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1.	Ahmad, T, et al. (author) In-hospital clinical outcomes after upper gastrointestinal surgery: Data from an international observational study 2017 In: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. - : Elsevier BV. - 1532-2157 .- 0748-7983. ; 43:12, s. 2324-2332 Journal article (peer-reviewed)
2.	Ahmad, T, et al. (author) Use of failure-to-rescue to identify international variation in postoperative care in low-, middle- and high-income countries: a 7-day cohort study of elective surgery 2017 In: British journal of anaesthesia. - : Elsevier BV. - 1471-6771 .- 0007-0912. ; 119:2, s. 258-266 Journal article (peer-reviewed)
3.	Herrick, Ariane L, et al. (author) Treatment outcome in early diffuse cutaneous systemic sclerosis : The European Scleroderma Observational Study (ESOS) 2017 In: Annals of the Rheumatic Diseases. - : BMJ. - 0003-4967 .- 1468-2060. ; 76:7, s. 1207-1218 Journal article (peer-reviewed)abstract Objectives: The rarity of early diffuse cutaneous systemic sclerosis (dcSSc) makes randomised controlled trials very difficult. We aimed to use an observational approach to compare effectiveness of currently used treatment approaches. Methods: This was a prospective, observational cohort study of early dcSSc (within three years of onset of skin thickening). Clinicians selected one of four protocols for each patient: methotrexate, mycophenolate mofetil (MMF), cyclophosphamide or 'no immunosuppressant'. Patients were assessed three-monthly for up to 24 months. The primary outcome was the change in modified Rodnan skin score (mRSS). Confounding by indication at baseline was accounted for using inverse probability of treatment (IPT) weights. As a secondary outcome, an IPT-weighted Cox model was used to test for differences in survival. Results Of 326 patients recruited from 50 centres, 65 were prescribed methotrexate, 118 MMF, 87 cyclophosphamide and 56 no immunosuppressant. 276 (84.7%) patients completed 12 and 234 (71.7%) 24 months follow-up (or reached last visit date). There were statistically significant reductions in mRSS at 12 months in all groups: -4.0 (-5.2 to -2.7) units for methotrexate, -4.1 (-5.3 to -2.9) for MMF, -3.3 (-4.9 to -1.7) for cyclophosphamide and -2.2 (-4.0 to -0.3) for no immunosuppressant (p value for between-group differences=0.346). There were no statistically significant differences in survival between protocols before (p=0.389) or after weighting (p=0.440), but survival was poorest in the no immunosuppressant group (84.0%) at 24 months. Conclusions: These findings may support using immunosuppressants for early dcSSc but suggest that overall benefit is modest over 12 months and that better treatments are needed.

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Type of publication: journal article (3)

Type of content: peer-reviewed (3)

Author/Editor: Bai, Y. (2); Brown, J. (2); Chen, C. (2); Chen, H. (2); Chen, S. (2); Francis, D. (2); show more...; Huang, Y. (2); Li, B. (2); Li, H. (2); Liu, B. (2); Liu, M. (2); Liu, Y. (2); March, L. (2); Pinder, A. (2); Sanchez, A. (2); Silva, J. (2); Walker, R. (2); Wang, F. (2); Wang, J. (2); Webb, S. (2); White, S. (2); Williams, S. (2); Wilson, A. (2); Xu, L. (2); Yang, Y. (2); Zhang, H. (2); Zhang, J. (2); Zhang, L. (2); Zhu, Y. (2); Brenner, L. (2); Simon, D. (2); Zhou, C. (2); Brown, G. (2); Ellis, K. (2); Rose, A. (2); Zhao, L. (2); Ahmad, A. (2); He, M. (2); Ryan, P. (2); Schmitz, M. (2); Zhao, T. (2); Gupta, A. (2); Joseph, J. (2); Kennedy, J. (2); Li, J. (2); Yuan, J. (2); Zhang, Q. (2); Ren, Y. (2); Martin, J. (2); Alexander, M. (2); show less...

University: Lund University (2); Karolinska Institutet (2); University of Gothenburg (1)

Language: English (3)

Research subject (UKÄ/SCB): Medical and Health Sciences (3)

Year: 2017 (3)Undo refine

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