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- Kjellman, Arne, et al.
(author)
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Open Peer Commentaries
- 2008
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In: Constructivist Foundations. - : ALEXANDER RIEGLER. - 1782-348X. ; 3:2, s. 65-108
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Journal article (other academic/artistic)abstract
- Open peer commentary on the target article "Who Conceives of Society?" by Ernst von Glasersfeld. First paragraph: Ernst von Glasersfeld sets out to explain how familiar patterns (signs) arise in private experience - and how they are extracted or " recognized" as such. These patterns are recursive, which imposes significance (familiarity) on them, and are, in the course of time, collected into a " bulk of experience." I think a convinced constructivist can - if hesitantly - accept his rendering, even though it is one that lacks the stringency one expects from a supposedly natural scientist ( 46). However, the crucial point is that this paper does not address the convinced constructivist but rather the opposite camps, and I doubt he succeeds in convincing them.
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- Meyer-Spradow, Jennis, et al.
(author)
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Voreen : A Rapid-Prototyping Environment for Ray-Casting-Based Volume Visualizations
- 2009
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In: IEEE Computer Graphics and Applications. - : IEEE. - 0272-1716 .- 1558-1756. ; 29:6, s. 6-13
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Journal article (peer-reviewed)abstract
- By splitting a complex ray-casting process into different tasks performed on different processors, Voreen provides a lot of flexibility because users can intervene at different points during ray casting. Voreen's object-oriented design lets users easily create customized processor classes that cooperate seamlessly with existing classes. A user-friendly GUI supports rapid prototyping of visualization ideas. We've implemented several applications based on our library. In the future, we'd like to further extend Voreen's capabilities to make visualization prototyping even easier on all abstraction levels. Thus, we plan to realize a set of dedicated processor skeletons, which are solely configured through shader programs and can thus be modified at runtime.
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- Vollset, Stein Emil, et al.
(author)
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The association of gastric cancer risk with plasma folate, cobalamin, and Methylenetetrahydrofolate reductase polymorphisms in the European prospective investigation into cancer and nutrition
- 2007
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In: Cancer Epidemiology Biomarkers & Prevention. - 1538-7755. ; 16:11, s. 2416-2424
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Journal article (peer-reviewed)abstract
- Previous studies have shown inconsistent associations of folate intake and polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene with gastric cancer risk. Our nested case-control study within the European Prospective Investigation into Cancer and Nutrition cohort is the first prospective study of blood folate levels and gastric cancer. Gastric cancer cases (n = 247) and controls (n = 631) were matched for study center, age, sex, and time of blood donation. Two common single nucleotide polymorphisms of the MTHFR gene were determined, as were plasma concentrations of folate, cobalamin (vitamin B12), total homocysteine, and methylmalonic acid (cobalamin deficiency marker) in prediagnostic plasma. Risk measures were calculated with conditional logistic regression. Although no relations were observed between plasma folate or total homocysteine concentrations and gastric cancer, we observed a trend toward lower risk of gastric cancer with increasing cobalamin concentrations (odds ratio, 0.79 per SD increase in cobalamin; P = 0.01). Further analyses showed that the inverse association between cobalamin and gastric cancer was confined to cancer cases with low pepsinogen A levels (marker of severe chronic atrophic gastritis) at the time of blood sampling. The 677 C -> T MTHFR polymorphism was not associated with gastric cancer, but we observed an increased risk with the variant genotype of the 1298 A -> C polymorphism (odds ratio, 1.47 for CC versus AA; P = 0.04). In conclusion, we found no evidence of a role of folate in gastric cancer etiology. However, we observed increased gastric cancer risk at low cobalamin levels that was most likely due to compromised cobalamin status in atrophic gastritis preceding gastric cancer.
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