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Search: WFRF:(Mariani P) > (2015-2019)

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  • Joffrin, E., et al. (author)
  • Overview of the JET preparation for deuterium-tritium operation with the ITER like-wall
  • 2019
  • In: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 59:11
  • Research review (peer-reviewed)abstract
    • For the past several years, the JET scientific programme (Pamela et al 2007 Fusion Eng. Des. 82 590) has been engaged in a multi-campaign effort, including experiments in D, H and T, leading up to 2020 and the first experiments with 50%/50% D-T mixtures since 1997 and the first ever D-T plasmas with the ITER mix of plasma-facing component materials. For this purpose, a concerted physics and technology programme was launched with a view to prepare the D-T campaign (DTE2). This paper addresses the key elements developed by the JET programme directly contributing to the D-T preparation. This intense preparation includes the review of the physics basis for the D-T operational scenarios, including the fusion power predictions through first principle and integrated modelling, and the impact of isotopes in the operation and physics of D-T plasmas (thermal and particle transport, high confinement mode (H-mode) access, Be and W erosion, fuel recovery, etc). This effort also requires improving several aspects of plasma operation for DTE2, such as real time control schemes, heat load control, disruption avoidance and a mitigation system (including the installation of a new shattered pellet injector), novel ion cyclotron resonance heating schemes (such as the three-ions scheme), new diagnostics (neutron camera and spectrometer, active Alfven eigenmode antennas, neutral gauges, radiation hard imaging systems...) and the calibration of the JET neutron diagnostics at 14 MeV for accurate fusion power measurement. The active preparation of JET for the 2020 D-T campaign provides an incomparable source of information and a basis for the future D-T operation of ITER, and it is also foreseen that a large number of key physics issues will be addressed in support of burning plasmas.
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  • Thomas, HS, et al. (author)
  • 2019
  • swepub:Mat__t
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  • Labit, B., et al. (author)
  • Dependence on plasma shape and plasma fueling for small edge-localized mode regimes in TCV and ASDEX Upgrade
  • 2019
  • In: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 59:8
  • Journal article (peer-reviewed)abstract
    • © 2019 Institute of Physics Publishing. All rights reserved. Within the EUROfusion MST1 work package, a series of experiments has been conducted on AUG and TCV devices to disentangle the role of plasma fueling and plasma shape for the onset of small ELM regimes. On both devices, small ELM regimes with high confinement are achieved if and only if two conditions are fulfilled at the same time. Firstly, the plasma density at the separatrix must be large enough (ne,sep/nG ∼ 0.3), leading to a pressure profile flattening at the separatrix, which stabilizes type-I ELMs. Secondly, the magnetic configuration has to be close to a double null (DN), leading to a reduction of the magnetic shear in the extreme vicinity of the separatrix. As a consequence, its stabilizing effect on ballooning modes is weakened.
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  • Coda, S., et al. (author)
  • Physics research on the TCV tokamak facility: From conventional to alternative scenarios and beyond
  • 2019
  • In: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 59:11
  • Journal article (peer-reviewed)abstract
    • The research program of the TCV tokamak ranges from conventional to advanced-tokamak scenarios and alternative divertor configurations, to exploratory plasmas driven by theoretical insight, exploiting the device's unique shaping capabilities. Disruption avoidance by real-time locked mode prevention or unlocking with electron-cyclotron resonance heating (ECRH) was thoroughly documented, using magnetic and radiation triggers. Runaway generation with high-Z noble-gas injection and runaway dissipation by subsequent Ne or Ar injection were studied for model validation. The new 1 MW neutral beam injector has expanded the parameter range, now encompassing ELMy H-modes in an ITER-like shape and nearly non-inductive H-mode discharges sustained by electron cyclotron and neutral beam current drive. In the H-mode, the pedestal pressure increases modestly with nitrogen seeding while fueling moves the density pedestal outwards, but the plasma stored energy is largely uncorrelated to either seeding or fueling. High fueling at high triangularity is key to accessing the attractive small edge-localized mode (type-II) regime. Turbulence is reduced in the core at negative triangularity, consistent with increased confinement and in accord with global gyrokinetic simulations. The geodesic acoustic mode, possibly coupled with avalanche events, has been linked with particle flow to the wall in diverted plasmas. Detachment, scrape-off layer transport, and turbulence were studied in L- and H-modes in both standard and alternative configurations (snowflake, super-X, and beyond). The detachment process is caused by power 'starvation' reducing the ionization source, with volume recombination playing only a minor role. Partial detachment in the H-mode is obtained with impurity seeding and has shown little dependence on flux expansion in standard single-null geometry. In the attached L-mode phase, increasing the outer connection length reduces the in-out heat-flow asymmetry. A doublet plasma, featuring an internal X-point, was achieved successfully, and a transport barrier was observed in the mantle just outside the internal separatrix. In the near future variable-configuration baffles and possibly divertor pumping will be introduced to investigate the effect of divertor closure on exhaust and performance, and 3.5 MW ECRH and 1 MW neutral beam injection heating will be added.
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  • Betti, M. G., et al. (author)
  • A design for an electromagnetic filter for precision energy measurements at the tritium endpoint
  • 2019
  • In: Progress in Particle and Nuclear Physics. - : Elsevier BV. - 0146-6410 .- 1873-2224. ; 106, s. 120-131
  • Research review (peer-reviewed)abstract
    • We present a detailed description of the electromagnetic filter for the PTOLEMY project to directly detect the Cosmic Neutrino Background (CNB). Starting with an initial estimate for the orbital magnetic moment, the higher-order drift process of E x B is configured to balance the gradient-B drift motion of the electron in such a way as to guide the trajectory into the standing voltage potential along the mid-plane of the filter. As a function of drift distance along the length of the filter, the filter zooms in with exponentially increasing precision on the transverse velocity component of the electron kinetic energy. This yields a linear dimension for the total filter length that is exceptionally compact compared to previous techniques for electromagnetic filtering. The parallel velocity component of the electron kinetic energy oscillates in an electrostatic harmonic trap as the electron drifts along the length of the filter. An analysis of the phase-space volume conservation validates the expected behavior of the filter from the adiabatic invariance of the orbital magnetic moment and energy conservation following Liouville's theorem for Hamiltonian systems.
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13.
  • Betti, M. G., et al. (author)
  • Neutrino physics with the PTOLEMY project : active neutrino properties and the light sterile case
  • 2019
  • In: Journal of Cosmology and Astroparticle Physics. - : IOP PUBLISHING LTD. - 1475-7516. ; :7
  • Journal article (peer-reviewed)abstract
    • The PTOLEMY project aims to develop a scalable design for a Cosmic Neutrino Background (CNB) detector, the first of its kind and the only one conceived that can look directly at the image of the Universe encoded in neutrino background produced in the first second after the Big Bang. The scope of the work for the next three years is to complete the conceptual design of this detector and to validate with direct measurements that the non-neutrino backgrounds are below the expected cosmological signal. In this paper we discuss in details the theoretical aspects of the experiment and its physics goals. In particular, we mainly address three issues. First we discuss the sensitivity of PTOLEMY to the standard neutrino mass scale. We then study the perspectives of the experiment to detect the CNB via neutrino capture on tritium as a function of the neutrino mass scale and the energy resolution of the apparatus. Finally, we consider an extra sterile neutrino with mass in the eV range, coupled to the active states via oscillations, which has been advocated in view of neutrino oscillation anomalies. This extra state would contribute to the tritium decay spectrum, and its properties, mass and mixing angle, could be studied by analyzing the features in the beta decay electron spectrum.
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14.
  • Wiedorn, Max O., et al. (author)
  • Megahertz serial crystallography
  • 2018
  • In: Nature Communications. - : Nature Publishing Group. - 2041-1723. ; 9
  • Journal article (peer-reviewed)abstract
    • The new European X-ray Free-Electron Laser is the first X-ray free-electron laser capable of delivering X-ray pulses with a megahertz inter-pulse spacing, more than four orders of magnitude higher than previously possible. However, to date, it has been unclear whether it would indeed be possible to measure high-quality diffraction data at megahertz pulse repetition rates. Here, we show that high-quality structures can indeed be obtained using currently available operating conditions at the European XFEL. We present two complete data sets, one from the well-known model system lysozyme and the other from a so far unknown complex of a beta-lactamase from K. pneumoniae involved in antibiotic resistance. This result opens up megahertz serial femtosecond crystallography (SFX) as a tool for reliable structure determination, substrate screening and the efficient measurement of the evolution and dynamics of molecular structures using megahertz repetition rate pulses available at this new class of X-ray laser source.
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15.
  • Yefanov, Oleksandr, et al. (author)
  • Evaluation of serial crystallographic structure determination within megahertz pulse trains
  • 2019
  • In: Structural Dynamics. - : AMER INST PHYSICS. - 2329-7778. ; 6:6
  • Journal article (peer-reviewed)abstract
    • The new European X-ray Free-Electron Laser (European XFEL) is the first X-ray free-electron laser capable of delivering intense X-ray pulses with a megahertz interpulse spacing in a wavelength range suitable for atomic resolution structure determination. An outstanding but crucial question is whether the use of a pulse repetition rate nearly four orders of magnitude higher than previously possible results in unwanted structural changes due to either radiation damage or systematic effects on data quality. Here, separate structures from the first and subsequent pulses in the European XFEL pulse train were determined, showing that there is essentially no difference between structures determined from different pulses under currently available operating conditions at the European XFEL.
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16.
  • Benisek, Martin, et al. (author)
  • Dioxins and dioxin-like compounds in composts and digestates from European countries as determined by the in vitro bioassay and chemical analysis
  • 2015
  • In: Chemosphere. - : Elsevier. - 0045-6535 .- 1879-1298. ; 122, s. 168-175
  • Journal article (peer-reviewed)abstract
    • Aerobic composting and anaerobic digestion plays an important role in reduction of organic waste by transforming the waste into humus, which is an excellent soil conditioner. However, applications of chemical-contaminated composts on soils may have unwanted consequences such as accumulation of persistent compounds and their transfer into food chains. The present study investigated burden of composts and digestates collected in 16 European countries (88 samples) by the compounds causing dioxin-like effects as determined by use of an in vitro transactivation assay to quantify total concentrations of aryl hydrocarbon receptor-(AhR) mediated potency. Measured concentrations of 2,3,7,8-Tetrachlorodibeno-p-dioxin (2,3,7,8-TCDD) equivalents (TEQ(bio)) were compared to concentrations of polycyclic aromatic hydrocarbons (PAHs) and selected chlorinated compounds, including polychlorinated dibenzo-p-dioxins/furans (PCDD/Fs), co-planar polychlorinated biphenyls (PCBs), indicator PCB congeners and organochlorine pesticides (OCPs). Median concentrations of TEQ(bio), (dioxin-like compounds) determined by the in vitro assay in crude extracts of various types of composts ranged from 0.05 to 1.2 with a maximum 8.22 mu g (TEQ(bio)) kg(-1) dry mass. Potencies were mostly associated with less persistent compounds such as PAHs because treatment with sulfuric acid removed bioactivity from most samples. The pan-European investigation of contamination by organic contaminants showed generally good quality of the composts, the majority of which were in compliance with conservative limits applied in some countries. Results demonstrate performance and added value of rapid, inexpensive, effect-based monitoring, and points out the need to derive corresponding effect-based trigger values for the risk assessment of complex contaminated matrices such as composts.
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  • Brunetti, D., et al. (author)
  • Analytic stability criteria for edge MHD oscillations in high performance ELM free tokamak regimes
  • 2018
  • In: Nuclear Fusion. - : IOP Publishing. - 0029-5515 .- 1741-4326. ; 58:1
  • Journal article (peer-reviewed)abstract
    • A new dispersion relation, and associated stability criteria, is derived for low-n external kink and infernal modes, and is applied to modelling the stability properties of quiescent H-mode like regimes. The analysis, performed in toroidal geometry with large edge pressure gradients associated with a local flattening of the safety factor, includes a pedestal, sheared toroidal rotation and a vacuum region separating the plasma from an ideal metallic wall. The external kink-infernal modes found here exhibit similarities with experimentally observed edge harmonic oscillations.
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18.
  • Brunetti, Daniele, et al. (author)
  • Analytic study on low-n external ideal infernal modes in tokamaks with large edge pressure gradients
  • 2018
  • In: Journal of Plasma Physics. - 0022-3778 .- 1469-7807. ; 84:2
  • Journal article (peer-reviewed)abstract
    • The problem of pressure driven infernal type perturbations near the plasma edge is addressed analytically for a circular limited tokamak configuration which presents an edge flattened safety factor. The plasma is separated from a metallic wall, either ideally conducting or resistive, by a vacuum region. The dispersion relation for such types of instabilities is derived and discussed for two classes of equilibrium profiles for pressure and mass density.
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  • Brunetti, D., et al. (author)
  • Excitation Mechanism of Low-n Edge Harmonic Oscillations in Edge Localized Mode-Free, High Performance, Tokamak Plasmas
  • 2019
  • In: Physical Review Letters. - : AMER PHYSICAL SOC. - 0031-9007 .- 1079-7114. ; 122:15
  • Journal article (peer-reviewed)abstract
    • The excitation mechanism for low-n edge harmonic oscillations in quiescent H-mode regimes is identified analytically. We show that the combined effect of diamagnetic and poloidal magnetohydrodynamic flows, with the constraint of a Doppler-like effect of the ion flow, leads to the stabilization of short wavelength modes, allowing low-n perturbation to grow. The analysis, performed in tokamak toroidal geometry, includes the effects of large edge pressure gradients, associated with the local flattening of the safety factor and diamagnetic flows, sheared parallel and E x B rotation, and a vacuum region between plasma and the ideal metallic wall. The separatrix also is modeled analytically.
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20.
  • Brunetti, D., et al. (author)
  • Helical equilibrium magnetohydrodynamic flow effects on the stability properties of low-n ideal external-infernal modes in weak shear tokamak configurations
  • 2019
  • In: Plasma Physics and Controlled Fusion. - : IOP Publishing. - 0741-3335 .- 1361-6587. ; 61:6
  • Journal article (peer-reviewed)abstract
    • The impact of equilibrium helical flows on the stability properties of low shear tokamak plasmas is assessed. The corrections due to such helical flow to the equilibrium profiles (mass density, pressure, Shafranov shift, magnetic fluxes) are computed by minimising order by order the generalised Grad-Shafranov equation. By applying the same minimisation procedure, a set of three coupled equations, suitable for the study of magnetohydrodynamic perturbations localised within core or edge transport barriers is derived in circular tokamak geometry. We apply these equations to modelling the impact of strong poloidal flow shear in the edge region caused by a radial electric field on the stability of edge infernal modes retaining vacuum effects. Due to the poloidal flow shearing, the effect of plasma rotation is not simply a Doppler shift of the eigenfrequency. Stabilisation is found even for weak flow amplitude.
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  • Hamdi, Yosr, et al. (author)
  • Association of breast cancer risk in BRCA1 and BRCA2 mutation carriers with genetic variants showing differential allelic expression : identification of a modifier of breast cancer risk at locus 11q22.3
  • 2017
  • In: Breast Cancer Research and Treatment. - : Springer Science and Business Media LLC. - 0167-6806 .- 1573-7217. ; 161:1, s. 117-134
  • Journal article (peer-reviewed)abstract
    • Purpose: Cis-acting regulatory SNPs resulting in differential allelic expression (DAE) may, in part, explain the underlying phenotypic variation associated with many complex diseases. To investigate whether common variants associated with DAE were involved in breast cancer susceptibility among BRCA1 and BRCA2 mutation carriers, a list of 175 genes was developed based of their involvement in cancer-related pathways. Methods: Using data from a genome-wide map of SNPs associated with allelic expression, we assessed the association of ~320 SNPs located in the vicinity of these genes with breast and ovarian cancer risks in 15,252 BRCA1 and 8211 BRCA2 mutation carriers ascertained from 54 studies participating in the Consortium of Investigators of Modifiers of BRCA1/2. Results: We identified a region on 11q22.3 that is significantly associated with breast cancer risk in BRCA1 mutation carriers (most significant SNP rs228595 p = 7 × 10−6). This association was absent in BRCA2 carriers (p = 0.57). The 11q22.3 region notably encompasses genes such as ACAT1, NPAT, and ATM. Expression quantitative trait loci associations were observed in both normal breast and tumors across this region, namely for ACAT1, ATM, and other genes. In silico analysis revealed some overlap between top risk-associated SNPs and relevant biological features in mammary cell data, which suggests potential functional significance. Conclusion: We identified 11q22.3 as a new modifier locus in BRCA1 carriers. Replication in larger studies using estrogen receptor (ER)-negative or triple-negative (i.e., ER-, progesterone receptor-, and HER2-negative) cases could therefore be helpful to confirm the association of this locus with breast cancer risk.
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22.
  • Manes, G, et al. (author)
  • Endoscopic management of common bile duct stones: European Society of Gastrointestinal Endoscopy (ESGE) guideline
  • 2019
  • In: Endoscopy. - : Georg Thieme Verlag KG. - 1438-8812 .- 0013-726X. ; 51:5, s. 472-491
  • Journal article (peer-reviewed)abstract
    • ESGE recommends offering stone extraction to all patients with common bile duct stones, symptomatic or not, who are fit enough to tolerate the intervention.Strong recommendation, low quality evidence.ESGE recommends liver function tests and abdominal ultrasonography as the initial diagnostic steps for suspected common bile duct stones. Combining these tests defines the probability of having common bile duct stones.Strong recommendation, moderate quality evidence.ESGE recommends endoscopic ultrasonography or magnetic resonance cholangiopancreatography to diagnose common bile duct stones in patients with persistent clinical suspicion but insufficient evidence of stones on abdominal ultrasonography.Strong recommendation, moderate quality evidence.ESGE recommends the following timing for biliary drainage, preferably endoscopic, in patients with acute cholangitis, classified according to the 2018 revision of the Tokyo Guidelines:– severe, as soon as possible and within 12 hours for patients with septic shock– moderate, within 48 – 72 hours– mild, elective.Strong recommendation, low quality evidence.ESGE recommends endoscopic placement of a temporary biliary plastic stent in patients with irretrievable biliary stones that warrant biliary drainage.Strong recommendation, moderate quality of evidence.ESGE recommends limited sphincterotomy combined with endoscopic papillary large-balloon dilation as the first-line approach to remove difficult common bile duct stones. Strong recommendation, high quality evidence.ESGE recommends the use of cholangioscopy-assisted intraluminal lithotripsy (electrohydraulic or laser) as an effective and safe treatment of difficult bile duct stones.Strong recommendation, moderate quality evidence.ESGE recommends performing a laparoscopic cholecystectomy within 2 weeks from ERCP for patients treated for choledocholithiasis to reduce the conversion rate and the risk of recurrent biliary events. Strong recommendation, moderate quality evidence.
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  • Martelotto, L. G., et al. (author)
  • Genomic landscape of adenoid cystic carcinoma of the breast
  • 2015
  • In: Journal of Pathology. - : Wiley. - 0022-3417. ; 237:2, s. 179-189
  • Journal article (peer-reviewed)abstract
    • Adenoid cystic carcinoma (AdCC) is a rare type of triple-negative breast cancer (TNBC) characterized by the presence of the MYB-NFIB fusion gene. The molecular underpinning of breast AdCCs other than the MYB-NFIB fusion gene remains largely unexplored. Here we sought to define the repertoire of somatic genetic alterations of breast AdCCs. We performed whole-exome sequencing, followed by orthogonal validation, of 12 breast AdCCs to determine the landscape of somatic mutations and gene copy number alterations. Fluorescence in situ hybridization and reverse-transcription PCR were used to define the presence of MYB gene rearrangements and MYB-NFIB chimeric transcripts. Unlike common forms of TNBC, we found that AdCCs have a low mutation rate (0.27 non-silent mutations/Mb), lack mutations in TP53 and PIK3CA and display a heterogeneous constellation of known cancer genes affected by somatic mutations, including MYB, BRAF, FBXW7, SMARCA5, SF3B1 and FGFR2. MYB and TLN2 were affected by somatic mutations in two cases each. Akin to salivary gland AdCCs, breast AdCCs were found to harbour mutations targeting chromatin remodelling, cell adhesion, RNA biology, ubiquitination and canonical signalling pathway genes. We observed that, although breast AdCCs had rather simple genomes, they likely display intra-tumour genetic heterogeneity at diagnosis. Taken together, these findings demonstrate that the mutational burden and mutational repertoire of breast AdCCs are more similar to those of salivary gland AdCCs than to those of other types of TNBCs, emphasizing the importance of histological subtyping of TNBCs. Furthermore, our data provide direct evidence that AdCCs harbour a distinctive mutational landscape and genomic structure, irrespective of the disease site of origin. Copyright (c) 2015 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
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24.
  • Tala, T., et al. (author)
  • Density peaking in JET-determined by fuelling or transport?
  • 2019
  • In: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 59:12
  • Journal article (peer-reviewed)abstract
    • Core density profile peaking and electron particle transport have been extensively studied by performing several dimensionless collisionality (upsilon*) scans with other matched dimensionless profiles in various plasma operation scenarios on the Joint European Torus (JET). This is the first time when electron particle transport coefficients in the H-mode have been measured on JET with high resolution diagnostics, and therefore we are in a position to distinguish between the neutral beam injection (NBI) source and inward electron particle pinch in contributing to core density peaking. The NBI particle source is found to contribute typically 50%-60% to the electron density peaking in JET H-mode plasmas where T-e/T-i similar to 1 or smaller and at upsilon* = 0.1-0.5 (averaged between r/a = 0.3-0.8), and being independent of upsilon* within that range. In these H-mode plasmas, the electron particle transport coefficients, D-e and v(e), are small, thus giving rise to the large influence of NBI fueling with respect to transport effect on peaking. In L-mode plasma conditions, the role of the NBI source is small, typically 10%-20%, and the electron particle transport coefficients are large. These dimensionless upsilon* scans give the best possible data for model validation. TGLF simulations are in good agreement with the experimental results with respect to the role of NBI particle source versus inward pinch in affecting density peaking, both for the H-mode and L-mode upsilon* scans. It predicts, similarly to experimental results, that typically about half of the peaking originates from the NBI fuelling in the H-mode and 10%-20% in the L-mode. GENE simulation results also support the key role of NBI fuelling in causing a peaked density profile in JET H-mode plasma (T-e/T-i similar to 1 and upsilon* = 0.1-0.5) and, in fact, give an even higher weight on NBI fuelling than that experimentally observed or predicted by TGLF. For the non-fuelled H-mode plasma at higher T-e/T-i = 1.5 and lower beta(N) and upsilon*, both TGLF and GENE predict peaked density profiles, therefore agreeing well with experimental steady-state density peaking. Overall, the various modelling results give a fairly good confidence in using TGLF and GENE in predicting density peaking in quite a wide range of plasma conditions in JET.
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  • Wei, X. F., et al. (author)
  • Mitigation of under-expanded supersonic jet noise through stepped nozzles
  • 2019
  • In: Journal of Sound and Vibration. - : Academic Press. - 0022-460X .- 1095-8568. ; 459
  • Journal article (peer-reviewed)abstract
    • An experimental investigation into noise reduction of supersonic jets through nozzle trailing-edge modifications was conducted, whereby far-field acoustic measurements were captured for two different stepped nozzles under two distinct under-expanded conditions. When compared to a baseline nozzle, results show that stepped nozzles lead to significant noise reductions at certain polar and azimuthal angles. In particular, a maximum noise reduction of 6 dB is observed for the longest stepped nozzle at a nozzle-pressure-ratio of 4 and 0 degrees azimuthal angle. Spectral analysis shows that the noise reduction is mainly due to reduction in broadband shock associated noise and elimination of jet screech phenomenon. Abrupt changes in nozzle lip lengths of the stepped nozzles appear to disrupt acoustic feedback loop, thus resulting in screech cessation. Qualitative schlieren imaging and quantitative schlieren measurements were subsequently performed to correlate the shock structures and density gradient fields with the resulting noise components. Unlike those produced by the baseline nozzle, shock structures generated by the stepped nozzles are highly irregular and the jet plumes undergo discernible deflections. Lastly, the reduction in broadband shock associated noise is related to the lower shock strengths, as demonstrated by the density gradient profiles.
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