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Träfflista för sökning "WFRF:(Maeurer M) srt2:(2010-2014)"

Search: WFRF:(Maeurer M) > (2010-2014)

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  • O'Grady, J, et al. (author)
  • Tuberculosis in prisons: anatomy of global neglect
  • 2011
  • In: The European respiratory journal. - : European Respiratory Society (ERS). - 1399-3003 .- 0903-1936. ; 38:4, s. 752-754
  • Journal article (other academic/artistic)
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  • Pasetto, A, et al. (author)
  • Generation of T-cell receptors targeting a genetically stable and immunodominant cytotoxic T-lymphocyte epitope within hepatitis C virus non-structural protein 3
  • 2012
  • In: The Journal of general virology. - : Microbiology Society. - 1465-2099 .- 0022-1317. ; 93:Pt 2, s. 247-258
  • Journal article (peer-reviewed)abstract
    • Hepatitis C virus (HCV) is a major cause of severe liver disease, and one major contributing factor is thought to involve a dysfunction of virus-specific T-cells. T-cell receptor (TCR) gene therapy with HCV-specific TCRs would increase the number of effector T-cells to promote virus clearance. We therefore took advantage of HLA-A2 transgenic mice to generate multiple TCR candidates against HCV using DNA vaccination followed by generation of stable T-cell–BW (T-BW) tumour hybrid cells. Using this approach, large numbers of non-structural protein 3 (NS3)-specific functional T-BW hybrids can be generated efficiently. These predominantly target the genetically stable HCV genotype 1 NS31073–1081 CTL epitope, frequently associated with clearance of HCV in humans. These T-BW hybrid clones recognized the NS31073 peptide with a high avidity. The hybridoma effectively recognized virus variants and targeted cells with low HLA-A2 expression, which has not been reported previously. Importantly, high-avidity murine TCRs effectively redirected human non-HCV-specific T-lymphocytes to recognize human hepatoma cells with HCV RNA replication driven by a subgenomic HCV replicon. Taken together, TCR candidates with a range of functional avidities, which can be used to study immune recognition of HCV-positive targets, have been generated. This has implications for TCR-related immunotherapy against HCV.
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  • Uhlin, M, et al. (author)
  • Adjunct immunotherapies for tuberculosis
  • 2012
  • In: The Journal of infectious diseases. - : Oxford University Press (OUP). - 1537-6613 .- 0022-1899. ; 205205 Suppl 2, s. S325-S334
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  • Zumla, A, et al. (author)
  • Pregnancy and infection
  • 2014
  • In: The New England journal of medicine. - 1533-4406. ; 371:11, s. 1076-1076
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  • Result 1-50 of 73

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