/Ti3C2Tz//MnO2/CNT AZIBs deliver high operation voltage (2.0 V) and impressive long-term cycling stability (with a capacity retention of 97% after 5000 cycles) which outperforms almost all reported Vanadium-based electrodes for AZIBs. The effective modulation of the material structure through nanocomposite engineering effectively enhances the stability of VS2, which shows great potential in Zn2+ storage. This work will hasten and stimulate further development of such composite material in the direction of energy storage.
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| 39. |
- Žliobaitė, Indrė, et al.
(author)
-
Herbivore teeth predict climatic limits in Kenyan ecosystems
- 2016
-
In: Proceedings of the National Academy of Science of the United States of America. - Boston, U.S.A. : Proceedings of the National Academy of Sciences. - 1091-6490. ; 113, s. 12751-12756
-
Research review (peer-reviewed)abstract
- A major focus in evolutionary biology is to understand how the evolution of organisms relates to changes in their physical environment. In the terrestrial realm, the interrelationships among climate,vegetation, and herbivores lie at the heart of this question. Here we introduce and test a scoring scheme for functional traits present on theworn surfaces of large mammalian herbivore teeth to capture their relationship to environmental conditions. We modeled local precipitation, temperature, primary productivity, and vegetation index as functions of dental traits of large mammal species in 13 national parks in Kenya over the past 60 y. We found that these dental traits can accurately estimate local climate and environment, even at small spatial scales within areas of relatively uniform climate (within two ecoregions), and that they predict limiting conditions better than average conditions. These findings demonstrate that the evolution of key functional properties of organisms may be more reflective of demands during recurring adverse episodes than under average conditions or during isolated severe events.
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| 40. |
- Zu, L., et al.
(author)
-
Joint optimization in multi-user MIMO-OFDMA relay-enhanced cellular networks
- 2011
-
In: 2011 IEEE Wireless Communications and Networking Conferenc. - : IEEE. - 9781612842547 ; , s. 13-18
-
Conference paper (peer-reviewed)abstract
- MIMO, OFDMA and cooperative relaying are the key technologies in future wireless communication systems. However, under the usage of these technologies, resource allocation becomes a more crucial and challenging task. In multi-user MIMO-OFDMA relay-enhanced cellular networks, we formulate the optimal instantaneous resource allocation problem including user group selection, path selection, power allocation, and subchannel scheduling to maximize system capacity. We first propose a low-complex resource allocation algorithm named CP-CP under constant uniform power allocation and then use a water-filling method named CP-AP to allocate power among transmitting antennas. Moreover, we solve the original optimization problem efficiently by using the Jensen's inequality and propose a modified iterative water-filling algorithm named AP-CP. Based on AP-CP, the AP-AP algorithm is proposed to allocate power adaptively not only among subchannels but also among multiple transmitting. Finally, we compare the performance of the four schemes. Our results show that allocating power among subchannels is more effective than among transmitting antennas if the average signal-to-noise radio of users is low, and vice versa. Furthermore, the AP-AP algorithm achieves the highest throughout especially for users near the cell edge.
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