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| 7. |
- Wahlin, T B, et al.
(author)
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Reactions to predictive testing in Huntington disease : case reports of coping with a new genetic status.
- 1997
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In: American Journal of Medical Genetics. - 0148-7299 .- 1096-8628. ; 73:3, s. 356-65
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Journal article (peer-reviewed)abstract
- A predictive testing program for Huntington disease has been available in Stockholm, Sweden since October 1990. Psychosocial assessments were performed throughout the testing program to evaluate the impact of the risk situation itself and the effect of predictive testing, and to identify those individuals who were most vulnerable to severe stress and anxiety reactions. All subjects underwent neurological, neuropsychological, and psychiatric examinations. Individuals undergoing predictive testing were assessed twice by a genetic counsellor before receiving their results, and at 10 days (gene carriers only) and then 2, 6, 12, and 24 months after receiving the results. The process of coping with the test results and the psychological adjustment to knowledge about new genetic status have been shown to vary considerably. In this report, we describe the results obtained from two gene carriers and two noncarriers. The four persons chosen represent different ways of coping with the outcome of the test and of integrating knowledge about their genetic status into everyday life. These cases illustrate common themes and recurrent problems often surfacing during the counselling and testing process. The longitudinal evaluations provide information about the impact, adaptation, and long-term effects of living with a new genetic status.
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| 10. |
- Dahlman-Höglund, Anna, 1964, et al.
(author)
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Antibodies given orally in the neonatal period can affect the immune response for two generations: evidence for active maternal influence on the newborn's immune system.
- 1999
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In: Scandinavian journal of immunology. - 0300-9475. ; 50:6, s. 651-6
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Journal article (peer-reviewed)abstract
- Two day old Wistar rats were tube fed with 1 or 10 micrograms of a mouse IgG1 monoclonal anti-idiotypic (a-Id) antibody that was directed against an anti-Escherichia coli-K13 capsular polysaccharide antibody. A control group was given 10 micrograms of an unrelated control antibody. Six weeks after the administration of antibodies, the rats were intestinally colonised with an ovalbumin (OVA)-producing E. coli O6K13 strain. At 8 weeks of age, the male rats (first generation) and the offsprings of the female rats (second generation), were parenterally immunised with OVA and dead wild type E. coli O6K13, and the immune response was followed. In the rats of the first generation, there were no major differences between the groups in the immune response to the bacterium. However, the offspring of the neonatally a-Id administered rats had a profoundly affected immune response to the idiotypically connected antigen K13, but also to other antigens on the bacteria. Thus, a-Id treatment in the first generation gave, in the second generation, a greatly enhanced serum antibody response to the spatially related antigens OVA and O6 LPS, as well as to the idiotypically connected antigen K13. Concurrently, the in vitro spleen cell proliferative response to both OVA and the wild type bacterium was lowered. Overall, greater effects were seen with the higher dose of a-Id. In conclusion, our results demonstrate that by giving monoclonal antibodies idiotypically connected to a single bacterial component to neonatal rats, one profoundly influence the immune response also to other-spatially related-bacterial antigens in their offsprings.
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| 12. |
- Hansson, Lars, et al.
(author)
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Annie, a Tool for Integrating Ergonomics in the Design of Car Interiors
- 1999
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Conference paper (other academic/artistic)abstract
- An example of a result from a long-term cooperation with Lund University (together with professor Roland Axelsson at the Department for Work Environment) there some of the authors. (Engström) gained extensive grants (Wallenberg Stifelsen regarding equipment as well as other founding from e.g. the Swedish Work Environment Found).
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| 16. |
- Lundin, Anders, et al.
(author)
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Compressibility of C61D2 up to 1 GPa in the temperature range 175 - 345 K
- 1996
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In: Carbon. - : Elsevier Science Ltd.. - 0008-6223 .- 1873-3891. ; 34:9, s. 1119-1121
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Journal article (peer-reviewed)abstract
- We have measured the bulk modulus K for C61D2 up to 1 GPa in the temperature range 175–343 K. For face-centered cubic C61D2 above 290 K, we find an anomalously low value for K below about 0.15 GPa, possibly indicating pressure-induced changes in the structure. The (extrapolated) zero-p bulk modulus K(0) decreases with increasing T from 6.7 GPa at 175 K to 5.2 GPa at 343 K. A comparison with hypothetical expanded f.c.c. C60 with the same lattice constant shows that K(0) values are similar, indicating that the main intermolecular interactions are still between molecular bellies, not the sidegroups.
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| 17. |
- Lundin, A., et al.
(author)
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Thermophysical properties of C70 up to 1.2 GPa
- 1995
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In: Science and technology of fullerene materials. - Pittsburgh, Pa : Materials Research Society. - 155899260X ; , s. 555-560
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Conference paper (peer-reviewed)
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| 19. |
- Lundin, Lars-Christer, et al.
(author)
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System of information in NOPEX : retrieval, use, and query of climate data
- 1999
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In: Agricultural and Forest Meteorology. - 0168-1923 .- 1873-2240. ; 98-99, s. 31-51
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Journal article (peer-reviewed)abstract
- The uncertainty in climate predictions caused by improper understanding of the role of the land-surface is underestimated and easy access to data from a series of landscape types around the globe would improve this. Such data exist from a series of large-scale land-surface experiments but access to them has been difficult. It is the objective of this paper to demonstrate how the System for Information in NOPEX (SINOP) could be set up to provide a combination of data archive and tool for executing various time-limited and long-term field activities. Setting up and running SINOP involved both technical and psychological issues. The major technical problems were associated with (i) the uninterrupted flow of large data volumes, (ii) data homogeneity, and (iii) the exploding technology development. The psychological and organisational problems were more difficult to tackle than the technical problems. Funding agencies assumed somebody else would take care of data archiving and documentation, academic organisations have difficulties to compete with the private market for database managers, many individual scientists were unwilling to deliver their datasets and, especially, unwilling to document them. It is suggested that changes in attitudes from scientists, academic organisations, and publishers are needed to give credit for the publication of good datasets and for the production of good documentation about them. CDs incorporating a subset of SINOP with well-documented datasets from NOPEX operations in 1994 and 1995 are published together with this NOPEX Special Issue. The CDs include climate variables, such as radiation, fluxes of heat, momentum, and water vapour, and various energy storage terms as well as hydrological variables from 13 sites within the central-Swedish NOPEX region, at the southern boundary of the boreal zone. The publication of these data is seen as a step towards giving data-set owners proper and citeable credit for their work.
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| 20. |
- Lundin, L-C, et al.
(author)
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System of information in NOPEX - retrieval, use, and query of climate data
- 1999
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In: AGRICULTURAL AND FOREST METEOROLOGY. - : ELSEVIER SCIENCE BV. - 0168-1923. ; 98-9, s. 31-51
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Journal article (peer-reviewed)abstract
- The uncertainty in climate predictions caused by improper understanding of the role of the land-surface is underestimated and easy access to data from a series of landscape types around the globe would improve this. Such data exist from a series of large-
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| 21. |
- Lundin, L-C, et al.
(author)
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Water resources and water supply
- 1999
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In: Sustainable Water Management in the Baltic Sea Basin. 2. Water Use and Management. - : The Baltic University Programme, Uppsala University. ; , s. 17-24
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Book chapter (other academic/artistic)
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| 22. |
- Lundin, Leif, et al.
(author)
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NIR spectra in relation to viscoelastic properties of mixtures of Na-?-Carrageenan, locust bean gum and casein
- 1998
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In: Food Hydrocolloids. - 0268-005X .- 1873-7137. ; 12:2, s. 189-193
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Journal article (peer-reviewed)abstract
- Near-infrared spectral data were correlated with the viscoelastic property storage modulus, G?, for mixtures of five biopolymers using multivariate analysis. Gels containing Na-?-carrageenan (0.5-1.0%) mixed with locust bean gums with two different mannose to galactose ratios, ?-casein and/or ?-casein (0-0.5%, polymer concentration) in 0.25 M NaCl were studied. Forty-two experiments based on a multivariate, central composite circumscribed design (CCC) were performed. Partial least square (PLS) regression was used to find a model relation between NIR transmittance spectra, recorded at 15°C in the wavelength interval 400-2500 nm, and the G? for the biopolymer gels at 15°C. Depending on sample composition, the G? varies between 0 and 3500Pa. Cross-validation using a designed data set led to a model based on 11 principal components with a correlation coefficient of 0.85 and a root mean square error of prediction of 540 Pa. © 1998 Published by Elsevier Science Ltd. All rights reserved.
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| 25. |
- Lundin, S.E., et al.
(author)
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Solvärme och säsongslagring med borrhål i berg och llågtemperatur för bostadsområdet Anneberg, Danderyd : Förprojektering
- 1998
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Reports (other academic/artistic)abstract
- In the planning of a new housing area for 100 dwellings, a pre-design has been made for a solar heating plant. The aim of designing a layout, is to compare the solar system with more conventional heating systems. Developers and contractors are invited for turn-key tenders of the different systems. The single family houses, apartments and service premises in two storey, will have a total floor area of 9000 m{sup 2}. The heating demand is estimated to 1100 MWh/year (120 kWh/m{sup 2}) and the power to 450 kW. A new concept system is designed with low temperatures in all essential parts, but heat pumps are not needed. (1) Flat plate solar collectors, mean temperature 60 deg C; (2) Seasonal bore hole heat store in rock, temperature level 30-45 deg C; (3) Heat distribution network, working temperature 20-80 deg C; (4) Floor heating coils, temperature 25-32 deg C; (5) Peak electrical heaters in houses; (6) Solar DHW and auxiliary individual electrical final heaters. The system has only one general heat fluid with a mixture of water and glycol flowing through solar collectors, store, culverts and the floor heating coils. In all operation modes the heat carrier has the same flow direction and even act as a`buffer volume`. The bedrock consist of outcrops of granite and the GWL is at a depth of 4 m below the ground. In a 120 m investigation bore hole, a so called`Response test` is made in situ of the rock and the duct system. The obtained thermal results are: Conductivity{lambda}= 4.1 W/m,K, Capacity C 0.6 kWh/K, m{sup 3}, Resistance total of PEM-tubes and rock mass R= 0.02 K/(W/m). The investment cost have been calculated to 5.4 mil SEK ({approx} 0.7 mil USD) excl. culvert, floor heating system, DHW tanks/heaters. The annual capital and running costs are 0.73 mil SEK (0.1 mil USD), calculated with an interest rate of 6% over 25 years (0.078). The total system heating cost will be 0.68 SEK/kWh (0.1 USD/kWh). With received EU- and -governmental subsides up to 2.0 mil SEK the heating costs drop to 0.54 SEK/kWh (0.07 USD/kWh). Solar energy is by that means cost-effective to conventional alternatives as district heating, bio-fuel block centrals, ground heat pumps or 100% electrical heating. The solar heating project seems in all respects possible to carry through - but the final decision is taken of the market response
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| 26. |
- Lundin, U, et al.
(author)
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Are there two types of f-electrons in Pr-metal?
- 1999
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In: PHYSICA B. - : ELSEVIER SCIENCE BV. - 0921-4526. ; 261, s. 231-232
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Journal article (other academic/artistic)abstract
- We show that in order to properly describe the bonding properties of strongly correlated systems, here demonstrated for praseodymium metal, it is necessary to split the f-electron system into two parts. Using perturbation theory from the atomic limit we s
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| 27. |
- Lundin, U, et al.
(author)
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Periodical Anderson model for Pr metal
- 1997
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In: PHYSICA B. - : ELSEVIER SCIENCE BV. - 0921-4526. ; 230, s. 445-447
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Journal article (other academic/artistic)abstract
- By means of diagram technique for Hubbard operators we inspect if the multi-orbital periodical Anderson model can be used for eliminating difficulties in the theoretical description of Pr metal. The answer seems to be positive.
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| 28. |
- Lundin, U, et al.
(author)
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Transition-metal dioxides with a bulk modulus comparable to diamond
- 1998
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In: PHYSICAL REVIEW B-CONDENSED MATTER. - : AMERICAN PHYSICAL SOC. - 0163-1829. ; 57:9, s. 4979-4982
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Journal article (other academic/artistic)abstract
- Recently it has been reported that a high-pressure cubic phase of ruthenium dioxide has an unusually large bulk modulus, and consequently is a most interesting candidate as a very hard material. Based on ab initio calculations it is shown that the high bu
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| 30. |
- Michaëlsson, Gerd, et al.
(author)
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Patients with psoriasis have elevated levels of serum eosinophil cationic protein and increased numbers of EG2 positive eosinophils in the duodenal stroma
- 1996
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In: British Journal of Dermatology. - 0007-0963 .- 1365-2133. ; 135:3, s. 371-378
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Journal article (peer-reviewed)abstract
- The occurrence of EG2-positive (EG2+) eosinophils and IgE in biopsy specimens of duodenal mucosa and skin from 39 psoriasis patients was studied, with emphasis on the relation to serum eosinophil cationic protein (ECP), serum IgE and the presence or absence of serum IgA and IgG antigliadin antibodies. Psoriasis patients had significantly elevated serum levels of ECP even after exclusion of five of 37 sera which were Phadiatop positive. The elevated serum ECP was not associated with the presence of IgA or IgG antibodies to gliadin. After exclusion of Phadiatop positive sera the serum IgE values did not differ from those of a group of healthy blood donors. Patients with psoriasis had a pronounced increase of EG2+ cells in their duodenal stroma. Patients without antibodies to gliadin tended to have even more EG2+ cells than those with such antibodies and those with increased duodenal intraepithelial lymphocytes. IgE+ cells were present in most duodenal specimens, and in some specimens there were > 100 IgE+ cells/section. The number of EG2+ cells was increased in lesional skin and, in some patients, also in non-involved skin, but there was a more pronounced increase in EG2 reactivity in the duodenal than in the skin specimens. IgE reactivity was increased both in non-involved and involved skin and was significantly related to the number of IgE-positive cells in the duodenal stroma. The results of this study indicate that the gastrointestinal tract and the eosinophil granulocyte might be involved in psoriasis in a hitherto unknown way.
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| 31. |
- Proff, S, et al.
(author)
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Electromagnetic polarizabilities of nucleons bound in 40Ca, 16O and 4He
- 1999
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In: Nuclear Physics A. - 0375-9474. ; 646:1, s. 67-82
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Journal article (peer-reviewed)abstract
- Differential cross sections for elastic scattering of photons have been measured for 40Ca at energies of 58 and 74 MeV and for 16O and 4He at 61 MeV, in the angular range from 45° to 150°. Evidence is obtained that there are no significant in-medium modifications of the electromagnetic polarizabilities except for those originating from meson exchange currents.
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| 35. |
- Sundqvist, B., et al.
(author)
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Measurements of thermophysical properties as tools to study the phase diagrams of fullerenes under pressure
- 1997
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In: High Temperatures-High Pressures. - 0018-1544 .- 1472-3441. ; 29:1, s. 119-124
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Journal article (peer-reviewed)abstract
- The 14th ECTP is part of a conference series initiated in 1968 in Baden-Baden, Germany, as a European effort to collect expertise and to present the latest research in the area of measurement and theoretical predictions of thermophysical properties of materials -solids and fluids- which are of technical and industrial interest
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| 36. |
- Sundqvist, B., et al.
(author)
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Orientational disorder and the p-T phase diagrams of fullerenes
- 1995
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In: Proceedings of the Symposium on Recent Advances in the Chemistry and Physics of Fullerenes and Related Materials. - Pennington, NJ : Electrochemical Society, Incorporated. - 1566771048 ; , s. 891-905
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Conference paper (peer-reviewed)
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| 39. |
- Wretenberg, Per, 1963-, et al.
(author)
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Passive knee muscle moment arms measured in vivo with MRI
- 1996
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In: Clinical Biomechanics. - Oxon, United Kingdom : Butterworth-Heinemann. - 0268-0033 .- 1879-1271. ; 11:8, s. 439-446
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Journal article (peer-reviewed)abstract
- Objective: To determine moment arm lengths from seven knee muscles and the patellar tendon. The knee muscles were the biceps femoris, semitendinosus, semimembranosus, gracilis, sartorius, and the lateral and medial gastrocnemius muscles.Design: The moment arms were calculated based on MRI measurements.Background: Moment arm lengths of different muscles with respect to the joint centre of rotation (CR) or the centre of the contact point between joint surfaces are necessary basic data for biomechanical models predicting joint load.Methods: Ten male and seven female subjects participated. Using a 1.5 Tesla magnetic resonance imaging system, 3-dimensional coordinates of relevant points were recorded from a 3-D volume reconstruction of the right knee at knee flexion angles of 0, 30 and 60 degrees. Muscular moment arms were calculated in both the sagittal and frontal planes. The recordings were all made during passive mode, which means that no muscular contraction was performed.Results: All muscles except the lateral gastrocnemius showed statistically significant differences (P<0.05) of moment arm lengths between gender in the frontal plane. All muscles except biceps femoris and sartorius showed significant differences (P<0.05) of moment arm lengths between gender in the sagittal plane. Most muscles also showed a linear or quadratic trend of changing moment arms with varying knee angle. CONCLUSIONS: Our results indicate that for most biomechanical analyses involving knee muscles, gender- and angle-specific moment arms should be used.
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