1. |
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2. |
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3. |
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4. |
- Articus, Kristina, et al.
(author)
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Phylogenetic studies in Usnea.
- 2000
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In: The Fourth IAL Symposium Progress and Problems in Lichenology at the Turn of the Millenium, Abstracts: 100. Barcelona..
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Conference paper (other academic/artistic)
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5. |
- Articus, Kristina, 1971-
(author)
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Phylogenetic Studies in Usnea (Parmeliaceae) and Allied Genera
- 2004
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Doctoral thesis (other academic/artistic)abstract
- This thesis deals with the phylogeny of the lichen genus Usnea (Parmeliaceae, Ascomycetes). The relationships and the morphological variation among Usnea species has been studied, as well as the relationship of Usnea to allied genera. Two species, U. florida and U. subfloridana, which earlier were regarded to form two separate species have been synonymized. In an analysis based on sequence data these two taxa formed a monophyletic group of intermixed specimens. Usnea florida and U. subfloridana have earlier been regarded to form a species pair, but the species pairs concept cannot be applied in this case. The morphological characters traditionally used for species recognition of a number of European Usnea species have been analyzed regarding their reliability. The evolution and distribution of the morphological characters was studied in relation to a phylogeny based on sequence data. Most characters proved to be homoplastic in relation to the phylogeny. Few characters were consistent in a clade, and the same character could be inconsistent in another clade. Therefore a combination of several characters is recommended for species recognition. The relationship of Neuropogon to Usnea was investigated based on sequence data. Neuropogon showed to be closely related to Usnea subg. Usnea. The subgenera Eumitria and Dolichousnea formed the sister group to the clade comprising subg. Usnea and Neuropogon. Usnea is paraphyletic in this investigation. Eumitria is treated as a genus and the subgenus Dolichousnea is elevated to generic rank. The position of Usnea, Neuropogon, Eumitria, and Dolichousnea in the family Parmeliaceae was investigated based on a phylogeny obtained by sequence data. Protousnea probably forms the sister group to the clade of Usnea, Neuropogon, Eumitria, and Dolichousnea. Several monophyletic groups in the family Parmeliaceae were identified.
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6. |
- Articus, Kristina, et al.
(author)
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Ribosomal DNA and beta-tubulin data do not support the separation of the lichens Usnea florida and U-subfloridana as distinct species
- 2002
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In: Mycological Research. - 0953-7562 .- 1469-8102. ; 106, s. 412-418
-
Journal article (peer-reviewed)abstract
- The lichens Usnea florida and U. subfloridana have since long been recognised as distinct species. They show many similarities in morphology, but have different reproductive strategies. Usnea florida is always provided with many apothecia and produces no specialised asexual propagules. Usnea subfloridana has soralia, isidiomorphs and occasionally apothecia. Phylogenetic analyses based on continuous sequences of the ITS and LSU regions of the nuclear ribosomal DNA and the gene coding for beta-tubulin, show that specimens of the two species form one monophyletic group of intermixed specimens, and not two groups corresponding to morphology, which Would have been expected if two species were at hand. The 'species pair' concept in lichenology is discussed. Other Usnea species included in the study are: U. articulata, U. barbata, U. ceratina, U. filipendula. U. hirta, U. rigida and U. wasmuthii.
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7. |
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8. |
- Backlund, Ingegerd, et al.
(author)
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Biorefinery product potentials using tree biomass as feedstock - A survey on opportunities and threats to the new wood products industry
- 2014
-
In: Biomass and Bioenergy. - : Elsevier BV. - 0961-9534 .- 1873-2909. ; 70, s. 207-216
-
Journal article (peer-reviewed)abstract
- A questionnaire survey on the potential of biorefinery products was carried out along with an analysis of energy prices and wood assortments. Electricity production was considered to have the potential for the highest investment return over ten years, followed by solid wood products, bioenergy assortments and textiles. Only pulp and paper were perceived as returning lower potential investment values over the next ten years than over the next five. Of the survey respondents, 95% believed that the value of woody biomass will increase over the next ten years, mainly through its replacement of oil-based products, although there will be problems due to lack of suitable raw material. A wide range of chemical products were described but a greater confidence in more traditional solid fuel products still prevails. Stemwood is the most favored part of the tree with only a few respondents saying that they wanted specific chemicals extracted. The electricity price and wood fuel price were found to be strongly correlated and 91% of respondents said their products would be affected by the electricity price. Electricity prices within OECD countries are expected to increase by 15% from 2011 to 2035, with wood fuel prices increasing by roughly 10% during the same period. Therefore, the electricity price could become a decisive factor in the future use of biomass in biorefineries. Our results suggest that large-scale commercial biorefinery production will soon be possible but new wood assortment classifications are needed that include both fiber properties and chemical properties such as extractive content.
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9. |
- Bergström, Roger, et al.
(author)
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Ökande viltstammar, medbestämmande, konflikter 1967-2016
- 2016
-
In: Jaktens historia i Sverige: vilt, människa, samhälle, kultur. - 9789147112944 ; , s. 256-271
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Book chapter (pop. science, debate, etc.)
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10. |
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11. |
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12. |
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13. |
- Boman, Mattias, et al.
(author)
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Moose Hunting Values in Sweden Now and Two Decades Ago : The Swedish Hunters Revisited
- 2011
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In: Environmental and Resource Economics. - : Springer Science and Business Media LLC. - 0924-6460 .- 1573-1502. ; 50:4, s. 515-530
-
Journal article (peer-reviewed)abstract
- This paper is based on two national contingent valuation studies dealing with the extent and economic values of hunting in Sweden. The first valuation study was conducted in 1987 and the second in 2006. Both the game resource and the hunter community have undergone changes in the two decades covered by the surveys. An important purpose of the latter survey was to repeat relevant parts of the former one, which created a rare opportunity to compare valuations covering a very long time span. Moose hunting value and its determinants were compared between the two studies, showing that significant changes have taken place. Our analysis suggests caution in using results from old contingent valuation studies for e.g. benefits transfer exercises.
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14. |
- Boman, Mattias, et al.
(author)
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The hunting value of game in Sweden: Have changes occurred over recent decades?
- 2012
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In: Scandinavian Journal of Forest Research. - : Informa UK Limited. - 0282-7581 .- 1651-1891. ; 27, s. 669-674
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Journal article (peer-reviewed)abstract
- This short communication deals with the hunting value of all game in Sweden, specifically changes over time in value and value components, and differences between the northern and southern parts of the country. The investigation was based on two mail surveys, one conducted in 1987 and the other in 2006. The results suggested that the gross hunting value and the hunting cost share of this value increased over the two decades. The consumer surplus (net value) share decreased correspondingly, while the recreation share and the meat share of the hunting value were more stable over time. It appeared that in 1987 as well as in 2006 the southern Swedish hunters tended to value their hunting higher than the hunters in northern Sweden, especially when it came to the recreation. The results should be relevant in the context of game management, adaptive game management in particular.
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15. |
- Bostedt, Göran, 1966-, et al.
(author)
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A note of benefits and costs of adjusting forestry to meet recreational demands
- 2006
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In: Journal of Forest Economics. - : Elsevier. - 1104-6899 .- 1618-1530. ; 12:1, s. 75-81
-
Journal article (peer-reviewed)abstract
- Economic studies concerning environmental functions of forests are often partial in the sense that they focus on either benefits or costs. In other words, benefit/cost analyses indicating whether it is economically motivated to change forestry to make it compatible with environmental demands are relatively rare. This benefit/cost analysis deals with the forest as recreation environment, where benefit estimates from a study conducted in the county of Västerbotten, Sweden, are compared with cost estimates from another study in the same county. It is shown that adjustments of forest management to meet recreational demands do largely affect both benefits and costs, and that the results are sensitive to how soon the effects on the recreation environment occur after the adjustments of forest management.
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16. |
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17. |
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18. |
- Bostedt, Göran, 1966-, et al.
(author)
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The value of forests for tourism in Sweden
- 1995
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In: Annals of Tourism Research. - : Elsevier. - 0160-7383 .- 1873-7722. ; 22:3, s. 671-680
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Journal article (peer-reviewed)abstract
- Sweden has a vast quantity of forests and the Right of Common Access allows tourists to freely enter any forest no matter who owns it. An economic valuation study was carried out in two tourism areas, one in the southern part of the country and one in the northern part. It was shown that a considerable portion of the value to tourists is attributable to forest characteristics. Furthermore, the results suggest that this value can be increased by modifying forest management practices; for example, by making clearcuts smaller, even if there were more of them, and by increasing the proportion of broad leaved trees in forest stands.
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19. |
- Carlsson, Daniel O., et al.
(author)
-
Cooxidant-free TEMPO-mediated oxidation of highly crystalline nanocellulose in water
- 2014
-
In: RSC Advances. - : Royal Society of Chemistry (RSC). - 2046-2069. ; 4:94, s. 52289-52298
-
Journal article (peer-reviewed)abstract
- Selective oxidation of C6 hydroxyls to carboxyls through 2,2,6,6,-tetramethylpiperidine-1-oxyl (TEMPO)-mediated oxidation, where the oxidizing species (TEMPO+) is generated by cooxidants, such as NaBrO, NaClO or NaClO2, has become a popular way to modify the surfaces of nanocellulose fibrils in aqueous solutions. Employing highly crystalline nanocellulose from Cladophora sp. algae we demonstrate that the same degree of oxidation (D.O.) can be achieved within approximately the same time by replacing the cooxidants with electrogeneration of TEMPO+ in a bulk electrolysis setup. The D.O. is controlled by the oxidation time and the maximum D.O. achieved (D.O. 9.8%, 0.60 mmol g-1 of carboxylic acids and 0 mmol g-1 aldehydes) corresponds to complete oxidation of the surface-confined C6. This shows that TEMPO+ is not sterically hindered from completely oxidizing the fibril surface of Cladophora nanocellulose, in contrast to earlier hypotheses that were based on results with wood-derived nanocellulose. The oxidation does not significantly affect the morphology, the specific surface area (>115 m2 g-1) or the pore characteristics of the water-insoluble fibrous particles that were obtained after drying, but depolymerization corresponding to ∼20% was observed. For extensive oxidation times, the product recovery of water-insoluble fibrils decreased significantly while significant amounts of charge passed through the system. This could indicate that the oxidation proceeds beyond the fibril surface, in contrast to the current view that TEMPO-mediated oxidation is confined only to the surface.
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20. |
- Carlsson, Lars, et al.
(author)
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Adaptiv förvaltning
- 2010
-
In: Vilt, människa, samhälle. - Stockholm : Liber. - 9789147094189 ; , s. 227-239
-
Book chapter (other academic/artistic)
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21. |
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22. |
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23. |
- Clark, DW, et al.
(author)
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Associations of autozygosity with a broad range of human phenotypes
- 2019
-
In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 4957-
-
Journal article (peer-reviewed)abstract
- In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is both rare and frequently associated with confounding social factors. Here, using genomic inbreeding coefficients (FROH) for >1.4 million individuals, we show that FROH is significantly associated (p < 0.0005) with apparently deleterious changes in 32 out of 100 traits analysed. These changes are associated with runs of homozygosity (ROH), but not with common variant homozygosity, suggesting that genetic variants associated with inbreeding depression are predominantly rare. The effect on fertility is striking: FROH equivalent to the offspring of first cousins is associated with a 55% decrease [95% CI 44–66%] in the odds of having children. Finally, the effects of FROH are confirmed within full-sibling pairs, where the variation in FROH is independent of all environmental confounding.
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24. |
- Danell, Kjell, et al.
(author)
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Förord
- 2016
-
In: Jaktens historia i Sverige: vilt, människa, samhälle, kultur. - 9789147112944 ; , s. 8-9
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Book chapter (pop. science, debate, etc.)
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25. |
- Danell, Kjell, et al.
(author)
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Jakt och fångst
- 2016
-
In: Jaktens historia i Sverige: vilt, människa, samhälle, kultur. - 9789147112944 ; , s. 34-63
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Book chapter (pop. science, debate, etc.)
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26. |
- Edgren, FRedrik, et al.
(author)
-
Formation of damage and its effects on non-crimp fabric reinforced composites loaded in tension
- 2004
-
In: Composites Science And Technology. - 0266-3538 .- 1879-1050. ; 64:5, s. 675-692
-
Journal article (peer-reviewed)abstract
- Non-crimp fabric (NCF) composites, manufactured by resin infusion techniques are one of the most promising next generation composite materials. They offer large potential for application in primary structures as they give excellent performance at low production costs. However, before NCF composites will be efficiently used in design, detailed understanding of governing micro mechanisms must be accumulated and described by predictive models. In the present study, NCF cross-ply laminates have been tested in tension. Intralaminar cracks caused in the 90° fibre bundle layers and their effect on laminate mechanical properties have been monitored. Occurrence of 'novel' type of cracks propagating in the load direction (longitudinal cracks) is explained by a thorough FE analysis using an Representative Volume Element (RVE) approach, revealing stress concentrations caused by 0° fibre bundle waviness. Effects of damage on mechanical properties are modelled using modified micro mechanical models developed for analysis of conventional laminated composites. The analysis reveals mechanical degradation to be ruled by the crack opening displacement (COD). However, unlike traditional composites, transverse cracks do not generally extend through the entire thickness of the 90° layer, but are rather contained in single fibre bundles, limiting the COD. © 2003 Elsevier Ltd. All rights reserved.
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27. |
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28. |
- Ericsson, Göran, et al.
(author)
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Viltet och människan
- 2010
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In: Vilt, människa, samhälle. - 9789147094189 ; , s. 169-182
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Book chapter (pop. science, debate, etc.)
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29. |
- Ertzgaard, Per, 1958-, et al.
(author)
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Ryggmärgsskador och ryggmärgsbråck
- 2006. - 1
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In: Rehabiliteringsmedicin. - Lund : Studenlitteratur. - 9144045077 - 9789144045078 ; , s. 276-287
-
Book chapter (other academic/artistic)abstract
- Kapitel om rehabiliteringsmedicinens utveckling och nuvarande plats i sjukvården samt begrepp och metodik inleder boken. I två delar ges därefter rehabiliteringsmedicinska aspekter på de dominerande sjukdomsgrupperna - komplexa smärttillstånd respektive skador och sjukdomar i nervsystemet. Som avslutning beskrivs bland annat stressrelaterade tillstånd. Läroboken är avsedd för grundutbildning av läkare, arbetsterapeuter och sjukgymnaster, logopeder samt för läkare under AT-tjänstgöring. Den är också lämplig som introduktion i specialistutbildningen i rehabiliteringsmedicin, geriatrik, neurologi och smärtlindring. Vidareutbildningar av olika vårdyrkesgrupper kan ha nytta av boken och den kan också användas som referenslitteratur av yrkesverksamma med intresse för rehabiliteringsmedicin.
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30. |
- Ertzgaard, Per, et al.
(author)
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Ryggmärgsskador och ryggmärgsbråck
- 2006
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In: Rehabiliteringsmedicin. - : Studentlitteratur. - 9144045077
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Book chapter (other academic/artistic)
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31. |
- Ezebilo, Eugene Ejike, et al.
(author)
-
Contribution of non-timber forest products to livelihoods of communities in southeast Nigeria
- 2010
-
In: International Journal of Sustainable Development and World Ecology. - : Informa UK Limited. - 1350-4509 .- 1745-2627. ; 17, s. 231-235
-
Journal article (peer-reviewed)abstract
- This paper examines the value of non-timber forest products (NTFP) and their determinants in communities in the vicinity of the Okwangwo Division of the Cross River National Park, Nigeria. The data for this study were generated from personal interviews conducted in three villages located near the buffer area of the national park. The study showed that income from NTFP was almost 13% of the total annual income of the respondents. Income from NTFP was influenced by factors such as income from non-traditional employment, the distance of respondents' residences to the park, income from farming and age. The results suggest that a shift from primarily subsistence to a more of cash economy may lead to unsustainable exploitation of NTFP.
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32. |
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33. |
- Ezebilo, Eugene Ejike, et al.
(author)
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Preferences and willingness to pay for close to home nature for outdoor recreation in Sweden
- 2015
-
In: Journal of Environmental Planning and Management. - : Informa UK Limited. - 0964-0568 .- 1360-0559. ; 58, s. 283-296
-
Journal article (peer-reviewed)abstract
- In Sweden there is a strong tradition of using nature areas for outdoor recreation. This paper reports on a study which explored preferences and willingness to pay for outdoor recreation close to home (<= 100km away from home and <= 24hours stay at a recreation site) using the contingent valuation method. The data originated from a mail survey that involved Swedish residents who were randomly selected from a national register. An ordinary least squares regression model was used to account for factors influencing willingness to pay. The results showed that approximately 50% of the respondents used nature areas close to their home for recreation and their average frequency of visits to these areas was 74times annually. Areas dominated by forests were the most preferred, followed by water. The respondents were willing to pay approximately 7200 SEK (US$1080) annually. Their willingness to pay was influenced by factors such as type of nature area, distance to and time spent at the recreation site and income. The results provide one input to the land use planning process by considering the demand for nature-based outdoor recreation close to home.
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34. |
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35. |
- Ezebilo, Eugene Ejike, et al.
(author)
-
Socio-economic benefits of protected areas as perceived by local people around Cross River National Park, Nigeria
- 2010
-
In: Forest Policy and Economics. - : Elsevier BV. - 1389-9341 .- 1872-7050. ; 12, s. 189-193
-
Journal article (peer-reviewed)abstract
- The main objectives of a national park are environmental and biodiversity conservation. However, in most developing nations local people who reside at the vicinity of the park expect that it should also contribute to the social and economic well-being of the people. This paper examines the contribution of the Okwangwo Division of the Cross River National Park, Nigeria, to the provision of various types of infrastructure and income from tourism. Personal interviews were conducted in 150 households in three villages around the park. The study showed that the park has contributed to the provision of infrastructure. Some of the projects, undertaken by the park management, appear to be capital intensive both in the short and long term, thus, risking to make them unsustainable. The results revealed that only one of the villages in the study area benefits from the income from tourism. We suggest that simple, non-capital intensive and sustainable developmental projects should be undertaken. The tourism sector of the local economy should be developed to make income from tourism attractive for more of the local people. (C) 2009 Elsevier B.V. All rights reserved.
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36. |
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37. |
- Fredman, Peter, et al.
(author)
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Economic values in the Swedish nature-based recreation sector : a synthesis
- 2012
-
In: Tourism Economics. - London : IP Publishing. - 1354-8166 .- 2044-0375. ; 18:4, s. 903-910
-
Research review (peer-reviewed)abstract
- This research synthesis reports the main findings from a review of economic values associated with nature-based recreation in Sweden. The purpose of the work was to support policy and to identify areas for future research. Data came from over 150 scientific publications and other public sources. The authors find inter alia a lack of systematic data for several recreation activities (including naturebased tourism), a significant growth in the outdoor equipment industry and a relatively modest economic involvement by the public sector. The information is structured under different categories to illustrate the significance and range of different economic values. The authors conclude that there is a need for more comprehensive and systematically collected data, methodological development and interdisciplinary research.
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38. |
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39. |
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40. |
- Hauffman, Anna, et al.
(author)
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Cocreated internet-based stepped care for individuals with cancer and concurrent symptoms of anxiety and depression : Results from the U-CARE AdultCan randomized controlled trial
- 2020
-
In: Psycho-Oncology. - : John Wiley & Sons. - 1057-9249 .- 1099-1611. ; 29:12, s. 2012-2018
-
Journal article (peer-reviewed)abstract
- Objective The aim was to evaluate the effects of cocreated internet-based stepped care (iCAN-DO) on anxiety, depression, posttraumatic stress, and health-related quality of life (HRQoL) in individuals with cancer and self-reported anxiety and/or depression symptoms, compared with standard care.Methods Clinically recruited individuals with breast, colorectal, or prostate cancer underwent online screening with the Hospital Anxiety and Depression Scale (HADS). Those with anxiety and/or depression symptoms (>7 on any of the HADS subscales) were randomized to iCAN-DO or standard care. iCAN-DO comprised psychoeducation and self-care strategies (step 1) and internet-based cognitive behavioral therapy (iCBT, step 2). Data were collected before randomization and at 1, 4, 7, and 10 months and analyzed with intention-to-treat regression analysis and randomization tests.Results Online screening identified 245 (27%) of 909 individuals who reported anxiety and/or depression symptoms. They were randomized to iCAN-DO (n = 124) or standard care (n = 121). Of them 49% completed the 10-month assessment, and in the iCAN-DO group 85% accessed step 1 and 13% underwent iCBT. iCAN-DO decreased the levels of symptoms of depression (−0.54, 95% confidence interval: −1.08 to −0.01, P < .05) and the proportion of individuals with symptoms of depression (P < .01) at 10 months, compared with standard care, according to HADS. There were no significant effects on anxiety, posttraumatic stress, or HRQoL.Conclusion Internet-based stepped care improves symptoms of depression in individuals with cancer. Further studies are needed to gain knowledge on how to optimize and implement internet-based support in oncology care.
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41. |
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42. |
- Helldin, Jan Olof, et al.
(author)
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Viltet i samhället
- 2010
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In: Vilt, människa, samhälle. - 9789147094189 ; , s. 135-168
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Book chapter (pop. science, debate, etc.)
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43. |
- Herrmann, Björn, et al.
(author)
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Differentiation of Chlamydia spp by sequence determination and restriction endonuclease cleavage of RNase P RNA genes
- 1996
-
In: Journal of Clinical Microbiology. - 0095-1137 .- 1098-660X. ; 34:8, s. 1897-1902
-
Journal article (peer-reviewed)abstract
- The amplification of DNA from Chlamydia trachomatis by PCR with degenerated primers yielded a 345-bp fragment of the putative RNase P RNA gene. From the deduced DNA sequence of this gene in C. trachomatis, a modified primer pair was designed. The primer pair was subsequently used to obtain the corresponding gene products from Chlamydia pneumoniae and Chlamydia psittaci. Sequence comparisons revealed similarities of 76.6% between C. trachomatis and C. pneumoniae, 79.5% between C. trachomatis and C. psittaci, and 84.7% between C. pneumoniae and C. psittaci. Furthermore, the three species were differentiated by fragment length polymorphism analysis after restriction enzyme cleavage of the PCR products. Sequence variations among 14 serotypes of C. trachomatis were confined to one purine base substitution in the putative RNase P RNA gene of lymphogranuloma venereum strains L1 to L3. Complete sequence similarity was found for nine strains of C. pneumoniae of different geographic origins. Taken together, our results indicate a possibility of the general application of this method in clinical bacteriology. Analysis of the secondary structures of the putative RNase P RNA genes from the different Chlamydia species suggested that a novel structural element in the domain of RNase P RNA is involved in base pairing with the 3'-terminal CCA motif of a tRNA precursor. This structure has not previously been found among RNase P RNAs of members of the division Bacteria.
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44. |
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45. |
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46. |
- Johansson, Magnus, et al.
(author)
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Islet endothelial cells and pancreatic beta-cell proliferation : studies in vitro and during pregnancy in adult rats
- 2006
-
In: Endocrinology. - : The Endocrine Society. - 0013-7227 .- 1945-7170. ; 147:5, s. 2315-2324
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Journal article (peer-reviewed)abstract
- The growth of both tumors and nonneoplastic tissues may be influenced by signals from the vascular endothelium. In the present investigation we show that purified proliferating endothelial cells from pancreatic islets can stimulate beta-cell proliferation through secretion of hepatocyte growth factor (HGF). This secretion could be induced by soluble signals from the islets, such as vascular endothelial growth factor-A (VEGF-A) and insulin. During pregnancy, the pancreatic beta-cells display a highly reproducible physiological proliferation. We show that islet endothelial cell proliferation precedes beta-cell proliferation in pregnant animals. Vascular growth was closely associated with endocrine cell proliferation, and prominent expression of HGF was observed in islet endothelium on d 15 of pregnancy, i.e. coinciding with the peak of beta-cell proliferation. In summary, our results suggest the existence of an endothelial-endocrine axis within adult pancreatic islets, which is of importance for adult beta-cell proliferation.
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47. |
- Kajko-Mattsson, Mira, et al.
(author)
-
Everything is possible to structure-even the software engineering body of knowledge
- 2017
-
In: Proceedings - 2017 IEEE/ACM 1st International Workshop on Software Engineering Curricula for Millennials, SECM 2017. - : Institute of Electrical and Electronics Engineers (IEEE). - 9781538627952 ; , s. 61-67
-
Conference paper (peer-reviewed)abstract
- Everything is possible to structure, even the software engineering body of knowledge. In this paper, we suggest a conceptual model of the software engineering body of knowledge. The model is a restructured version of SWEBOK and ACM/IEEE Curriculum Guidelines. It constitutes the first attempt to create an underlying structure that is common to most of the software engineering bodies of knowledge.
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48. |
- Lau, Joey, et al.
(author)
-
Implantation site-dependent dysfunction of transplanted pancreatic islets
- 2007
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In: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 56:6, s. 1544-1550
-
Journal article (peer-reviewed)abstract
- OBJECTIVE—Clinical islet transplantations are performed through infusion of islets via the portal vein into the liver. This study aimed at characterizing the influence of the implantation microenvironment on islet graft metabolism and function. RESEARCH DESIGN AND METHODS—Islets were transplanted into their normal environment, i.e., the pancreas, or intraportally into the liver of mice. One month posttransplantation, the transplanted islets were retrieved and investigated for changes in function and gene expression. RESULTS—Insulin content, glucose-stimulated insulin release, (pro)insulin biosynthesis, and glucose oxidation rate were markedly decreased in islets retrieved from the liver, both when compared with islets transplanted into the pancreas and endogenous islets. Islets transplanted into the pancreas showed normal insulin content, (pro)insulin biosynthesis, and glucose oxidation rate but increased basal insulin secretion and impaired glucose stimulation index. Gene expression data for retrieved islets showed downregulation of pancreatic and duodenal homeobox gene-1, GLUT-2, glucokinase, mitochondrial glycerol-phosphate dehydrogenase, and pyruvate carboxylase, preferentially in intraportally transplanted islets. CONCLUSIONS—Islets transplanted into their normal microenvironment, i.e., the pancreas, display gene expression changes when compared with endogenous islets but only moderate changes in metabolic functions. In contrast, site-specific properties of the liver markedly impaired the metabolic functions of intraportally transplanted islets.
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49. |
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50. |
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