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- Bergström, Mats, et al.
(author)
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Modulation of organ uptake of 11C-labelled L-DOPA
- 1997
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In: Nuclear Medicine and Biology. - 0969-8051 .- 1872-9614. ; 24:1, s. 15-19
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Journal article (peer-reviewed)abstract
- The present study was undertaken to investigate if pretreatment with pharmacological agents could change the organ uptake of 11C-labelled L-DOPA, and especially if the urinary excretion could be decreased. L-[beta-11C]DOPA was injected IV into unanesthetized Sprague-Dawley rats. After 20 min the rats were decapitated and organs taken out for radioactivity measurements. The uptake in the organs was investigated in animals only given the tracer, and in animals pretreated with drugs such as decarboxylase inhibitors carbidopa and benserazide as well as the monoamine oxidase inhibitors deprenyl, clorgyline, and the COMT inhibitor OR-486. A marked decrease in the urinary radioactivity was observed after carbidopa and benserazide administration. HPLC analysis revealed that under native conditions the major part of urinary radioactivity existed as dopamine, which was eliminated by the decarboxylase inhibitors. After pretreatment with the COMT inhibitor OR-486, the radioactivity uptake in the pancreas increased fourfold as compared to non-treated animals. HPLC analysis showed that this correlated with a marked increase in radiolabelled DOPAC. In the other organs and with the other drugs, only small effects were observed. With L-[beta-11C]fluoroDOPA as a tracer, similar results were observed although the increase in the pancreas by OR-486 had a lower magnitude. These studies suggest that it might be possible to improve the diagnostic ratio of L-[beta-11C]DOPA or L-[18F]fluoroDOPA in whole-body PET studies by pretreating the patient with decarboxylase inhibitor for reducing the urinary excretion and potentially increase the target organ uptake by COMT inhibition.
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- Lu, W., et al.
(author)
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Nondestructive determination of sheet carrier density in pseudomorphic AlGaAs/InGaAs/GaAs high electron mobility transistor structures by room-temperature photoluminescence spectra
- 1998
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In: Journal of Physics D-Applied Physics. ; 31:2, s. 159-164
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Journal article (peer-reviewed)abstract
- This paper describes a nondestructive method to determine the sheet carrier density of pseudomorphic high electron mobility transistor structures by fitting the room-temperature photoluminescence (PL) spectra. The sheet carrier densities determined were in sufficiently good agreement with values determined by Hall measurements for different samples with different mole fractions, delta-doping densities and well widths. For single-doped AlGaAs/InGaAs quantum wells, the dominant emission is the transitions from the first electron subband to the first heavy hole subband, from the first electron subband to the second heavy hole subband, and from the second electron subband to the first heavy hole subband.
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