| 1. |
- Abat, E., et al.
(author)
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Study of the response of the ATLAS central calorimeter to pions of energies from 3 to 9 GeV
- 2009
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In: Nuclear Instruments & Methods in Physics Research. Section A: Accelerators, Spectrometers, Detectors, and Associated Equipment. - : Elsevier BV. - 0167-5087 .- 0168-9002 .- 1872-9576. ; 607:2, s. 372-386
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Journal article (peer-reviewed)abstract
- A fully instrumented slice of the ATLAS central detector was exposed to test beams from the SPS (Super Proton Synchrotron) at CERN in 2004. in this paper, the response of the central calorimeters to pions with energies in the range between 3 and 9 GeV is presented. The linearity and the resolution of the combined calorimetry (electromagnetic and hadronic calorimeters) was measured and compared to the prediction of a detector simulation program using the toolkit Geant 4. (C) 2009 Elsevier B.V. All rights reserved.
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| 2. |
- Papini, P., et al.
(author)
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In-flight performances of the PAMELA satellite experiment
- 2008
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In: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 588:1-2, s. 259-266
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Journal article (peer-reviewed)abstract
- PAMELA is a satcllite-borne experiment designed to study with great accuracy charged particles in the cosmic radiation with a particular focus on antiparticles. The experiment, housed on board the Russian Resurs-DK1 satellite, was launched on June 15, 2006 in a 350 x 600 km orbit with an inclination of 70 degrees. The apparatus comprises a time-of-flight system, a silicon-microstrip magnetic spectrometer, a silicon-tungsten electromagnetic calorimeter, an anticoincidence system, a shower tail catcher scintillator and a neutron detector. The combination of these devices allows charged particle identification over a wide energy range. In this work, the detector design is reviewed and the in-orbit performances in the first months after the launch are presented.
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| 3. |
- Casolino, M., et al.
(author)
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Cosmic-ray observations of the heliosphere with the PAMELA experiment
- 2006
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In: Astrophysics. - : Elsevier BV. ; , s. 1848-1852
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Conference paper (peer-reviewed)abstract
- The PAMELA experiment is a multi-purpose apparatus built around a permanent magnet spectrometer, with the main goal of studying in detail the antiparticle component of cosmic rays. The apparatus will be carried in space by means of a Russian satellite, due to launch in 2005, for a three year-long mission. The characteristics of the detectors composing the instrument, alongside the long lifetime of the mission and the orbital characteristics of the satellite, will allow to address several items of cosmic-ray physics. In this paper, we will focus on the solar and heliospheric observation capabilities of PAMELA.
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| 4. |
- Casolino, M., et al.
(author)
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Launch of the space experiment PAMELA
- 2008
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In: Advances in Space Research. - : Elsevier. - 0273-1177 .- 1879-1948. ; 42:3, s. 455-466
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Journal article (peer-reviewed)abstract
- PAMELA is a satellite borne experiment designed to study with great accuracy cosmic rays of galactic, solar, and trapped nature in a wide energy range (protons 80 MeV-700 GeV, electrons 50 MeV-400 GeV). Main objective is the study of the antimatter component: antiprotons (80 MeV-190 GeV), positrons (50 MeV-270 GeV) and search for antimatter with a precision of the order of 10-8. The experiment, housed on board the Russian Resurs-DK I satellite, was launched on June 15th, 2006 in a 350 x 600 km orbit with all inclination of 70'. The detector is composed of a series of scintillator counters arranged at the extremities of a permanent magnet spectrometer to provide charge, time-of-flight, and rigidity information. Lepton/hadron identification is performed by a silicon-tungsten calorimeter and a neutron detector placed at the bottom of the device. An anticounter system is used offline to reject false triggers coming from the satellite. In self-trigger mode the calorimeter, the neutron detector, and a shower tail catcher are capable of an independent measure of the lepton component up to 2 TeV. In this work we describe the experiment, its scientific objectives, and the performance in the first months after launch.
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| 5. |
- Stozhkov, Y. I., et al.
(author)
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About Separation of Hadron and Electromagnetic Cascades in the Pamela Calorimeter
- 2005
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In: International Journal of Modern Physics A. - 0217-751X .- 1793-656X. ; 20:29, s. 6745-6748
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Journal article (peer-reviewed)abstract
- Results of calibration of the PAMELA instrument at the CERN facilities are discussed. In September, 2003, the calibration of the Neutron Detector together with the Calorimeter was performed with the CERN beams of electrons and protons with energies of 20-180 GeV. The implementation of the Neutron Detector increases a rejection factor of hadrons from electrons about ten times. The results of calibration are in agreement with calculations.
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| 6. |
- Gorshkov, A.V., et al.
(author)
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Liquid Chromatography at Critical Conditions : Comprehensive approach to sequence-dependent retention time prediction
- 2006
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In: Analytical Chemistry. - : American Chemical Society (ACS). - 0003-2700 .- 1520-6882. ; 78:22, s. 7770-7777
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Journal article (peer-reviewed)abstract
- An approach to sequence-dependent retention time prediction of peptides based on the concept of liquid chromatography at critical conditions (LCCC) is presented. Within the LCCC approach applied to biopolymers (BioLCCC), the specific retention time corresponds to a particular sequence. In combination with mass spectrometry, this approach provides an efficient tool to solve problems wherein the protein sequencing is essential. In this work, we present a theoretical background of the BioLCCC concept and demonstrate experimentally its feasibility for sequence-dependent LC retention time prediction for peptides. BioLCCC model is based on three notions: ( a) a random walk model for a macromolecule chain; (b) an entropy and energy compensation for the macromolecules within the adsorbent pore; and ( c) a set of phenomenological parameters for the effective interaction energies of interactions between the amino acid residues and the adsorbent surface. In this work, the phenomenological parameters have been obtained for C-18 reversed-phase HPLC. Note, that contrary to alternative additive models for retention time prediction based on summation of the so-called "retention coefficients", the BioLCCC approach takes into account the location of amino acids within the primary structure of a peptide and, thus, allows the identification of the peptides having the same composition of amino acids but differing by their arrangement. As a result, this new approach allows prediction of retention time for any possible amino acid sequence in particular HPLC experiments. In addition, the BioLCCC model lacks of main drawbacks of additive approaches that predict retention time for sequences of limited chain lengths and provide information about amino acid composition only. The proposed BioLCCC approach was characterized experimentally using LTQ FT LC-MS and LC-MS/MS data obtained earlier for Escherichia coli. The HPLC system calibration was performed using peptide retention standards. The results received show a linear correlation between predicted and experimental retention times, with a correlation coefficient, R-2, of 0.97 for a peptide standard mixture and 0.9 for E. coli data, respectively, with the standard error below 1 min. The work presents the first description of a BioLCCC approach for high-throughput peptide characterization and preliminary results of its feasibility tests.
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| 7. |
- Engeset, D, et al.
(author)
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Fish consumption and breast cancer risk. The European Prospective Investigation into Cancer and Nutrition (EPIC)
- 2006
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In: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 119:1, s. 175-182
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Journal article (peer-reviewed)abstract
- There is current interest in fish consumption and marine omega-3 (n-3) fatty acids and breast cancer risk. Some in vitro and animal studies have suggested an inhibitory effect of marine n-3 fatty acids on breast cancer growth, but the results from epidemiological studies that have examined the association between fish consumption and breast cancer risk in humans are inconsistent. We examined fish consumption and breast cancer risk in 310,671 women aged between 25 and 70 yr at recruitment into the European Prospective Investigation Into Cancer and Nutrition (EPIC). The participants completed a dietary questionnaire between 1992-98 and were followed up for incidence of breast cancer for a median of 6.4 yr. Hazard ratio for breast cancer by intake of total and lean and fatty fish were estimated, stratified by study centre and adjusted for established breast cancer risk factors. During follow-up, 4,776 invasive incident breast cancers were reported. No significant associations between intake of total fish and breast cancer risk were observed, hazard ratio (HR) 1.01 (95% confidence interval [CI] 0.99-1.02; p = 0.28 per 10 g fish/day). When examining lean and ratty fish separately, we round a positive significant association only in the highest quintile for fatty fish (HR 1.13, 95% CI 1.01-1.26), but test for trend was not significant (p = 0.10). No associations with breast cancer risk were observed when the study participants were subdivided by menopausal status. Although the period of follow-up is relatively short, the results provide no evidence for an association between fish intake and breast cancer risk. (c) 2006 Wiley-Liss, Inc.
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| 8. |
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| 9. |
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| 10. |
- Lundquist, J., et al.
(author)
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The PAMELA Calorimeter Identification Capabilities
- 2005
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In: Proceedings of the 29th International Cosmic Ray Conference, vol 3:OG1. ; , s. 305-308
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Conference paper (peer-reviewed)abstract
- A silicon-tungsten imaging calorimeter has been designed, built and successfully integrated in the PAMELA satellite-bome apparatus. The main physics task of the experiment is the measurement of the flux of antiprotons, positrons and light nuclei in the cosmic radiation. The purpose of the calorimeter is to separate antiprotons and positrons from the vast background of cosmic-ray electrons and protons, respectively. In this work we present the identification capabilities of the calorimeter obtained using both Monte Carlo and test beam data. We show that the calorimeter can provide a proton rejection factor of about 105 while keeping a similar to 90% efficiency in selecting electrons and positrons. The PAMELA calorimeter is therefore able to provide the identification power needed to reach the primary scientific objectives of PAMELA.
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| 11. |
- Nuzhdin, K.B., et al.
(author)
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Structure of radical cations of saturated heterocyclic compounds with two heteroatoms as studied by electron paramagnetic resonance, electron-nuclear double resonance, and density functional theory calculations
- 2005
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In: Journal of Physical Chemistry A. - : American Chemical Society (ACS). - 1089-5639 .- 1520-5215. ; 109:28, s. 6166-6173
-
Journal article (peer-reviewed)abstract
- The radical cations of piperazine, morpholine, thiomorpholine, and thioxane were investigated by electron paramagnetic resonance (EPR) and electron-nuclear double resonance (ENDOR) spectroscopy in a solid Freon matrix. Optimized geometry and magnetic parameters of the radical cations were calculated using a density functional theory (DFT)/Perdew-Burke-Ernzerhof (PBE) method. Both experimental and theoretical results suggest that all the studied species adopt chair (or distorted chair) conformations. No evidence for the boat conformers with intramolecular σ*-bonding between heteroatoms were obtained. In the cases of morpholine and thioxane, the oxygen atoms are characterized by relatively small spin populations, whereas a major part of spin density is located at N and S atoms, respectively. The thiomorpholine radical cation exhibits nearly equal spin population of N and S atoms. In most cases (except for thioxane), the calculated magnetic parameters agree with the experimental data reasonably well. © 2005 American Chemical Society.
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| 12. |
- Aad, G., et al.
(author)
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The ATLAS Experiment at the CERN Large Hadron Collider
- 2008
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In: Journal of Instrumentation. - 1748-0221. ; 3:S08003
-
Research review (peer-reviewed)abstract
- The ATLAS detector as installed in its experimental cavern at point 1 at CERN is described in this paper. A brief overview of the expected performance of the detector when the Large Hadron Collider begins operation is also presented.
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| 13. |
- Al-Delaimy, WK, et al.
(author)
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Plasma carotenoids as biomarkers of intake of fruits and vegetables: individual-level correlations in the European Prospective Investigation into Cancer and Nutrition (EPIC)
- 2005
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In: European Journal of Clinical Nutrition. - : Springer Science and Business Media LLC. - 1476-5640 .- 0954-3007. ; 59:12, s. 1387-1396
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Journal article (peer-reviewed)abstract
- Objective: The aim in this study was to assess the association between individual plasma carotenoid levels (alpha-carotene, beta-carotene, lycopene, beta-cryptoxanthin, lutein, zeaxanthin) and fruit and vegetable intakes recorded by a calibrated food questionnaire (FQ) and 24- h dietary recall records (24HDR) in nine different European countries with diverse populations and widely varying intakes of plant foods. Design: A stratified random subsample of 3089 men and women from nine countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC), who had provided blood samples and dietary and other lifestyle information between 1992 and 2000, were included. Results: beta-Cryptoxanthin was most strongly correlated with total fruits (FQ r = 0.52, 24HDR r = 0.39), lycopene with tomato and tomato products (FQ r = 0.38, 24HDR r = 0.25), and alpha-carotene with intake of root vegetables (r = 0.39) and of total carrots (r = 0.38) for FQ only. Based on diet measured by FQ and adjusting for possible confounding by body mass index (BMI), age, gender, smoking status, alcohol intake, and energy intake, the strongest predictors of individual plasma carotenoid levels were fruits (R-partial(2) = 17.2%) for beta-cryptoxanthin, total carrots (R-partial(2) = 13.4%) and root vegetables (R-partial(2) = 13.3%) for alpha-carotene, and tomato products (R-partial(2) = 13.8%) for lycopene. For 24HDR, the highest R-partial(2) was for fruits in relation to beta-cryptoxanthin (7.9%). Conclusions: Intakes of specific fruits and vegetables as measured by food questionnaires are good predictors of certain individual plasma carotenoid levels in our multicentre European study. At individual subject levels, FQ measurements of fruits, root vegetables and carrots, and tomato products are, respectively, good predictors of beta-cryptoxanthin, alpha-carotene, and lycopene in plasma.
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| 14. |
- Bachert, C., et al.
(author)
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Important research questions in allergy and related diseases: 3-chronic rhinosinusitis and nasal polyposis - a GA(2)LEN study
- 2009
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In: Allergy. - : Wiley. - 1398-9995 .- 0105-4538. ; 64:4, s. 520-533
-
Research review (peer-reviewed)abstract
- Chronic rhinosinusitis is one of the most common health care challenges, with significant direct medical costs and severe impact on lower airway disease and general health outcomes. The diagnosis of chronic rhinosinusitis (CRS) currently is based on clinical signs, nasal endoscopy and CT scanning, and therapeutic recommendations are focussing on 2 classes of drugs, corticosteroids and antibiotics. A better understanding of the pathogenesis and the factors amplifying mucosal inflammation therefore seems to be crucial for the development of new diagnostic and therapeutic tools. In an effort to extend knowledge in this area, the WP 2.7.2 of the GA(2)LEN network of excellence currently collects data and samples of 1000 CRS patients and 250 control subjects. The main objective of this project is to characterize patients with upper airway disease on the basis of clinical parameters, infectious agents, inflammatory mechanisms and remodeling processes. This collaborative research will result in better knowledge on patient phenotypes, pathomechanisms, and subtypes in chronic rhinosinusitis. This review summarizes the state of the art on chronic rhinosinusitis and nasal polyposis in different aspects of the disease. It defines potential gaps in the current research, and points to future research perspectives and targets.
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| 15. |
- Boezio, Mirko, et al.
(author)
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The electron-hadron separation performance of the PAMELA electromagnetic calorimeter
- 2006
-
In: Astroparticle physics. - : Elsevier BV. - 0927-6505 .- 1873-2852. ; 26:2, s. 111-118
-
Conference paper (peer-reviewed)abstract
- A silicon-tungsten sampling imaging calorimeter has been designed and built for thePAMELA satellite-borne experiment. The main physics goals of the experiment are themeasurement of the flux of antiprotons (80 MeV-190 GeV) and positrons (50 MeV-270 GeV) in the cosmic radiation. The calorimeter has been designed to identify antiprotons from an electron background and positrons in a background of protons with a high efficiency and rejection power. This work presents the electron-hadron separationcapabilities of the calorimeter as obtained using both Monte Carlo and test beam data.The calorimeter is found to have sufficient performance to reach the primary scientific objectives of PAMELA, providing a proton rejection factor of ∼105 while keeping a ∼90% efficiency in selecting electrons and positrons. From simulations, an electron rejection factor of ∼105 in antiproton measurements (∼90% antiproton identification efficiency) is demonstrated.
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| 16. |
- Di Mauro, A., et al.
(author)
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Development of innovative micro-pattern gaseous detectors with resistive electrodes and first results of their applications
- 2007
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In: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 581:1-2, s. 225-231
-
Journal article (peer-reviewed)abstract
- The paper summarizes our latest progress in the development of newly introduced micro-pattern gaseous detectors with resistive electrodes. These resistive electrodes protect the detector and the front-end electronics in case of occasional discharges and thus make the detectors very robust and reliable in operation. As an example, we describe in greater detail a recently developed GEM-like detector, fully spark-protected with electrodes made of resistive kapton. We discovered that all resistive layers used in these studies (including kapton) that are coated with photosensitive layers, such as CsI, can be used as efficient photocathodes for detectors operating in a pulse counting mode. There is a description of the first applications of such detectors combined with CsI or SbCs photocathodes for the detection of UV photons at room and cryogenic temperatures.
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| 17. |
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| 18. |
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| 19. |
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| 20. |
- Holt, A., et al.
(author)
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Nordic Centre of Excellence in Photovoltaics (NCOE in PV)
- 2008
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Conference paper (peer-reviewed)abstract
- A NCoE in PV has been formed by seven research institutions in the Nordic region. The centre is funded by Nordic Energy Research, Renewable Energy Corporation ASA, Elkem Solar AS, Solibro Research AB, Topsil A/S, Energinet.dk, and Luvata as well as the participating research organisations. The main objective is to strengthen the already formed Nordic R&D network and to serve the fast-growing and demanding Nordic PV industry. This will be achieved by educating PhD students with compulsory mobility of the students, arranging general workshops within solar cell research, organizing in-depth workshops on selected topics, giving hands-on workshops on processing of solar cells, and actively disseminate results both in public and scientific media channels.
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| 21. |
- Iacobaeus, C., et al.
(author)
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A high position resolution X-ray detector : An Edge on illuminated capillary plate combined with a gas amplification structure
- 2006
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In: IEEE Transactions on Nuclear Science. - : Institute of Electrical and Electronics Engineers (IEEE). - 0018-9499 .- 1558-1578. ; 53:2, s. 554-561
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Journal article (peer-reviewed)abstract
- We have developed and successfully tested a prototype of a new high position resolution hybrid X-ray detector. It contains a thin-wall lead glass capillary plate converter of X-rays combined with a microgap parallel-plate avalanche chamber operating in various gas mixtures at 1 atm. The operation of these converters was studied in a wide range of X-ray energies (from 6 to 60 keV) at incident angles varying from 0-90 degrees. The detection efficiency, depending on the geometry, photon's energy, incident angle and the mode of operation was between 5-30% in single step mode and up to 50% in a multi-layered combination. Depending on the capillary's geometry, the position resolution achieved was between 50-250 mu m in digital form and was practically independent of the photon's energy or gas mixture. The usual lead glass capillary plates operated without noticeable charging up effects at counting rates of 50 Hz/mm(2) and hydrogen treated capillaries-up to 10(5) Hz/mm(2). The developed detector has several important potential advantages over the exciting X-ray detectors and may open new possibilities for medical imaging, for example in mammography, portal imaging, radiography (including security devices), as well as many other applications.
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| 22. |
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| 23. |
- Iacobaeus, C., et al.
(author)
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An X-ray scanner prototype based on a novel hybrid gaseous detector
- 2007
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In: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 573:02-jan, s. 61-64
-
Journal article (peer-reviewed)abstract
- We have developed a prototype of a new type of hybrid X-ray detector. It contains a thin wall (few mu m) edge-illuminated lead glass capillary plate (acting as a converter of X-rays photons to primary electrons) combined with a microgap parallel-plate avalanche chamber operating in various gas mixtures at 1 atm. The operation of these converters was studied in a wide range of X-ray energies (from 6 to 60 keV) at incident angles varying from 0 degrees to 90 degrees. The detection efficiency, depending on the geometry, photon's energy, incident angle and the mode of operation, was between a few and similar to 40%. The position resolution achieved was similar to 50 mu m in digital form and was practically independent of the photon's energy or gas mixture. The developed detector may open new possibilities for medical imaging, for example in mammography, portal imaging, radiography (including security devices), crystallography and many other applications.
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| 24. |
- Jenab, M., et al.
(author)
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Dietary intakes of retinol, beta-carotene, vitamin D and vitamin E in the European Prospective Investigation into Cancer and Nutrition cohort
- 2009
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In: European Journal of Clinical Nutrition. - : Springer Science and Business Media LLC. - 1476-5640 .- 0954-3007. ; 63:4s, s. 150-178
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Journal article (peer-reviewed)abstract
- Objectives: To describe the intake of the fat-soluble nutrients retinol, beta-carotene, vitamin E and vitamin D and their food sources among 27 redefined centres in 10 countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Methods: Between 1995 and 2000, 36 034 subjects (age range: 35-74 years) completed a single standardized 24-h dietary recall using a computerized interview software program (EPIC-SOFT). Intakes of the fat-soluble nutrients were estimated using the standardized EPIC Nutrient Database. Results: For all the nutrients, in most centres, men had a higher level of intake than did women, even after adjustments for total energy intake and anthropometric confounders. Distinct regional gradients from northern to southern European countries were observed for all nutrients. The level intake of beta-carotene and vitamin E also showed some differences by level of education, smoking status and physical activity. No meaningful differences in the nutrient intake were observed by age range. Conclusions: These results show differences by study centre, gender, age and various lifestyle variables in the intake of retinol, beta-carotene, vitamin E and vitamin D between 10 European countries. European Journal of Clinical Nutrition (2009) 63, S150-S178; doi: 10.1038/ejcn.2009.79
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| 25. |
- Jenab, M, et al.
(author)
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Plasma and dietary carotenoid, retinol and tocopherol levels and the risk of gastric adenocarcinomas in the European prospective investigation into cancer and nutrition
- 2006
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In: British Journal of Cancer. - : Springer Science and Business Media LLC. - 1532-1827 .- 0007-0920. ; 95:3, s. 406-415
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Journal article (peer-reviewed)abstract
- Despite declining incidence rates, gastric cancer (GC) is a major cause of death worldwide. Its aetiology may involve dietary antioxidant micronutrients such as carotenoids and tocopherols. The objective of this study was to determine the association of plasma levels of seven common carotenoids, their total plasma concentration, retinol and alpha- and gamma-tocopherol, with the risk of gastric adenocarcinoma in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC), a large cohort involving 10 countries. A secondary objective was to determine the association of total sum of carotenoids, retinol and alpha-tocopherol on GCs by anatomical subsite (cardia/noncardia) and histological subtype (diffuse/intestinal). Analytes were measured by high-performance liquid chromatography in prediagnostic plasma from 244 GC cases and 645 controls matched by age, gender, study centre and date of blood donation. Conditional logistic regression models adjusted by body mass index, total energy intake, smoking and Helicobacter pylori infection status were used to estimate relative cancer risks. After an average 3.2 years of follow-up, a negative association with GC risk was observed in the highest vs the lowest quartiles of plasma beta-cryptoxanthin (odds ratio (OR) = 0.53, 95% confidence intervals (CI) = 0.30-0.94, P(trend) = 0.006), zeaxanthin (OR = 0.39, 95% CI = 0.22-0.69, P(trend) = 0.005), retinol (OR = 0.55, 95% CI = 0.33-0.93, P(trend) = 0.005) and lipid-unadjusted alpha-tocopherol (OR = 0.59, 95% CI = 0.37-0.94, P(trend) = 0.022). For all analytes, no heterogeneity of risk estimates or significant associations were observed by anatomical subsite. In the diffuse histological subtype, an inverse association was observed with the highest vs lowest quartile of lipid-unadjusted alpha-tocopherol (OR = 0.26, 95% CI = 0.11-0.65, P(trend) = 0.003). These results show that higher plasma concentrations of some carotenoids, retinol and alpha-tocopherol are associated with reduced risk of GC.
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| 26. |
- Linseisen, J., et al.
(author)
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Dietary fat intake in the European Prospective Investigation into Cancer and Nutrition: results from the 24-h dietary recalls
- 2009
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In: European Journal of Clinical Nutrition. - : Springer Science and Business Media LLC. - 1476-5640 .- 0954-3007. ; 63:4s, s. 61-80
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Journal article (peer-reviewed)abstract
- Objectives: This paper describes the dietary intake of total fat, saturated (SFA), monounsaturated (MUFA) and polyunsaturated fatty acids (PUFA) and cholesterol of participants in the European Prospective Investigation into Cancer and Nutrition (EPIC) in 27 centres across 10 countries. Methods: Between 1995 and 2000, a stratified random sample of 36 034 participants (age range 35-74 years) completed a standardized 24-h dietary recall, assessed by means of the computer software EPIC-SOFT. Lipid intake data were calculated using a standardized nutrient database. Results: On average, the contribution of fat to total energy intake was >= 34% of energy intake (% en) in women and >= 36% en in men for most EPIC centres, except for the British, Dutch and most Italian cohorts. Total fat (> 40% en) and MUFA intakes (21% en, mainly from olive oil) were highest in Greece. Except for the Greek, Spanish and Italian centres, the average MUFA intake ranged between 10 and 13% en, with a high proportion derived from animal sources. SFA intake in women and men was lowest in the Greek, Spanish, Italian and UK cohorts with an average of <= 13% en (down to 9% en), and highest in the Swedish centres (16% en). The mean PUFA intake was in the range of 4-8% en, being highest in the UK health-conscious cohort. The average cholesterol intake across EPIC varied from 140 to 384 mg/d in women and 215-583 mg/d in men. Conclusions: The presented data show differences and similarities in lipid intake across the European EPIC cohorts and also show differences in food sources of dietary lipids. European Journal of Clinical Nutrition (2009) 63, S61-S80; doi: 10.1038/ejcn.2009.75
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| 27. |
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| 28. |
- Lumbreras, B., et al.
(author)
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Meat intake and bladder cancer in a prospective study: a role for heterocyclic aromatic amines?
- 2008
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In: Cancer Causes and Control. - : Springer Science and Business Media LLC. - 1573-7225 .- 0957-5243. ; 19:6, s. 649-656
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Journal article (peer-reviewed)abstract
- Objective The suspect carcinogens, heterocyclic amines (HAAs), found in well-done meat require host-mediated metabolic activation before inducing DNA mutations. The role of SULT1A1 and of NAT2 on the activation of HAAs suggests that NAT2 rapid acetylator genotype and SULT1A1 allele variants can have an effect on HAA carcinogenicity. Methods Data were collected as part of a case-control study nested within the EPIC cohort, the Gen Air investigation. EPIC is a prospective study designed to investigate the relationship between nutrition and cancer. Information was collected through a non-dietary questionnaire on lifestyle variables and through a dietary questionnaire. The subjects were restricted to non-smokers. We calculated the matched odds ratio for bladder cancer risk using logistic regression, controlling for potential confounders. Results There were 227 bladder cases and 612 controls matched 1:3. Meat intake and NAT2 genotype were not independently associated with bladder cancer risk. A significant relationship was observed between bladder cancer risk and consumption of meat only among subjects with the rapid NAT2 genotype (odds ratios [OR] 2.9, 95% CI 1.0-7.9 for the 2nd quartile of meat intake; 3.6, 95% CI 1.3-9.7 for the 3rd quartile; and 3.5, 95% CI 1.2-9.7 for the 4th quartile), and was not present among subjects with the slow genotype. An interaction between NAT2 and meat intake was found in logistic regression (P = 0.034). No association was observed for SULT1A *1/2 genotype (1.0; 95% CI 0.7-1.5) and for SULT1A1 *2/2 genotype (0.9; 95% CI 0.5-1.7). Conclusions These results are suggestive of a role of meat intake and NAT2 on bladder cancer risk. They support the hypothesis that among subjects with the rapid NAT2 acetylation genotype higher levels of HAAs exposure are a bladder cancer risk factor. We did not observe an effect of SULT1A1 allele variants on this cancer. The present study adds new information on the possible long-term adverse effects of diets with high meat intake.
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| 29. |
- Lund, Soren S., et al.
(author)
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Combining insulin with metformin or an insulin secretagogue in non-obese patients with type 2 diabetes: 12 month, randomised, double blind trial
- 2009
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In: BMJ (International Edition). - : BMJ. - 0959-8146 .- 0959-8138 .- 1468-5833. ; 339
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Journal article (peer-reviewed)abstract
- Objectives To study the effect of insulin treatment in combination with metformin or an insulin secretagogue, repaglinide, on glycaemic regulation in non-obese patients with type 2 diabetes. Design Randomised, double blind, double dummy, parallel trial. Setting Secondary care in Denmark between 2003 and 2006. Participants Non-obese patients (BMI <= 27) with preserved beta cell function. Interventions After a four month run-in period with repaglinide plus metformin combination therapy, patients with a glycated haemoglobin (HbA(1c)) concentration of 6.5% or more were randomised to repaglinide 6 mg or metformin 2000 mg. All patients also received biphasic insulin aspart 70/30 (30% soluble insulin aspart and 70% intermediate acting insulin aspart) 6 units once a day before dinner for 12 months. Insulin dose was adjusted aiming for a fasting plasma glucose concentration of 4.0-6.0 mmol/l. The target of HbA(1c) concentration was less than 6.5%. Treatment was intensified to two or three insulin injections a day if glycaemic targets were not reached. Main outcome measure HbA(1c) concentration. Results Of the 459 patients who were eligible, 102 were randomised, and 97 completed the trial. Patients had had type 2 diabetes for approximately 10 years. At the end of treatment, HbA(1c) concentration was reduced by a similar amount in the two treatment groups (insulin plus metformin: mean (standard deviation) HbA(1c) 8.15% (1.32) v 6.72% (0.66); insulin plus repaglinide: 8.07% (1.49) v 6.90% (0.68); P=0.177). Total daily insulin dose and risk of hypoglycaemia were also similar in the two treatment groups. Weight gain was less with metformin plus biphasic insulin aspart 70/30 than with repaglinide plus biphasic insulin aspart 70/30 (difference in mean body weight between treatments -2.51 kg, 95% confidence interval -4.07 to -0.95). Conclusions In non-obese patients with type 2 diabetes and poor glycaemic regulation on oral hypoglycaemic agents, overall glycaemic regulation with insulin in combination with metformin was equivalent to that with insulin plus repaglinide. Weight gain seemed less with insulin plus metformin than with insulin plus repaglinide.
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| 30. |
- Manuguerra, M., et al.
(author)
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Multi-factor dimensionality reduction applied to a large prospective investigation on gene-gene and gene-environment interactions
- 2007
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In: Carcinogenesis. - : Oxford University Press (OUP). - 0143-3334 .- 1460-2180. ; 28:2, s. 414-422
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Journal article (peer-reviewed)abstract
- It is becoming increasingly evident that single-locus effects cannot explain complex multifactorial human diseases like cancer. We applied the multi-factor dimensionality reduction (MDR) method to a large cohort study on gene-environment and gene-gene interactions. The study (case-control nested in the EPIC cohort) was established to investigate molecular changes and genetic susceptibility in relation to air pollution and environmental tobacco smoke (ETS) in non-smokers. We have analyzed 757 controls and 409 cases with bladder cancer (n = 124), lung cancer (n = 116) and myeloid leukemia (n = 169). Thirty-six gene variants (DNA repair and metabolic genes) and three environmental exposure variables (measures of air pollution and ETS at home and at work) were analyzed. Interactions were assessed by prediction error percentage and cross-validation consistency (CVC) frequency. For lung cancer, the best model was given by a significant gene-environment association between the base excision repair (BER) XRCC1-Arg399Gln polymorphism, the double-strand break repair (DSBR) BRCA2-Asn372His polymorphism and the exposure variable 'distance from heavy traffic road', an indirect and robust indicator of air pollution (mean prediction error of 26%, P < 0.001, mean CVC of 6.60, P = 0.02). For bladder cancer, we found a significant 4-loci association between the BER APE1-Asp148Glu polymorphism, the DSBR RAD52-3'-untranslated region (3'-UTR) polymorphism and the metabolic gene polymorphisms COMT-Val158Met and MTHFR-677C > T (mean prediction error of 22%, P < 0.001, mean CVC consistency of 7.40, P < 0.037). For leukemia, a 3-loci model including RAD52-2259C > T, MnSOD-Ala9Val and CYP1A1-Ile462Val had a minimum prediction error of 31% (P < 0.001) and a maximum CVC of 4.40 (P = 0.086). The MDR method seems promising, because it provides a limited number of statistically stable interactions; however, the biological interpretation remains to be understood.
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| 31. |
- Mocchiutti, E., et al.
(author)
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The PAMELA electromagnetic calorimeter : performances
- 2006
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In: Calorimetry in High Energy Physics. - : American Institute of Physics (AIP). - 0735403643 ; , s. 159-166
-
Conference paper (peer-reviewed)abstract
- A sampling silicon-tungsten imaging calorimeter has been designed and built for the PAMELA satellite-borne experiment. The calorimeter has been designed to identify antiprotons from an electron background and positrons in a background of protons with a high efficiency and rejection power. In this work we present the identification capabilities of the calorimeter obtained using both Monte Carlo and test beam data. We show that the calorimeter provides a proton rejection factor of at least 105 while keeping a high efficiency in selecting electrons and positrons. Hence, the calorimeter will fulfill the identification power needed to reach the primary scientific objectives of PAMELA, that are the measurement of the flux of antiprotons, positrons and light isotopes in the cosmic radiation.
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| 32. |
- Orfanos, P, et al.
(author)
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Eating out of home and its correlates in 10 European countries. The European Prospective Investigation into Cancer and Nutrition (EPIC) study
- 2007
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In: Public Health Nutrition. - 1475-2727 .- 1368-9800. ; 10:12, s. 1515-1525
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Journal article (peer-reviewed)abstract
- OBJECTIVE: To compare the average out-of-home (OH) consumption of foods and beverages, as well as energy intake, among populations from 10 European countries and to describe the characteristics of substantial OH eaters, as defined for the purpose of the present study, in comparison to other individuals. DESIGN: Cross-sectional study. Dietary data were collected through single 24-hour dietary recalls, in which the place of consumption was recorded. For the present study, substantial OH eaters were defined as those who consumed more than 25% of total daily energy intake at locations other than the household premises. Mean dietary intakes and the proportion of substantial OH eaters are presented by food group and country. Logistic regression analyses were used to estimate the odds of being a substantial OH eater in comparison to not being one, using mutually adjusted possible non-dietary determinants. SETTING: Ten European countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC). SUBJECTS: The subjects were 34 270 individuals, 12 537 men and 21 733 women, aged 35-74 years. RESULTS: The fraction of energy intake during OH eating was generally higher in northern European countries than in the southern ones. Among the food and beverage groups, those selectively consumed outside the home were coffee/tea/waters and sweets and, to a lesser extent, cereals, meats, added lipids and vegetables. Substantial OH eating was positively associated with energy intake and inversely associated with age and physical activity. Substantial OH eating was less common among the less educated compared with the more educated, and more common during weekdays in central and north Europe and during the weekend in south Europe. CONCLUSIONS: Eating outside the home was associated with sedentary lifestyle and increased energy intake; it was more common among the young and concerned in particular coffee/tea/waters and sweets.
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| 33. |
- Orsi, S., et al.
(author)
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A second level trigger for the PAMELA satellite experiment
- 2006
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In: Astroparticle physics. - : Elsevier BV. - 0927-6505 .- 1873-2852. ; 25:1, s. 33-40
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Journal article (peer-reviewed)abstract
- The PAMELA space experiment will be launched on-board of a Russian Resurs DK1 satellite towards the end of 2005. The main scientific goal is the study of the antimatter component of the cosmic radiation. Three years of data taking will provide unprecedented statistics for antiprotons (80 MeV-190 GeV) and positrons (50 MeV-270 GeV) and will set the upper limit for the ratio He/He below 10(-8). PAMELA is built around a permanent magnet silicon spectrometer, surrounded by a plastic scintillator anticoincidence shield. An electromagnetic calorimeter is used for particle identification and energy measurements. If PAMELA data exceed the storage allowance on the satellite or the daily downlink quota (20 GB), a second level trigger may be activated by uplink from ground. Information from the anticoincidence system and from the calorimeter will be included in the second level trigger condition, providing a selective reduction of data. The second level trigger condition provides a reduction of data of similar to 60%, with a maximum systematic uncertainty in the proton (electron) spectra of 10% (3%). This uncertainty will be assessed during flight measuring one event every 10 without the second level trigger condition.
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| 34. |
- Periale, L., et al.
(author)
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A study of the operation of especially designed photosensitive gaseous detectors at cryogenic temperatures
- 2006
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In: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 567:1, s. 381-385
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Journal article (peer-reviewed)abstract
- In some experiments and applications there is need for large-area photosensitive detectors to operate at cryogenic temperatures. Nowadays, vacuum PMs are usually used for this purpose. We have developed special designs of planar photosensitive gaseous detectors able to operate at cryogenic temperatures. Such detectors are much cheaper than PMs and are almost insensitive to magnetic fields. Results of systematic measurements of their quantum efficiencies, the maximum achievable gains and long-term stabilities will be presented. The successful operation of these detectors open realistic possibilities in replacing PMs by photosensitive gaseous detectors in some applications dealing with cryogenic liquids; for example in experiments using noble liquid TPCs or noble liquid scintillating calorimeters.
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| 35. |
- Periale, L., et al.
(author)
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Photosensitive gaseous detectors for cryogenic temperature applications
- 2007
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In: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 573:1-2, s. 302-305
-
Journal article (peer-reviewed)abstract
- There are several proposals and projects today for building LXe time projection chambers (TPCs) for dark matter search. Important elements of these TPCs are the photomultipliers operating either inside LXe or in vapours above the liquid. We have recently demonstrated that photosensitive gaseous detectors (wire type and hole type) can operate perfectly well, until temperatures of LN2. In this paper, results of systematic studies of operation of the photosensitive version of these detectors (combined with reflective or semi-transparent CsI photocathodes) in the temperature interval of 300-150K are presented. In particular, it was demonstrated that both sealed and flushed by a gas detectors could operate at a quite stable fashion in a year/time scale. Obtained results strongly indicate that they can be cheap and simple alternatives to photomultipliers or avalanche solid-state detectors in LXe TPC applications.
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| 36. |
- Periale, L., et al.
(author)
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The successful operation of hole-type gaseous detectors at cryogenic temperatures
- 2005
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In: IEEE Transactions on Nuclear Science. - : Institute of Electrical and Electronics Engineers (IEEE). - 0018-9499 .- 1558-1578. ; 52:4, s. 927-931
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Journal article (peer-reviewed)abstract
- We have demonstrated that hole-type gaseous detectors, gas electron multipliers and capillary plates (CPs) can operate at temperatures down to 77 K. For example, a single CP can operate at gains above 10(3) in the entire temperature interval between 77 and 300 K. The same CP combined with CsI photocathodes operates perfectly well at gains of 100-1000, depending on the gas mixture. The obtained results open new fields of applications for CPs as detectors of ultraviolet light and charged particles at cryogenic temperatures: liquid noble gas time-projection chambers, detectors for weakly interacting massive particles or liquid Xe scintillating calorimeters, and cryogenic positron-emission tomography.
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| 37. |
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| 38. |
- Peskov, V., et al.
(author)
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Development and first tests of GEM-Like detectors with resistive electrodes
- 2007
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In: IEEE Transactions on Nuclear Science. - : Institute of Electrical and Electronics Engineers (IEEE). - 0018-9499 .- 1558-1578. ; 54:5, s. 1784-1791
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Journal article (peer-reviewed)abstract
- We have developed and tested several prototypes of GEM-like detectors with electrodes coated with resistive layers or completely made of resistive materials. These detectors can operate stably at gains close to 10(5). The resistive layers limit the energy of discharges appearing at higher gains thus making the detectors very robust. We demonstrated that the cathodes of some of these detectors could be coated by CsI or SbCs layers to enhance the detection efficiency for the UV and visible photons. We also discovered that such detectors can operate stably in the cascade mode and high overall gains (similar to 10(6)) are reachable. Applications in several areas, for example in RICH or in noble liquid TPCs are therefore possible. The first results from the detection of UV photons at room and cryogenic temperatures will be given.
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| 39. |
- Picozza, P., et al.
(author)
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PAMELA - A payload for antimatter matter exploration and light-nuclei astrophysics
- 2007
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In: Astroparticle physics. - : Elsevier BV. - 0927-6505 .- 1873-2852. ; 27:4, s. 296-315
-
Journal article (peer-reviewed)abstract
- The PAMELA experiment is a satellite-borne apparatus designed to study charged particles in the cosmic radiation with a particular focus on antiparticles. PAMELA is mounted on the Resurs DK1 satellite that was launched from the Baikonur cosmodrome on June 15th 2006. The PAMELA apparatus comprises a time-of-flight system, a magnetic spectrometer, a silicon-tungsten electromagnetic calorimeter, an anticoincidence system, a shower tail catcher scintillator and a neutron detector. The combination of these devices allows antiparticles to be reliably identified from a large background of other charged particles. This paper reviewsthe design, space qualification and on-ground performance of PAMELA. The in-orbit performance will be discussed in future publications.
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| 40. |
- Pischon, T., et al.
(author)
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General and Abdominal Adiposity and Risk of Death in Europe
- 2008
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In: New England Journal of Medicine. - 0028-4793. ; 359:20, s. 2105-2120
-
Journal article (peer-reviewed)abstract
- BACKGROUND Previous studies have relied predominantly on the body-mass index (BMI, the weight in kilograms divided by the square of the height in meters) to assess the association of adiposity with the risk of death, but few have examined whether the distribution of body fat contributes to the prediction of death. METHODS We examined the association of BMI, waist circumference, and waist-to-hip ratio with the risk of death among 359,387 participants from nine countries in the European Prospective Investigation into Cancer and Nutrition (EPIC). We used a Cox regression analysis, with age as the time variable, and stratified the models according to study center and age at recruitment, with further adjustment for educational level, smoking status, alcohol consumption, physical activity, and height. RESULTS During a mean follow-up of 9.7 years, 14,723 participants died. The lowest risks of death related to BMI were observed at a BMI of 25.3 for men and 24.3 for women. After adjustment for BMI, waist circumference and waist-to-hip ratio were strongly associated with the risk of death. Relative risks among men and women in the highest quintile of waist circumference were 2.05 (95% confidence interval [CI], 1.80 to 2.33) and 1.78 (95% CI, 1.56 to 2.04), respectively, and in the highest quintile of waist-to-hip ratio, the relative risks were 1.68 (95% CI, 1.53 to 1.84) and 1.51 (95% CI, 1.37 to 1.66), respectively. BMI remained significantly associated with the risk of death in models that included waist circumference or waist-to-hip ratio (P<0.001). CONCLUSIONS These data suggest that both general adiposity and abdominal adiposity are associated with the risk of death and support the use of waist circumference or waist-tohip ratio in addition to BMI in assessing the risk of death.
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| 41. |
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| 42. |
- Sinilnikova, Olga M., et al.
(author)
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Haplotype-based analysis of common variation in the acetyl-CoA carboxyiase alpha gene and breast cancer risk: A case-control study nested within the European prospective investigation into cancer and nutrition
- 2007
-
In: Cancer Epidemiology Biomarkers & Prevention. - 1538-7755. ; 16:3, s. 409-415
-
Journal article (peer-reviewed)abstract
- A key fatty acid synthesis enzyme, acetyl-CoA carboxylase alpha(ACC-alpha), has been shown to be highly expressed in human breast cancer and other tumor types and also to specifically interact with the protein coded by one of two major breast cancer susceptibility genes BRCA1. We used a comprehensive haplotype analysis to examine the contribution of the ACC-alpha common genetic variation (allele frequency > 5%) to breast cancer in a case-control study (1,588 cases/2,600 controls) nested within the European Prospective Investigation into Cancer and Nutrition. We identified 21 haplotypetagging polymorphisms efficiently capturing common variation within 325 kb of ACC-alpha and surrounding sequences using genotype data from the HapMap project and our resequencing data. We found an effect on overall risk of breast cancer in homozygous carriers of one common haplotype [odds ratio (OR), 1.74; 95% confidence interval (95% CI), 1.03-2.94]. When the data were subdivided by menopausal status, we found statistical evidence of heterogeneity for two other common haplotypes (P value for heterogeneity = 0.016 and 0.045). In premenopausal women, the carriers of these haplotypes, compared with noncarriers, had an altered risk of breast cancer (OR, 0.70; 95% CI, 0.53-0.92 and OR, 1.35; 95% CI, 1.04-1.76). These findings were not significant after adjustment for multiple testing and therefore should be considered as preliminary and evaluated in larger independent studies. However, they suggest a possible role of the ACC-alpha common sequence variants in susceptibility to breast cancer and encourage studies of other genes involved in fatty acid synthesis.
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| 43. |
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| 44. |
- Skeie, G., et al.
(author)
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Use of dietary supplements in the European Prospective Investigation into Cancer and Nutrition calibration study
- 2009
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In: European Journal of Clinical Nutrition. - : Springer Science and Business Media LLC. - 1476-5640 .- 0954-3007. ; 63:4s, s. 226-238
-
Journal article (peer-reviewed)abstract
- Background: Dietary supplement use is increasing, but there are few comparable data on supplement intakes and how they affect the nutrition and health of European consumers. The aim of this study was to describe the use of dietary supplements in subsamples of the 10 countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: Specific questions on dietary supplement use were asked as a part of single 24-h recalls performed on 36 034 men and women aged 35-74 years from 1995 to 2000. Results: Between countries, the mean percentage of dietary supplement use varied almost 10-fold among women and even more among men. There was a clear north-south gradient in use, with a higher consumption in northern countries. The lowest crude mean percentage of use was found in Greece (2.0% among men, 6.7% among women), and the highest was in Denmark (51.0% among men, 65.8% among women). Use was higher in women than in men. Vitamins, minerals or combinations of them were the predominant types of supplements reported, but there were striking differences between countries. Conclusions: This study indicates that there are wide variations in supplement use in Europe, which may affect individual and population nutrient intakes. The results underline the need to monitor consumption of dietary supplements in Europe, as well as to evaluate the risks and benefits. European Journal of Clinical Nutrition (2009) 63, S226-S238; doi: 10.1038/ejcn.2009.83
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| 45. |
- Sliwinska-Kowalska, Mariola, et al.
(author)
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Ototoxicity of organic solvents - from scientific evidence to health policy.
- 2007
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In: International journal of occupational medicine and environmental health. - Lodz : Nofer Institute of Occupational Medicine. - 1232-1087 .- 1896-494X. ; 20:2, s. 215-22
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Journal article (peer-reviewed)abstract
- The scientific workshop, organized under the 6th European Framework Programme, the Marie Curie Host Fellowship for the Transfer of Knowledge "NoiseHear" Project, by the Nofer Institute of Occupational Medicine (Åódź, Poland, 15-16 November 2006), gathered world specialists in noise, chemicals, and ototoxicity, including hearing researchers, toxicologists, otolaryngologists, audiologists and occupational health physicians.The workshop examined the evidence and the links between isolated exposure to organic solvents, combined exposure to noise and solvents, and effects on the auditory system. Its main purpose was to review the key scientific evidence to gather the necessary knowledge for developing adequate occupational health policies. This paper summarizes the workshop sessions and subsequent discussions.
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| 46. |
- Welch, A. A., et al.
(author)
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Variation in intakes of calcium, phosphorus, magnesium, iron and potassium in 10 countries in the European Prospective Investigation into Cancer and Nutrition study
- 2009
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In: European Journal of Clinical Nutrition. - : Springer Science and Business Media LLC. - 1476-5640 .- 0954-3007. ; 63:4s, s. 101-121
-
Journal article (peer-reviewed)abstract
- Background/objectives: Adequate mineral intake is important for the maintenance of bone health, cellular function and general metabolism, and possibly in the aetiology of cancer and other chronic diseases. This study aimed at investigating variation in intakes of selected minerals across 10 European countries participating in the EPIC (European Prospective Investigation into Cancer and Nutrition) study. Methods: Nutrient intakes for 36 034 subjects, aged between 35 and 74 years, in 27 centres were obtained using standardized 24-h dietary recall software (EPIC-SOFT). Mean intakes of calcium, phosphorus, magnesium, iron and potassium were calculated by centre and weighted by season and day of the week and were also stratified by age group. The contribution of food groups to total nutrient intake was calculated. Results: There was clear geographical variability in intakes, with differences ranging from 35% for magnesium to 90% for iron in men and 36% for potassium to 75% for calcium in women, and a twofold difference in sources of haem iron (meat and fish). There was a geographical gradient in iron intake, with higher intakes in Southern than in Northern Europe and also around a twofold north-south gradient in the contribution of fruits and vegetables to potassium intake. Compared with reference intakes, the majority of age groups and centres had intakes above the recommended levels. Dairy foods and products contributed the most to calcium and phosphorus intake in almost all centres. Cereals and cereal products contributed the most to magnesium and iron intakes, except in Greece and Germany. Conclusions: Intakes of minerals vary substantially throughout Europe, with some geographical variability in their food sources. European Journal of Clinical Nutrition (2009) 63, S101-S121; doi: 10.1038/ejcn.2009.77
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