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- Simonsson, Per, et al.
(författare)
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Peripheral serotonergic markers in patients with suicidal behavior
- 1991
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Ingår i: European Neuropsychopharmacology. - 1873-7862. ; 1:4, s. 503-510
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Tidskriftsartikel (refereegranskat)abstract
- Peripheral serotonergic parameters were studied in 17 patients with a history of suicidal behavior and in 17 age- and sex-matched healthy controls. Serotonin2 receptor function in platelets, measured as serotonin-induced [32P]phosphatidylinositol 4,5-bisphosphate hydrolysis, was significantly higher in patients than in age- and sex-matched controls. Increased serotonin2 receptor transduction was not correlated to psychiatric diagnosis, drug treatment or a history of violent suicide attempt. Monoamine oxidase activity was lower in platelets from patients with a history of suicidal behavior than in controls. In addition, whole blood serotonin was analyzed but no significant alterations were found in blood from patients.
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