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Träfflista för sökning "WFRF:(Morrison L.) srt2:(1995-1999)"

Search: WFRF:(Morrison L.) > (1995-1999)

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1.	Clarke, M, et al. (author) Ovarian ablation in early breast cancer: overview of the randomised trials. Early Breast Cancer Trialists' Collaborative Group 1996 In: Lancet (London, England). - 0140-6736. ; 348:9036, s. 1189-1196 Journal article (peer-reviewed)
2.	ABE, O, et al. (author) EFFECTS OF RADIOTHERAPY AND SURGERY IN EARLY BREAST-CANCER - AN OVERVIEW OF THE RANDOMIZED TRIALS 1995 In: NEW ENGLAND JOURNAL OF MEDICINE. - 0028-4793. ; 333:22, s. 1444-1455 Journal article (other academic/artistic)
3.	Møller, P, et al. (author) Guidelines for follow-up of women at high risk for inherited breast cancer : consensus statement from the Biomed 2 Demonstration Programme on Inherited Breast Cancer 1999 In: Disease Markers. - 0278-0240. ; 15:1-3, s. 11-207 Journal article (peer-reviewed)
4.	Wang, Z. Q., et al. (author) PARP is important for genomic stability but dispensable in apoptosis 1997 In: Genes & Development. - : Cold Spring Harbor Laboratory Press (CSHL). - 0890-9369 .- 1549-5477. ; 11:18, s. 2347-2358 Journal article (peer-reviewed)abstract Mice lacking the gene encoding poly(ADP-ribosyl) transferase (PARP or ADPRT) display no phenotypic abnormalities, although aged mice are susceptible to epidermal hyperplasia and obesity in a mixed genetic background. Whereas embryonic fibroblasts lacking PARP exhibit normal DNA excision repair, they grow more slowly in vitro. Here we investigated the putative roles of PARP in cell proliferation, cell death, radiosensitivity, and DNA recombination, as well as chromosomal stability. We show that the proliferation deficiency in vitro and in vive is most likely caused by a hypersensitive response to environmental stress. Although PARP is specifically cleaved during apoptosis, cells Backing this molecule apoptosed normally in response to treatment with anti-Fas, tumor neurosis factor alpha, gamma-irradiation, and dexamethasone, indicating that PARP is dispensable in apoptosis and that PARP-/-thymocytes are not hypersensitive to ionizing radiation. Furthermore, the capacity of mutant cells to carry out immunoglobulin class switching and V(D)J recombination is normal. Finally, primary PARP mutant fibroblasts and splenocytes exhibited an elevated frequency of spontaneous sister chromatid exchanges and elevated micronuclei formation after treatment with genotoxic agents, establishing an important role for PARP in the maintenance of genomic integrity.

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Result 1-4 of 4

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Type of publication: journal article (4)

Type of content: peer-reviewed (3); other academic/artistic (1)

Author/Editor: Schumacher, M. (2); Brown, A. (2); Simon, R. (2); Jonat, W. (2); James, S. (2); Jackson, S. (2); show more...; Soderberg, M (2); Cross, M (2); Hill, C. (2); Collins, R (2); Nakamura, Y. (2); Martin, P. (2); Yoshida, M. (2); Abe, O (2); Abe, R (2); Enomoto, K (2); Kikuchi, K (2); Koyama, H (2); Nomura, Y (2); Uchino, J (2); Haybittle, JL (2); Davies, C (2); Harvey, VJ (2); Holdaway, TM (2); Kay, RG (2); Mason, BH (2); Forbes, JF (2); Jakesz, R (2); Yosef, HMA (2); Focan, C (2); Lobelle, JP (2); Peek, U (2); Oates, GD (2); Powell, J (2); Ragaz, J (2); Cirrincione, C (2); Norton, L (2); Weiss, RB (2); Baum, M (2); Cuzick, J (2); Houghton, J (2); Riley, D (2); Gordon, NH (2); Davis, HL (2); Naja, A (2); Dubois, JB (2); Delozier, T (2); Rambert, P (2); Andrysek, O (2); Barkmanova, J (2); show less...

University: Karolinska Institutet (2); Linköping University (1); Lund University (1)

Language: English (4)

Research subject (UKÄ/SCB): Natural sciences (1); Medical and Health Sciences (1)

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