| 1. |
- Dunham, I, et al.
(author)
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The DNA sequence of human chromosome 22
- 1999
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In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 402:6761, s. 489-495
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Journal article (peer-reviewed)
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| 2. |
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| 3. |
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| 4. |
- Miller, T. C., et al.
(author)
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Particle astrophysics in antarctica
- 1996
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In: International School of Cosmic Ray Astrophysics: 10th Course: Toward the Millennium in Astrophysics: Problems and Prospects 16-26 Jun 1996. Erice, Italy. ; , s. 157-166
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Conference paper (peer-reviewed)
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| 5. |
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| 6. |
- Kudryashov, V, et al.
(author)
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Characterization of a mouse monoclonal IgG3 antibody to the tumor-associated globo H structure produced by immunization with a synthetic glycoconjugate.
- 1998
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In: Glycoconjugate journal. - 0282-0080. ; 15:3, s. 243-9
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Journal article (peer-reviewed)abstract
- Globo H (Fuc alpha1 --> 2Galbeta1 --> 3GalNAcbeta1 --> 3Gal alpha1 --> 4Galbeta1 --> 4Glc) is a carbohydrate structure that shows enhanced expression in many human carcinomas. From mice immunized with a globo H-KLH (keyhole limpet hemocyanin) synthetic conjugate an IgG3 monoclonal antibody (mAb VK-9) was derived that recognizes the globo H structure. Serological analysis showed that the minimal structure recognized by this mAb was the tetrasaccharide sequence Fuc alpha1 --> 2Galbeta1 --> 3GalNAcbeta1 --> 3Gal. An isomeric structure with an internal alphaGalNAc linkage was also recognized but less efficiently. mAb VK-9 did not react with many related structures, such as galactosylgloboside, globoside, H type 1, H type 2 blood group structures or fucosyl-gangliotetraosyl ceramide, but did react weakly with globo A ceramide. Not only did mAb VK-9 react with carbohydrate-protein conjugates but it could also recognize globo H-ceramide and human tumor cells expressing globo H. These results suggest that globo H-KLH could be explored as a vaccine in the treatment of carcinoma patients.
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| 7. |
- Zubkans, J., et al.
(author)
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In-situ modification of the NOx sensitivity of thin discontinuous platinum films as gates of chemical sensors
- 1995
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In: Thin Solid Films. - : Elsevier. - 0040-6090 .- 1879-2731. ; 268:1-2, s. 140-143
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Journal article (peer-reviewed)abstract
- It is shown how chemically sensitive metal-oxide semiconductor field-effect transistors with a thin discontinuous platinum gate can be modified for the detection of NOx. After a pulse of ammonia the sensors show an increased sensitivity to NOx. The threshold voltage shift induced by NOx is opposite to the direction before the ammonia pulse. The threshold voltage now increases due to NOx exposure, while hydrogen, ammonia and hydrocarbons cause a decrease of the threshold voltage. The temperature dependence of the NOx sensitivity suggests that after the ammonia pulse there are two competing polarisation phenomena caused by the interaction between NOx and the sensing surface. The results are of general interest since they indicate how thin sensing layers can be modified after fabrication to promote sensitivity towards specific molecules. Furthermore they shed some new light on the detection mechanisms of thin discontinuous metal gates.
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| 8. |
- Baranzahi, Amir, et al.
(author)
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Response of metal-oxide-silicon carbide sensors to simulated and real exhaust gases
- 1997
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In: Sensors and actuators. B, Chemical. - : Elsevier. - 0925-4005 .- 1873-3077. ; 43:1-3, s. 52-59
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Journal article (peer-reviewed)abstract
- Field effect devices based on catalytic metal-oxide-silicon carbide (MOSiC) structures can be used as high temperature gas sensors. The devices are sensitive to hydrocarbons and hydrogen and can be operated up to at least 900 degrees C, which make them suitable for several combustion applications, Simulated and real exhaust gases from a car engine have been studied at sensor temperatures from 200 to 650 degrees C, and it was round that the sensor signal is high for excess hydrocarbon and low for excess oxygen. The response time is less than 100 ms and only a small degradation of the devices was observed after several days of operation. The devices also react to changes of the gas composition In the fuel-rich and fuel-lean region. The devices show an interesting temperature dependence in the fuel rich region.
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| 9. |
- Lloyd, MD, et al.
(author)
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Studies on the active site of deacetoxycephalosporin C synthase
- 1999
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In: JOURNAL OF MOLECULAR BIOLOGY. - : ACADEMIC PRESS LTD. - 0022-2836. ; 287:5, s. 943-960
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Journal article (peer-reviewed)abstract
- The Fe(II) and 2-oxogolutarate-dependent dioxygenase deacetoxycephalosporin C synthase (DAOCS) from Streptomyces clavuligerus was expressed at ca 25% of total soluble protein in Escherichia coli and purified by an efficient large-scale procedure. Purified
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| 10. |
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| 11. |
- Valegard, K, et al.
(author)
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Structure of a cephalosporin synthase
- 1998
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In: NATURE. - : MACMILLAN MAGAZINES LTD. - 0028-0836. ; 394:6695, s. 805-809
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Journal article (peer-reviewed)abstract
- Penicillins and cephalosporins are among the most widely used therapeutic agents. These antibiotics are produced from fermentation-derived materials as their chemical synthesis is not commercially viable. Unconventional steps in their biosynthesis are cat
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