| 1. |
- Badylak, S, et al.
(author)
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Resorbable Bioscaffold for Esophageal Repair in a Dog Model
- 2000
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In: Journal of Pediatric Surgery. - : Elsevier BV. - 0022-3468 .- 1531-5037. ; 35:7, s. 1097-1103
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Journal article (peer-reviewed)abstract
- Purpose: Porcine-derived, xenogeneic extracellular matrix (ECM) derived from either the small intestinal submucosa (SIS) or urinary bladder submucosa (UBS) was used as a tissue scaffold for esophageal repair in a dog model. Methods: Patch defects measuring approximately 5 cm in length and encompassing 40% to 50% of the circumference of the esophagus or complete circumferential segmental defects measuring 5 cm in length were created by surgical resection in healthy adult female dogs. The defects were repaired with ECM scaffolds derived from either SIS or UBS. The animals were kept alive for periods ranging from 4 days to 15 months. Results: The xenogeneic scaffolds used for repair of the patch defects were resorbed completely within 30 to 60 days and showed replacement by skeletal muscle, which was oriented appropriately and contiguous with adjacent normal esophageal skeletal muscle, organized collagenous connective tissue, and a complete and intact squamous epithelium. No signs of clinical esophageal dysfunction were seen in any of the animals with the patch defect repair. The xenogeneic scaffolds configured into tubes for repair of the segmental defects all showed stricture within 45 days of surgery. Conclusion: These ECMs show promise as a treatment option for esophageal repair, but stricture remains problematic for complete tube grafts.
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| 2. |
- Herlenius, Gustaf, et al.
(author)
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Tarmtransplantation : experimentell terapi som blivit realistiskt alternativ
- 2004
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In: Läkartidningen. - 0023-7205 .- 1652-7518. ; 101:38, s. 2874-2878
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Journal article (peer-reviewed)abstract
- Outcome after intestinal transplantation has improved dramatically since the introduction of novel immunosuppressive agents and refined surgical techniques. Small bowel transplantation is now considered to be the best treatment modality for patients with life threatening complications of intestinal failure and parenteral nutrition. We hereby review the international experience as well as the first ten cases of intestinal transplantation performed in Sweden.
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| 3. |
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| 4. |
- Meurling, Staffan, et al.
(author)
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Short bowel syndrome
- 2000
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In: Journal of the Japanese Society of Pediatric Surgeons. - 0288-609X. ; 36:1, s. 77-80
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Journal article (peer-reviewed)abstract
- Children with SBS have a high morbidity and mortality rate despite improvements in both enteral and parenteral nutrition. Improved medical treatment must sometimes be combined with surgical procedures including intestinal lengthening and transplantation, thereby improving the status of these children.
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