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- Lindqvist, Richard, 1974-, et al.
(author)
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An information-model approach for systematic and holistic geometrical inspection and control planning (GICP)
- 2009
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In: Journal of the CMSC. - : CMSC. - 2328-6067. ; 4:2, s. 20-26
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Journal article (peer-reviewed)abstract
- The purpose of this article is to present research results performed within the field of geometrical inspection and control planning (GICP) applied for complex products. Geometrical and dimensional inspection and control planning are vitally important activities in modern manufacturing of complex products. These functions are interesting to manufacturers due to the demands and focus on quality work and the aim towards zero defects. The GICP model can be extended to a fully automatic process but more likely it will be implemented as a manual iterative and parallel process in the development and industrialization process of complex products. Applications for our new GICP information model will hopefully be implemented and used not only in large manufacturing plants but also in smaller companies that lack easy-to-use instructions and guidelines regarding geometrical inspection and control planning. It will also be instrumental academically, in the education of new industrial metrology engineers. In this article, our new systematic and holistic information model based on the ASTRAKAN modeling language is proposed and presented. The relation and integration of the quality assurance matrix and methodology (QAM) is also discussed and presented.
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- Mattsson, Niclas, 1967, et al.
(author)
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Effects of perturbations in a dynamic system – The case of Nordic power production
- 2008
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Journal article (other academic/artistic)abstract
- We use a dynamic model of the production of electricity and district heat in the Nordic countries to investigate the effects of small changes in the Nordic power-supply system. Our aim is to improve the understanding concerning marginal effects in this system and in dynamic production systems in general. Specifically, we investigate the effects of an earlier closing of a nuclear reactor, and of increases in short-term and long-term electricity demand. Our results demonstrate that a long-term perturbation has both short-term and long-term effects. To account for short-term effects only can be a serious limitation in a study aiming at describing the effects of decisions. Marginal effects in a dynamic system are likely to involve a complex and uncertain mix of different technologies. The magnitude of the effects can be greater than the perturbation itself and remain long after it has ended. Perturbations in one production system can also have marginal effects outside this system.
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- Mattsson, Tomas, et al.
(author)
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Sympathetic Nerve Dysfunction is Common in Patients With Chronic Intestinal Pseudo-obstruction.
- 2008
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In: Journal of Clinical Gastroenterology. - : Ovid Technologies (Wolters Kluwer Health). - 1539-2031 .- 0192-0790. ; 42:2, s. 174-177
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Journal article (peer-reviewed)abstract
- GOAL: To clarify whether disturbances in the autonomic nervous system, reflected in abnormal cardiovascular reflexes, could explain symptoms of impaired heat regulation in patients with intestinal pseudo-obstruction. BACKGROUND: Chronic intestinal pseudo-obstruction is a clinical syndrome characterized by diffuse, unspecific gastrointestinal symptoms due to damage to the enteric nervous system or the smooth muscle cells. These patients often complain of excessive sweating or feeling cold, suggesting disturbances in the autonomic nervous system. Earlier studies have pointed to a coexistence of autonomic disturbances in the enteric and cardiovascular nervous system. STUDY: Thirteen consecutive patients (age range 23 to 79, mean 44 y) fulfilling the criteria for chronic intestinal pseudo-obstruction were investigated. Six of them complained of sweating or a feeling of cold. Examination of autonomic reflexes included heart rate variation to deep-breathing (expiration/inspiration index), heart rate reaction to tilt (acceleration index, brake index), and vasoconstriction (VAC) due to indirect cooling by laser doppler (VAC-index; high index indicates impaired VAC). Test results in patients were compared with healthy individuals. RESULTS: Patients had significantly higher (more abnormal) median VAC-index compared with healthy controls [1.79 (interquartile ranges 1.89) vs. 0.08 (interquartile ranges 1.29); P=0.0007]. However, symptoms of impaired heat regulation were not related to the VAC-index. There were no differences in expiration/inspiration, acceleration index, or brake index between patients and controls. CONCLUSIONS: The patients with severe gastrointestinal dysmotility showed impaired sympathetic nerve function which, however, did not seem to be associated with symptoms of impaired heat regulation.
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| 6. |
- Sonesson, Ulf, et al.
(author)
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Industrial processing versus home cooking : An environmental comparison between three ways to prepare a meal
- 2005
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In: Ambio. - 0044-7447 .- 1654-7209. ; 34:42099, s. 414-421
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Journal article (peer-reviewed)abstract
- Today there is a strong trend in Sweden for industrially processed meals to replace homemade meals. In the public debate this is often claimed to increase the environmental impact from foods. In the study presented in this article, we used life-cycle assessment to quantify the environmental impact of three meals: homemade, semiprepared, and ready-to-eat. The differences in environmental impact between the meals were small; the ready-to-eat meal used the most energy, whereas the homemade meal had higher emissions causing eutrophication and global warming. The dominating contributor to the environmental impact was agriculture, accounting for 30% of the impact related to energy and 95% of that related to eutrophication. Industry, packaging, and consumer home transport and food preparation also contributed significantly. Important factors were raw material use, energy efficiency in industry and households, packaging, and residue treatment. To decrease the overall environmental impact of food consumption, improvements in agriculture are very important, together with raw-material use within industry and households. © Royal Swedish Academy of Sciences 2005.
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| 7. |
- Sven, Nylander, 1967-, et al.
(author)
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Characterisation of species differences in the platelet ADP and thrombin response
- 2006
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In: Thrombosis Research. - : Elsevier BV. - 0049-3848 .- 1879-2472. ; 117:5, s. 543-549
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Journal article (peer-reviewed)abstract
- Introduction:A number of animal models are used to study platelet-dependent diseases. In the present investigation, we have used a simple flow cytometry assay to evaluate platelet function in man, rat, mouse, guinea pig and dog.Materials and methods:Platelet activation was evaluated in diluted whole blood by measuring fibrinogen binding to activated platelets using a polyclonal anti-human fibrinogen antibody that cross-reacts with fibrinogen from all species tested. The assay was used to evaluate platelet function with respect to ADP and thrombin sensitivity. The relative importance of the two platelet ADP receptors and total ADP in the thrombin response was also studied by using receptor-specific antagonists and apyrase, respectively.Results:Mouse platelets were most sensitive to both agonists. Unlike in man and dog the maximal response to ADP was greater than to thrombin in mouse, rat and guinea pig. P2Y12 blockade was in all species equally effective as ADP removal in inhibiting thrombin-induced platelet activation whereas P2Y1 blockade was almost ineffective.Conclusion:The present study describes a simple platelet function test that can be used to evaluate platelet function in man, rat, mouse, guinea pig and dog. Platelets from the tested species differed in their sensitivity to ADP and thrombin. In contrast to human and canine platelets, mouse, rat and guinea pig platelets displayed a stronger maximal response to ADP than to thrombin. In terms of the relative contribution of P2Y1 and P2Y12 in the thrombin response, the P2Y12 receptor was the key receptor in all species and its blockade gave equal effect as total removal of ADP.
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