| 1. |
- Aad, G, et al.
(författare)
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- 2015
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swepub:Mat__t
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| 2. |
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| 3. |
- Meyer, H.F., et al.
(författare)
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Overview of physics studies on ASDEX Upgrade
- 2019
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 59:11
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Forskningsöversikt (refereegranskat)abstract
- The ASDEX Upgrade (AUG) programme, jointly run with the EUROfusion MST1 task force, continues to significantly enhance the physics base of ITER and DEMO. Here, the full tungsten wall is a key asset for extrapolating to future devices. The high overall heating power, flexible heating mix and comprehensive diagnostic set allows studies ranging from mimicking the scrape-off-layer and divertor conditions of ITER and DEMO at high density to fully non-inductive operation (q 95 = 5.5, ) at low density. Higher installed electron cyclotron resonance heating power 6 MW, new diagnostics and improved analysis techniques have further enhanced the capabilities of AUG. Stable high-density H-modes with MW m-1 with fully detached strike-points have been demonstrated. The ballooning instability close to the separatrix has been identified as a potential cause leading to the H-mode density limit and is also found to play an important role for the access to small edge-localized modes (ELMs). Density limit disruptions have been successfully avoided using a path-oriented approach to disruption handling and progress has been made in understanding the dissipation and avoidance of runaway electron beams. ELM suppression with resonant magnetic perturbations is now routinely achieved reaching transiently . This gives new insight into the field penetration physics, in particular with respect to plasma flows. Modelling agrees well with plasma response measurements and a helically localised ballooning structure observed prior to the ELM is evidence for the changed edge stability due to the magnetic perturbations. The impact of 3D perturbations on heat load patterns and fast-ion losses have been further elaborated. Progress has also been made in understanding the ELM cycle itself. Here, new fast measurements of and E r allow for inter ELM transport analysis confirming that E r is dominated by the diamagnetic term even for fast timescales. New analysis techniques allow detailed comparison of the ELM crash and are in good agreement with nonlinear MHD modelling. The observation of accelerated ions during the ELM crash can be seen as evidence for the reconnection during the ELM. As type-I ELMs (even mitigated) are likely not a viable operational regime in DEMO studies of 'natural' no ELM regimes have been extended. Stable I-modes up to have been characterised using -feedback. Core physics has been advanced by more detailed characterisation of the turbulence with new measurements such as the eddy tilt angle - measured for the first time - or the cross-phase angle of and fluctuations. These new data put strong constraints on gyro-kinetic turbulence modelling. In addition, carefully executed studies in different main species (H, D and He) and with different heating mixes highlight the importance of the collisional energy exchange for interpreting energy confinement. A new regime with a hollow profile now gives access to regimes mimicking aspects of burning plasma conditions and lead to nonlinear interactions of energetic particle modes despite the sub-Alfvénic beam energy. This will help to validate the fast-ion codes for predicting ITER and DEMO.
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| 4. |
- Bousquet, J., et al.
(författare)
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Building Bridges for Innovation in Ageing : Synergies between Action Groups of the EIP on AHA
- 2017
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Ingår i: The Journal of Nutrition, Health & Aging. - : Springer Nature. - 1279-7707 .- 1760-4788. ; 21:1, s. 92-104
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Tidskriftsartikel (refereegranskat)abstract
- The Strategic Implementation Plan of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) proposed six Action Groups. After almost three years of activity, many achievements have been obtained through commitments or collaborative work of the Action Groups. However, they have often worked in silos and, consequently, synergies between Action Groups have been proposed to strengthen the triple win of the EIP on AHA. The paper presents the methodology and current status of the Task Force on EIP on AHA synergies. Synergies are in line with the Action Groups' new Renovated Action Plan (2016-2018) to ensure that their future objectives are coherent and fully connected. The outcomes and impact of synergies are using the Monitoring and Assessment Framework for the EIP on AHA (MAFEIP). Eight proposals for synergies have been approved by the Task Force: Five cross-cutting synergies which can be used for all current and future synergies as they consider overarching domains (appropriate polypharmacy, citizen empowerment, teaching and coaching on AHA, deployment of synergies to EU regions, Responsible Research and Innovation), and three cross-cutting synergies focussing on current Action Group activities (falls, frailty, integrated care and chronic respiratory diseases).
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| 5. |
- Abdellaoui, G., et al.
(författare)
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Meteor studies in the framework of the JEM-EUSO program
- 2017
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Ingår i: Planetary and Space Science. - : Elsevier. - 0032-0633 .- 1873-5088. ; 143, s. 245-255
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Tidskriftsartikel (refereegranskat)abstract
- We summarize the state of the art of a program of UV observations from space of meteor phenomena, a secondary objective of the JEM-EUSO international collaboration. Our preliminary analysis indicates that JEM-EUSO, taking advantage of its large FOV and good sensitivity, should be able to detect meteors down to absolute magnitude close to 7. This means that JEM-EUSO should be able to record a statistically significant flux of meteors, including both sporadic ones, and events produced by different meteor streams. Being unaffected by adverse weather conditions, JEM-EUSO can also be a very important facility for the detection of bright meteors and fireballs, as these events can be detected even in conditions of very high sky background. In the case of bright events, moreover, exhibiting some persistence of the meteor train, preliminary simulations show that it should be possible to exploit the motion of the ISS itself and derive at least a rough 3D reconstruction of the meteor trajectory. Moreover, the observing strategy developed to detect meteors may also be applied to the detection of nuclearites, exotic particles whose existence has been suggested by some theoretical investigations. Nuclearites are expected to move at higher velocities than meteoroids, and to exhibit a wider range of possible trajectories, including particles moving upward after crossing the Earth. Some pilot studies, including the approved Mini-EUSO mission, a precursor of JEM-EUSO, are currently operational or in preparation. We are doing simulations to assess the performance of Mini-EUSO for meteor studies, while a few meteor events have been already detected using the ground-based facility EUSO-TA.
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| 6. |
- Abdellaoui, G., et al.
(författare)
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First observations of speed of light tracks by a fluorescence detector looking down on the atmosphere
- 2018
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Ingår i: Journal of Instrumentation. - : IOP PUBLISHING LTD. - 1748-0221. ; 13
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Tidskriftsartikel (refereegranskat)abstract
- EUSO-Balloon is a pathfinder mission for the Extreme Universe Space Observatory onboard the Japanese Experiment Module (JEM-EUSO). It was launched on the moonless night of the 25(th) of August 2014 from Timmins, Canada. The flight ended successfully after maintaining the target altitude of 38 km for five hours. One part of the mission was a 2.5 hour underflight using a helicopter equipped with three UV light sources (LED, xenon flasher and laser) to perform an inflight calibration and examine the detectors capability to measure tracks moving at the speed of light. We describe the helicopter laser system and details of the underflight as well as how the laser tracks were recorded and found in the data. These are the first recorded laser tracks measured from a fluorescence detector looking down on the atmosphere. Finally, we present a first reconstruction of the direction of the laser tracks relative to the detector.
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| 7. |
- Weiner, D. J., et al.
(författare)
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Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders
- 2017
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 49:7
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Tidskriftsartikel (refereegranskat)abstract
- Autism spectrum disorder (ASD) risk is influenced by common polygenic and de novo variation. We aimed to clarify the influence of polygenic risk for ASD and to identify subgroups of ASD cases, including those with strongly acting de novo variants, in which polygenic risk is relevant. Using a novel approach called the polygenic transmission disequilibrium test and data from 6,454 families with a child with ASD, we show that polygenic risk for ASD, schizophrenia, and greater educational attainment is over-transmitted to children with ASD. These findings hold independent of proband IQ. We find that polygenic variation contributes additively to risk in ASD cases who carry a strongly acting de novo variant. Lastly, we show that elements of polygenic risk are independent and differ in their relationship with phenotype. These results confirm that the genetic influences on ASD are additive and suggest that they create risk through at least partially distinct etiologic pathways.
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| 8. |
- Anney, R. J. L., et al.
(författare)
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Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia
- 2017
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Ingår i: Molecular Autism. - : Springer Science and Business Media LLC. - 2040-2392. ; 8
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Tidskriftsartikel (refereegranskat)abstract
- Background: Over the past decade genome-wide association studies (GWAS) have been applied to aid in the understanding of the biology of traits. The success of this approach is governed by the underlying effect sizes carried by the true risk variants and the corresponding statistical power to observe such effects given the study design and sample size under investigation. Previous ASD GWAS have identified genome-wide significant (GWS) risk loci; however, these studies were of only of low statistical power to identify GWS loci at the lower effect sizes (odds ratio (OR) < 1.15). Methods: We conducted a large-scale coordinated international collaboration to combine independent genotyping data to improve the statistical power and aid in robust discovery of GWS loci. This study uses genome-wide genotyping data from a discovery sample (7387 ASD cases and 8567 controls) followed by meta-analysis of summary statistics from two replication sets (7783 ASD cases and 11359 controls; and 1369 ASD cases and 137308 controls). Results: We observe a GWS locus at 10q24.32 that overlaps several genes including PITX3, which encodes a transcription factor identified as playing a role in neuronal differentiation and CUEDC2 previously reported to be associated with social skills in an independent population cohort. We also observe overlap with regions previously implicated in schizophrenia which was further supported by a strong genetic correlation between these disorders (Rg = 0.23; P= 9 x10(-6)). We further combined these Psychiatric Genomics Consortium (PGC) ASD GWAS data with the recent PGC schizophrenia GWAS to identify additional regions which may be important in a common neurodevelopmental phenotype and identified 12 novel GWS loci. These include loci previously implicated in ASD such as FOXP1 at 3p13, ATP2B2 at 3p25.3, and a 'neurodevelopmental hub' on chromosome 8p11.23. Conclusions: This study is an important step in the ongoing endeavour to identify the loci which underpin the common variant signal in ASD. In addition to novel GWS loci, we have identified a significant genetic correlation with schizophrenia and association of ASD with several neurodevelopmental- related genes such as EXT1, ASTN2, MACROD2, and HDAC4.
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| 9. |
- Elhai, M, et al.
(författare)
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Outcomes of patients with systemic sclerosis treated with rituximab in contemporary practice: a prospective cohort study
- 2019
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Ingår i: Annals of the rheumatic diseases. - : BMJ. - 1468-2060 .- 0003-4967. ; 78:7, s. 979-987
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Tidskriftsartikel (refereegranskat)abstract
- To assess the safety and efficacy of rituximab in systemic sclerosis (SSc) in clinical practice.MethodsWe performed a prospective study including patients with SSc from the European Scleroderma Trials and Research (EUSTAR) network treated with rituximab and matched with untreated patients with SSc. The main outcomes measures were adverse events, skin fibrosis improvement, lung fibrosis worsening and steroids use among propensity score-matched patients treated or not with rituximab.Results254 patients were treated with rituximab, in 58% for lung and in 32% for skin involvement. After a median follow-up of 2 years, about 70% of the patients had no side effect. Comparison of treated patients with 9575 propensity-score matched patients showed that patients treated with rituximab were more likely to have skin fibrosis improvement (22.7 vs 14.03 events per 100 person-years; OR: 2.79 [1.47–5.32]; p=0.002). Treated patients did not have significantly different rates of decrease in forced vital capacity (FVC)>10% (OR: 1.03 [0.55–1.94]; p=0.93) nor in carbon monoxide diffusing capacity (DLCO) decrease. Patients having received rituximab were more prone to stop or decrease steroids (OR: 2.34 [1.56–3.53], p<0.0001). Patients treated concomitantly with mycophenolate mofetil had a trend for better outcomes as compared with patients receiving rituximab alone (delta FVC: 5.22 [0.83–9.62]; p=0.019 as compared with controls vs 3 [0.66–5.35]; p=0.012).ConclusionRituximab use was associated with a good safety profile in this large SSc-cohort. Significant change was observed on skin fibrosis, but not on lung. However, the limitation is the observational design. The potential stabilisation of lung fibrosis by rituximab has to be addressed by a randomised trial.
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| 10. |
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| 11. |
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| 12. |
- Mayorov, A. G., et al.
(författare)
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Solar modulation of galactic cosmic rays during 2006-2015 based on PAMELA and ARINA data
- 2017
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Ingår i: International Conference On Particle Physics And Astrophysics. - : Institute of Physics Publishing (IOPP).
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Konferensbidrag (refereegranskat)abstract
- Solar modulation of galactic protons with energies from 50 MeV up to dozens of GeV during July '06 - January '16 studied based on a data of the magnetic spectrometer PAMELA and scintillation spectrometer ARINA. This period is interesting because it covers the end of 23(rd) and current 24(th) cycles of solar activity, including the abnormally long transient period and change of the polarity of solar magnetic field.
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| 13. |
- Mikhailov, V V, et al.
(författare)
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Cosmic ray electron and positron spectrum with the PAMELA experiment
- 2019
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Ingår i: 36th International Cosmic Ray Conference, ICRC 2019. - : Sissa Medialab Srl.
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Konferensbidrag (refereegranskat)abstract
- The PAMELA magnetic spectrometer, located on board the Resurs-DK1 satellite on Earth polar orbit with altitude of 350-600 km, measured the fluxes of cosmic ray particles and antiparticles in a wide energy range from 50 MeV to several TeVs. In this paper new results on the "all-electron" (sum electrons and positrons) spectrum are presented. New improved analysis on the full data set from 2006 to 2016 allows a significant increase in statistic compared to previously published results and an extension of energy interval up to 1 TeV.
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| 14. |
- Bogomolov, E. A., et al.
(författare)
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Spectra of solar neutrons with energies of ~10–1000 MeV in the PAMELA experiment in the flare events of 2006–2015
- 2017
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Ingår i: Bulletin of the Russian Academy of Sciences: Physics. - : Allerton Press Incorporation. - 1062-8738. ; 81:2, s. 132-135
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Tidskriftsartikel (refereegranskat)abstract
- The first results from measuring the spectra of solar neutrons with energies of ~10–1000 MeV in the solar flares of 2006–2015 observed by the PAMELA international space experiment are presented. The PAMELA neutron detector with 3He counters and a moderator with an area of 0.18 m2 allows us to estimate the flux of solar neutrons during solar flares. Solar neutrons with energies of ~10–1000 MeV likely occurred in 21 out of the 24 analyzed flares of 2006–2015.
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| 15. |
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| 16. |
- Koldobskiy, S. A., et al.
(författare)
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Deuteron spectrum measurements under radiation belt with PAMELA instrument
- 2016
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Ingår i: Nuclear and Particle Physics Proceedings. - : Elsevier. - 2405-6014. ; 273-275, s. 2345-2347
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Tidskriftsartikel (refereegranskat)abstract
- In this work the results of data analysis of the deuteron albedo radiation obtained in the PAMELA experiment are presented. PAMELA is an international space experiment carried out on board of the satellite Resurs DK-1. The high precision detectors allow to register and identify cosmic ray particles in a wide energy range. The albedo deuteron spectrum in the energy range 70 - 600 MeV/nucleon has been measured.
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| 17. |
- Koldobskiy, S. A., et al.
(författare)
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Solar modulation of cosmic deuteron fluxes in the PAMELA experiment
- 2017
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Ingår i: Bulletin of the Russian Academy of Sciences: Physics. - : Allerton Press Incorporation. - 1062-8738. ; 81:2, s. 151-153
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Tidskriftsartikel (refereegranskat)abstract
- The preliminary results from measurements of deuteron fluxes in galactic cosmic rays (GCR) in the vicinity of the Earth in 2006–2009 are presented. The results are obtained by analyzing data from the PAMELA experiment aboard the Resurs DK-1 satellite. High-precision detection instruments provided an opportunity to identify GCR deuterons and measure their spectrum in the energy interval of 90–650MeV/nucleon. Spectra averaged over six-month intervals from the summer of 2006 to the summer of 2009 (the solar activity minimum) are presented. The influence of solar modulation on the observed spectrum is clearly seen in the results.
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| 18. |
- Koldobskiy, S. A., et al.
(författare)
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Study of deuteron spectra under radiation belt with PAMELA instrument
- 2015
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Ingår i: 24TH EUROPEAN COSMIC RAY SYMPOSIUM (ECRS). - : IOP Publishing.
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Konferensbidrag (refereegranskat)abstract
- This paper presents the results of measurements of proton and deuteron fluxes of albedo radiation in the Earth vicinity, obtained in the PAMELA experiment. PAMELA is an international experiment meant to study cosmic rays. PAMELA is carried out on board the satellite Resurs-DK1. High-precision equipment of the experiment allows registration and identification of cosmic ray particles of different varieties in a wide energy range. The albedo deuteron spectrum and albedo deuteron-to-proton fluxes ratio in the energy range 70 - 600 MeV/nucleon at altitude of 350 - 600 km for different geomagnetic latitudes is presented.
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| 19. |
- Malakhov, V. V., et al.
(författare)
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Time variations of proton flux in Earth inner radiation belt during 23/24 solar cycles based on the PAMELA and the ARINA data.
- 2015
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Ingår i: 24TH EUROPEAN COSMIC RAY SYMPOSIUM (ECRS). - : IOP Publishing.
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Konferensbidrag (refereegranskat)abstract
- The PAMELA and the ARINA experiments are carried out on the board of satellite RESURS-DK1 since 2006 up to now. Main goal of the PAMELA instrument is measurements of high energy antiparticles in cosmic rays while the ARINA instrument is intended studying high energy charged particle bursts in the magnetosphere. Both of these experiments have a possibility to study trapped particles in the inner radiation belt. Complex of these two instruments covers proton energy range from 30 MeV up to trapping limit (E= similar to 2 GeV). Continuous measurements with the PAMELA and the ARINA spectrometers include falling and rising phases of 23/24 solar cycles and maximum of 24th one. In this report we present temporal profiles of proton flux in the inner zone of the radiation belt (1.11 < L < 1.18, 0.18 < B < 0.22G). Dependence of proton fluxes on a magnitude of the solar activity was studied for various phases of 23/24 solar cycles. At that it was shown that proton fluxes at the solar minimum are several times greater than at the solar maximum.
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| 20. |
- Mikhailov, V. V., et al.
(författare)
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Galactic Cosmic Ray Electrons and Positrons over a Decade of Observations in the PAMELA Experiment
- 2019
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Ingår i: Bulletin of the Russian Academy of Sciences: Physics. - : Pleiades Publishing. - 1062-8738. ; 83:8, s. 974-976
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Tidskriftsartikel (refereegranskat)abstract
- The PAMELA magnetic spectrometer was launched onboard the Resurs-DK1 satellite into a near-polar Earth orbit with an altitude of 350–600 km, in order to study fluxes of cosmic ray particles and antiparticles in the wide energy range of ~80 MeV to hundreds of GeV. The results from observations of electron and positron fluxes in 2006–2016 are presented.
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| 21. |
- Mikhailov, V. V., et al.
(författare)
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Modulation of electrons and positrons in 2006–2015 in the PAMELA experiment
- 2017
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Ingår i: Bulletin of the Russian Academy of Sciences: Physics. - : Allerton Press Incorporation. - 1062-8738. ; 81:2, s. 154-156
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Tidskriftsartikel (refereegranskat)abstract
- The PAMELA magnetic spectrometer was launched aboard the Resurs DK-1 satellite into a nearpolar circumterrestrial orbit with an altitude of 350–600 km to study fluxes of the particles and antiparticles of cosmic rays in the wide energy range of ~80 MeV to several hundred gigaelectronvolts. The results from observations of temporal variations in electron and positron fluxes in 2006–2015 are presented. The ratio of electron and positron fluxes measured in this time interval reveals a dependence on the rigidity of particles, the solar activity, and the polarity of the solar magnetic field.
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| 22. |
- Mikhailov, V. V., et al.
(författare)
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Secondary positrons and electrons in near-Earth space in the PAMELA experiment
- 2017
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Ingår i: Bulletin of the Russian Academy of Sciences: Physics. - : Allerton Press Incorporation. - 1062-8738. ; 81:2, s. 203-205
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Tidskriftsartikel (refereegranskat)abstract
- Fluxes of electrons and positrons with energies above ~100 MeV in the near-Earth space are measured with the PAMELA magnetic spectrometer aboard the Resurs DK-1 satellite launched on June 15, 2006, into a quasipolar orbit with an altitude of 350–600 km and an inclination of 70°. Calculating the trajectories of detected electrons and positrons in the magnetosphere of the Earth allows us to determine their origin and isolate particles produced during interaction between cosmic rays and the residual atmosphere. Spatial distributions of albedo, quasitrapped, and trapped (in the radiation belt) positrons and electrons are presented. The ratio of positron and electron fluxes suggests that the fluxes of trapped particles of the radiation belt and quasitrapped secondary particles have different mechanisms of formation.
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| 23. |
- Mikhailov, V. V., et al.
(författare)
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Trapped Positrons and Electrons in the Inner Radiation Belt According to Data of the PAMELA Experiment
- 2018
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Ingår i: Physics of Atomic Nuclei. - : PLEIADES PUBLISHING INC. - 1063-7788 .- 1562-692X. ; 81:4, s. 515-519
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Tidskriftsartikel (refereegranskat)abstract
- Measurements of secondary-electron and secondary-positron fluxes below the geomagnetic cutoff in near-Earth space were performed by means of the PAMELA magnetic spectrometer installed on board the Resurs-DK1 satellite launched on June 15, 2006, in an elliptical orbit of inclination 70A degrees and altitude 350 to 600 km. This spectrometer permits measuring the fluxes of electrons and positrons over a wide energy range, as well as determining their spatial distributions to a precision of about 2A degrees. A calculation of particle trajectories in the geomagnetic field makes it possible to separate electrons and positrons originating from cosmic-ray interactions in the Earth's magnetosphere. The spatial distributions of quasitrapped, trapped, and short-lived albedo positrons and electrons of energy above 70 MeV in the radiation belt were analyzed. The ratio of the electron-to-positron fluxes and the energy spectra of the electrons and positrons in question are indicative of different productionmechanisms for stably trapped and quasitrapped secondary particles.
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| 24. |
- Altavilla, R., et al.
(författare)
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Anticoagulation After Stroke in Patients With Atrial Fibrillation: To Bridge or Not With Low-Molecular-Weight Heparin?
- 2019
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Ingår i: Stroke. - : Ovid Technologies (Wolters Kluwer Health). - 0039-2499 .- 1524-4628. ; 50:8, s. 2093-2100
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Tidskriftsartikel (refereegranskat)abstract
- Background and Purpose- Bridging therapy with low-molecular-weight heparin reportedly leads to a worse outcome for acute cardioembolic stroke patients because of a higher incidence of intracerebral bleeding. However, this practice is common in clinical settings. This observational study aimed to compare (1) the clinical profiles of patients receiving and not receiving bridging therapy, (2) overall group outcomes, and (3) outcomes according to the type of anticoagulant prescribed. Methods- We analyzed data of patients from the prospective RAF and RAF-NOACs studies. The primary outcome was defined as the composite of ischemic stroke, transient ischemic attack, systemic embolism, symptomatic cerebral bleeding, and major extracerebral bleeding observed at 90 days after the acute stroke. Results- Of 1810 patients who initiated oral anticoagulant therapy, 371 (20%) underwent bridging therapy with full-dose low-molecular-weight heparin. Older age and the presence of leukoaraiosis were inversely correlated with the use of bridging therapy. Forty-two bridged patients (11.3%) reached the combined outcome versus 72 (5.0%) of the nonbridged patients (P=0.0001). At multivariable analysis, bridging therapy was associated with the composite end point (odds ratio, 2.3; 95% CI, 1.4-3.7; P<0.0001), as well as ischemic (odds ratio, 2.2; 95% CI, 1.3-3.9; P=0.005) and hemorrhagic (odds ratio, 2.4; 95% CI, 1.2-4.9; P=0.01) end points separately. Conclusions- Our findings suggest that patients receiving low-molecular-weight heparin have a higher risk of early ischemic recurrence and hemorrhagic transformation compared with nonbridged patients.
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| 25. |
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| 26. |
- Koldobskiy, S., et al.
(författare)
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Measuring the albedo deuteron flux in the PAMELA satellite experiment
- 2015
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Ingår i: Bulletin of the Russian Academy of Sciences: Physics. - 1062-8738. ; 79:3, s. 294-297
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Tidskriftsartikel (refereegranskat)abstract
- The results of measuring albedo deuteron fluxes in the vicinity of the Earth are presented. The data were obtained in the PAMELA experiment conducted aboard the Resurs DK-1 artificial Earth satellite. High-precision detectors of the instrument setup allow us to identify albedo deuterons and measure their spectra in the energy interval from 70 to 600 MeV/nucleon at altitudes of 350–600 km for different geomagnetic latitudes.
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| 27. |
- Paciaroni, M., et al.
(författare)
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Hemorrhagic transformation in patients with acute ischemic stroke and atrial fibrillation: Time to initiation of oral anticoagulant therapy and outcomes
- 2018
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Ingår i: Journal of the American Heart Association. - 2047-9980. ; 7:22
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Tidskriftsartikel (refereegranskat)abstract
- Background—In patients with acute ischemic stroke and atrial fibrillation, early anticoagulation prevents ischemic recurrence but with the risk of hemorrhagic transformation (HT). The aims of this study were to evaluate in consecutive patients with acute stroke and atrial fibrillation (1) the incidence of early HT, (2) the time to initiation of anticoagulation in patients with HT, (3) the association of HT with ischemic recurrences, and (4) the association of HT with clinical outcome at 90 days. Methods and Results—HT was diagnosed by a second brain computed tomographic scan performed 24 to 72 hours after stroke onset. The incidence of ischemic recurrences as well as mortality or disability (modified Rankin Scale scores >2) were evaluated at 90 days. Ischemic recurrences were the composite of ischemic stroke, transient ischemic attack, or systemic embolism. Among the 2183 patients included in the study, 241 (11.0%) had HT. Patients with and without HT initiated anticoagulant therapy after a mean 23.3 and 11.6 days, respectively, from index stroke. At 90 days, 4.6% (95% confidence interval, 2.3-8.0) of the patients with HT had ischemic recurrences compared with 4.9% (95% confidence interval, 4.0-6.0) of those without HT; 53.1% of patients with HT were deceased or disabled compared with 35.8% of those without HT. On multivariable analysis, HT was associated with mortality or disability (odds ratio, 1.71; 95% confidence interval, 1.24-2.35). Conclusions—In patients with HT, anticoagulation was initiated about 12 days later than patients without HT. This delay was not associated with increased detection of ischemic recurrence. HT was associated with increased mortality or disability. © 2018 The Authors.
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| 28. |
- Paciaroni, M., et al.
(författare)
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Prediction of Early Recurrent Thromboembolic Event and Major Bleeding in Patients With Acute Stroke and Atrial Fibrillation by a Risk Stratification Schema The ALESSA Score Study
- 2017
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Ingår i: Stroke. - : Ovid Technologies (Wolters Kluwer Health). - 0039-2499 .- 1524-4628. ; 48:3, s. 726-732
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Tidskriftsartikel (refereegranskat)abstract
- Background and Purposes-This study was designed to derive and validate a score to predict early ischemic events and major bleedings after an acute ischemic stroke in patients with atrial fibrillation. Methods-The derivation cohort consisted of 854 patients with acute ischemic stroke and atrial fibrillation included in prospective series between January 2012 and March 2014. Older age (hazard ratio 1.06 for each additional year; 95% confidence interval, 1.00-1.11) and severe atrial enlargement (hazard ratio, 2.05; 95% confidence interval, 1.08-2.87) were predictors for ischemic outcome events (stroke, transient ischemic attack, and systemic embolism) at 90 days from acute stroke. Small lesions (1.5 cm) were inversely correlated with both major bleeding (hazard ratio, 0.39; P=0.03) and ischemic outcome events (hazard ratio, 0.55; 95% confidence interval, 0.30-1.00). We assigned to age 80 years 2 points and between 70 and 79 years 1 point; ischemic index lesion >1.5 cm, 1 point; severe atrial enlargement, 1 point (ALESSA score). A logistic regression with the receiver-operating characteristic graph procedure (C statistic) showed an area under the curve of 0.697 (0.632-0.763; P=0.0001) for ischemic outcome events and 0.585 (0.493-0.678; P=0.10) for major bleedings. Results-The validation cohort consisted of 994 patients included in prospective series between April 2014 and June 2016. Logistic regression with the receiver-operating characteristic graph procedure showed an area under the curve of 0.646 (0.529-0.763; P=0.009) for ischemic outcome events and 0.407 (0.275-0.540; P=0.14) for hemorrhagic outcome events. Conclusions-In acute stroke patients with atrial fibrillation, high ALESSA scores were associated with a high risk of ischemic events but not of major bleedings.
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| 29. |
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| 30. |
- Karelin, A. V., et al.
(författare)
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Measurement of electron-positron spectrum in high-energy cosmic rays in the PAMELA experiment
- 2015
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Ingår i: 24TH EUROPEAN COSMIC RAY SYMPOSIUM (ECRS). - : IOP Publishing.
-
Konferensbidrag (refereegranskat)abstract
- At present the existing data on the cosmic ray electron energy spectra in the high energy range are fragmented, and the situation is exacerbated by their small number. In the satellite PAMELA experiment measurements at high energies are carried out by the calorimeter. The experimental data accumulated for more than 8 years of measurements, with the information of the calorimeter, the neutron detector and the scintillation counters made it possible to obtain the total spectrum of high-energy electrons and positrons in energy range 0.3-3 TeV.
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| 31. |
- Karelin, A. V., et al.
(författare)
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Measurement of the large-scale anisotropy of cosmic rays in the PAMELA experiment
- 2015
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Ingår i: JETP Letters. - 0021-3640 .- 1090-6487. ; 101:5, s. 295-298
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Tidskriftsartikel (refereegranskat)abstract
- Large-scale anisotropy or so-called sidereal-diurnal wave has been detected in the PAMELA satellite experiment in the time interval of 2006–2014. The magnitude of anisotropy has been measured simultaneously for the Southern and Northern Hemispheres in the equatorial coordinate system. The results confirm the data of ground-based experiments.
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| 32. |
- Karelin, A. V., et al.
(författare)
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Measuring the spectra of high-energy cosmic-ray particles in the PAMELA experiment
- 2015
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Ingår i: Bulletin of the Russian Academy of Sciences: Physics. - 1062-8738. ; 79:3, s. 289-293
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Tidskriftsartikel (refereegranskat)abstract
- The available data on the energy spectra of electrons, protons, and helium nuclei in the high-energy region are fragmentary, a situation made worse by their scarcity. Due to limitations imposed on the use of the magnetic spectrometer in the PAMELA satellite experiment, the calorimeter must be used for measurements performed in the high-energy region. The processing of experimental data accumulated in more than eight years of measurements with the calorimeter, neutron detector, and scintillation counters allows the spectra of high-energy particles to be obtained, greatly expanding our understanding of the nature of primary cosmic rays.
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| 33. |
- Koldobskiy, S. A., et al.
(författare)
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Measurement of trapped and quasitrapped deuteron populations in PAMELA experiment
- 2015
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Ingår i: Proceedings of Science. - : Proceedings of Science (PoS).
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Konferensbidrag (refereegranskat)abstract
- The results of measurements of trapped and albedo cosmic ray deuteron fluxes obtained in the PAMELA experiment are presented in this work. The PAMELA is an international experiment aimed for measurements of cosmic ray particle fluxes in wide energy range. In particular, analysis of PAMELA data gives possibility to identify deuterons and to reconstruct deuteron spectra of different origin (galactic cosmic ray, re-entrant albedo and radiation belt particles). The first results of trajcectory reconstruction for trapped and albedo deuterons are presented in this work. This investigation was done by solving equations of particle motion in Earth's magnetic field by means of numerical integration methods.
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| 34. |
- Mikhailov, V., et al.
(författare)
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Measurements of electron and positron fluxes below the geomagnetic cutoff by the PAMELA magnetic spectrometer
- 2017
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Ingår i: Proceedings of Science. - : Sissa Medialab Srl.
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Konferensbidrag (refereegranskat)abstract
- We present a measurements of electron and positron fluxes below the geomagnetic cutoff rigidity in wide energy range from 50 MeV to several GeVs by the PAMELA magnetic spectrometer. The instrument was launched on June 15th 2006 on-board the Resurs-DK satellite on low orbit with 70 degrees inclination and altitude between 350 and 600 km. Features of spatial distributions of secondary electrons and positrons in the near Earth space, including the South Atlantic Anomaly, were investigated in terms of lifetime and geographical origin. The separation in stably trapped, long lifetime quasi-trapped, and short lifetime albedo components was performed on base of back tracing procedure in geomagnetic field. A significant difference in relative abundance of positrons with respect to electrons is seen for the stable trapped and the quasi-trapped populations what pointing out on differences in trapping mechanism of those populations.
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| 35. |
- Mikhailov, V. V., et al.
(författare)
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Searching for anisotropy of positrons and electrons in the PAMELA experiment
- 2015
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Ingår i: Bulletin of the Russian Academy of Sciences: Physics. - 1062-8738. ; 79:3, s. 298-301
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Tidskriftsartikel (refereegranskat)abstract
- The PAMELA experiment has been under way aboard the Resurs DK-1 satellite since June 2006. The results have revealed an increase in the ratio of the positron intensity to the total electron and positron intensity at energies in excess of 10 GeV. This increase suggests an additional source of cosmic rays that is associated with either some astrophysical objects (e.g., pulsars) or the probable annihilation of particles of dark matter. Local positron sources can produce notable anisotropy in their flux. The results from the search for anisotropy of positrons and electrons in the events detected by the PAMELA experiment in the 2006–2013 timeframe are described in detail in this work.
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| 36. |
- Acciarresi, M., et al.
(författare)
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Prestroke CHA(2)DS(2)-VASc Score and Severity of Acute Stroke in Patients with Atrial Fibrillation: Findings from RAF Study
- 2017
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Ingår i: Journal of Stroke & Cerebrovascular Diseases. - : Elsevier BV. - 1052-3057. ; 26:6, s. 1363-1368
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Tidskriftsartikel (refereegranskat)abstract
- Background and Purpose: The aim of this study was to investigate for a possible association between both prestroke CHA(2)DS(2)-VASc score and the severity of stroke at presentation, as well as disability and mortality at 90 days, in patients with acute stroke and atrial fibrillation (AF). Methods: This prospective study enrolled consecutive patients with acute ischemic stroke, AF, and assessment of prestroke CHA2DS2-VASc score. Severity of stroke was assessed on admission using the National Institutes of Health Stroke Scale (NIHSS) score (severe stroke: NIHSS >= 10). Disability and mortality at 90 days were assessed by the modified Rankin Scale (mRS < 3 or >= 3). Multiple logistic regression was used to correlate prestroke CHA(2)DS(2)-VASc and severity of stroke, as well as disability and mortality at 90 days. Results: Of the 1020 patients included in the analysis, 606 patients had an admission NIHSS score lower and 414 patients higher than 10. At 90 days, 510 patients had mRS >= 3. A linear correlation was found between the prestroke CHA(2)DS(2)-VASc score and severity of stroke (P = .001). On multivariate analysis, CHA(2)DS(2)-VASc score correlated with severity of stroke (P = .041) and adverse functional outcome (mRS = 3) (P = .001). A logistic regression with the receiver operating characteristic graph procedure (C-statistics) evidenced an area under the curve of .60 (P = .0001) for severe stroke. Furthermore, a correlation was found between prestroke CHA(2)DS(2)-VASc score and lesion size. Conclusions: In patients with AF, in addition to the risk of stroke, a high CHA(2)DS(2)-VASc score was independently associated with both stroke severity at onset and disability and mortality at 90 days.
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| 37. |
- Adriani, O., et al.
(författare)
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Pamela's measurements of magnetospheric effects on high-energy solar particles
- 2015
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Ingår i: Astrophysical Journal Letters. - 2041-8205 .- 2041-8213. ; 801:1
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Tidskriftsartikel (refereegranskat)abstract
- The nature of particle acceleration at the Sun, whether through flare reconnection processes or through shocks driven by coronal mass ejections, is still under scrutiny despite decades of research. The measured properties of solar energetic particles (SEPs) have long been modeled in different particle-acceleration scenarios. The challenge has been to disentangle the effects of transport from those of acceleration. The Payload for Antimatter Matter Exploration and Light-nuclei Astrophysics (PAMELA) instrument enables unique observations of SEPs including the composition and angular distribution of the particles about the magnetic field, i.e., pitch angle distribution, over a broad energy range (>80 MeV)-bridging a critical gap between space-based and ground-based measurements. We present high-energy SEP data from PAMELA acquired during the 2012 May 17 SEP event. These data exhibit differential anisotropies and thus transport features over the instrument rigidity range. SEP protons exhibit two distinct pitch angle distributions: a low-energy population that extends to 90 degrees and a population that is beamed at high energies (>1 GeV), consistent with neutron monitor measurements. To explain a low-energy SEP population that exhibits significant scattering or redistribution accompanied by a high-energy population that reaches the Earth relatively unaffected by dispersive transport effects, we postulate that the scattering or redistribution takes place locally. We believe that these are the first comprehensive measurements of the effects of solar energetic particle transport in the Earth's magnetosheath.
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| 38. |
- Adriani, O., et al.
(författare)
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Time Dependence of the Electron and Positron Components of the Cosmic Radiation Measured by the PAMELA Experiment between July 2006 and December 2015
- 2016
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 116:24
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Tidskriftsartikel (refereegranskat)abstract
- Cosmic-ray electrons and positrons are a unique probe of the propagation of cosmic rays as well as of the nature and distribution of particle sources in our Galaxy. Recent measurements of these particles are challenging our basic understanding of the mechanisms of production, acceleration, and propagation of cosmic rays. Particularly striking are the differences between the low energy results collected by the space-borne PAMELA and AMS-02 experiments and older measurements pointing to sign-charge dependence of the solar modulation of cosmic-ray spectra. The PAMELA experiment has been measuring the time variation of the positron and electron intensity at Earth from July 2006 to December 2015 covering the period for the minimum of solar cycle 23 (2006-2009) until the middle of the maximum of solar cycle 24, through the polarity reversal of the heliospheric magnetic field which took place between 2013 and 2014. The positron to electron ratio measured in this time period clearly shows a sign-charge dependence of the solar modulation introduced by particle drifts. These results provide the first clear and continuous observation of how drift effects on solar modulation have unfolded with time from solar minimum to solar maximum and their dependence on the particle rigidity and the cyclic polarity of the solar magnetic field.
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| 39. |
- Bruno, A., et al.
(författare)
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Geomagnetically trapped, albedo and solar energetic particles : Trajectory analysis and flux reconstruction with PAMELA
- 2017
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Ingår i: Advances in Space Research. - : Elsevier. - 0273-1177 .- 1879-1948. ; 60:4, s. 788-795
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Tidskriftsartikel (refereegranskat)abstract
- The PAMELA satellite experiment is providing comprehensive observations of the interplanetary and magnetospheric radiation in the near-Earth environment. Thanks to its identification capabilities and the semi-polar orbit, PAMELA is able to precisely measure the energetic spectra and the angular distributions of the different cosmic-ray populations over a wide latitude region, including geomagnetically trapped and albedo particles. Its observations comprise the solar energetic particle events between solar cycles 23 and 24, and the geomagnetic cutoff variations during magnetospheric storms. PAMELA's measurements are supported by an accurate analysis of particle trajectories in the Earth's magnetosphere based on a realistic geomagnetic field modeling, which allows the classification of particle populations of different origin and the investigation of the asymptotic directions of arrival.
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| 40. |
- Bruno, A., et al.
(författare)
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Solar energetic particle events : Trajectory analysis and flux reconstruction with PAMELA
- 2015
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Ingår i: Proceedings of Science. - : Proceedings of science.
-
Konferensbidrag (refereegranskat)abstract
- The PAMELA satellite experiment is providing first direct measurements of Solar Energetic Particles (SEPs) with energies from about 80 MeV to several GeV in near-Earth space, bridging the low energy data by other space-based instruments and the Ground Level Enhancement (GLE) data by the worldwide network of neutron monitors. Its unique observational capabilities include the possibility of measuring the flux angular distribution and thus investigating possible anisotropies. This work reports the analysis methods developed to estimate the SEP energy spectra as a function of the particle pitch-angle with respect to the Interplanetary Magnetic Field (IMF) direction. The crucial ingredient is provided by an accurate simulation of the asymptotic exposition of the PAMELA apparatus, based on a realistic reconstruction of particle trajectories in the Earth's magnetosphere. As case study, the results for the May 17, 2012 event are presented.
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| 41. |
- Karelin, A. V., et al.
(författare)
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The high energy cosmic ray particle spectra measurements with the PAMELA calorimeter
- 2016
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Ingår i: Nuclear and Particle Physics Proceedings. - : Elsevier. - 2405-6014. ; 273-275, s. 275-281
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Tidskriftsartikel (refereegranskat)abstract
- Up until now there has been limited, contradictive data on the high energy range of the cosmic ray electron-positron, proton and helium spectra. Due to the limitations of the use of a magnetic spectrometer, over 8 years experimental data was processed using information from a sampling electro-magnetic calorimeter, a neutron detector and scintillator detectors. The use of these devices allowed us to successfully obtain the high energy cosmic ray particle spectra measurements. The results of this study clarify previous findings and greaten our understanding of the origin of cosmic rays.
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| 42. |
- Martucci, M., et al.
(författare)
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Magnetospheric effects on high-energy solar particles during the 2012 May 17th event measured with the PAMELA experiment
- 2015
-
Ingår i: Proceedings of Science. - : Proceedings of Science (PoS).
-
Konferensbidrag (refereegranskat)abstract
- The great challenge in constraining scenarios for solar energetic particle (SEP) acceleration is due to the fact that the signatures of acceleration itself are heavily modified by transport within interplanetary space. During transport, SEPs are subject to pitch angle scattering by the turbulent magnetic field, adiabatic focusing, or reflecting magnetic structures. Ground Level Enhancements (GLEs) provide an ideal way to study acceleration with minimal transport. In this work, we present a unique high-energy SEP observation from PAMELA of the 2012 May 17 GLE and interpret the observed pitch angle distributions as a result of local scattering (1 AU) by the Earth's magnetosheath.
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| 43. |
- Mergè, M., et al.
(författare)
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PAMELA measurements of solar energetic particle spectra
- 2017
-
Ingår i: Proceedings of Science. - : Sissa Medialab Srl.
-
Konferensbidrag (refereegranskat)abstract
- The charged particle acceleration and transport during solar events have been widely studied in the past decades. The satellite-borne PAMELA experiment has been continuously collecting data since 2006. The apparatus is designed to study charged particles in the cosmic radiation. The combination of permanent magnet, silicon micro-strip spectrometer and silicon-tungsten imaging calorimeter, with the redundancy of instrumentation allows very precise studies on the physics of cosmic rays in a wide energy range and with high statistics. This makes PAMELA a well suited instrument for Solar Energetic Particles (SEP) observations. Not only it spans the energy range between the ground-based neutron monitor data and the observations of SEPs from space, but also PAMELA carries out the first direct measurements of SEP energy spectra, composition and angular distribution. PAMELA has observed many SEP events in solar cycle 24, offering unique opportunity to address several questions on high-energy SEP origin. A preliminary analysis on proton spectra during several events of the 24th solar cycle is presented.
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| 44. |
- Mikhailov, V. V., et al.
(författare)
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Cosmic ray electrons and positrons over decade with the PAMELA experiment
- 2019
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Ingår i: Journal of Physics. - : Institute of Physics Publishing.
-
Konferensbidrag (refereegranskat)abstract
- The PAMELA experiment has measured cosmic ray particles and antiparticles fluxes at Earth orbit from June 2006 till January 2016 onboard the Resurs-DK1 satellite. Measurements were carried out during the solar minimum of 23 solar cycle with negative polarity A < 0 of heliospheric magnetic field till the beginning of 24 cycle with positive polarity A > 0. In this paper, the results of observations of electron and positron fluxes are presented in wide energy range from several hundreds MeVs till several TeVs These measurements provide important information to study cosmic ray sources and propagation in Galaxy and heliosphere.
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| 45. |
- Mikhailov, V. V., et al.
(författare)
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Sharp increasing of positron to electron fluxes ratio below 2 GV measured by the PAMELA
- 2017
-
Ingår i: Journal of Physics, Conference Series. - : Institute of Physics Publishing (IOPP). - 1742-6588 .- 1742-6596. ; 798:1
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Tidskriftsartikel (refereegranskat)abstract
- Magnetic spectrometer PAMELA was launched onboard a satellite Resurs-DK1 into low-Earth polar orbit with altitude 350-600 km to study cosmic ray antiparticle fluxes in a wide energy range from ∼ 100 MeV to hundreds GeV. This paper presents the results of observations of temporal variations of the positron and electron fluxes in the 2006-2015. The ratio of the positron and electron fluxes below 2 GV shows sharp increasing since 2014 due to changing of the polarity of the solar magnetic field.
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| 46. |
- Mori, N., et al.
(författare)
-
The PAMELA experiment and cosmic ray observations
- 2015
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Ingår i: NUCLEAR AND PARTICLE PHYSICS PROCEEDINGS. - : Elsevier. - 2405-6014. ; , s. 242-244
-
Konferensbidrag (refereegranskat)abstract
- The PAMELA space experiment is aimed at precise measurements of the charged light component of the cosmic ray spectrum in the energy range spanning from the sub-GeV region to the TeV region, with a particular focus on antimatter. The instrument consists of a magnetic spectrometer, an electromagnetic sampling calorimeter,a time-off-light system, an anticoincidence shield, a tail-catcher scintillator and a neutron detector. Launched in June 2006 and hosted on the Resurs-DK1 satellite, PAMELA has been taking data for more than eight years, providing scientific results with unprecedented statistics and a continuous monitoring of the sun activity and the heliosphere.
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| 47. |
- Munini, R., et al.
(författare)
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Short-term variation in the galactic cosmic ray intensity measured with the PAMELA experiment
- 2017
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Ingår i: Proceedings of Science. - : Sissa Medialab Srl.
-
Konferensbidrag (refereegranskat)abstract
- New results on the galactic cosmic ray (GCR) short-term intensity variation associated with Forbush decrease and co-rotating interaction regions (CIRs) measured by the PAMELA instrument between November 2006 and March 2007 are presented. Most of the past measurements on Forbush decrease events were carried out with neutron monitor detector. This tecnique allows only indirect detection of the overall GCR intensity over an integrated energy range. For the first time, thanks to the unique features of the PAMELA magnetic spectrometer, the Forbush decrease associated with the December 13th coronal mass ejection (CME) was studied in a wide rigidity range (0.4 - 20 GV) and for different species of GCRs detected directly in space. Using GCR protons, the amplitude and the recovery time of the Forbush decrease were studied for ten rigidity interval with a temporal resolution of one day. For comparison the helium and the electron intensity over time were also studied. The temporal evolution of the helium and proton intensity was found in good agreement while the electrons show, on average, a faster recovery time. This was interpreted as a charge-sign dependence introduced by drift motion experienced by the low rigidity (< 5 GV) GCRs during their propagation through the heliosphere. Moreover a clear 13.5 days cyclical variation was observed in the GCR proton intensity after the Forbush decrease. This phenomena could be interpreted as an effect of prominent structures of compressed plasma in the solar wind, i.e. CIRs, or to the latitudinal gradient due to the crossing of the heliospheric current sheet (HCS).
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| 48. |
- Toppi, M., et al.
(författare)
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Measurement of fragmentation cross sections of C-12 ions on a thin gold target with the FIRST apparatus
- 2016
-
Ingår i: Physical Review C. - 2469-9985 .- 2469-9993. ; 93:6
-
Tidskriftsartikel (refereegranskat)abstract
- A detailed knowledge of the light ions interaction processes with matter is of great interest in basic and applied physics. As an example, particle therapy and space radioprotection require highly accurate fragmentation cross-section measurements to develop shielding materials and estimate acute and late health risks for manned missions in space and for treatment planning in particle therapy. The Fragmentation of Ions Relevant for Space and Therapy experiment at the Helmholtz Center for Heavy Ion research (GSI) was designed and built by an international collaboration from France, Germany, Italy, and Spain for studying the collisions of a C-12 ion beam with thin targets. The collaboration's main purpose is to provide the double-differential cross-section measurement of carbon-ion fragmentation at energies that are relevant for both tumor therapy and space radiation protection applications. Fragmentation cross sections of light ions impinging on a wide range of thin targets are also essential to validate the nuclear models implemented in MC simulations that, in such an energy range, fail to reproduce the data with the required accuracy. This paper presents the single differential carbon-ion fragmentation cross sections on a thin gold target, measured as a function of the fragment angle and kinetic energy in the forward angular region (theta less than or similar to 6 degrees), aiming to provide useful data for the benchmarking of the simulation softwares used in light ions fragmentation applications. The C-12 ions used in the measurement were accelerated at the energy of 400 MeV/nucleon by the SIS (heavy ion synchrotron) GSI facility.
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| 49. |
- Usoskin, I. G., et al.
(författare)
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Force-field parameterization of the galactic cosmic ray spectrum : Validation for Forbush decreases
- 2015
-
Ingår i: Advances in Space Research. - : Elsevier BV. - 0273-1177 .- 1879-1948. ; 55:12, s. 2940-2945
-
Tidskriftsartikel (refereegranskat)abstract
- A useful parametrization of the energy spectrum of galactic cosmic rays (GCR) near Earth is offered by the so-called force-field model which describes the shape of the entire spectrum with a single parameter, the modulation potential. While the usefulness of the force-field approximation has been confirmed for regular periods of solar modulation, it was not tested explicitly for disturbed periods, when GCR are locally modulated by strong interplanetary transients. Here we use direct measurements of protons and alpha-particles performed by the PAMELA space-borne instrument during December 2006, including a major Forbush decrease, in order to directly test the validity of the force-field parameterization. We conclude that (1) The force-field parametrization works very well in describing the energy spectra of protons and alpha-particles directly measured by PAMELA outside the Earths atmosphere; (2) The energy spectrum of GCR can be well parameterized by the force-field model also during a strong Forbush decrease; (3) The estimate of the GCR modulation parameter, obtained using data from the world-wide neutron monitor network, is in good agreement with the spectra directly measured by PAMELA during the studied interval. This result is obtained on the basis of a single event analysis, more events need to be analyzed.
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| 50. |
- Adriani, O., et al.
(författare)
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MEASUREMENTS OF COSMIC-RAY HYDROGEN AND HELIUM ISOTOPES WITH THE PAMELA EXPERIMENT
- 2016
-
Ingår i: Astrophysical Journal. - 0004-637X .- 1538-4357. ; 818:1
-
Tidskriftsartikel (refereegranskat)abstract
- The cosmic-ray hydrogen and helium (H-1, H-2, He-3, He-4) isotopic composition has been measured with the satellite-borne experiment PAMELA, which was launched into low-Earth orbit on board the Resurs-DK1 satellite on 2006 June 15. The rare isotopes H-2 and He-3 in cosmic rays are believed to originate mainly from the interaction of high-energy protons and helium with the galactic interstellar medium. The isotopic composition was measured between 100 and 1100 MeV/n for hydrogen and between 100 and 1400 MeV/n for helium isotopes using two different detector systems over the 23rd solar minimum from 2006 July to 2007 December.
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